Activation of Trp3 by inositol 1,4,5-trisphosphate receptors through displacement of inhibitory calmodulin from a common binding domain.

abstract：:Experimental work in animals has shown that memory formation depends on a cascade of molecular events. Here we show that variability of human memory performance is related to variability in genes encoding proteins of this signaling cascade, including the NMDA and metabotrobic glutamate receptors, adenylyl cyclase, CAM...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： de Quervain DJ,Papassotiropoulos A

更新日期：2006-03-14 00:00:00

abstract：:The amino-terminal amino acid sequence and several internal peptide sequences of angiotensin I-converting enzyme (ACE; peptidyl-dipeptidase A, kininase II; EC 3.4.15.1) purified from human kidney were used to design oligonucleotide probes. The nucleotide sequence of ACE mRNA was determined by molecular cloning of the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Soubrier F,Alhenc-Gelas F,Hubert C,Allegrini J,John M,Tregear G,Corvol P

更新日期：1988-12-01 00:00:00

abstract：:Age-related macular degeneration (AMD) is the most common cause of blindness for individuals age 50 and above in the developed world. Abnormal growth of choroidal blood vessels, or choroidal neovascularization (CNV), is a hallmark of the neovascular (wet) form of advanced AMD and leads to significant vision loss. A gr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hasegawa E,Inafuku S,Mulki L,Okunuki Y,Yanai R,Smith KE,Kim CB,Klokman G,Bielenberg DR,Puli N,Falck JR,Husain D,Miller JW,Edin ML,Zeldin DC,Lee KSS,Hammock BD,Schunck WH,Connor KM

更新日期：2017-09-05 00:00:00

abstract：:Some dinosaurs reached masses that were approximately 8 times those of the largest, ecologically equivalent terrestrial mammals. The factors most responsible for setting the maximal body size of vertebrates are resource quality and quantity, as modified by the mobility of the consumer, and the vertebrate's rate of ene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McNab BK

更新日期：2009-07-21 00:00:00

abstract：:Membranes were purified from rat muscle by a differential centrifugation method that avoids the use of salt extraction or incubations at elevated temperature. Three populations of membrane-limited vesicles were defined having average densities of 1.112 (fraction I), 1.141 (fraction II), and 1.158 (fraction III) g/ml i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barchi RL,Bonilla E,Wong M

更新日期：1977-01-01 00:00:00

abstract：:If, because of trade-offs or similar considerations, components of fitness are negatively correlated in equilibrium populations, they may then exhibit no correlation with total fitness. Lack of correlation with fitness is a fundamental characteristic of selective neutrality. Hence, selectively important traits become ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reeve R,Smith E,Wallace B

更新日期：1990-03-01 00:00:00

abstract：:Eosinophils have been associated with fibrosis. To investigate their direct role in fibrosis, human peripheral blood eosinophil sonicate was added to human lung or dermal fibroblasts, and proliferation ([(3)H]thymidine) and collagen synthesis ([(3)H]proline) were evaluated. Proliferation was enhanced significantly in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levi-Schaffer F,Garbuzenko E,Rubin A,Reich R,Pickholz D,Gillery P,Emonard H,Nagler A,Maquart FA

更新日期：1999-08-17 00:00:00

abstract：:The Raf family includes three members, of which B-Raf is frequently mutated in melanoma and other tumors. We show that Raf-1 and A-Raf require Hsp90 for stability, whereas B-Raf does not. In contrast, mutated, activated B-Raf binds to an Hsp90-cdc37 complex, which is required for its stability and function. Exposure o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grbovic OM,Basso AD,Sawai A,Ye Q,Friedlander P,Solit D,Rosen N

更新日期：2006-01-03 00:00:00

abstract：:The template-directed synthesis of a bistable donor-acceptor [2]catenane wherein both translational isomers--one in which a tetrathiafulvalene unit in a mechanically interlocked crown ether occupies the cavity of a cyclobis(paraquat-p-phenylene) ring and the other in which a 1,5-dioxynaphthalene unit in the crown ethe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang C,Olson MA,Fang L,Benítez D,Tkatchouk E,Basu S,Basuray AN,Zhang D,Zhu D,Goddard WA,Stoddart JF

更新日期：2010-08-10 00:00:00

abstract：:Activation of naïve cluster of differentiation (CD)8(+) cytotoxic T lymphocytes (CTLs) is a tightly regulated process, and specific dendritic cell (DC) subsets are typically required to activate naive CTLs. Potential pathways for antigen presentation leading to CD8(+) T-cell priming include direct presentation, cross-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li L,Kim S,Herndon JM,Goedegebuure P,Belt BA,Satpathy AT,Fleming TP,Hansen TH,Murphy KM,Gillanders WE

