Interaction instability of localization in quasiperiodic systems.

abstract：:E2F is a heterodimeric transcription factor that regulates the expression of genes at the G1/S boundary and is composed of two related but distinct families of proteins, E2F and DP. E2F/DP heterodimers form complexes with the retinoblastoma (Rb) protein, the Rb-related proteins p107 and p130, and cyclins/cdks in a cel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rogers KT,Higgins PD,Milla MM,Phillips RS,Horowitz JM

更新日期：1996-07-23 00:00:00

abstract：:Galanin is a neuropeptide with a wide variety of biological functions, including that of a strong endogenous anticonvulsant. No nonpeptide ligands, capable of activating galanin receptors, are available today. Based on known pharmacophores of galanin, a combinatorial library was designed, synthesized, and screened at ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saar K,Mazarati AM,Mahlapuu R,Hallnemo G,Soomets U,Kilk K,Hellberg S,Pooga M,Tolf BR,Shi TS,Hökfelt T,Wasterlain C,Bartfai T,Langel U

更新日期：2002-05-14 00:00:00

abstract：:Elastogenesis is a hierarchical process by which cells form functional elastic fibers, providing elasticity and the ability to regulate growth factor bioavailability in tissues, including blood vessels, lung, and skin. This process requires accessory proteins, including fibulin-4 and -5, and latent TGF binding protein...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kumra H,Nelea V,Hakami H,Pagliuzza A,Djokic J,Xu J,Yanagisawa H,Reinhardt DP

更新日期：2019-10-08 00:00:00

abstract：:Germ cells are required for the successful propagation of sexually reproducing species. Understanding the mechanisms by which these cells are specified and how their totipotency is established and maintained has important biomedical and evolutionary implications. Freshwater planarians serve as fascinating models for s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang Y,Zayas RM,Guo T,Newmark PA

更新日期：2007-04-03 00:00:00

abstract：:The DnaE intein in Synechocystis sp. strain PCC6803 is the first and only naturally split intein that has been identified so far. It is capable of catalyzing a protein trans-splicing mechanism to assemble a mature protein from two separate precursors. Therefore, it is a powerful tool for protein modification and engin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang J,Fox GC Jr,Henry-Smith TV

更新日期：2003-03-18 00:00:00

abstract：:Physiological properties of the flagellar rotary motor have been taken to indicate a tightly coupled mechanism in which each revolution is driven by a fixed number of energizing ions. Measurements that would directly test the tight-coupling hypothesis have not been made. Energizing ions flow through membrane-bound com...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boschert R,Adler FR,Blair DF

更新日期：2015-04-14 00:00:00

abstract：:The phagocyte NADPH oxidase, dormant in resting cells, is activated during phagocytosis to produce superoxide, a precursor of microbicidal oxidants. The activated oxidase is a complex of membrane-integrated cytochrome b558, composed of 91-kDa (gp91phox) and 22-kDa (p22phox) subunits, and two cytosolic factors (p47phox...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sumimoto H,Kage Y,Nunoi H,Sasaki H,Nose T,Fukumaki Y,Ohno M,Minakami S,Takeshige K

更新日期：1994-06-07 00:00:00

abstract：:Proopiomelanocortin (POMC), a major pituitary product, is also present in the adult mouse testis. We have shown previously that POMC mRNAs are most abundant in a subpopulation of Leydig cells associated with tubules in specific stages of the cycle of the seminiferous epithelium. In the present study, we examined the e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gizang-Ginsberg E,Wolgemuth DJ

更新日期：1987-03-01 00:00:00

abstract：:Neuronal progenitors and tumor cells possess propensity to proliferate and to migrate. Glutamate regulates proliferation and migration of neurons during development, but it is not known whether it influences proliferation and migration of tumor cells. We demonstrate that glutamate antagonists inhibit proliferation of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rzeski W,Turski L,Ikonomidou C

更新日期：2001-05-22 00:00:00

abstract：:A methylcholanthrene-induced glioblastoma of the C57BL/6 inbred mouse strain was used to raise antibodies in C57BL/6 and C57BL/10 inbred mice and in (C57BL/6 x DBA/2) and (C57BL/6 x Balb/c) F(1) hybrids. When examined by the cytotoxicity test, these antibodies define a cell-surface component (or components) found excl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schachner M

