Older mothers produce more successful daughters.

Abstract:

:Annual reproductive success and senescence patterns vary substantially among individuals in the wild. However, it is still seldom considered that senescence may not only affect an individual but also affect age-specific reproductive success in its offspring, generating transgenerational reproductive senescence. We used long-term data from wild yellow-bellied marmots (Marmota flaviventer) living in two different elevational environments to quantify age-specific reproductive success of daughters born to mothers differing in age. Contrary to prediction, daughters born to older mothers had greater annual reproductive success on average than daughters born to younger mothers, and this translated into greater lifetime reproductive success. However, in the favorable lower elevation environment, daughters born to older mothers also had greater age-specific decreases in annual reproductive success. In the harsher higher elevation environment on the other hand, daughters born to older mothers tended to die before reaching ages at which such senescent decreases could be observed. Our study highlights the importance of incorporating environment-specific transgenerational parent age effects on adult offspring age-specific life-history traits to fully understand the substantial variation observed in senescence patterns in wild populations.

authors

Kroeger SB,Blumstein DT,Armitage KB,Reid JM,Martin JGA

doi

10.1073/pnas.1908551117

subject

Has Abstract

pub_date

2020-03-03 00:00:00

pages

4809-4814

issue

9

eissn

0027-8424

issn

1091-6490

pii

1908551117

journal_volume

117

pub_type

杂志文章
  • Fermi surface nesting induced strong pairing in iron-based superconductors.

    abstract::The discovery of high-temperature superconductivity in iron pnictides raised the possibility of an unconventional superconducting mechanism in multiband materials. The observation of Fermi-surface (FS)-dependent nodeless superconducting gaps suggested that inter-FS interactions may play a crucial role in superconducti...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0900469106

    authors: Terashima K,Sekiba Y,Bowen JH,Nakayama K,Kawahara T,Sato T,Richard P,Xu YM,Li LJ,Cao GH,Xu ZA,Ding H,Takahashi T

    更新日期:2009-05-05 00:00:00

  • Na+ coordination at the Na2 site of the Na+/I- symporter.

    abstract::The sodium/iodide symporter (NIS) mediates active I(-) transport in the thyroid-the first step in thyroid hormone biosynthesis-with a 2 Na(+): 1 I(-) stoichiometry. The two Na(+) binding sites (Na1 and Na2) and the I(-) binding site interact allosterically: when Na(+) binds to a Na(+) site, the affinity of NIS for the...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1607231113

    authors: Ferrandino G,Nicola JP,Sánchez YE,Echeverria I,Liu Y,Amzel LM,Carrasco N

    更新日期:2016-09-13 00:00:00

  • Patches of synchronized activity in the cerebellar cortex evoked by mossy-fiber stimulation: questioning the role of parallel fibers.

    abstract::The discrepancy between the structural longitudinal organization of the parallel-fiber system in the cerebellar cortex and the functional mosaic-like organization of the cortex has provoked controversial theories about the flow of information in the cerebellum. We address this issue by characterizing the spatiotempora...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.95.25.15032

    authors: Cohen D,Yarom Y

    更新日期:1998-12-08 00:00:00

  • SGTA antagonizes BAG6-mediated protein triage.

    abstract::The BAG6 complex was first identified as an upstream loading factor for tail-anchored membrane proteins entering the TRC40-dependent pathway for posttranslational delivery to the endoplasmic reticulum. Subsequently, BAG6 was shown to enhance the proteasomal degradation of mislocalized proteins by selectively promoting...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1209997109

    authors: Leznicki P,High S

    更新日期:2012-11-20 00:00:00

  • Induction of glucose-regulated proteins during anaerobic exposure and of heat-shock proteins after reoxygenation.

    abstract::In this report we examine the effects of chronic anaerobic exposure and subsequent reoxygenation on protein synthesis patterns in Chinese hamster ovary cells. It is observed by two-dimensional gel electrophoresis (isoelectric focusing/NaDodSO4/PAGE) that the transition from an atmospheric environment to an anaerobic s...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.81.15.4843

    authors: Sciandra JJ,Subjeck JR,Hughes CS

    更新日期:1984-08-01 00:00:00

  • Targeted disruption of the interferon-gamma receptor 2 gene results in severe immune defects in mice.

    abstract::To study the role of the interferon- (IFN) gammaR2 chain in IFN-gamma signaling and immune function, IFN-gammaR2-deficient mice have been generated and characterized. Cells derived from IFN-gammaR2 -/- mice are unable to activate either JAK/STAT signaling proteins or gene transcription in response to IFN-gamma. The la...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.95.14.8233

    authors: Lu B,Ebensperger C,Dembic Z,Wang Y,Kvatyuk M,Lu T,Coffman RL,Pestka S,Rothman PB

