The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response.

abstract：:Renal cell carcinoma (RCC) and normal kidney tissues have been examined from 34 patients with sporadic, nonhereditary RCC. Eighteen of the 21 cytogenetically examined tumors (86%) had a detectable anomaly of chromosome arm 3p distal to band 3p11.2-p13, manifested as a deletion, combined with the nonreciprocal transloc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kovacs G,Erlandsson R,Boldog F,Ingvarsson S,Müller-Brechlin R,Klein G,Sümegi J

更新日期：1988-03-01 00:00:00

abstract：:Interleukin 2 (IL-2) plays a critical role in the growth and differentiation of lymphoid cells. The IL-2 signal is delivered intracellularly by the IL-2 receptor beta chain (IL-2R beta); however, the mechanism by which the signal reaches the nucleus remains unclear. In this study, we demonstrate the rapid activation o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hatakeyama M,Kawahara A,Mori H,Shibuya H,Taniguchi T

更新日期：1992-03-15 00:00:00

abstract：:Trace greenhouse gases are a fundamentally important component of Earth's global climate system sensitive to global change. However, their concentration in the pre-Pleistocene atmosphere during past warm greenhouse climates is highly uncertain because we lack suitable geochemical or biological proxies. This long-stand...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Beerling DJ,Fox A,Stevenson DS,Valdes PJ

更新日期：2011-06-14 00:00:00

abstract：:Caenorhabditis elegans sqv mutants are defective in vulval epithelial invagination and have a severe reduction in hermaphrodite fertility. The gene sqv-7 encodes a multitransmembrane hydrophobic protein resembling nucleotide sugar transporters of the Golgi membrane. A Golgi vesicle enriched fraction of Saccharomyces c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berninsone P,Hwang HY,Zemtseva I,Horvitz HR,Hirschberg CB

更新日期：2001-03-27 00:00:00

abstract：:The conversion of cells from a normal phenotype to full malignancy apparently requires multiple genetic events. Efforts to reconstruct multistep tumorigenesis in cell culture have shown that two types of oncogenes (typified by HRAS and MYC) can cooperate to elicit complete transformation. Transformation of embryonic r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hjelle B,Liu E,Bishop JM

更新日期：1988-06-01 00:00:00

abstract：:Adrenocortical carcinomas (ACCs) are rare and highly malignant cancers associated with poor survival of patients. Currently, mitotane, a nonspecific derivative of the pesticide DDT (1,1-(dichlorobiphenyl)-2,2-dichloroethane), is used as the standard treatment, but its mechanism of action in ACCs remains elusive. Here ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Belavgeni A,Bornstein SR,von Mässenhausen A,Tonnus W,Stumpf J,Meyer C,Othmar E,Latk M,Kanczkowski W,Kroiss M,Hantel C,Hugo C,Fassnacht M,Ziegler CG,Schally AV,Krone NP,Linkermann A

更新日期：2019-10-29 00:00:00

abstract：:The Alzheimer A beta amyloid peptide (A beta) is the principal proteinaceous component of amyloid associated with Alzheimer disease (AD). We have determined the relative abundance of A beta structural variants present in amyloid from brains of 10 individuals with sporadic AD, 2 individuals with familial AD carrying sp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Näslund J,Schierhorn A,Hellman U,Lannfelt L,Roses AD,Tjernberg LO,Silberring J,Gandy SE,Winblad B,Greengard P

更新日期：1994-08-30 00:00:00

abstract：:Despite structural knowledge of broadly neutralizing monoclonal antibodies (NMAbs) complexed to HIV-1 gp120 and gp41 envelope glycoproteins, virus inactivation mechanisms have been difficult to prove, in part because neutralization assays are complex and were previously not understood. Concordant with recent evidence ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Platt EJ,Gomes MM,Kabat D

更新日期：2012-05-15 00:00:00

abstract：:The effect of reflex splanchnic nerve stimulation on proenkephalin A biosynthesis was investigated in the rat adrenal medulla. Tissue levels of native [Met5]enkephalin-like immunoreactivity (IR) (measured by direct RIA of tissue extracts), cryptic [Met5]enkephalin-like IR (calculated as the increase in [Met5]enkephali...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kanamatsu T,Unsworth CD,Diliberto EJ Jr,Viveros OH,Hong JS

更新日期：1986-12-01 00:00:00

abstract：:Seamless and minimally invasive integration of 3D electronic circuitry within host materials could enable the development of materials systems that are self-monitoring and allow for communication with external environments. Here, we report a general strategy for preparing ordered 3D interconnected and addressable macr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu J,Xie C,Dai X,Jin L,Zhou W,Lieber CM

