Redox-induced activation of the proton pump in the respiratory complex I.

abstract：:Transcriptional network evolution is central to the development of complex biological systems. Networks can evolve through variation of master regulators and/or by changes in regulation of genes within networks. To gain insight into meaningful evolutionary differences in large networks, it is essential to address the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jegga AG,Inga A,Menendez D,Aronow BJ,Resnick MA

更新日期：2008-01-22 00:00:00

abstract：:Fish stocks experiencing high fishing mortality show a tendency to mature earlier and at a smaller size, which may have a genetic component and therefore long-lasting economic and biological effects. To date, the economic effects of such ecoevolutionary dynamics have not been empirically investigated. Using 70 y of da...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eikeset AM,Richter A,Dunlop ES,Dieckmann U,Stenseth NC

更新日期：2013-07-23 00:00:00

abstract：:Elucidating the mechanism of folding of polynucleotides depends on accurate estimates of free energy surfaces and a quantitative description of the kinetics of structure formation. Here, the kinetics of hairpin formation in single-stranded DNA are measured after a laser temperature jump. The kinetics are modeled as co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ansari A,Kuznetsov SV,Shen Y

更新日期：2001-07-03 00:00:00

abstract：:Bone marrow mononuclear cells (BMC) from patients with ischemic cardiomyopathy (ICMP) show a reduced neovascularization capacity in vivo. NO plays an important role in neovascularization, and NO bioavailability is typically reduced in patients with ICMP. We investigated whether the impaired neovascularization capacity...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sasaki K,Heeschen C,Aicher A,Ziebart T,Honold J,Urbich C,Rossig L,Koehl U,Koyanagi M,Mohamed A,Brandes RP,Martin H,Zeiher AM,Dimmeler S

更新日期：2006-09-26 00:00:00

abstract：:Voltage-gated Na channels in several classes of neurons, including cells of the cerebellum, are subject to an open-channel block and unblock by an endogenous protein. The Na(V)beta4 (Scn4b) subunit is a candidate blocking protein because a free peptide from its cytoplasmic tail, the beta4 peptide, can block open Na ch...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bant JS,Raman IM

更新日期：2010-07-06 00:00:00

abstract：:There is great interest in understanding the mechanisms of expression underlying long-term potentiation (LTP). They are agreed to involve an increase in synaptic efficacy, which is described by three multiplicative parameters: p, the probability of neurotransmitter release; n, the number of active release sites; and q...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schulz PE

更新日期：1997-05-27 00:00:00

abstract：:The secreted Bv8 protein has been recently characterized as a regulator of myeloid cell mobilization and a neutrophil-derived mediator of tumor angiogenesis in several xenografts, but its role in tumor progression in an endogenous setting was unknown. The rat insulin promoter (RIP)-T-antigen (Tag) is a well characteri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shojaei F,Singh M,Thompson JD,Ferrara N

更新日期：2008-02-19 00:00:00

abstract：:We have isolated a lymphoid cell line, MDS, from the pleural exudate of a patient with chronic myelomonocytic leukemia. The cells are biphenotypic, containing various T-cell and myeloid markers, and are surface negative for CD4 and CD8 but have low CD4 mRNA. The cells grow in suspension with a doubling time of 15 hr, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Banerjee R,Bekesi JG,Tarcsafalvi A,Sperber K,Deak G,Choi HS,Paronetto F,Holland JF,Acs G

更新日期：1992-11-01 00:00:00

abstract：:Blot hybridization analysis that used labeled tubulin cDNA probes revealed that N6,O2'-dibutyryladenosine 3',5'-cyclic monophosphate [dibutyryl cyclic AMP (Bt2cAMP)] initially increases and later decreases the level of tubulin mRNA in a neuroblastoma-glioma hybrid cell line as well as in the parent cells. A significan...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ginzburg I,Rybak S,Kimhi Y,Littauer UZ

更新日期：1983-07-01 00:00:00

abstract：:The binding of interferons to distinct cell surface receptors leads to the induction of synthesis of several unique polypeptides and their corresponding mRNAs (1-6). We have isolated two cDNAs that are complementary to nuclear RNA whose synthesis is induced from undetectable levels to maximal rates of transcription wi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Larner AC,Jonak G,Cheng YS,Korant B,Knight E,Darnell JE Jr

