Functional evolution of the p53 regulatory network through its target response elements.

abstract：:Chlorophyll d-producing cyanobacteria are a recently described group of phototrophic bacteria that is a major focus of photosynthesis research, previously known only from marine environments in symbiosis with eukaryotes. We have discovered a free-living member of this group from a eutrophic hypersaline lake. Phylogene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miller SR,Augustine S,Olson TL,Blankenship RE,Selker J,Wood AM

更新日期：2005-01-18 00:00:00

abstract：:Several groups have attempted to develop gene therapy strategies to treat cancer via introduction of the wild-type (wt) p53 cDNA into cancer cells. Unfortunately, these approaches do not result in regulated expression of the p53 gene and do not reduce expression of the mutant p53 that is overexpressed in cancerous cel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Watanabe T,Sullenger BA

更新日期：2000-07-18 00:00:00

abstract：:Small ubiquitin-like modifier (SUMO) modification is emerging as an important control in transcription regulation. Here, we show that CREB-binding protein (CBP), a versatile transcriptional coactivator for numerous transcription factors in response to diverse signaling events, can be modified by SUMO-1 at lysine resid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kuo HY,Chang CC,Jeng JC,Hu HM,Lin DY,Maul GG,Kwok RP,Shih HM

更新日期：2005-11-22 00:00:00

abstract：:Cdc20/fizzy family proteins are involved in activation of the anaphase-promoting complex/cyclosome, which catalyzes the ubiquitin-dependent proteolysis of cell cycle regulatory proteins such as anaphase inhibitors and mitotic cyclins, leading to chromosome segregation and exit from mitosis. Previous work has shown tha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Farruggio DC,Townsley FM,Ruderman JV

更新日期：1999-06-22 00:00:00

abstract：:A solid-phase immunoadsorbent capable of binding mouse interferon has been prepared. Starting from crude tissue-culture material, interferon could be purified 1990 times in a single step of affinity chromatography. Overall recovery ranged from 55 to 103% with tissue culture and mouse-brain interferon; however, only 5%...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sipe JD,de Maeyer-Guignard J,Fauconnier B,de Maeyer E

更新日期：1973-04-01 00:00:00

abstract：:The uterine epithelium of mice and humans undergoes cyclical waves of cell proliferation and differentiation under the regulation of estradiol-17β (E2) and progesterone (P4). These epithelial cells respond to E2 with increased protein and DNA synthesis, whereas P4 inhibits only the E2-induced DNA synthetic response. H...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang Y,Zhu L,Kuokkanen S,Pollard JW

更新日期：2015-03-17 00:00:00

abstract：:The beta plasmid from Streptococcus faecalis strain DS5, which codes for resistance to erythromycin and lincomycin, was introduced into a Lancefield group F streptococcus, strain DR1501, by transformation. This strain, DR1501 (beta), was found to be an excellent donor of the beta plasmid and readily transferred the re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： LeBlanc DJ,Hawley RJ,Lee LN,St Martin EJ

更新日期：1978-07-01 00:00:00

abstract：:Mutations in the DAX-1 [dosage-sensitive sex reversal-adrenal hypoplasia congenita (AHC) critical region on the X chromosome; NR0B1] gene cause X-linked AHC associated with hypogonadotropic hypogonadism. DAX-1 encodes an unusual orphan member of the nuclear hormone receptor superfamily, acting as a transcriptional rep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lehmann SG,Lalli E,Sassone-Corsi P

更新日期：2002-06-11 00:00:00

abstract：:Inflammation is a major factor in heart disease. IκB kinase (IKK) and its downstream target NF-κB are regulators of inflammation and are activated in cardiac disorders, but their precise contributions and targets are unclear. We analyzed IKK/NF-κB function in the heart by a gain-of-function approach, generating an ind...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maier HJ,Schips TG,Wietelmann A,Krüger M,Brunner C,Sauter M,Klingel K,Böttger T,Braun T,Wirth T

更新日期：2012-07-17 00:00:00

abstract：:Snakes are limbless predators, and many species use venom to help overpower relatively large, agile prey. Snake venoms are complex protein mixtures encoded by several multilocus gene families that function synergistically to cause incapacitation. To examine venom evolution, we sequenced and interrogated the genome of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vonk FJ,Casewell NR,Henkel CV,Heimberg AM,Jansen HJ,McCleary RJ,Kerkkamp HM,Vos RA,Guerreiro I,Calvete JJ,Wüster W,Woods AE,Logan JM,Harrison RA,Castoe TA,de Koning AP,Pollock DD,Yandell M,Calderon D,Renjifo C,Cur