    更新日期:1998-07-07 00:00:00

  • Cholecystokinin release triggered by NMDA receptors produces LTP and sound-sound associative memory.

    abstract::Memory is stored in neural networks via changes in synaptic strength mediated in part by NMDA receptor (NMDAR)-dependent long-term potentiation (LTP). Here we show that a cholecystokinin (CCK)-B receptor (CCKBR) antagonist blocks high-frequency stimulation-induced neocortical LTP, whereas local infusion of CCK induces...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1816833116

    authors: Chen X,Li X,Wong YT,Zheng X,Wang H,Peng Y,Feng H,Feng J,Baibado JT,Jesky R,Wang Z,Xie H,Sun W,Zhang Z,Zhang X,He L,Zhang N,Zhang Z,Tang P,Su J,Hu LL,Liu Q,He X,Tan A,Sun X,Li M,Wong K,Wang X,Cheung

    更新日期:2019-03-26 00:00:00

  • Myostatin modulates adipogenesis to generate adipocytes with favorable metabolic effects.

    abstract::A pluripotent cell line, C3H10T1/2, is induced to undergo adipogenesis by a mixture of factors that includes a glucocorticoid such as dexamethasone. We found that expression of myostatin (MSTN), a TGF-beta family member extensively studied in muscle, was induced by dexamethasone under those differentiation conditions....

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0607501103

    authors: Feldman BJ,Streeper RS,Farese RV Jr,Yamamoto KR

    更新日期:2006-10-17 00:00:00

  • Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells.

    abstract::During cellular stresses, phosphorylation of eukaryotic initiation factor-2 (eIF2) elicits gene expression designed to ameliorate the underlying cellular disturbance. Central to this stress response is the transcriptional regulator activating transcription factor, ATF4. Here we describe the mechanism regulating ATF4 e...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0400541101

    authors: Vattem KM,Wek RC

    更新日期:2004-08-03 00:00:00

  • Small fragments from the A subunit of cholera toxin capable of activating adenylate cyclase.

    abstract::Exposure of cholera toxin to membrane particles prepared from sarcoma 180 cells gives rise to a variety of fragments which are capable of activating adenylate cyclase [ATP:pyrophosphate-lyase (cyclizing), EC 4.6.1.1]. A major component of these fragments has an apparent molecular weight in the 8,000-10,000 range. The ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.73.8.2654

    authors: Matuo Y,Wheeler MA,Bitensky MW

    更新日期:1976-08-01 00:00:00

  • Altered neural odometry in the vertical dimension.

    abstract::Entorhinal grid cells integrate sensory and self-motion inputs to provide a spatial metric of a characteristic scale. One function of this metric may be to help localize the firing fields of hippocampal place cells during formation and use of the hippocampal spatial representation ("cognitive map"). Of theoretical imp...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1811867116

    authors: Casali G,Bush D,Jeffery K

    更新日期:2019-03-05 00:00:00

  • Circulating nerve growth factor levels are increased in humans with allergic diseases and asthma.

    abstract::Nerve growth factor (NGF) serum levels were measured in 49 patients with asthma and/or rhinoconjunctivitis and/or urticaria-angioedema. Clinical and biochemical parameters, such as bronchial reactivity, total and specific serum IgE levels, and circulating eosinophil cationic protein levels, were evaluated in relation ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.93.20.10955

    authors: Bonini S,Lambiase A,Bonini S,Angelucci F,Magrini L,Manni L,Aloe L

    更新日期:1996-10-01 00:00:00

  • Surfactant protein A mediates mycoplasmacidal activity of alveolar macrophages by production of peroxynitrite.

    abstract::We have previously shown that surfactant protein A (SP-A) mediates in vitro killing of mycoplasmas by alveolar macrophages (AMs) from resistant C57BL/6 mice through a nitric oxide (.NO)-dependent mechanism. Herein, SP-A-deficient [SP-A(-/-)] and inducible.NO synthase-deficient [iNOS(-/-)] mice were infected intranasal...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.96.9.4953

    authors: Hickman-Davis J,Gibbs-Erwin J,Lindsey JR,Matalon S

    更新日期:1999-04-27 00:00:00

  • A vimentin binding small molecule leads to mitotic disruption in mesenchymal cancers.

    abstract::Expression of the transcription factor FOXC2 is induced and necessary for successful epithelial-mesenchymal transition, a developmental program that when activated in cancer endows cells with metastatic potential and the properties of stem cells. As such, identifying agents that inhibit the growth of FOXC2-transformed...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1716009114

    authors: Bollong MJ,Pietilä M,Pearson AD,Sarkar TR,Ahmad I,Soundararajan R,Lyssiotis CA,Mani SA,Schultz PG,Lairson LL