更新日期：1984-11-01 00:00:00

abstract：:The utility of adenovirus (Ad) vectors for gene transduction can be limited by receptor specificity. We developed a gene-delivery vehicle in which the potent Ad5 vector was genetically reengineered to display the mucosal-targeting sigma1 protein of reovirus type 3 Dearing (T3D). A sigma1 construct containing all but a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mercier GT,Campbell JA,Chappell JD,Stehle T,Dermody TS,Barry MA

更新日期：2004-04-20 00:00:00

abstract：:Cyanobacterial clock proteins KaiA and KaiC are proposed as positive and negative regulators in the autoregulatory circadian kaiBC expression, respectively. Here, we show that activation of kaiBC expression by kaiA requires KaiC, suggesting a positive feedback control in the cyanobacterial clockwork. We found that rob...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Iwasaki H,Nishiwaki T,Kitayama Y,Nakajima M,Kondo T

更新日期：2002-11-26 00:00:00

abstract：:The major obstacle to the study of functional/structural interrelationships of spinach chloroplasts by using spin labels has been the rapid loss of the electron paramagnetic resonance (EPR) signals upon illumination with visible light. The present study demonstrates that the addition of ferredoxin and NADP+ in the pre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sun AS,Calvin M

更新日期：1975-08-01 00:00:00

abstract：:The Paleocene-Eocene Thermal Maximum (PETM) (∼56 Ma) was a ∼170,000-y (∼170-kyr) period of global warming associated with rapid and massive injections of 13C-depleted carbon into the ocean-atmosphere system, reflected in sedimentary components as a negative carbon isotope excursion (CIE). Carbon cycle modeling has ind...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Frieling J,Svensen HH,Planke S,Cramwinckel MJ,Selnes H,Sluijs A

更新日期：2016-10-25 00:00:00

abstract：:Uropathogenic Escherichia coli invade bladder epithelial cells (BECs) by direct entry into specialized cAMP regulated exocytic compartments. Remarkably, a significant number of these intracellular bacteria are subsequently expelled in a nonlytic and piecemeal fashion by infected BECs. Here, we report that expulsion of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Song J,Bishop BL,Li G,Grady R,Stapleton A,Abraham SN

更新日期：2009-09-01 00:00:00

abstract：:We prove that the property of excision in algebraic K-theory is for a Q-algebra A equivalent to the H-unitality of the latter. Our excision theorem, in particular, implies Karoubi's conjecture on the equality of algebraic and topological K-theory groups of stable C*-algebras. It also allows us to identify the algebrai...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Suslin AA,Wodzicki M

更新日期：1990-12-15 00:00:00

abstract：:Exercise promotes longevity and ameliorates type 2 diabetes mellitus and insulin resistance. However, exercise also increases mitochondrial formation of presumably harmful reactive oxygen species (ROS). Antioxidants are widely used as supplements but whether they affect the health-promoting effects of exercise is unkn...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ristow M,Zarse K,Oberbach A,Klöting N,Birringer M,Kiehntopf M,Stumvoll M,Kahn CR,Blüher M

更新日期：2009-05-26 00:00:00

abstract：:Stimulation of the phosphatidylinositol cycle by neurotransmitters generates diacylglycerol, an activator of protein kinase C, which may regulate some forms of neurotransmission. Phorbol esters, potent inflammatory and tumor-promoting compounds, also activate protein kinase C. We demonstrate potent and selective effec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baraban JM,Gould RJ,Peroutka SJ,Snyder SH

更新日期：1985-01-01 00:00:00

abstract：:Excitation of HbCO by a single 6-psec 530-nm pulse results in photodissociation with a first-order constant of 0.89 X 10(11) sec-1. The kinetics of photodissociation, monitored by following absorbance changes in the Soret band at 440 nm, are interpreted as corresponding to predissociation followed by a corssing into a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Noe LJ,Eisert WG,Rentzepis PM

更新日期：1978-02-01 00:00:00

abstract：:We have shown that rat glioma tumors contain a protein that crossreacts with antibody against mouse 2.5S nerve growth factor prepared in rabbit in microcomplement fixation assays and has analogous isoelectric points to all the hybrids of 2.5S nerve growth factor (a dimer). Partially purified protein preparations from ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Longo AM,Penhoet EE

