Mutagenic and cytotoxic activity of benzol[a]pyrene 4,5-, 7,8-, and 9,10-oxides and the six corresponding phenols.

abstract：:Cellular regulation by certain growth factor receptors and protooncogene products involves tyrosine kinase activity with the resultant tyrosine phosphorylation of protein substrates. In the present report we describe the distribution of phosphotyrosine-containing material detected by immunocytochemistry (ICC) in the r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moss AM,Unger JW,Moxley RT,Livingston JN

更新日期：1990-06-01 00:00:00

abstract：:Inhibition of eicosanoid formation in larvae of the tobacco hornworm Manduca sexta, using specific inhibitors of phospholipase A2, cyclooxygenase, and lipoxygenase, severely weakened the ability of larvae to clear the bacterium Serratia marscescens from their hemolymph. The reduced capability to remove bacteria is ass...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stanley-Samuelson DW,Jensen E,Nickerson KW,Tiebel K,Ogg CL,Howard RW

更新日期：1991-02-01 00:00:00

abstract：:Adoptive T cell therapy, involving the ex vivo selection and expansion of antigen-specific T cell clones, provides a means of augmenting antigen-specific immunity without the in vivo constraints that can accompany vaccine-based strategies. A phase I study was performed to evaluate the safety, in vivo persistence, and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yee C,Thompson JA,Byrd D,Riddell SR,Roche P,Celis E,Greenberg PD

更新日期：2002-12-10 00:00:00

abstract：:The protein kinase A stimulator cAMP can potentiate the ability of progestins to induce the transactivation function of the human progesterone receptor (hPR). We questioned in the present study whether cAMP could functionally cooperate with the progestin antagonist RU486. In T47D human breast cancer cells, RU486 behav...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Beck CA,Weigel NL,Moyer ML,Nordeen SK,Edwards DP

更新日期：1993-05-15 00:00:00

abstract：:Substantial proportions of mammalian genomes comprise repetitive elements including endogenous retrotransposons. Although these play diverse roles during development, their appropriate silencing is critically important in maintaining genomic integrity in the host cells. The major mechanism for retrotransposon silencin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hatanaka Y,Inoue K,Oikawa M,Kamimura S,Ogonuki N,Kodama EN,Ohkawa Y,Tsukada Y,Ogura A

更新日期：2015-11-24 00:00:00

abstract：:Paleoanthropologists and vertebrate paleontologists have for decades debated the etiology of tooth wear and its implications for understanding the diets of human ancestors and other extinct mammals. The debate has recently taken a twist, calling into question the efficacy of dental microwear to reveal diet. Some argue...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xia J,Zheng J,Huang D,Tian ZR,Chen L,Zhou Z,Ungar PS,Qian L

更新日期：2015-08-25 00:00:00

abstract：:Lactobacillus acidophilus NCFM is a probiotic bacterium that has been produced commercially since 1972. The complete genome is 1,993,564 nt and devoid of plasmids. The average GC content is 34.71% with 1,864 predicted ORFs, of which 72.5% were functionally classified. Nine phage-related integrases were predicted, but ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Altermann E,Russell WM,Azcarate-Peril MA,Barrangou R,Buck BL,McAuliffe O,Souther N,Dobson A,Duong T,Callanan M,Lick S,Hamrick A,Cano R,Klaenhammer TR

更新日期：2005-03-15 00:00:00

abstract：:Among the earliest and most important stages during tumorigenesis is the activation of the angiogenic process, an event that is termed the "switch to the angiogenic phenotype." We have developed an in vivo system that can reliably recapitulate the stages in tumor development that represent this transition. Using this ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fang J,Shing Y,Wiederschain D,Yan L,Butterfield C,Jackson G,Harper J,Tamvakopoulos G,Moses MA

更新日期：2000-04-11 00:00:00

abstract：:Physiological sensing of O(2) tension (partial O(2) pressure, pO(2)) plays an important role in some mammalian cellular systems, but striated muscle generally is not considered to be among them. Here we describe a molecular mechanism in skeletal muscle that acutely couples changes in pO(2) to altered calcium release t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sun QA,Hess DT,Nogueira L,Yong S,Bowles DE,Eu J,Laurita KR,Meissner G,Stamler JS