    更新日期:2017-11-14 00:00:00

  • The importance of the Montreal Protocol in protecting climate.

    abstract::The 1987 Montreal Protocol on Substances that Deplete the Ozone Layer is a landmark agreement that has successfully reduced the global production, consumption, and emissions of ozone-depleting substances (ODSs). ODSs are also greenhouse gases that contribute to the radiative forcing of climate change. Using historical...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0610328104

    authors: Velders GJ,Andersen SO,Daniel JS,Fahey DW,McFarland M

    更新日期:2007-03-20 00:00:00

  • Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast.

    abstract::The Cdc6 protein is essential for the assembly of pre-replicative complexes (pre-RCs) at origins of DNA replication in the budding yeast Saccharomyces cerevisiae. This reaction is blocked in vivo by the cyclin-dependent kinase Cdc28p, together with its regulatory subunits, the B type cyclins that are present throughou...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.94.11.5611

    authors: Donovan S,Harwood J,Drury LS,Diffley JF

    更新日期:1997-05-27 00:00:00

  • Variability, compensation, and modulation in neurons and circuits.

    abstract::I summarize recent computational and experimental work that addresses the inherent variability in the synaptic and intrinsic conductances in normal healthy brains and shows that multiple solutions (sets of parameters) can produce similar circuit performance. I then discuss a number of issues raised by this observation...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章,评审

    doi:10.1073/pnas.1010674108

    authors: Marder E

    更新日期:2011-09-13 00:00:00

  • von Willebrand disease type B: a missense mutation selectively abolishes ristocetin-induced von Willebrand factor binding to platelet glycoprotein Ib.

    abstract::von Willebrand factor (vWF) is a multimeric glycoprotein that mediates the adhesion of platelets to the subendothelium by binding to platelet glycoprotein Ib. For human vWF, this interaction can be induced in vitro by the antibiotic ristocetin or the snake venom protein botrocetin. A missense mutation, Gly-561-->Ser, ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.89.20.9846

    authors: Rabinowitz I,Tuley EA,Mancuso DJ,Randi AM,Firkin BG,Howard MA,Sadler JE

    更新日期:1992-10-15 00:00:00

  • Influenza virus aerosol exposure and analytical system for ferrets.

    abstract::Understanding the transmission ability of newly emerging influenza viruses is central to the development of public health preparedness and prevention strategies. Animals are used to model influenza virus infection and transmission, but the routinely used intranasal inoculation of a liquid virus suspension does not ref...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1100768108

    authors: Gustin KM,Belser JA,Wadford DA,Pearce MB,Katz JM,Tumpey TM,Maines TR

    更新日期:2011-05-17 00:00:00

  • In vivo NMR and MRI using injection delivery of laser-polarized xenon.

    abstract::Because xenon NMR is highly sensitive to the local environment, laser-polarized xenon could be a unique probe of living tissues. Realization of clinical and medical science applications beyond lung airspace imaging requires methods of efficient delivery of laser-polarized xenon to tissues, because of the short spin-la...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.94.26.14725

    authors: Goodson BM,Song Y,Taylor RE,Schepkin VD,Brennan KM,Chingas GC,Budinger TF,Navon G,Pines A

    更新日期:1997-12-23 00:00:00

  • In vivo evidence for dysregulation of mGluR5 as a biomarker of suicidal ideation.

    abstract::Recent evidence implicates dysregulation of metabotropic glutamatergic receptor 5 (mGluR5) in pathophysiology of PTSD and suicidality. Using positron emission tomography and [18F]FPEB, we quantified mGluR5 availability in vivo in individuals with PTSD (n = 29) and MDD (n = 29) as a function of suicidal ideation (SI) t...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1818871116

    authors: Davis MT,Hillmer A,Holmes SE,Pietrzak RH,DellaGioia N,Nabulsi N,Matuskey D,Angarita GA,Carson RE,Krystal JH,Esterlis I

    更新日期:2019-06-04 00:00:00

  • Transcription of a quail gene expressed in embryonic retinal cells is shut off sharply at hatching.

    abstract::The avian neuroretina (NR) is part of the central nervous system and is composed of photoreceptors, neuronal cells, and Müller (glial) cells. These cells are derived from proliferating neuroectodermal precursors that differentiate after terminal mitosis and become organized in cell strata. Genes that are specifically ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.88.10.4503

    authors: Guermah M,Crisanti P,Laugier D,Dezelee P,Bidou L,Pessac B,Calothy G

    更新日期:1991-05-15 00:00:00

  • Protein kinase C is present in human sperm: possible role in flagellar motility.

