A glycopeptide in complex with MHC class I uses the GalNAc residue as an anchor.

abstract：:Antibody raised against the purified human erythrocyte glucose transporter specifically precipitated four proteins from normal and Rous sarcoma virus-transformed chicken embryo cells: a major protein of Mr 41,000 and minor proteins of Mr 68,000, 73,000, and 82,000. The Mr 41,000 and 82,000 proteins were found only in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Salter DW,Baldwin SA,Lienhard GE,Weber MJ

更新日期：1982-03-01 00:00:00

abstract：:A cDNA library derived from human cerebral cortex was screened for the presence of sodium channel alpha subunit-specific clones. Ligation of three overlapping clones generated a full-length cDNA clone, HBA, that provided the complete nucleotide sequence coding for a protein of 2005 amino acids. The predicted structure...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ahmed CM,Ware DH,Lee SC,Patten CD,Ferrer-Montiel AV,Schinder AF,McPherson JD,Wagner-McPherson CB,Wasmuth JJ,Evans GA

更新日期：1992-09-01 00:00:00

abstract：:129/SvEv mice with a loss-of-function mutation in the heterotrimeric G protein α-subunit gene Gnai3 have fusions of ribs and lumbar vertebrae, indicating a requirement for Gα(i) (the "inhibitory" class of α-subunits) in somite derivatives. Mice with mutations of Gnai1 or Gnai2 have neither defect, but loss of both Gna...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Plummer NW,Spicher K,Malphurs J,Akiyama H,Abramowitz J,Nürnberg B,Birnbaumer L

更新日期：2012-12-26 00:00:00

abstract：:Lissencephaly is a severe brain malformation in humans. To study the function of the gene mutated in lissencephaly (LIS1), we deleted the first coding exon from the mouse Lis1 gene. The deletion resulted in a shorter protein (sLIS1) that initiates from the second methionine, a unique situation because most LIS1 mutati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cahana A,Escamez T,Nowakowski RS,Hayes NL,Giacobini M,von Holst A,Shmueli O,Sapir T,McConnell SK,Wurst W,Martinez S,Reiner O

更新日期：2001-05-22 00:00:00

abstract：:Programmed cell death (apoptosis) is a normal physiological process, which could in principle be manipulated to play an important role in cancer therapy. The key importance of p53 expression in the apoptotic response to DNA-damaging agents has been stressed because mutant or deleted p53 is so common in most kinds of c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu C,Meikrantz W,Schlegel R,Sager R

更新日期：1995-08-15 00:00:00

abstract：:Transgenic mice have been used to address the issue of the oncogenic potential of mutant guanine nucleotide stimulatory factor (Gs) alpha subunit in the thyroid gland. The expression of the mutant Arg-201-->His Gs alpha subunit transgene has been directed to murine thyroid epithelial cells by bovine thyroglobulin prom...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Michiels FM,Caillou B,Talbot M,Dessarps-Freichey F,Maunoury MT,Schlumberger M,Mercken L,Monier R,Feunteun J

更新日期：1994-10-25 00:00:00

abstract：:Tumor hypoxia and the hypoxia-inducible factors (HIFs) play a central role in the development of cancer. To study the relationship between tumor growth, tumor hypoxia, the stabilization of HIF-1alpha, and HIF transcriptional activity, we have established an in vivo imaging tool that allows longitudinal and noninvasive...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lehmann S,Stiehl DP,Honer M,Dominietto M,Keist R,Kotevic I,Wollenick K,Ametamey S,Wenger RH,Rudin M

更新日期：2009-08-18 00:00:00

abstract：:A natural (evolutionary) classification is provided for 242 basic helix-loop-helix (bHLH) motif-containing proteins. Phylogenetic analyses of amino acid sequences describe the patterns of evolutionary change within the motif and delimit evolutionary lineages. These evolutionary lineages represent well known functional...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Atchley WR,Fitch WM

更新日期：1997-05-13 00:00:00

abstract：:Vascular endothelial growth factor C (VEGF-C) recently has been described to be a relatively specific growth factor for the lymphatic vascular system. Here we report that ectopic application of recombinant VEGF-C also has potent angiogenic effects in vivo. VEGF-C is sufficiently potent to stimulate neovascularization ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cao Y,Linden P,Farnebo J,Cao R,Eriksson A,Kumar V,Qi JH,Claesson-Welsh L,Alitalo K