更新日期：2013-12-17 00:00:00

abstract：:The involvement of methylation in the chemosensory response of bacteria to many attractants has been clearly established by studies in several laboratories. It has been assumed that adaptation of Salmonella typhimurium and Escherichia coli to all attractants involves methylation of a transmembrane methyl-accepting che...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Niwano M,Taylor BL

更新日期：1982-01-01 00:00:00

abstract：:Although much of the brain's functional organization is genetically predetermined, it appears that some noninnate functions can come to depend on dedicated and segregated neural tissue. In this paper, we describe a series of experiments that have investigated the neural development and organization of one such noninna...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Polk TA,Farah MJ

更新日期：1998-02-03 00:00:00

abstract：:It has long been known that cholera outbreaks can be initiated when Vibrio cholerae, the bacterium that causes cholera, is present in drinking water in sufficient numbers to constitute an infective dose, if ingested by humans. Outbreaks associated with drinking or bathing in unpurified river or brackish water may dire...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lobitz B,Beck L,Huq A,Wood B,Fuchs G,Faruque AS,Colwell R

更新日期：2000-02-15 00:00:00

abstract：:In systemic lupus erythematosus (SLE), T helper cells exhibit increased and prolonged expression of cell-surface CD40 ligand (CD154), spontaneously overproduce interleukin-10 (IL-10), but underproduce interferon-gamma (IFN-gamma). We tested the hypothesis that the imbalance of these gene products reflects skewed expre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mishra N,Brown DR,Olorenshaw IM,Kammer GM

更新日期：2001-02-27 00:00:00

abstract：:We synthesized a series of octapeptide analogs of somatostatin, containing N-terminal tryptophan or another amino acid followed by the hexapeptide sequences Cys-Phe-D-Trp-Lys-Thr-Cys or Cys-Tyr-D-Trp-Lys-Val-Cys and a C-terminal threoninamide or tryptophanamide. After purification by HPLC, the inhibitory activities of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cai RZ,Karashima T,Guoth J,Szoke B,Olsen D,Schally AV

更新日期：1987-04-01 00:00:00

abstract：:The designed assembly of proteins into well-defined supramolecular architectures not only tests our understanding of protein-protein interactions, but it also provides an opportunity to tailor materials with new physical and chemical properties. Previously, we described that RIDC3, a designed variant of the monomeric ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brodin JD,Carr JR,Sontz PA,Tezcan FA

更新日期：2014-02-25 00:00:00

abstract：:The pathogenic species of Yersinia contain the transcriptional regulator RovA. In Yersinia pseudotuberculosis and Yersinia enterocolitica, RovA regulates expression of the invasion factor invasin (inv), which mediates translocation across the intestinal epithelium. A Y. enterocolitica rovA mutant has a significant dec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cathelyn JS,Crosby SD,Lathem WW,Goldman WE,Miller VL

更新日期：2006-09-05 00:00:00

abstract：:Studies on the structure-function relationship of diphtheria toxin are reported. New methods are described for the preparation of pure intact ("unnicked") toxin and for the preparation of the individual A and B chains. A biological assay method for the B chain is also presented, as well as a method for the labelling o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Everse J,Lappi DA,Beglau JM,Lee CL,Kaplan NO

更新日期：1977-02-01 00:00:00

abstract：:Annealed metals are surprisingly difficult to cut, involving high forces and an unusually thick "chip." This anomaly has long been explained, based on ex situ observations, using a model of smooth plastic flow with uniform shear to describe material removal by chip formation. Here we show that this phenomenon is actua...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yeung H,Viswanathan K,Compton WD,Chandrasekar S

更新日期：2015-08-11 00:00:00

abstract：:In this contribution, we study situations in which nanoparticles in a fluid are strongly heated, generating high heat fluxes. This situation is relevant to experiments in which a fluid is locally heated by using selective absorption of radiation by solid particles. We first study this situation for different types of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Merabia S,Shenogin S,Joly L,Keblinski P,Barrat JL