更新日期：2011-09-20 00:00:00

abstract：:The chimaeric protein repressor-galactosidase, in which fully active lac repressor is covalently linked to the active enzyme beta-galactosidase, was used as a system for probing the quaternary structure of lac repressor. Electron micrographs revealed repressor-galactosidase to be a tetrameric aggregate. When lac repre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kania J,Brown DT

更新日期：1976-10-01 00:00:00

abstract：:Soluble extracts of adenovirus-infected HeLa cell nuclei support DNA replication on exogenous adenovirus DNA templates. Conditions of synthesis using both wild-type and temperature-sensitive extracts have been defined. Nuclear extracts prepared from cells permissively infected with the adenovirus mutant H5ts125 expres...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaplan LM,Ariga H,Hurwitz J,Horwitz MS

更新日期：1979-11-01 00:00:00

abstract：:An enzyme that reduces methionine sulfoxide [Met(O)] residues in proteins [peptide Met(O) reductase (MsrA), EC 1.8.4.6; originally identified in Escherichia coli] was purified from bovine liver, and the cDNA encoding this enzyme was cloned and sequenced. The mammalian homologue of E. coli msrA (also called pmsR) cDNA ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moskovitz J,Weissbach H,Brot N

更新日期：1996-03-05 00:00:00

abstract：:We investigate the problem of learning to play the game of rock-paper-scissors. Each player attempts to improve her/his average score by adjusting the frequency of the three possible responses, using reinforcement learning. For the zero sum game the learning process displays Hamiltonian chaos. Thus, the learning traje...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sato Y,Akiyama E,Farmer JD

更新日期：2002-04-02 00:00:00

abstract：:The immune response is normally controlled by regulatory T cells (Tregs). However, Treg deficits are found in autoimmune diseases, and therefore the induction of functional Tregs is considered a potential therapeutic approach for autoimmune disorders. The activation of the ligand-activated transcription factor aryl hy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yeste A,Nadeau M,Burns EJ,Weiner HL,Quintana FJ

更新日期：2012-07-10 00:00:00

abstract：:How genome divergence eventually leads to speciation is a topic of prime evolutionary interest. Genomic islands of elevated divergence are frequently reported between diverging lineages, and their size is expected to increase with time and gene flow under the speciation-with-gene-flow model. However, such islands can ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ma T,Wang K,Hu Q,Xi Z,Wan D,Wang Q,Feng J,Jiang D,Ahani H,Abbott RJ,Lascoux M,Nevo E,Liu J

更新日期：2018-01-09 00:00:00

abstract：:Glyceraldehyde-3-phosphate dehydrogenase [GAPDH; D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating), EC 1.2.1.12] mRNA levels are induced by physiologic concentrations of insulin in cultured 3T3-F442A adipocyte and H35 hepatoma cell lines. To examine the mechanism by which insulin regulates GAPDH mRNA ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alexander MC,Lomanto M,Nasrin N,Ramaika C

更新日期：1988-07-01 00:00:00

abstract：:Proteins, nucleic acids, and fluorescein-conjugated antibody are shown to be identifidable in situ via the fluorescence excited by the focused electron beam of a canning electron microscope. A molecular species is identified by its characteristic fluorescence spectrum and by a characteristic alteration of the spectrum...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hough PV,McKinney WR,Ledbeter MC,Pollack RE,Moos HW

更新日期：1976-02-01 00:00:00

abstract：:A Mr 35,000 calmodulin-binding protein, which also possesses the ability to interact with a number of cytoskeletal elements, was purified from bovine synaptosomal membranes, using hydroxylapatite and phosphocellulose column chromatography. We call this protein "cytosynalin," which is derived from a combination of the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sobue K,Okabe T,Kadowaki K,Itoh K,Tanaka T,Fujio Y

更新日期：1987-04-01 00:00:00

abstract：:Human appropriation of net primary production (HANPP), the aggregate impact of land use on biomass available each year in ecosystems, is a prominent measure of the human domination of the biosphere. We present a comprehensive assessment of global HANPP based on vegetation modeling, agricultural and forestry statistics...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Haberl H,Erb KH,Krausmann F,Gaube V,Bondeau A,Plutzar C,Gingrich S,Lucht W,Fischer-Kowalski M