更新日期：1974-06-01 00:00:00

abstract：:Accurate replication in the presence of DNA damage is essential to genome stability and viability in all cells. In Escherichia coli, DNA replication forks blocked by UV-induced damage undergo a partial resection and RecF-catalyzed regression before synthesis resumes. These processing events generate distinct structura...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jeiranian HA,Schalow BJ,Courcelle CT,Courcelle J

更新日期：2013-07-09 00:00:00

abstract：:Carbon can exist as isolated dumbbell, 1D chain, 2D plane, and 3D network in carbon solids or carbon-based compounds, which attributes to its rich chemical binding way, including sp-, sp(2)-, and sp(3)-hybridized bonds. sp(2)-hybridizing carbon always captures special attention due to its unique physical and chemical ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li YL,Luo W,Zeng Z,Lin HQ,Mao HK,Ahuja R

更新日期：2013-06-04 00:00:00

abstract：:Despite the ubiquitous use of phosphoramidite chemistry in the synthesis of biophosphates, catalytic asymmetric phosphoramidite transfer remains largely unexplored for phosphate ester synthesis. We have discovered that a tetrazole-functionalized peptide, in the presence of 10-Å molecular sieves, functions as an enanti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jordan PA,Kayser-Bricker KJ,Miller SJ

更新日期：2010-11-30 00:00:00

abstract：:Many cyanobacteria alter their phycobilisome composition in response to changes in light wavelength in a process termed complementary chromatic adaptation. Mutant strains FdR1 and FdR2 of the filamentous cyanobacterium Fremyella diplosiphon are characterized by aberrant chromatic adaptation. Instead of adjusting to di...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chiang GG,Schaefer MR,Grossman AR

更新日期：1992-10-15 00:00:00

abstract：:USF is a family of transcription factors characterized by a highly conserved basic-helix-loop-helix-leucine zipper (bHLH-zip) DNA-binding domain. Two different USF genes, termed USF1 and USF2, are ubiquitously expressed in both humans and mice. The USF1 and USF2 proteins contain highly divergent transcriptional activa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luo X,Sawadogo M

更新日期：1996-02-06 00:00:00

abstract：:The kinase Cdc2p is a central regulator of entry into and progression through nuclear division during mitosis and meiosis in eukaryotes. Cdc2p is activated at the onset of mitosis by dephosphorylation on tyrosine-15, the phosphorylation status of which is determined mainly by the kinase Wee1p and the phosphatase Cdc25...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murakami-Tonami Y,Yamada-Namikawa C,Tochigi A,Hasegawa N,Kojima H,Kunimatsu M,Nakanishi M,Murakami H

更新日期：2007-09-11 00:00:00

abstract：:The x-ray structure of rubredoxin has been refined by energy minimization. The computed structure is constrained to have standard bond lengths, bond angles, and planar trans peptide groups. Also, since most of the steric overlaps have been relieved, it has a very low energy. As judged by the root mean square (RMS) dev...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rasse D,Warme PK,Scheraga HA

更新日期：1974-09-01 00:00:00

abstract：:The virB operon of the Agrobacterium tume-faciens pTiA6NC plasmid likely plays a role in directing T-DNA transfer events at the bacterial membrane, as determined previously by mutagenesis and cellular fractionation studies and by DNA sequence analysis of the approximately 12-kilobase-pair operon. The DNA sequence anal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Christie PJ,Ward JE Jr,Gordon MP,Nester EW

更新日期：1989-12-01 00:00:00

abstract：:By analogy with receptor-mediated endocytosis, clathrin-coated membrane segments at locations other than at the plasma membrane have been implicated in intracellular membrane transport/sorting. The crucial role of the Golgi apparatus in these processes prompted us to study the distribution at this level of clathrin-im...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Orci L,Ravazzola M,Amherdt M,Louvard D,Perrelet A

更新日期：1985-08-01 00:00:00

abstract：:Populations of jellyfish, Mastigias sp., landlocked in tropical marine lakes during the Holocene, show extreme genetic isolation (0.74 < or = phiST < or = 1.00), founder effects (genetic diversity: 0.000 < or = pi < or = 0.001), rapid morphological evolution, and behavioral adaptation. These results demonstrate incipi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dawson MN,Hamner WM

更新日期：2005-06-28 00:00:00