Cerebellar theta oscillations are synchronized during hippocampal theta-contingent trace conditioning.

Abstract:

:The hippocampus and cerebellum are critically involved in trace eyeblink classical conditioning (EBCC). The mechanisms underlying the hippocampal-cerebellar interaction during this task are not well-understood, although hippocampal theta (3-7 Hz) oscillations are known to reflect a favorable state for EBCC. Two groups of rabbits received trace EBCC in which a brain-computer interface administered trials in either the explicit presence or absence of naturally occurring hippocampal theta. A high percentage of robust theta led to a striking enhancement of learning accompanied by rhythmic theta-band (6-7 Hz) oscillations in the interpositus nucleus (IPN) and cerebellar cortex that were time-locked both to hippocampal rhythms and sensory stimuli during training. Rhythmic oscillations were absent in the cerebellum of the non-theta group. These data strongly suggest a beneficial impact of theta-based coordination of hippocampus and cerebellum and, importantly, demonstrate that hippocampal theta oscillations can be used to index, and perhaps modulate, the functional properties of the cerebellum.

authors

Hoffmann LC,Berry SD

doi

10.1073/pnas.0908403106

subject

Has Abstract

pub_date

2009-12-15 00:00:00

pages

21371-6

issue

50

eissn

0027-8424

issn

1091-6490

pii

0908403106

journal_volume

106

pub_type

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