Insect immune response to bacterial infection is mediated by eicosanoids.

abstract：:We analyzed the relationship of genetic factors determining the expression of endogenous type-C RNA tumor viruses and other host-gene markers to tumorigenesis. A hybridization experiment was performed with mice of strains AKR/J and C57L, the first filial (F(1)) generation hybrids, the second filial (F(2)) generation h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meier H,Taylor BA,Cherry M,Buebner RJ

更新日期：1973-05-01 00:00:00

abstract：:Eosinophil-derived neurotoxin (EDN) and eosinophil cationic protein (ECP) were isolated from lysates of human eosinophil granules by gel filtration and ion exchange chromatography on heparin-Sepharose. Radioimmunoassay, using monoclonal antibodies, of fractions from the heparin-Sepharose chromatography showed one peak...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gleich GJ,Loegering DA,Bell MP,Checkel JL,Ackerman SJ,McKean DJ

更新日期：1986-05-01 00:00:00

abstract：:Genomic analyses of patients with congenital heart disease (CHD) have identified significant contribution from mutations affecting cilia genes and chromatin remodeling genes; however, the mechanism(s) connecting chromatin remodeling to CHD is unknown. Histone H2B monoubiquitination (H2Bub1) is catalyzed by the RNF20 c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Robson A,Makova SZ,Barish S,Zaidi S,Mehta S,Drozd J,Jin SC,Gelb BD,Seidman CE,Chung WK,Lifton RP,Khokha MK,Brueckner M

更新日期：2019-07-09 00:00:00

abstract：:Previous studies have identified lipid-poor high density lipoproteins with electrophoretic pre-beta mobility as the initial acceptors of cell-derived cholesterol in human plasma. These lipoproteins contain apolipoprotein A-I (apo A-I) as their sole apolipoprotein. In the present study, incubation of human plasma with ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang Y,von Eckardstein A,Wu S,Maeda N,Assmann G

更新日期：1994-03-01 00:00:00

abstract：:The central administration of the fatty acid synthase (FAS) inhibitor, C75, rapidly suppresses the expression of orexigenic neuropeptides [neuropeptide Y (NPY) and agouti-related protein (AgRP)] and activates expression of anorexigenic neuropeptides [proopiomelanocortin (POMC) and cocaine- and amphetamine-regulated tr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hu Z,Cha SH,van Haasteren G,Wang J,Lane MD

更新日期：2005-03-15 00:00:00

abstract：:The effect of plasmin-derived fibrinogen fragments on the biosynthesis of fibrinogen was investigated in cultured monolayers of rat hepatocytes. Incubating the cells with several concentrations of either fibrinogen or fibrin fragment D or E had no effect on the synthesis and secretion of fibrinogen by these cells. How...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ritchie DG,Levy BA,Adams MA,Fuller GM

更新日期：1982-03-01 00:00:00

abstract：:Treatment of human fibroblast cells with human fibroblast (beta)interferon for up to 8 hr resulted in the accumulation of at least four mRNAs. The mRNAs were isolated from cellular polysomes and characterized by stimulation of translation in a wheat germ cell-free protein synthesis system. The mRNAs appear as early as...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Colonno RJ

更新日期：1981-08-01 00:00:00

abstract：:Claspin is a homolog of Mrc1, a checkpoint protein required for the DNA replication checkpoint in yeast. In Xenopus, phosphorylated Claspin binds to xChk1 and regulates xChk1 activation in response to replication stress. In this study, we have shown that the human homolog of Claspin is required for resistance to multi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin SY,Li K,Stewart GS,Elledge SJ

更新日期：2004-04-27 00:00:00

abstract：:The frequencies of diverse rearrangements of variable (V)lambda to joining (J)lambda gene segments were examined by Southern blot hybridization in 30 murine B-cell lines, each producing an immunoglobulin lambda light chain of known subtype (lambda 1, lambda 2, or lambda 3). For 11 out of 12 lambda 1 chains, the rearra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reilly EB,Blomberg B,Imanishi-Kari T,Tonegawa S,Eisen HN

更新日期：1984-04-01 00:00:00

abstract：:Laser-induced fluorescence at 337-nm excitation was used in vivo to differentiate neoplastic [cervical intraepithelial neoplasia (CIN)], nonneoplastic abnormal (inflammation and human papilloma viral infection), and normal cervical tissues. A colposcope (low-magnification microscope used to view the cervix with reflec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ramanujam N,Mitchell MF,Mahadevan A,Warren S,Thomsen S,Silva E,Richards-Kortum R

