Abstract:
:Low passage Fischer rat embryo cultures, which are normally very resistant to transformation by 3-methylcholanthrene but are highly susceptible when chronically infected with the Rauscher murine leukemia virus, were completely protected from transformation by methylcholanthrene when treated with neutralizing antibody specific for the leukemia virus prior to and during treatment with methylcholanthrene. Sister cultures were not protected by neutralizing antibody specific for the B-tropic radiation leukemia virus. This demonstrates clearly a definite type specific role for Rauscher murine leukemia virus in the 2-methylcholanthrene transformation system in rat cells.
journal_name
Proc Natl Acad Sci U S Aauthors
Price PJ,Bellew TM,King MP,Freeman AE,Gilden RV,Huebner RJdoi
10.1073/pnas.73.1.152keywords:
subject
Has Abstractpub_date
1976-01-01 00:00:00pages
152-5issue
1eissn
0027-8424issn
1091-6490journal_volume
73pub_type
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