The p53-dependent effects of macrophage migration inhibitory factor revealed by gene targeting.

abstract：:Arginine methylation has emerged as a widespread and reversible protein modification with the potential to regulate a multitude of cellular processes, but its function is poorly understood. Endolysosomes play an important role in Wnt signaling, in which glycogen synthase kinase 3 (GSK3) becomes sequestered inside mult...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Albrecht LV,Ploper D,Tejeda-Muñoz N,De Robertis EM

更新日期：2018-06-05 00:00:00

abstract：:Three classes of heterogeneous nuclear RNA (HnRNA) alpha, beta, and gamma, with different chemical and physical properties, can be identified in the early sea urchin embryo by hybridization with poly(U). The relative amounts of these classes vary as a function of embryonic development. It is demonstrated here that the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dubroff LM

更新日期：1977-06-01 00:00:00

abstract：:8-Oxoguanine (8OG) is efficiently bypassed by RNA polymerases in vitro and in bacterial cells in vivo, leading to mutant transcripts by directing incorporation of an incorrect nucleotide during transcription. Such transcriptional mutagenesis (TM) may produce a pool of mutant proteins. In contrast, transcription-couple...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saxowsky TT,Meadows KL,Klungland A,Doetsch PW

更新日期：2008-12-02 00:00:00

abstract：:The precipitation and assembly of calcium carbonate skeletons by stony corals is a precisely controlled process regulated by the secretion of an ECM. Recently, it has been reported that the proteome of the skeletal organic matrix (SOM) contains a group of coral acid-rich proteins as well as an assemblage of adhesion a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mass T,Drake JL,Peters EC,Jiang W,Falkowski PG

更新日期：2014-09-02 00:00:00

abstract：:Cysteine site-directed mutagenesis was used to create variants of Escherichia coli ribosomal protein L7/L12 that have single cysteine substitutions, at residues 63 or 89, located in different exposed loops in the structure of the globular C-terminal domain indicated by the crystallographic structure. That structure sh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oleinikov AV,Jokhadze GG,Traut RR

更新日期：1993-11-01 00:00:00

abstract：:The Prisoner's Dilemma (PD) is a widely employed metaphor for problems associated with the evolution of cooperative behavior. We have recently proposed an alternative approach to the PD, by exploring "spatial games" in which players--who are either pure cooperators, C, or pure defectors, D--interact with neighbors in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nowak MA,Bonhoeffer S,May RM

更新日期：1994-05-24 00:00:00

abstract：:Beneficial mutations are the driving force of adaptive evolution. In asexual populations, the identification of beneficial alleles is confounded by the presence of genetically linked hitchhiker mutations. Parallel evolution experiments enable the recognition of common targets of selection; yet these targets are inhere...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Buskirk SW,Peace RE,Lang GI

更新日期：2017-08-01 00:00:00

abstract：:Arabidopsis thaliana endosperm, a transient tissue that nourishes the embryo, exhibits extensive localized DNA demethylation on maternally inherited chromosomes. Demethylation mediates parent-of-origin-specific (imprinted) gene expression but is apparently unnecessary for the extensive accumulation of maternally biase...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rodrigues JA,Ruan R,Nishimura T,Sharma MK,Sharma R,Ronald PC,Fischer RL,Zilberman D

更新日期：2013-05-07 00:00:00

abstract：:The circadian clock is based on a transcriptional feedback loop with an essential time delay before feedback inhibition. Previous work has shown that PERIOD (PER) proteins generate circadian time cues through rhythmic nuclear accumulation of the inhibitor complex and subsequent interaction with the activator complex i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Beesley S,Kim DW,D'Alessandro M,Jin Y,Lee K,Joo H,Young Y,Tomko RJ Jr,Faulkner J,Gamsby J,Kim JK,Lee C

更新日期：2020-11-10 00:00:00

abstract：:A sensitive, labor-saving, and easily automatable nonradioactive procedure named APEX-FCS (amplified probe extension detected by fluorescence correlation spectroscopy) has been established to detect specific in vitro amplification of pathogen genomic sequences. As an example, Mycobacterium tuberculosis genomic DNA was...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Walter NG,Schwille P,Eigen M