更新日期：1994-10-11 00:00:00

abstract：:Monoclonal antibodies can block cellular interactions that negatively regulate T-cell immune responses, such as CD80/CTLA-4 and PD-1/PD1-L, amplifying preexisting immunity and thereby evoking antitumor immune responses. Ibrutinib, an approved therapy for B-cell malignancies, is a covalent inhibitor of BTK, a member of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sagiv-Barfi I,Kohrt HE,Czerwinski DK,Ng PP,Chang BY,Levy R

更新日期：2015-03-03 00:00:00

abstract：:TAL1 is a critical transcription factor required for hematopoiesis. However, perturbation of its activity often leads to T cell leukemia. Whether and how its transcriptional activities are regulated during hematopoiesis remains to be addressed. Here, we show that TAL1 is associated with histone demethylase complexes c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hu X,Li X,Valverde K,Fu X,Noguchi C,Qiu Y,Huang S

更新日期：2009-06-23 00:00:00

abstract：:Arabinose-binding protein, maltose-binding protein, and lambda receptor are synthesized in vitro on membrane-bound polysomes from Escherichia coli. All three proteins are exported from the cytoplasm of E. coli and all three are made in vitro in a form a few thousand daltons larger than the authentic protein. The large...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Randall LL,Hardy SJ,Josefsson LG

更新日期：1978-03-01 00:00:00

abstract：:The conformation of the pressure-dissociated monomer of Arc repressor was characterized by 1H NMR spectroscopy. The NMR spectra of the monomer under pressure (up to 5.0 kbar; 1 bar = 100 kPa) are typical of a molten globule and they are considerably different from those of the native dimer and thermally denatured mono...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Peng X,Jonas J,Silva JL

更新日期：1993-03-01 00:00:00

abstract：:The primary structure of the beta chain of human glycoprotein Ib (GPIb), the platelet receptor for von Willebrand factor, has been established by a combination of cDNA cloning and amino acid sequence analysis. A lambda phage cDNA expression library prepared from human erythroleukemia cells (HEL cells) was screened wit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lopez JA,Chung DW,Fujikawa K,Hagen FS,Davie EW,Roth GJ

更新日期：1988-04-01 00:00:00

abstract：:In this article we report an experiment that examines how demand-side bidding can discipline generators in a market for electric power. First we develop a treatment without demand-side bidding; two large firms are allocated baseload and intermediate cost generators such that either firm might unilaterally withhold the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rassenti SJ,Smith VL,Wilson BJ

更新日期：2003-03-04 00:00:00

abstract：:Groups of subjects with different degrees of glucose intolerance were examined in order to determine, first, the capacity of the beta cells to release insulin upon glucose stimulation and, second, sensitivity to insulin. The groups were selected on the basis of fasting blood glucose value and tolerances to oral and in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Efendić S,Wajngot A,Cerasi E,Luft R

更新日期：1980-12-01 00:00:00

abstract：:Deficiency in PTEN (phosphatase and tensin homolog deleted on chromosome 10) is the underlying cause of PTEN hamartoma tumor syndrome and a wide variety of human cancers. In skin epidermis, we have previously identified an autocrine FGF signaling induced by loss of Pten in keratinocytes. In this study, we demonstrate ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mathew G,Hannan A,Hertzler-Schaefer K,Wang F,Feng GS,Zhong J,Zhao JJ,Downward J,Zhang X

更新日期：2016-11-15 00:00:00

abstract：:Hox genes are conserved transcription factor-encoding genes that specify the identity of body regions in bilaterally symmetrical animals. In the cricket Gryllus bimaculatus, a member of the hemimetabolous insect group Orthoptera, the induction of a subset of mesodermal cells to form the primordial germ cells (PGCs) is...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barnett AA,Nakamura T,Extavour CG

更新日期：2019-08-13 00:00:00

abstract：:Somatic hypermutation (SHM) and class-switch recombination (CSR) of the Ig gene require both the transcription of the locus and the expression of activation-induced cytidine deaminase (AID). During CSR, AID decreases the amount of topoisomerase I (Top1); this decrease alters the DNA structure and induces cleavage in t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kobayashi M,Sabouri Z,Sabouri S,Kitawaki Y,Pommier Y,Abe T,Kiyonari H,Honjo T

更新日期：2011-11-29 00:00:00

abstract：:Werner syndrome and Bloom syndrome result from defects in the RecQ helicases Werner (WRN) and Bloom (BLM), respectively, and display premature aging phenotypes. Similarly, XFE progeroid syndrome results from defects in the ERCC1-XPF DNA repair endonuclease. To gain insight into the origin of cellular senescence and hu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hagelstrom RT,Blagoev KB,Niedernhofer LJ,Goodwin EH,Bailey SM