更新日期：2007-07-31 00:00:00

abstract：:The recent emergence and reemergence of viruses in the human population has highlighted the need to develop broader panels of therapeutic molecules. High-throughput screening assays opening access to untargeted steps of the viral replication cycle will provide powerful leverage to identify innovative antiviral molecul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fernandez J,Hassen-Khodja C,Georget V,Rose T,Jacob Y,Janin YL,Nisole S,Vidalain PO,Arhel NJ

更新日期：2021-01-12 00:00:00

abstract：:Because many survivors of mass extinctions do not participate in postrecovery diversifications, and therefore fall into a pattern that can be termed "Dead Clade Walking" (DCW), the effects of mass extinctions extend beyond the losses observed during the event itself. Analyses at two taxonomic levels provide a first-or...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jablonski D

更新日期：2002-06-11 00:00:00

abstract：:Control of transcription and enzyme activities are two interwoven regulatory systems essential for the function of a metabolic node. Saccharomyces cerevisiae strains differing in enzyme activities at the chorismate branch point of aromatic amino acid biosynthesis were constructed by recombinant DNA technology. Express...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Krappmann S,Lipscomb WN,Braus GH

更新日期：2000-12-05 00:00:00

abstract：:Identifying the drivers and processes that determine globally the geographic range size of species is crucial to understanding the geographic distribution of biodiversity and further predicting the response of species to current global changes. However, these drivers and processes are still poorly understood, and no e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carvajal-Quintero J,Villalobos F,Oberdorff T,Grenouillet G,Brosse S,Hugueny B,Jézéquel C,Tedesco PA

更新日期：2019-07-02 00:00:00

abstract：:Saccharomyces cerevisiae is one of the most important model organisms and has been a valuable asset to human civilization. However, despite its extensive use in the last 9,000 y, the existence of a seasonal cycle outside human-made environments has not yet been described. We demonstrate the role of social wasps as vec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stefanini I,Dapporto L,Legras JL,Calabretta A,Di Paola M,De Filippo C,Viola R,Capretti P,Polsinelli M,Turillazzi S,Cavalieri D

更新日期：2012-08-14 00:00:00

abstract：:To investigate the evolution of the mammalian sex chromosomes, we have compared the gene content of the X chromosomes in the mammalian groups most distantly related to man (marsupials and monotremes). Previous work established that genes on the long arm of the human X chromosome are conserved on the X chromosomes in a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Watson JM,Spencer JA,Riggs AD,Graves JA

更新日期：1991-12-15 00:00:00

abstract：:A major protein tyrosine phosphatase (PTPase 1B) has been isolated in essentially homogeneous form from the soluble and particulate fractions of human placenta. Unexpectedly, partial amino acid sequences displayed no homology with the primary structures of the protein Ser/Thr phosphatases deduced from cDNA clones. How...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Charbonneau H,Tonks NK,Walsh KA,Fischer EH

更新日期：1988-10-01 00:00:00

abstract：:Integrable models form pillars of theoretical physics because they allow for full analytical understanding. Despite being rare, many realistic systems can be described by models that are close to integrable. Therefore, an important question is how small perturbations influence the behavior of solvable models. This is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Žnidarič M,Ljubotina M

更新日期：2018-05-01 00:00:00

abstract：:Complex I functions as a redox-linked proton pump in the respiratory chains of mitochondria and bacteria, driven by the reduction of quinone (Q) by NADH. Remarkably, the distance between the Q reduction site and the most distant proton channels extends nearly 200 Å. To elucidate the molecular origin of this long-range...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sharma V,Belevich G,Gamiz-Hernandez AP,Róg T,Vattulainen I,Verkhovskaya ML,Wikström M,Hummer G,Kaila VR

更新日期：2015-09-15 00:00:00

abstract：:Atmospheric models generally assume that aerosol particles are in equilibrium with the surrounding gas phase. However, recent observations that secondary organic aerosols can exist in a glassy state have highlighted the need to more fully understand the kinetic limitations that may control water partitioning in ambien...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bones DL,Reid JP,Lienhard DM,Krieger UK

更新日期：2012-07-17 00:00:00

abstract：:The present study examined the social skills of previously institutionalized, 8-y-old Romanian children from the Bucharest Early Intervention Project and the influence of attachment security and brain electrical activity (alpha power) on these skills. Participants included children randomized to an intervention involv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Almas AN,Degnan KA,Radulescu A,Nelson CA 3rd,Zeanah CH,Fox NA

更新日期：2012-10-16 00:00:00