更新日期：1996-11-12 00:00:00

abstract：:Traits that enable species to persist in ecological environments are often maintained over time, a phenomenon known as niche conservatism. Here we argue that ecological niches function at levels above species, notably at the level of genus for mammals, and that niche conservatism is also evident above the species leve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hadly EA,Spaeth PA,Li C

更新日期：2009-11-17 00:00:00

abstract：:Electron collisions with atoms, ions, molecules, and surfaces are critically important to the understanding and modeling of low-temperature plasmas (LTPs), and so in the development of technologies based on LTPs. Recent progress in obtaining experimental benchmark data and the development of highly sophisticated compu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bartschat K,Kushner MJ

更新日期：2016-06-28 00:00:00

abstract：:Modern European genetic structure demonstrates strong correlations with geography, while genetic analysis of prehistoric humans has indicated at least two major waves of immigration from outside the continent during periods of cultural change. However, population-level genome data that could shed light on the demograp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Veeramah KR,Rott A,Groß M,van Dorp L,López S,Kirsanow K,Sell C,Blöcher J,Wegmann D,Link V,Hofmanová Z,Peters J,Trautmann B,Gairhos A,Haberstroh J,Päffgen B,Hellenthal G,Haas-Gebhard B,Harbeck M,Burger J

更新日期：2018-03-27 00:00:00

abstract：:The discovery of high-temperature superconductivity in iron pnictides raised the possibility of an unconventional superconducting mechanism in multiband materials. The observation of Fermi-surface (FS)-dependent nodeless superconducting gaps suggested that inter-FS interactions may play a crucial role in superconducti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Terashima K,Sekiba Y,Bowen JH,Nakayama K,Kawahara T,Sato T,Richard P,Xu YM,Li LJ,Cao GH,Xu ZA,Ding H,Takahashi T

更新日期：2009-05-05 00:00:00

abstract：:Group A Streptococcus (GAS) and other bacterial pathogens are known to interact with integrins as an initial step in a complex pathway of bacterial ingestion by host cells. Efficient GAS invasion depends on the interaction of bound fibronectin (Fn) with integrins and activation of integrin signaling. TGF-beta1 regulat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang B,Li S,Southern PJ,Cleary PP

更新日期：2006-02-14 00:00:00

abstract：:Two human B-cell differentiation antigens, Bp35 and Bp50, apparently play distinct roles as signal receptors in B-cell activation. Monoclonal antibodies (mAbs) to either Bp35 or Bp50 deliver positive signals to B cells that stimulate their transition through the cell cycle. mAb to Bp35, like anti-immunoglobulin antibo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clark EA,Ledbetter JA

更新日期：1986-06-01 00:00:00

abstract：:The pore domain of voltage-gated potassium (Kv) channels consists of transmembrane helices S5 and S6, the turret, the pore helix, the selectivity filter, and the loop preceding S6, with a tertiary reentrant structure between S5 and S6. Using biogenic intermediates, mass tagging (pegylation), and a molecular tape measu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gajewski C,Dagcan A,Roux B,Deutsch C

更新日期：2011-02-22 00:00:00

abstract：:The role of chemotaxis in the virulence of gastrointestinal pathogens is ill defined. Counterintuitively, nonchemotactic mutants of the polarly flagellated pathogen Vibrio cholerae greatly out-compete the wild-type strain during infection of the small intestine. We show that the out-competition phenotype is dependent ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Butler SM,Camilli A

更新日期：2004-04-06 00:00:00

abstract：:The benzo[a]pyrene 4,5-, 7,8-, and 9,10-oxides and the six corresponding phenols (4-, 5-, 7-, 8-, 9-, and 10-hydroxybenzo[a]pyrene) have been tested for mutagenic and cytotoxic activity in bacteria and in a mammalian cell culture system. Benzo[a]pyrene 4,5-oxide (K-region) was highly mutagenic in two histidine-depende...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wood AW,Goode RL,Chang RL,Levin W,Conney AH,Yagi H,Dansette PM,Jerina DM

更新日期：1975-08-01 00:00:00

abstract：:In the last few years, data from experiments employing transgenic models of autoimmune disease have strengthened a particular concept of autoimmunity: disease results not so much from cracks in tolerance induction systems, leading to the generation of anti-self repertoire, as from the breakdown of secondary systems th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： André I,Gonzalez A,Wang B,Katz J,Benoist C,Mathis D