更新日期：1998-11-24 00:00:00

abstract：:The unfolded protein response (UPR) is an evolutionarily conserved mechanism by which all eukaryotic cells adapt to the accumulation of unfolded proteins in the endoplasmic reticulum (ER). Inositol-requiring kinase 1 (IRE1) and PKR-related ER kinase (PERK) are two type I transmembrane ER-localized protein kinase recep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou J,Liu CY,Back SH,Clark RL,Peisach D,Xu Z,Kaufman RJ

更新日期：2006-09-26 00:00:00

abstract：:The importance of dystrophin and its associated proteins in normal muscle function is now well established. Many of these proteins are expressed in nonmuscle tissues, particularly the brain. Here we describe the characterization of beta-dystrobrevin, a dystrophin-related protein that is abundantly expressed in brain a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blake DJ,Nawrotzki R,Loh NY,Górecki DC,Davies KE

更新日期：1998-01-06 00:00:00

abstract：:Sulfated glycosaminoglycans (GAGs) such as heparan sulfate (HS) are heteropolysaccharides implicated in the pathology of protein aggregation diseases including localized and systemic forms of amyloidosis. Among subdomains of sulfated GAGs, highly sulfated domains of HS, called HS S-domains, have been highlighted as be...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Iwahashi N,Ikezaki M,Nishikawa T,Namba N,Ohgita T,Saito H,Ihara Y,Shimanouchi T,Ino K,Uchimura K,Nishitsuji K

更新日期：2020-12-29 00:00:00

abstract：:Block of Ca2+ currents by the dihydropyridine drug nitrendipine was studied in single canine ventricular cells by using the whole-cell variant of the patch clamp technique. When cells were held at depolarized membrane potentials at which Ca2+ currents were approximately equal to 70% inactivated, nitrendipine blocked C...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bean BP

更新日期：1984-10-01 00:00:00

abstract：:We provide a framework for structural multiscale geometric organization of graphs and subsets of R(n). We use diffusion semigroups to generate multiscale geometries in order to organize and represent complex structures. We show that appropriately selected eigenfunctions or scaling functions of Markov matrices, which d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Coifman RR,Lafon S,Lee AB,Maggioni M,Nadler B,Warner F,Zucker SW

更新日期：2005-05-24 00:00:00

abstract：:In confluent fibroblast monolayers, an increase in the selective uptake of free cholesterol (FC) from plasma low density lipoprotein (LDL) was accompanied by an increase in FC efflux. The rate of FC efflux was proportional to the FC content of the cell surface caveolae and to mRNA levels of caveolin, an FC-binding pro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fielding CJ,Bist A,Fielding PE

更新日期：1997-04-15 00:00:00

abstract：:In response to insect attack, many plants exhibit dynamic biochemical changes, resulting in the induced production of direct and indirect defenses. Elicitors present in herbivore oral secretions are believed to positively regulate many inducible plant defenses; however, little is known about the specificity of elicito...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schmelz EA,Engelberth J,Alborn HT,Tumlinson JH 3rd,Teal PE

更新日期：2009-01-13 00:00:00

abstract：:The B-cell antigen receptor is composed of membrane immunoglobulin sheathed by an alpha/beta heterodimer. The complex is noncovalently associated with protein kinase activity, and crosslinking of the receptor leads to capping and transmembrane signaling. Here we show that the sheath is not necessary either for this ca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Williams GT,Peaker CJ,Patel KJ,Neuberger MS

更新日期：1994-01-18 00:00:00

abstract：:It has been recently shown that malignant activation of the c-has/bas proto-oncogene in T24 human bladder carcinoma cells was mediated by a single point mutation. A deoxyguanosine located at position 35 of the first exon of this proto-oncogene was substituted by thymidine. These findings predicted that the resulting o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Santos E,Reddy EP,Pulciani S,Feldmann RJ,Barbacid M

更新日期：1983-08-01 00:00:00

abstract：:The reported isolation of nanobacteria from human kidney stones raises the intriguing possibility that these microorganisms are etiological agents of pathological extraskeletal calcification [Kajander, E. O. & Ciftçioglu, N. (1998) Proc. Natl. Acad. Sci. USA 95, 8274-8279]. Nanobacteria were previously isolated from F...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cisar JO,Xu DQ,Thompson J,Swaim W,Hu L,Kopecko DJ

更新日期：2000-10-10 00:00:00

abstract：:Tubular membrane structures are widespread in eukaryotic cells, but the mechanisms underlying their formation and stability are not well understood. Previous work has focused on tube extrusion from cells and model membranes under the application of external forces. Here, we present novel membrane/polymer systems, wher...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li Y,Lipowsky R,Dimova R

