Abstract:
:Despite the ubiquitous use of phosphoramidite chemistry in the synthesis of biophosphates, catalytic asymmetric phosphoramidite transfer remains largely unexplored for phosphate ester synthesis. We have discovered that a tetrazole-functionalized peptide, in the presence of 10-Å molecular sieves, functions as an enantioselective catalyst for phosphite transfer. This chemistry in turn has been used as the key step in a streamlined synthesis of myo-inositol-6-phosphate. Mechanistic insights implicate phosphate as a directing group for a highly selective kinetic resolution of a protected inositol monophosphate. This work represents a distinct and efficient method for the selective catalytic phosphorylation of natural products.
journal_name
Proc Natl Acad Sci U S Aauthors
Jordan PA,Kayser-Bricker KJ,Miller SJdoi
10.1073/pnas.1001111107subject
Has Abstractpub_date
2010-11-30 00:00:00pages
20620-4issue
48eissn
0027-8424issn
1091-6490pii
1001111107journal_volume
107pub_type
杂志文章abstract::T cells that have been immunized to express optimal levels of contact hypersensitivity upon adoptive transfer to normal animals can be inhibited from doing so by incubating them with an antigen-specific T suppressor factor. This factor is composed of at least two subunits which come from cells expressing different Ly ...
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更新日期:2009-03-10 00:00:00