更新日期：2013-04-23 00:00:00

abstract：:Shiverer (shi) is an autosomal recessive mutation in the mouse characterized by an almost total lack of central nervous system myelin. While small amounts of other myelin components are present in the brain of the shi mouse, the four forms of myelin basic protein (MBP) are not detectable. Previous investigations by us...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Molineaux SM,Engh H,de Ferra F,Hudson L,Lazzarini RA

更新日期：1986-10-01 00:00:00

abstract：:A central tenet in understanding the biological effects of ionizing radiation has been that the initially affected cells were directly damaged by the radiation. By contrast, evidence has emerged concerning "bystander" responses involving damage to nearby cells that were not themselves directly traversed by the radiati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Belyakov OV,Mitchell SA,Parikh D,Randers-Pehrson G,Marino SA,Amundson SA,Geard CR,Brenner DJ

更新日期：2005-10-04 00:00:00

abstract：:Remembering is a complex process that involves recalling specific details, such as who you were with when you celebrated your last birthday, as well as contextual information, such as the place where you celebrated. It is well established that the act of remembering enhances long-term retention of the retrieved inform...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jonker TR,Dimsdale-Zucker H,Ritchey M,Clarke A,Ranganath C

更新日期：2018-10-23 00:00:00

abstract：:A vitamin D(3) metabolite in intestine more polar than 25-hydroxy-vitamin D(3)(25-OH D(3)) has been detected by countercurrent distribution. The intestinal metabolite is found also after administration of labeled hydroxy D(3), indicating that it arises from vitamin D(3) via the intermediate 25-hydroxy derivative. The ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Haussler MR,Boyce DW,Littledike ET,Rasmussen H

更新日期：1971-01-01 00:00:00

abstract：:If excision repair-proficient human cells are allowed time for repair before onset of S phase, the premutagenic lesions formed by (+/-)-7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy- 7,8,9,10-tetrahydrobenzo[a]pyrene (benzo[a]pyrene diol epoxide, BPDE) are lost from the transcribed strand of the hypoxanthine (guanin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen RH,Maher VM,Brouwer J,van de Putte P,McCormick JJ

更新日期：1992-06-15 00:00:00

abstract：:The bacterial pathogen Helicobacter pylori chronically infects the human gastric mucosa and is the leading risk factor for the development of gastric cancer. The molecular mechanisms of H. pylori-associated gastric carcinogenesis remain ill defined. In this study, we examined the possibility that H. pylori directly co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Toller IM,Neelsen KJ,Steger M,Hartung ML,Hottiger MO,Stucki M,Kalali B,Gerhard M,Sartori AA,Lopes M,Müller A

更新日期：2011-09-06 00:00:00

abstract：:Macrophage migration inhibitory factor (MIF) is a mediator of host immunity and functions as a high, upstream activator of cells within the innate and the adaptive immunological systems. Recent studies have suggested a potentially broader role for MIF in growth regulation because of its ability to antagonize p53-media...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fingerle-Rowson G,Petrenko O,Metz CN,Forsthuber TG,Mitchell R,Huss R,Moll U,Müller W,Bucala R

更新日期：2003-08-05 00:00:00

abstract：:Signals propagated by receptor tyrosine kinases (RTKs) can drive cell migration and proliferation, two cellular processes that do not occur simultaneously--a phenomenon called "migration-proliferation dichotomy." We previously showed that epidermal growth factor (EGF) signaling is skewed to favor migration over prolif...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bhandari D,Lopez-Sanchez I,To A,Lo IC,Aznar N,Leyme A,Gupta V,Niesman I,Maddox AL,Garcia-Marcos M,Farquhar MG,Ghosh P

更新日期：2015-09-01 00:00:00

abstract：:In the absence of adaptive immunity displayed by animals, plants respond locally to biotic challenge via inducible basal defense networks activated through recognition and response to conserved pathogen-associated molecular patterns. In addition, immunity can be induced in tissues remote from infection sites by system...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Truman W,Bennett MH,Kubigsteltig I,Turnbull C,Grant M