更新日期：2011-03-22 00:00:00

abstract：:We report the presence of protein kinase C (PKC) in ejaculated human sperm as revealed by enzymatic activity assay and indirect immunohistochemistry. PKC is localized in the equatorial segment and in the principal piece of the tail. Addition of phorbol 12-myristate 13-acetate resulted in increased flagellar motility t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rotem R,Paz GF,Homonnai ZT,Kalina M,Naor Z

更新日期：1990-09-01 00:00:00

abstract：:Neuronal signal integration as well as synaptic transmission and plasticity highly depend on the morphology of dendrites and their spines. Nogo-A is a membrane protein enriched in the adult central nervous system (CNS) myelin, where it restricts the capacity of axons to grow and regenerate after injury. Nogo-A is also...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Petrinovic MM,Hourez R,Aloy EM,Dewarrat G,Gall D,Weinmann O,Gaudias J,Bachmann LC,Schiffmann SN,Vogt KE,Schwab ME

更新日期：2013-01-15 00:00:00

abstract：:Seawater Mg:Ca and Sr:Ca ratios are biogeochemical parameters reflecting the Earth-ocean-atmosphere dynamic exchange of elements. The ratios' dependence on the environment and organisms' biology facilitates their application in marine sciences. Here, we present a measured single-laboratory dataset, combined with previ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lebrato M,Garbe-Schönberg D,Müller MN,Blanco-Ameijeiras S,Feely RA,Lorenzoni L,Molinero JC,Bremer K,Jones DOB,Iglesias-Rodriguez D,Greeley D,Lamare MD,Paulmier A,Graco M,Cartes J,Barcelos E Ramos J,de Lara A,Sanchez-Lea

更新日期：2020-09-08 00:00:00

abstract：:Mutation of the p53 gene is one of the most frequent genetic changes found in human cancers. Recent experiments indicated that p53 might contain a transcription-activating domain, which functions when directed to a promoter. This study shows that wild-type p53 suppresses transcription of the retinoblastoma (Rb) gene. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shiio Y,Yamamoto T,Yamaguchi N

更新日期：1992-06-15 00:00:00

abstract：:Seventeen monoclonal antibodies derived from fusions with spleen cells of mice immunized with established culture lines of renal cancers identified nine cell-surface antigenic systems. Six of the systems (gp160, S25, gp120r, gp120nr, gp115, and V1) represent antigens not previously described. The other three systems a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ueda R,Ogata S,Morrissey DM,Finstad CL,Szkudlarek J,Whitmore WF,Oettgen HF,Lloyd KO,Old LJ

更新日期：1981-08-01 00:00:00

abstract：:Embryonic stem cells can be induced in vitro, by coculture with the stromal line RP.0.10 and a mixture of interleukins 3, 6, and 7, to differentiate into T (Joro75+) and B (B-220+) lymphocyte progenitors and other (Thy-1+, PgP-1+, c-kit+, Joro75-, B-220-, F4/80-, Mac-1-) hemopoietic precursors. The progeny of in vitro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gutierrez-Ramos JC,Palacios R

更新日期：1992-10-01 00:00:00

abstract：:This paper presents a statistical framework for harnessing online activity data to better understand how people make decisions. Building on insights from cognitive science and decision theory, we develop a discrete choice model that allows for exploratory behavior and multiple stages of decision making, with different...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bruch E,Feinberg F,Lee KY

更新日期：2016-09-20 00:00:00

abstract：:We have investigated the role of cAMP in NO- and prostanoid-independent relaxations that are widely attributed to an endothelium-derived hyperpolarizing factor (EDHF). Under control conditions EDHF-type relaxations evoked by acetylcholine (ACh) in rabbit iliac arteries were transient, but in the presence of the cAMP p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Griffith TM,Chaytor AT,Taylor HJ,Giddings BD,Edwards DH

更新日期：2002-04-30 00:00:00

abstract：:Blood vessels and nerves often follow parallel trajectories, suggesting that distal targets use common cues that induce vascularization and innervation. Netrins are secreted by the floor plate and attract commissural axons toward the midline of the neural tube. Here, we show that Netrin-1 is also a potent vascular mit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park KW,Crouse D,Lee M,Karnik SK,Sorensen LK,Murphy KJ,Kuo CJ,Li DY

更新日期：2004-11-16 00:00:00

abstract：:Plants can sense the direction of gravity and change the growth orientation of their organs. The molecular mechanisms of gravity sensing and signal transduction during gravitropism are not well known. We have isolated several shoot gravitropism (sgr) mutants of Arabidopsis. The sgr3-1 mutant exhibits a reduced gravitr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yano D,Sato M,Saito C,Sato MH,Morita MT,Tasaka M

更新日期：2003-07-08 00:00:00