更新日期：2010-09-07 00:00:00

abstract：:The coordinated redistribution of sugars from mature "source" leaves to developing "sink" leaves requires tight regulation of sugar transport between cells via plasmodesmata (PD). Although fundamental to plant physiology, the mechanisms that control PD transport and thereby support development of new leaves have remai...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brunkard JO,Xu M,Scarpin MR,Chatterjee S,Shemyakina EA,Goodman HM,Zambryski P

更新日期：2020-03-03 00:00:00

abstract：:The respiratory burst oxidase of neutrophils can be activated in a cell-free system in which plasma membranes, cytosol, Mg2+, and a membrane-perturbing detergent, such as arachidonate or sodium dodecyl sulfate, are all required. Using the technique of preparative isoelectric focusing, the cytosol factor required for o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Curnutte JT,Scott PJ,Mayo LA

更新日期：1989-02-01 00:00:00

abstract：:Idiopathic interstitial pneumonias (IIPs) have a progressive and often fatal course, and their enigmatic etiology has complicated approaches to effective therapies. Idiopathic pulmonary fibrosis (IPF) is the most common of IIPs and shares with IIPs an increased incidence with age and unexplained scarring in the lung. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alder JK,Chen JJ,Lancaster L,Danoff S,Su SC,Cogan JD,Vulto I,Xie M,Qi X,Tuder RM,Phillips JA 3rd,Lansdorp PM,Loyd JE,Armanios MY

更新日期：2008-09-02 00:00:00

abstract：:A major challenge facing the genetics of autism spectrum disorders (ASDs) is the large and growing number of candidate risk genes and gene variants of unknown functional significance. Here, we used Caenorhabditis elegans to systematically functionally characterize ASD-associated genes in vivo. Using our custom machine...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McDiarmid TA,Belmadani M,Liang J,Meili F,Mathews EA,Mullen GP,Hendi A,Wong WR,Rand JB,Mizumoto K,Haas K,Pavlidis P,Rankin CH

更新日期：2020-01-07 00:00:00

abstract：:Invariant natural killer T (iNKT) cells recognize self lipid antigens presented by CD1d molecules. The nature of the self-antigens involved in the development and maturation of iNKT cells is poorly defined. Lysophospholipids are self-antigens presented by CD1d that are generated through the action of phospholipases A1...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Paduraru C,Bezbradica JS,Kunte A,Kelly R,Shayman JA,Veerapen N,Cox LR,Besra GS,Cresswell P

更新日期：2013-03-26 00:00:00

abstract：:Go is a specific class ("other") of signal-transducing heterotrimeric GTP-binding proteins (G proteins) that is expressed in high levels in mammalian brain. We have cloned two different rat cDNAs encoding the alpha subunit of Go (Go alpha-1 and Go alpha-2) and a human Go alpha chromosomal gene. The human Go alpha gene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsukamoto T,Toyama R,Itoh H,Kozasa T,Matsuoka M,Kaziro Y

更新日期：1991-04-15 00:00:00

abstract：:Many physical and chemical properties of the light rare-earths and actinides are governed by the active role of f electrons, and despite intensive efforts the details of the mechanisms of phase stability and transformation are not fully understood. A prominent example which has attracted a lot of interest, both experi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Krisch M,Farber DL,Xu R,Antonangeli D,Aracne CM,Beraud A,Chiang TC,Zarestky J,Kim DY,Isaev EI,Ahuja R,Johansson B

更新日期：2011-06-07 00:00:00

abstract：:During mitochondrial ATP synthesis, F1-ATPase-the portion of the ATP synthase that contains the catalytic and regulatory nucleotide binding sites-undergoes a series of concerted conformational changes that couple proton translocation to the synthesis of the high levels of ATP required for cellular function. In the str...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bianchet MA,Hullihen J,Pedersen PL,Amzel LM

更新日期：1998-09-15 00:00:00

abstract：:In the replication of human immunodeficiency virus type 1 (HIV-1), gag MA (matrix), a major structural protein of the virus, carries out opposing targeting functions. During virus assembly, gag MA is cotranslationally myristoylated, a modification required for membrane targeting of gag polyproteins. During virus infec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bukrinskaya AG,Ghorpade A,Heinzinger NK,Smithgall TE,Lewis RE,Stevenson M

更新日期：1996-01-09 00:00:00