更新日期：2007-01-16 00:00:00

abstract：:ErbB3 (HER3) is a member of the EGF receptor (EGFR) family of receptor tyrosine kinases, which, unlike the other three family members, contains a pseudo kinase in place of a tyrosine kinase domain. In cancer, ErbB3 activation is driven by a ligand-dependent mechanism through the formation of heterodimers with EGFR, Er...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee S,Greenlee EB,Amick JR,Ligon GF,Lillquist JS,Natoli EJ Jr,Hadari Y,Alvarado D,Schlessinger J

更新日期：2015-10-27 00:00:00

abstract：:Jasmonates (JAs) are plant-specific signaling molecules that steer a diverse set of physiological and developmental processes. Pathogen attack and wounding inflicted by herbivores induce the biosynthesis of these hormones, triggering defense responses both locally and systemically. We report on alterations in the tran...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pauwels L,Morreel K,De Witte E,Lammertyn F,Van Montagu M,Boerjan W,Inzé D,Goossens A

更新日期：2008-01-29 00:00:00

abstract：:Surface proteins of mouse thymus and spleen cells were radioiodinated with lactoperoxidase. After solubilization, the labeled proteins were precipitated by antibodies directed against mouse immunoglobulin chains; the precipitates were analyzed by radioautography after Na dodecyl sulfate-gel electrophoresis. Radioactiv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lisowska-Bernstein B,Rinuy A,Vassalli P

更新日期：1973-10-01 00:00:00

abstract：:Legionella pneumophila is an intracellular parasite of freshwater protozoa and human macrophages. Recent studies determined that the macrophage infectivity potentiator (Mip) surface protein, a prokaryotic homolog of the FK506-binding proteins, is required for optimal infection of macrophages. To determine whether Mip ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cianciotto NP,Fields BS

更新日期：1992-06-01 00:00:00

abstract：:Understanding the complexity of anisotropic turbulent processes over a wide range of spatiotemporal scales in engineering shear turbulence as well as climate atmosphere ocean science is a grand challenge of contemporary science with important societal impact. In such inhomogeneous turbulent dynamical systems there is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Majda AJ

更新日期：2015-07-21 00:00:00

abstract：:Aggregation of marine sponge cells (Microciona prolifera) resembles stimulus-response coupling of higher organisms in which activation of protein kinase C and movements of intracellular Ca provide twin signals. We now report that activators of protein kinase C (phorbol esters) and ionomycin act synergistically to aggr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weissmann G,Azaroff L,Davidson S,Dunham P

更新日期：1986-05-01 00:00:00

abstract：:Brain src protooncogene is expressed in two forms, one identical to message in other tissues, and one containing an 18-nucleotide insert specific to brain. We have mapped mRNA for the two forms of src in rat brain with selective antisense oligonucleotide probes to the brain (src+) and peripheral (src-) forms. Fetal ra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ross CA,Wright GE,Resh MD,Pearson RC,Snyder SH

更新日期：1988-12-01 00:00:00

abstract：:EF-hand Ca(II) binding sites share a conserved architecture and are prevalent in Ca(II) signaling pathways. The ion binding kinetics of these sites are carefully tuned to provide the physiologically appropriate activation and inactivation time scales. Here we examine kinetic tuning by the side chain at the ninth posit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Renner M,Danielson MA,Falke JJ

更新日期：1993-07-15 00:00:00

abstract：:Epigenetics regulation plays a critical role in determining cell identity by controlling the accessibility of lineage-specific regulatory regions. In muscle stem cells, epigenetic mechanisms of how chromatin accessibility is modulated during cell fate determination are not fully understood. Here, we identified a long ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dong A,Preusch CB,So WK,Lin K,Luan S,Yi R,Wong JW,Wu Z,Cheung TH

更新日期：2020-12-22 00:00:00

abstract：:Sugar transport across tonoplasts is essential for maintaining cellular sugar homeostasis and metabolic balance in plant cells. It remains unclear, however, how this process is regulated among different classes of sugar transporters. Here, we identified a tonoplast H+/glucose symporter, MdERDL6-1, from apples, which w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhu L,Li B,Wu L,Li H,Wang Z,Wei X,Ma B,Zhang Y,Ma F,Ruan YL,Li M

更新日期：2021-01-05 00:00:00

abstract：:Separation of cells is a critical process for studying cell properties, disease diagnostics, and therapeutics. Cell sorting by acoustic waves offers a means to separate cells on the basis of their size and physical properties in a label-free, contactless, and biocompatible manner. The separation sensitivity and effici...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ding X,Peng Z,Lin SC,Geri M,Li S,Li P,Chen Y,Dao M,Suresh S,Huang TJ

更新日期：2014-09-09 00:00:00