更新日期：1996-03-19 00:00:00

abstract：:Neuronal signal integration as well as synaptic transmission and plasticity highly depend on the morphology of dendrites and their spines. Nogo-A is a membrane protein enriched in the adult central nervous system (CNS) myelin, where it restricts the capacity of axons to grow and regenerate after injury. Nogo-A is also...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Petrinovic MM,Hourez R,Aloy EM,Dewarrat G,Gall D,Weinmann O,Gaudias J,Bachmann LC,Schiffmann SN,Vogt KE,Schwab ME

更新日期：2013-01-15 00:00:00

abstract：:The transformation of new experiences into lasting memories is thought to be mediated by postencoding reactivation or the reexpression of activity patterns that characterize prior encoding experiences during subsequent offline periods. Although hippocampal reactivation has been well-described in the rodent, evidence f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tambini A,Davachi L

更新日期：2013-11-26 00:00:00

abstract：:Hearing loss is the main limitation of radiation therapy for vestibular schwannoma (VS), and identifying treatment options that minimize hearing loss are urgently needed. Treatment with bevacizumab is associated with tumor control and hearing improvement in neurofibromatosis type 2 (NF2) patients; however, its effect ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gao X,Zhao Y,Stemmer-Rachamimov AO,Liu H,Huang P,Chin S,Selig MK,Plotkin SR,Jain RK,Xu L

更新日期：2015-11-24 00:00:00

abstract：:Gap junctions are specialized membrane regions that seem to mediate intercellular communication. They appear to contain closely packed arrays of equally sized particles all of which, upon freeze-cleaving, remain attached to one membrane leaflet and not to the other. One gap junction cleavage face, therefore, always ex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Staehelin LA

更新日期：1972-05-01 00:00:00

abstract：:Phosphorylation of inositol phospholipids plays a key role in cellular regulation via the generation of intracellular second messengers. In addition, it represents a mechanism to regulate interactions of the lipid bilayer with proteins and protein scaffolds involved in vesicle budding, cytoskeletal organization, and s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guo J,Wenk MR,Pellegrini L,Onofri F,Benfenati F,De Camilli P

更新日期：2003-04-01 00:00:00

abstract：:High genetic diversity of East Asian village dogs has recently been used to argue for an East Asian origin of the domestic dog. However, global village dog genetic diversity and the extent to which semiferal village dogs represent distinct, indigenous populations instead of admixtures of various dog breeds has not bee...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boyko AR,Boyko RH,Boyko CM,Parker HG,Castelhano M,Corey L,Degenhardt JD,Auton A,Hedimbi M,Kityo R,Ostrander EA,Schoenebeck J,Todhunter RJ,Jones P,Bustamante CD

更新日期：2009-08-18 00:00:00

abstract：:The CuAAC reaction (click chemistry) has been used in conjunction with solid-phase synthesis to produce catalytically active hairpin ribozymes around 100 nucleotides in length. Cross-strand ligation through neighboring nucleobases was successful in covalently linking presynthesized RNA strands with high efficiency (tr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： El-Sagheer AH,Brown T

更新日期：2010-08-31 00:00:00

abstract：:For a constant membrane potential, a predominantly inhibitory GABAergic synaptic response is shown to undergo long-term transformation into an excitatory response after pairing of exogenous gamma-aminobutyric acid (GABA) with postsynaptic depolarization or pairing of pre- and postsynaptic stimulation. Current- and vol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alkon DL,Sánchez-Andrés JV,Ito E,Oka K,Yoshioka T,Collin C

更新日期：1992-12-15 00:00:00

abstract：:The bottom-up design of protein-based signaling networks is a key goal of synthetic biology; yet, it remains elusive due to our inability to tailor-make signal transducers and receptors that can be readily compiled into defined signaling networks. Here, we report a generic approach for the construction of protein-base...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stein V,Alexandrov K

更新日期：2014-11-11 00:00:00

abstract：:PCR was used to isolate nucleotide sequences that may encode novel members of the neuropeptide Y receptor family. By use of a PCR product as a hybridization probe, a full-length human cDNA was isolated that encodes a 375-aa protein with a predicted membrane topology identifying it as a member of the G-protein-coupled ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yan H,Yang J,Marasco J,Yamaguchi K,Brenner S,Collins F,Karbon W

更新日期：1996-05-14 00:00:00