更新日期：2012-07-31 00:00:00

abstract：:Two prominent timekeeping systems, the cell cycle, which controls cell division, and the circadian system, which controls 24-h rhythms of physiology and behavior, are found in nearly all living organisms. A distinct feature of circadian rhythms is that they are temperature-compensated such that the period of the rhyth...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yeom M,Pendergast JS,Ohmiya Y,Yamazaki S

更新日期：2010-05-25 00:00:00

abstract：:Local tissue stem cells have been described in airways of the lung but their contribution to normal epithelial maintenance is currently unknown. We therefore developed aggregation chimera mice and a whole-lung imaging method to determine the relative contributions of progenitor (Clara) and bronchiolar stem cells to ep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Giangreco A,Arwert EN,Rosewell IR,Snyder J,Watt FM,Stripp BR

更新日期：2009-06-09 00:00:00

abstract：:Water oxidation by cyanobacteria, algae, and plants is pivotal in oxygenic photosynthesis, the process that powers life on Earth, and is the paradigm for engineering solar fuel-production systems. Each complete reaction cycle of photosynthetic water oxidation requires the removal of four electrons and four protons fro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Klauss A,Haumann M,Dau H

更新日期：2012-10-02 00:00:00

abstract：:The use of matching variable number of tandem repeat (VNTR) profiles to link suspects with crimes is potentially very powerful, but it has been quite controversial. Initial debate over laboratory procedures has largely given way to debate over the statistical and population genetic issues involved in calculating the f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weir BS

更新日期：1992-12-15 00:00:00

abstract：:Alphavirus envelope proteins, organized as trimers of E2-E1 heterodimers on the surface of the pathogenic alphavirus, mediate the low pH-triggered fusion of viral and endosomal membranes in human cells. The lack of specific treatment for alphaviral infections motivates our exploration of potential antiviral approaches...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zeng X,Mukhopadhyay S,Brooks CL 3rd

更新日期：2015-02-17 00:00:00

abstract：:Induction of transformation, cell lethality, and DNA lesions were quantitatively compared in Syrian hamster embryo cells (HEC) treated with three different methylating agents: N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), N-methyl-N-nitrosourea (MNU), or methyl methanesulfonate (MMS). Each induced transformation in a d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Doniger J,Day RS,DiPaolo JA

更新日期：1985-01-01 00:00:00

abstract：:Cytochrome c maturation in Escherichia coli requires the ccm operon, which encodes eight membrane proteins (CcmABCDEFGH). CcmE is a periplasmic heme chaperone that binds heme covalently and transfers it onto apocytochrome c in the presence of CcmF, CcmG, and CcmH. In this work we addressed the functions of the ccmABCD...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schulz H,Fabianek RA,Pellicioli EC,Hennecke H,Thöny-Meyer L

更新日期：1999-05-25 00:00:00

abstract：:Two molecular forms of pyrophosphate-dependent phosphofructokinase (PP(i)-PFK; pyrophosphate:D-fructose-6-phosphate 1-phosphotransferase; EC 2.7.1.90) have been found whose activity depends upon association and dissociation characteristics regulated by fructose 2,6-bisphosphate (Fru-2,6-P(2)). PP(i)-PFK was purified 2...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu MX,Smyth DA,Black CC

更新日期：1984-08-01 00:00:00

abstract：:Protein synthesis in all living organisms occurs on ribonucleoprotein particles, called ribosomes. Despite the universality of this process, eukaryotic ribosomes are significantly larger in size than their bacterial counterparts due in part to the presence of 80 r proteins rather than 54 in bacteria. Using cryoelectro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Armache JP,Jarasch A,Anger AM,Villa E,Becker T,Bhushan S,Jossinet F,Habeck M,Dindar G,Franckenberg S,Marquez V,Mielke T,Thomm M,Berninghausen O,Beatrix B,Söding J,Westhof E,Wilson DN,Beckmann R

更新日期：2010-11-16 00:00:00

abstract：:Nascent replicative form type II (RFII) DNA of coliphage M13 synthesized in an Escherichia coli mutant deficient in the 5' leads to 3' exonuclease associated uith DNA polymerase I contains ribonucleotides that are retained in the covalently closed RFI DNA sealed in vitro by the joint action of T5 phage DNA polymerase ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dasgupta S,Mitra S