更新日期：2009-09-08 00:00:00

abstract：:Muscarinic acetylcholine receptors (mAChR) in the embryonic chicken heart undergo agonist-induced internalization and a subsequent decrease in receptor number (downregulation). Cloning studies have identified two subtypes of mAChR expressed in the embryonic chicken heart, the cm2 and cm4 receptors. We report here that...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Habecker BA,Nathanson NM

更新日期：1992-06-01 00:00:00

abstract：:The presynaptic plasma membrane protein SNAP-25 (synaptosome-associated protein of 25 kDa) has been implicated as one of several neural-specific components that direct constitutive fusion mechanisms to the regulated vesicle trafficking and exocytosis of neurotransmitter release. There exist two alternatively spliced i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bark IC,Hahn KM,Ryabinin AE,Wilson MC

更新日期：1995-02-28 00:00:00

abstract：:The intracellular signaling mechanisms regulating the generation and long-term persistence of memory T cells in vivo remain unclear. In this study, we used mouse models with conditional deletion of the key T cell receptor (TCR)-coupled adaptor molecule SH2-domain-containing phosphoprotein of 76 kDa (SLP-76), to analyz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bushar ND,Corbo E,Schmidt M,Maltzman JS,Farber DL

更新日期：2010-01-12 00:00:00

abstract：:The pathogenicity of fixed rabies virus strains for adult mice depends on the presence of an antigenic determinant on the viral glycoprotein. Two virus-neutralizing monoclonal antibodies have been used to identify this determinant. All pathogenic strains of fixed rabies virus bind to these antibodies and are neutraliz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dietzschold B,Wunner WH,Wiktor TJ,Lopes AD,Lafon M,Smith CL,Koprowski H

更新日期：1983-01-01 00:00:00

abstract：:Lithium-air batteries have captured worldwide attention due to their highest energy density among the chemical batteries. To provide continuous oxygen channels, here, we synthesized hierarchical mesoporous perovskite La(0.5)Sr(0.5)CoO(2.91) (LSCO) nanowires. We tested the intrinsic oxygen reduction reaction (ORR) and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhao Y,Xu L,Mai L,Han C,An Q,Xu X,Liu X,Zhang Q

更新日期：2012-11-27 00:00:00

abstract：:The effect of reflex splanchnic nerve stimulation on proenkephalin A biosynthesis was investigated in the rat adrenal medulla. Tissue levels of native [Met5]enkephalin-like immunoreactivity (IR) (measured by direct RIA of tissue extracts), cryptic [Met5]enkephalin-like IR (calculated as the increase in [Met5]enkephali...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kanamatsu T,Unsworth CD,Diliberto EJ Jr,Viveros OH,Hong JS

更新日期：1986-12-01 00:00:00

abstract：:Sulfated glycosaminoglycans (GAGs) such as heparan sulfate (HS) are heteropolysaccharides implicated in the pathology of protein aggregation diseases including localized and systemic forms of amyloidosis. Among subdomains of sulfated GAGs, highly sulfated domains of HS, called HS S-domains, have been highlighted as be...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Iwahashi N,Ikezaki M,Nishikawa T,Namba N,Ohgita T,Saito H,Ihara Y,Shimanouchi T,Ino K,Uchimura K,Nishitsuji K

更新日期：2020-12-29 00:00:00

abstract：:Spontaneous reciprocal mitotic recombination in the yeast Saccharomyces cerevisiae, associated with heteroallelic recombination, occurs almost exclusively at the two-strand stage and involves recombination of unduplicated chromosomes (i.e., during G1) or the unduplicated regions of chromosomes during the S phase of mi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Esposito MS

更新日期：1978-09-01 00:00:00

abstract：:A molecular model of poorly understood hydrophobic effects is heuristically developed using the methods of information theory. Because primitive hydrophobic effects can be tied to the probability of observing a molecular-sized cavity in the solvent, the probability distribution of the number of solvent centers in a ca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hummer G,Garde S,García AE,Pohorille A,Pratt LR

更新日期：1996-08-20 00:00:00

abstract：:How genome divergence eventually leads to speciation is a topic of prime evolutionary interest. Genomic islands of elevated divergence are frequently reported between diverging lineages, and their size is expected to increase with time and gene flow under the speciation-with-gene-flow model. However, such islands can ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ma T,Wang K,Hu Q,Xi Z,Wan D,Wang Q,Feng J,Jiang D,Ahani H,Abbott RJ,Lascoux M,Nevo E,Liu J

更新日期：2018-01-09 00:00:00