The progesterone antagonist RU486 acquires agonist activity upon stimulation of cAMP signaling pathways.

abstract：:Tumor necrosis factor-related, activation-induced cytokine (TRANCE), a tumor necrosis factor family member, mediates survival of dendritic cells in the immune system and is required for osteoclast differentiation and activation in the skeleton. We report the skeletal phenotype of TRANCE-deficient mice and its rescue b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim N,Odgren PR,Kim DK,Marks SC Jr,Choi Y

更新日期：2000-09-26 00:00:00

abstract：:The ability of the isolated perfused rat liver to differentiate between chylomicrons and remnants with either high or low apoprotein E:C ratios was investigated. Remnants were prepared in hepatectomized rats injected with chylomicrons double-labeled with [3H]cholesterol and 14C-labeled fatty acids. By densitometric sc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Borensztajn J,Kotlar TJ

更新日期：1984-09-01 00:00:00

abstract：:We have determined the molecular genetic basis of congenital adrenal hyperplasia due to 21-hydroxylase (21-OHase) deficiency. This common disorder of cortisol biosynthesis is HLA-linked. The haplotype HLA-(A3);Bw47;DR7 is strongly associated with 21-OHase deficiency and always carries a null allele at the locus encodi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： White PC,New MI,Dupont B

更新日期：1984-12-01 00:00:00

abstract：:Scholander and his coworkers have described in These Proceedings several experiments in which the osmotic pressure exerted by colloidal particles appears to be altered when the particles are subject to an external force; they interpret the experiments as showing that the traditional explanation of osmotic pressure is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hobbie RK

更新日期：1974-08-01 00:00:00

abstract：:Peripheral blood leukocytes, obtained from volunteers after vaccination or natural illness with influenza, were assayed for cytotoxicity against influenza virus-infected cells. Approximately 7 days after vaccination or the onset of respiratory illness, peak cytotoxicity was demonstrated in a chromium-release assay. Se...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Greenberg SB,Six HR,Drake S,Couch RB

更新日期：1979-09-01 00:00:00

abstract：:A computer code to investigate the equilibrium and stability of a diffuse plasma in three dimensions is described that generalizes earlier work on a sharp free boundary model. Toroidal equilibria of a plasma are determined by considering paths of steepest descent associated with a new version of the variational princi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Betancourt O,Garabedian P

更新日期：1976-04-01 00:00:00

abstract：:The hypothalamic arcuate nucleus is involved in the control of energy intake and expenditure and may participate in the pathogenesis of eating disorders such as anorexia nervosa (AN) and bulimia nervosa (BN). Two systems are of particular interest in this respect, synthesizing alpha-melanocyte-stimulating hormone (alp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fetissov SO,Hallman J,Oreland L,Af Klinteberg B,Grenbäck E,Hulting AL,Hökfelt T

更新日期：2002-12-24 00:00:00

abstract：:The extensive refolding of the membrane-anchoring chain of hemagglutinin (HA) of influenza virus (termed HA2) in cellular endosomes, which initiates viral entry by membrane fusion, suggests that viral HA is meta-stable. HA2 polypeptide residues 38-175 expressed in Escherichia coli are reported here to fold in vivo int...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen J,Wharton SA,Weissenhorn W,Calder LJ,Hughson FM,Skehel JJ,Wiley DC

更新日期：1995-12-19 00:00:00

abstract：:The metal complex [(tpy)(Mebim-py)Ru(II)(S)](2+) (tpy = 2,2' : 6',2''-terpyridine; Mebim-py = 3-methyl-1-pyridylbenzimidazol-2-ylidene; S = solvent) is a robust, reactive electrocatalyst toward both water oxidation to oxygen and carbon dioxide reduction to carbon monoxide. Here we describe its use as a single electroc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen Z,Concepcion JJ,Brennaman MK,Kang P,Norris MR,Hoertz PG,Meyer TJ

更新日期：2012-09-25 00:00:00

abstract：:Relatively little is understood about the dynamics of global host-pathogen transcriptome changes that occur during bacterial infection of mucosal surfaces. To test the hypothesis that group A Streptococcus (GAS) infection of the oropharynx provokes a distinct host transcriptome response, we performed genome-wide trans...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shea PR,Virtaneva K,Kupko JJ 3rd,Porcella SF,Barry WT,Wright FA,Kobayashi SD,Carmody A,Ireland RM,Sturdevant DE,Ricklefs SM,Babar I,Johnson CA,Graham MR,Gardner DJ,Bailey JR,Parnell MJ,Deleo FR,Musser JM