更新日期：1974-05-01 00:00:00

abstract：:SsrA/SsrB is a primary two-component system that mediates the survival and replication of Salmonella within host cells. When activated, the SsrB response regulator directly promotes the transcription of multiple genes within Salmonella pathogenicity island 2 (SPI-2). As expression of the SsrB protein is promoted by se...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Choi J,Shin D,Yoon H,Kim J,Lee CR,Kim M,Seok YJ,Ryu S

更新日期：2010-11-23 00:00:00

abstract：:Genetic manipulation of nitrogenase and key glutamate-forming enzymes can provide mutants that excrete fixed N2 as NH4+. A derepressed N2 fxation mutant (SK-24) has been isolated , which excretes up to 20.2 mumol of fixed N2 as NH4+ per mg of cell protein in 24 hr at room temperature. Biochemical analysis shows that t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shanmugam KT,Valentine RC

更新日期：1975-01-01 00:00:00

abstract：:Low passage Fischer rat embryo cultures, which are normally very resistant to transformation by 3-methylcholanthrene but are highly susceptible when chronically infected with the Rauscher murine leukemia virus, were completely protected from transformation by methylcholanthrene when treated with neutralizing antibody ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Price PJ,Bellew TM,King MP,Freeman AE,Gilden RV,Huebner RJ

更新日期：1976-01-01 00:00:00

abstract：:In Salmonella typhimurium, the CobU, CobS, CobT, and CobC proteins have been proposed to catalyze the late steps in adenosylcobalamin biosynthesis, which define the nucleotide loop assembly pathway. This paper reports the in vitro assembly of the nucleotide loop of adenosylcobalamin from its precursors adenosylcobinam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maggio-Hall LA,Escalante-Semerena JC

更新日期：1999-10-12 00:00:00

abstract：:In experiments originally designed to examine selective turnover of methylated "caps" in renal mRNA, we observed that [3H]methyl label decayed from mRNA containing poly(A) with a half-life of 1-2 hr. (Caps are blocked, methylated mRNA sequences of the general structure m7GpppNm p(1 or 2)Np.). To distinguish between me...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ouellette AJ,Reed SL,Malt RA

更新日期：1976-08-01 00:00:00

abstract：:Like other guanine nucleotide-exchange proteins (GEPs) that activate ADP-ribosylation factor (ARF) GTPases, brefeldin A-inhibited GEP2, BIG2, contains an approximately 200-aa Sec7 domain that is responsible for this catalytic activity and its inhibition by brefeldin A. The Sec7 domain is located near the center of the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li H,Adamik R,Pacheco-Rodriguez G,Moss J,Vaughan M

更新日期：2003-02-18 00:00:00

abstract：:Throughout three domains of life, alanyl-tRNA synthetases (AlaRSs) recognize a G3:U70 base pair in the acceptor stem of tRNAAla as the major identity determinant of tRNAAla The crystal structure of the archaeon Archaeoglobus fulgidus AlaRS in complex with tRNAAla provided the basis for G3:U70 recognition with residues...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chong YE,Guo M,Yang XL,Kuhle B,Naganuma M,Sekine SI,Yokoyama S,Schimmel P

更新日期：2018-07-17 00:00:00

abstract：:Huntington disease (HD) is caused by an expansion mutation of the N-terminal polyglutamine of huntingtin (mHTT). mHTT is ubiquitously present, but it induces noticeable damage to the brain's striatum, thereby affecting motor, psychiatric, and cognitive functions. The striatal damage and progression of HD are associate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sharma M,Rajendrarao S,Shahani N,Ramírez-Jarquín UN,Subramaniam S

更新日期：2020-07-07 00:00:00

abstract：:Characterizing the entropy of a system is a crucial, and often computationally costly, step in understanding its thermodynamics. It plays a key role in the study of phase transitions, pattern formation, protein folding, and more. Current methods for entropy estimation suffer from a high computational cost, lack of gen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nir A,Sela E,Beck R,Bar-Sinai Y

更新日期：2020-12-01 00:00:00

abstract：:Selective lodgement or homing of transplanted hemopoietic stem cells in the recipient's bone marrow (BM) is a critical step in the establishment of long-term hemopoiesis after BM transplantation. However, despite its biologic and clinical significance, little is understood about the process of homing. In the present s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Papayannopoulou T,Craddock C,Nakamoto B,Priestley GV,Wolf NS