    abstract::We report the presence of protein kinase C (PKC) in ejaculated human sperm as revealed by enzymatic activity assay and indirect immunohistochemistry. PKC is localized in the equatorial segment and in the principal piece of the tail. Addition of phorbol 12-myristate 13-acetate resulted in increased flagellar motility t...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.87.18.7305

    authors: Rotem R,Paz GF,Homonnai ZT,Kalina M,Naor Z

    更新日期:1990-09-01 00:00:00

  • Enhancement of dendritic cell activation via CD40 ligand-expressing γδ T cells is responsible for protective immunity to Plasmodium parasites.

    abstract::Previous reports have shown that γδ T cells are important for the elimination of malaria parasites in humans and mice. However, how γδ T cells are involved in protective immunity against blood-stage malaria remains unknown. We infected γδ T-cell-deficient (TCRδ-KO) mice and control wild-type mice with Plasmodium bergh...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1204480109

    authors: Inoue S,Niikura M,Takeo S,Mineo S,Kawakami Y,Uchida A,Kamiya S,Kobayashi F

    更新日期:2012-07-24 00:00:00

  • High-level expression of a heterologous protein in the milk of transgenic swine using the cDNA encoding human protein C.

    abstract::Transgenic pigs were generated that produced human protein C in their milk at up to 1 g/liter. The gene construct was a fusion gene consisting of the cDNA for human protein C inserted into the first exon of the mouse whey acidic protein gene. These results demonstrate that the mouse whey acidic protein gene contains r...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.89.24.12003

    authors: Velander WH,Johnson JL,Page RL,Russell CG,Subramanian A,Wilkins TD,Gwazdauskas FC,Pittius C,Drohan WN

    更新日期:1992-12-15 00:00:00

  • Delineation of a T-cell activation motif required for binding of protein tyrosine kinases containing tandem SH2 domains.

    abstract::To define the T-cell receptor signal transduction motif, we have transfected human and murine T-cell lines with a chimeric receptor consisting of the extracellular and transmembrane domains of human CD8 alpha and the membrane-proximal portion of CD3 zeta containing at its C terminus either an 18-amino acid segment (NQ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.91.14.6693

    authors: Koyasu S,Tse AG,Moingeon P,Hussey RE,Mildonian A,Hannisian J,Clayton LK,Reinherz EL

    更新日期:1994-07-05 00:00:00

  • Effects of self-motion on auditory scene analysis.

    abstract::Auditory scene analysis requires the listener to parse the incoming flow of acoustic information into perceptual "streams," such as sentences from a single talker in the midst of background noise. Behavioral and neural data show that the formation of streams is not instantaneous; rather, streaming builds up over time ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1112852109

    authors: Kondo HM,Pressnitzer D,Toshima I,Kashino M

    更新日期:2012-04-24 00:00:00

  • Estrogen inhibits the vascular injury response in estrogen receptor beta-deficient female mice.

    abstract::The protective effects of estrogen in the cardiovascular system result from both systemic effects and direct actions of the hormone on the vasculature. Two estrogen receptors have been identified, ERalpha and ERbeta. We demonstrated previously that estrogen inhibits the response to vascular injury in both wild-type an...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.96.26.15133

    authors: Karas RH,Hodgin JB,Kwoun M,Krege JH,Aronovitz M,Mackey W,Gustafsson JA,Korach KS,Smithies O,Mendelsohn ME

    更新日期:1999-12-21 00:00:00

  • Role of the translocation partner in protection against AID-dependent chromosomal translocations.

    abstract::Chromosome translocations between Ig (Ig) and non-Ig genes are frequently associated with B-cell lymphomas in humans and mice. The best characterized of these is c-myc/IgH translocation, which is associated with Burkitt's lymphoma. These translocations are caused by activation-induced cytidine deaminase (AID), which p...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0908946107

    authors: Jankovic M,Robbiani DF,Dorsett Y,Eisenreich T,Xu Y,Tarakhovsky A,Nussenzweig A,Nussenzweig MC

    更新日期:2010-01-05 00:00:00

  • Retrovirus envelope protein complex structure in situ studied by cryo-electron tomography.

    abstract::We used cryo-electron tomography in conjunction with single-particle averaging techniques to study the structures of frozen-hydrated envelope glycoprotein (Env) complexes on intact Moloney murine leukemia retrovirus particles. Cryo-electron tomography allows 3D imaging of viruses in toto at a resolution sufficient to ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0409178102

    authors: Förster F,Medalia O,Zauberman N,Baumeister W,Fass D

    更新日期:2005-03-29 00:00:00