更新日期：2010-03-09 00:00:00

abstract：:Light activates rod outer segment (ROS) phosphodiesterase (PDEase), as shown by previous biochemical and physiological studies. We have further investigated the role of PDEase in this system by injecting trypsin-activated PDEase, purified from bovine ROS, into single ROS of the isolated retina of the toad Bufo marinus...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shimoda Y,Hurley JB,Miller WH

更新日期：1984-01-01 00:00:00

abstract：:Of the microsomal P450 cytochromes, the ethanol-inducible isoform, P450 2E1, is believed to be predominant in leading to oxidative damage, including the generation of radical species that contribute to lipid peroxidation, and in the reductive beta-scission of lipid hydroperoxides to give hydrocarbons and aldehydes. In...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bestervelt LL,Vaz AD,Coon MJ

更新日期：1995-04-25 00:00:00

abstract：:Meet Jonathan and Elizabeth. One person is a doctor and the other is a nurse. Who is the doctor? When nothing else is known, the base rate principle favors Jonathan to be the doctor and the fairness principle favors both individuals equally. However, when individuating facts reveal who is actually the doctor, base rat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cao J,Banaji MR

更新日期：2016-07-05 00:00:00

abstract：:The plant hormone ethylene is involved in many developmental processes, including fruit ripening, abscission, senescence, and leaf epinasty. Tomato contains a family of ethylene receptors, designated LeETR1, LeETR2, NR, LeETR4, and LeETR5, with homology to the Arabidopsis ETR1 ethylene receptor. Transgenic plants with...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tieman DM,Taylor MG,Ciardi JA,Klee HJ

更新日期：2000-05-09 00:00:00

abstract：:Lentiviruses, including HIV-1, have transmembrane envelope (Env) glycoproteins with cytoplasmic tails that are quite long compared with those of other retroviruses. However, mainly because of the lack of biochemical studies performed in cell types that are targets for HIV-1 infection, no clear consensus exists regardi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murakami T,Freed EO

更新日期：2000-01-04 00:00:00

abstract：:Plants produce a wide range of allelochemicals to defend against herbivore attack, and generalist herbivores have evolved mechanisms to avoid, sequester, or detoxify a broad spectrum of natural defense compounds. Successful arthropod pests have also developed resistance to diverse classes of pesticides and this adapta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dermauw W,Wybouw N,Rombauts S,Menten B,Vontas J,Grbic M,Clark RM,Feyereisen R,Van Leeuwen T

更新日期：2013-01-08 00:00:00

abstract：:Deamidation of asparaginyl and glutaminyl residues causes time-dependent changes in charge and conformation of peptides and proteins. Quantitative and experimentally verified predictive calculations of the deamidation rates of 1,371 asparaginyl residues in a representative collection of 126 human proteins have been pe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Robinson NE,Robinson AB

更新日期：2001-10-23 00:00:00

abstract：:The H2O2-requiring ligninase of the basidiomycete Phanerochaete chrysosporium oxidatively cleaves both lignin and lignin model compounds between C alpha and C beta (C-1 and C-2) of their aliphatic side chains. Previous work has demonstrated a reaction mechanism by which ligninase oxidizes aromatic substrates to their ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hammel KE,Kalyanaraman B,Kirk TK

更新日期：1986-06-01 00:00:00

abstract：:The ribonucleotide reductase system of Escherichia coli B participates in the biosynthesis of DNA by reducing ribonucleoside diphosphates to the corresponding deoxyribonucleotides. The enzyme is regulated in a complicated way by allosteric modifiers. We now find that infection of E. coli with the bacteriophage T4 resu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berglund O,Karlström O,Reichard P

更新日期：1969-03-01 00:00:00

abstract：:Most genetic regulatory mechanisms involve protein-DNA interactions. In these processes, the classical Watson-Crick DNA structure sometimes is distorted severely, which in turn enables the precise recognition of the specific sites by the protein. Despite its key importance, very little is known about such deformation ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leger JF,Robert J,Bourdieu L,Chatenay D,Marko JF