更新日期：1995-10-10 00:00:00

abstract：:AvrXa7 is a member of the avrBs3 avirulence gene family, which encodes proteins targeted to plant cells by a type III secretion apparatus. AvrXa7, the product of avrXa7, is also a virulence factor in strain PXO86 of Xanthomonas oryzae pv. oryzae. Avirulence and virulence specificities are associated with the central r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang B,Zhu W,Johnson LB,White FF

更新日期：2000-08-15 00:00:00

abstract：:The membrane protein complex between the sarcoplasmic reticulum Ca(2+)-ATPase (SERCA) and phospholamban (PLN) controls Ca(2+) transport in cardiomyocytes, thereby modulating cardiac contractility. β-Adrenergic-stimulated phosphorylation of PLN at Ser-16 enhances SERCA activity via an unknown mechanism. Using solid-sta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gustavsson M,Verardi R,Mullen DG,Mote KR,Traaseth NJ,Gopinath T,Veglia G

更新日期：2013-10-22 00:00:00

abstract：:Development of pharyngeal muscle in nematodes and cardiac muscle in vertebrates and insects involves the related homeobox genes ceh-22, nkx2.5, and tinman, respectively. To determine whether the nematode and vertebrate genes perform similar functions, we examined activity of the zebrafish nkx2.5 gene in transgenic Cae...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Haun C,Alexander J,Stainier DY,Okkema PG

更新日期：1998-04-28 00:00:00

abstract：:The hippocampus and cerebellum are critically involved in trace eyeblink classical conditioning (EBCC). The mechanisms underlying the hippocampal-cerebellar interaction during this task are not well-understood, although hippocampal theta (3-7 Hz) oscillations are known to reflect a favorable state for EBCC. Two groups...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoffmann LC,Berry SD

更新日期：2009-12-15 00:00:00

abstract：:We have expressed the recombinant squid kinesin head domain in Escherichia coli and studied its interaction with microtubules. The head is active as a microtubule-stimulated ATPase and binds to microtubules, but it does not support microtubule gliding by itself. The head binds to both microtubules and depolymerized tu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Song YH,Mandelkow E

更新日期：1993-03-01 00:00:00

abstract：:Cyanobacteria, blue-green algae, are the most abundant autotrophs in aquatic environments and form the base of all aquatic food chains by fixing carbon and nitrogen into cellular biomass. The single most important nutrient for photosynthesis and growth is nitrate, which is severely limiting in many aquatic environment...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koropatkin NM,Pakrasi HB,Smith TJ

更新日期：2006-06-27 00:00:00

abstract：:The field of perceptual learning has identified changes in perceptual templates as a powerful mechanism mediating the learning of statistical regularities in our environment. By measuring threshold-vs.-contrast curves using an orientation identification task under varying levels of external noise, the perceptual templ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bejjanki VR,Zhang R,Li R,Pouget A,Green CS,Lu ZL,Bavelier D

更新日期：2014-11-25 00:00:00

abstract：:AMP deaminase (adenylate deaminase; AMP aminohydrolase, EC 3.5.4.6), a large flat tetrameric enzyme found in skeletal muscle, binds strongly and specifically to the subfragment-2 region of rabbit skeletal muscle myosin. This allows its use as a structural probe in myosin and myosin rod aggregation studies. When mixed ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koretz JF

更新日期：1982-10-01 00:00:00

abstract：:Cell signaling systems sense and respond to ligands that bind cell surface receptors. These systems often respond to changes in the concentration of extracellular ligand more rapidly than the ligand equilibrates with its receptor. We demonstrate, by modeling and experiment, a general "systems level" mechanism cells us...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ventura AC,Bush A,Vasen G,Goldín MA,Burkinshaw B,Bhattacharjee N,Folch A,Brent R,Chernomoretz A,Colman-Lerner A

更新日期：2014-09-16 00:00:00

abstract：:Immobilizing a protein, that is fully compatible with the patient, on the surface of a biomedical device should make it possible to avoid adverse responses such as inflammation, rejection, or excessive fibrosis. A surface that strongly binds and does not denature the compatible protein is required. Hydrophilic surface...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bilek MM,Bax DV,Kondyurin A,Yin Y,Nosworthy NJ,Fisher K,Waterhouse A,Weiss AS,dos Remedios CG,McKenzie DR

更新日期：2011-08-30 00:00:00