更新日期：1978-01-01 00:00:00

abstract：:Voltage-gated channels maintain cellular resting potentials and generate neuronal action potentials by regulating ion flux. Here, we show that Ether-à-go-go (EAG) K+ channels also regulate intracellular signaling pathways by a mechanism that is independent of ion flux and depends on the position of the voltage sensor....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hegle AP,Marble DD,Wilson GF

更新日期：2006-02-21 00:00:00

abstract：:Insig-1 and -2 are closely related proteins of the endoplasmic reticulum (ER) that block proteolytic activation of sterol regulatory element-binding proteins (SREBPs), transcription factors that activate the synthesis of cholesterol and fatty acids in liver and other organs. When cellular cholesterol levels are high, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yabe D,Komuro R,Liang G,Goldstein JL,Brown MS

更新日期：2003-03-18 00:00:00

abstract：:Genetic data are commonly used to estimate connectivity between putative populations, but translating them to demographic dispersal rates is complicated. Theoretical equations that infer a migration rate based on the genetic estimator F ST , such as Wright's equation, F ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spies I,Hauser L,Jorde PE,Knutsen H,Punt AE,Rogers LA,Stenseth NC

更新日期：2018-05-08 00:00:00

abstract：:Neuropeptide B (NPB) and neuropeptide W (NPW) have been recently identified as ligands for the G protein-coupled receptor (GPR) 7 and GPR8. The precise in vivo role of this neuropeptide-receptor pathway has not been fully demonstrated. In this paper, we report that NPB-deficient mice manifest a mild adult-onset obesit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kelly MA,Beuckmann CT,Williams SC,Sinton CM,Motoike T,Richardson JA,Hammer RE,Garry MG,Yanagisawa M

更新日期：2005-07-12 00:00:00

abstract：:A central paradox in type 2 diabetes is the apparent selective nature of hepatic insulin resistance--wherein insulin fails to suppress hepatic glucose production yet continues to stimulate lipogenesis, resulting in hyperglycemia, hyperlipidemia, and hepatic steatosis. Although efforts to explain this have focused on f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vatner DF,Majumdar SK,Kumashiro N,Petersen MC,Rahimi Y,Gattu AK,Bears M,Camporez JP,Cline GW,Jurczak MJ,Samuel VT,Shulman GI

更新日期：2015-01-27 00:00:00

abstract：:Loss-of-function DJ-1 mutations can cause early-onset Parkinson's disease. The function of DJ-1 is unknown, but an acidic isoform accumulates after oxidative stress, leading to the suggestion that DJ-1 is protective under these conditions. We addressed whether this represents a posttranslational modification at cystei...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Canet-Avilés RM,Wilson MA,Miller DW,Ahmad R,McLendon C,Bandyopadhyay S,Baptista MJ,Ringe D,Petsko GA,Cookson MR

更新日期：2004-06-15 00:00:00

abstract：:The template for transcription and replication of negative-stranded RNA viruses is a ribonucleoprotein structure, the nucleocapsid. We have developed a system that supports assembly of the negative-stranded RNA genome of a defective interfering (DI) particle of vesicular stomatitis virus (VSV) into a nucleocapsid in v...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mirakhur B,Peluso RW

更新日期：1988-10-01 00:00:00

abstract：:Unit-resolution mass spectra have been obtained for peptides as large as 17 kDa, providing information on impurities and adduct ions, as well as accurate molecular weight values. Electrospray ionization produces many multiply-charged species of the same mass; isotopic peak resolution provides direct charge state assig...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Loo JA,Quinn JP,Ryu SI,Henry KD,Senko MW,McLafferty FW

更新日期：1992-01-01 00:00:00

abstract：:Reversible photoswitching of individual molecules has been demonstrated for a number of mutants of the green fluorescent protein (GFP). To date, however, a limited number of switching events with slow response to light have been achieved at the single-molecule level. Here, we report reversible photoswitching character...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Habuchi S,Ando R,Dedecker P,Verheijen W,Mizuno H,Miyawaki A,Hofkens J

更新日期：2005-07-05 00:00:00

abstract：:A 2.9-kilobase Acc I fragment of the DNA of the pneumococcal bacteriophage Cp-1, containing the cpl gene, hybridizes with the lytA gene encoding the pneumococcal amidase. The nucleotide sequence of the cpl gene of Cp-1, encoding a muramidase (CPL), has been determined. The 3' regions of the cpl and lytA coding sequenc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： García E,García JL,García P,Arrarás A,Sánchez-Puelles JM,López R

更新日期：1988-02-01 00:00:00