更新日期：1998-10-13 00:00:00

abstract：:CSB/ERCC6 belongs to an orphan subfamily of SWI2/SNF2-related chromatin remodelers and plays crucial roles in gene expression, DNA damage repair, and the maintenance of genome integrity. The molecular basis of chromatin remodeling by Cockayne syndrome B protein (CSB) is not well understood. Here we investigate the mol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang W,Xu J,Limbo O,Fei J,Kassavetis GA,Chong J,Kadonaga JT,Russell P,Li B,Wang D

更新日期：2019-03-26 00:00:00

abstract：:The lentiviruses are associated with a wide range of chronic diseases in mammals. These include immunodeficiencies (such as HIV/AIDS in humans), malignancies, and lymphatic and neurological disorders in primates, felids, and a variety of wild and domesticated ungulates. Evolutionary analyses of the genomic sequences o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Katzourakis A,Tristem M,Pybus OG,Gifford RJ

更新日期：2007-04-10 00:00:00

abstract：:We investigated the ability of targeted immunomicelles to detect and assess macrophages in atherosclerotic plaque using MRI in vivo. There is a large clinical need for a noninvasive tool to assess atherosclerosis from a molecular and cellular standpoint. Macrophages play a central role in atherosclerosis and are assoc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Amirbekian V,Lipinski MJ,Briley-Saebo KC,Amirbekian S,Aguinaldo JG,Weinreb DB,Vucic E,Frias JC,Hyafil F,Mani V,Fisher EA,Fayad ZA

更新日期：2007-01-16 00:00:00

abstract：:A genetic analysis is necessary to gain a greater understanding of the complex developmental processes in mammals. Toward this end, an insertional transgenic mouse mutant has been isolated that results in abnormal germ-cell development. This recessive mutation manifests as infertility in both males and females and is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pellas TC,Ramachandran B,Duncan M,Pan SS,Marone M,Chada K

更新日期：1991-10-01 00:00:00

abstract：:It is well established that the medial-temporal lobe (MTL) is critical for recognition memory. The MTL is known to be composed of distinct structures that are organized in a hierarchical manner. At present, it remains controversial whether lower structures in this hierarchy, such as perirhinal cortex, support memory f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bowles B,Crupi C,Mirsattari SM,Pigott SE,Parrent AG,Pruessner JC,Yonelinas AP,Köhler S

更新日期：2007-10-09 00:00:00

abstract：:Explanations for primate brain expansion and the evolution of human cognition and culture remain contentious despite extensive research. While multiple comparative analyses have investigated variation in brain size across primate species, very few have addressed why primates vary in how much they use social learning. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Street SE,Navarrete AF,Reader SM,Laland KN

更新日期：2017-07-25 00:00:00

abstract：:Electrophysiological mapping of chronic atrial fibrillation (AF) at high throughput and high resolution is critical for understanding its underlying mechanism and guiding definitive treatment such as cardiac ablation, but current electrophysiological tools are limited by either low spatial resolution or electromechani...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu J,Zhang X,Liu Y,Rodrigo M,Loftus PD,Aparicio-Valenzuela J,Zheng J,Pong T,Cyr KJ,Babakhanian M,Hasi J,Li J,Jiang Y,Kenney CJ,Wang PJ,Lee AM,Bao Z

更新日期：2020-06-30 00:00:00

abstract：:Foreign DNA molecules and chromosomal fragments are generally eliminated from proliferating cells, but we know little about how mammalian cells prevent their propagation. Here, we show that dividing human and canine cells partition transfected plasmid DNA asymmetrically, preferentially into the daughter cell harboring...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang X,Le N,Denoth-Lippuner A,Barral Y,Kroschewski R

更新日期：2016-06-28 00:00:00

abstract：:Adenosine 3':5'-cyclic monophosphate (cAMP) and guanosine 3':5'-cyclic monophosphate (cGMP) were localized in cells of rat kidney cortex by an immunocytochemical technique before and after perfusion with parathyroid hormone (PTH). In control tissues the cAMP antiserum detected approximately the same intensity of fluor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dousa TP,Barnes LD,Ong SH,Steiner AL

更新日期：1977-08-01 00:00:00

abstract：:We present a model to explain how the neurosecretory system of aquatic mollusks generates their diversity of shell structures and pigmentation patterns. The anatomical and physiological basis of this model sets it apart from other models used to explain shape and pattern. The model reproduces most known shell shapes a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boettiger A,Ermentrout B,Oster G

更新日期：2009-04-21 00:00:00