The wound repair response controls outcome to cutaneous leishmaniasis.

abstract：:A decade ago, it seemed rational that our rapidly increasing knowledge of the molecular identities of tumor antigens and a deeper understanding of basic immunology would point the way to an effective therapeutic cancer vaccine. Significant progress has been made, but we do not yet have a cancer vaccine that can reliab...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lewis JJ

更新日期：2004-10-05 00:00:00

abstract：:An integral mitochondrial membrane protein (p32) of yeast has previously been molecularly cloned and sequenced and suggested to function as a mitochondrial import receptor. However, this protein has also been proposed to function as phosphate translocator [Guérin, B., Bukusoglu, C., Rakotomanana, F. & Wohlrab, H. (199...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murakami H,Blobel G,Pain D

更新日期：1993-04-15 00:00:00

abstract：:A detailed model of the G(2) DNA damage checkpoint (G2DDC) system is presented that includes complex regulatory networks of the mitotic kinase Cdc2, phosphatase Cdc25, Wee1 kinase, and damage signal transduction pathways involving Chk1 and p53. Assumptions on the kinetic equations of the G2DDC are made, and computer s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aguda BD

更新日期：1999-09-28 00:00:00

abstract：:The use of matching variable number of tandem repeat (VNTR) profiles to link suspects with crimes is potentially very powerful, but it has been quite controversial. Initial debate over laboratory procedures has largely given way to debate over the statistical and population genetic issues involved in calculating the f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weir BS

更新日期：1992-12-15 00:00:00

abstract：:Regulated exocytosis requires tight coupling of the membrane fusion machinery to a triggering signal and a fast response time. Complexins are part of this regulation and, together with synaptotagmins, control calcium-dependent exocytosis. Stimulatory and inhibitory functions have been reported for complexins. To test ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Malsam J,Seiler F,Schollmeier Y,Rusu P,Krause JM,Söllner TH

更新日期：2009-02-10 00:00:00

abstract：:A cofactor needed for the reduction of CDP-4-keto-6-deoxy-D-glucose to CDP-4-keto-3,6-dideoxy D-glucose has been detected and purified. Its spectra in neutral, acid, and basic solutions, its behavior on thin-layer chromatography, and other properties led to its identification as pyridoxamine-5'-phosphate. Moreover, au...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gonzalez-Porque P,Strominger JL

更新日期：1972-06-01 00:00:00

abstract：:The CD4-8- thymocyte subset contains immature precursors for phenotypically and functionally mature CD4+8- and CD4-8+ thymocytes and peripheral T cells, as well as nonmature CD4+8+ thymocytes, most of which die in situ. The intrathymic death of most thymocytes is probably related to selective influences that ensure th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guidos CJ,Weissman IL,Adkins B

更新日期：1989-10-01 00:00:00

abstract：:mRNA for the large subunit (LS) of ribulose-1,5-bisphosphate carboxylase [3-phospho-D-glycerate carboxylase (dimerizing), EC 4.1.1.39] of Zea mays is complementary to an uninterrupted 1600-base-pair-long chloroplast DNA sequence that has been mapped precisely within the 4350-base-pair-long chloroplast DNA fragment Bam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Link G,Bogorad L

更新日期：1980-04-01 00:00:00

abstract：:We studied visual perception using an annular random-dot motion stimulus called the racetrack. We recorded neural activity using magnetoencephalography while subjects viewed variants of this stimulus that contained no inherent motion or various degrees of embedded motion. Subjects reported seeing rotary motion during ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Crowe DA,Leuthold AC,Georgopoulos AP

更新日期：2010-12-28 00:00:00

abstract：:Hox genes are located in highly conserved clusters. The significance of this organization is unclear, but one possibility is that regulatory regions for individual genes are dispersed throughout the cluster and shared with other Hox genes. This hypothesis is supported by studies on several Hox genes in which even larg...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bradshaw MS,Shashikant CS,Belting HG,Bollekens JA,Ruddle FH

更新日期：1996-03-19 00:00:00

abstract：:Arsenic has played a key medicinal role against a variety of ailments for several millennia, but during the past century its prominence has been displaced by modern therapeutics. Recently, attention has been drawn to arsenic by its dramatic clinical efficacy against acute promyelocytic leukemia. Although toxic reactiv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chou WC,Jie C,Kenedy AA,Jones RJ,Trush MA,Dang CV

更新日期：2004-03-30 00:00:00

abstract：:Controls of stem cell maintenance and early differentiation are known in several systems. However, the progression from stem cell self-renewal to overt signs of early differentiation is a poorly understood but important problem in stem cell biology. The Caenorhabditis elegans germ line provides a genetically defined m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cinquin O,Crittenden SL,Morgan DE,Kimble J

更新日期：2010-02-02 00:00:00

abstract：:Single molecule atomic force microscopy was used to characterize structure, binding strength (unbinding force), and binding kinetics of a classical cadherin, vascular endothelial (VE)-cadherin, secreted by transfected Chinese hamster ovary cells as cis-dimerized full-length external domain fused to Fc-portion of human...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baumgartner W,Hinterdorfer P,Ness W,Raab A,Vestweber D,Schindler H,Drenckhahn D

更新日期：2000-04-11 00:00:00

abstract：:The amino acid sequence for chicken smooth muscle myosin light chain kinase (smMLCK) was deduced from a full-length cDNA. This has allowed definition of both the complete sequence of the inactive 64-kDa proteolytic fragment, which contains the pseudosubstrate autoregulatory sequence, and of the active 61-kDa Ca2+/calm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Olson NJ,Pearson RB,Needleman DS,Hurwitz MY,Kemp BE,Means AR

更新日期：1990-03-01 00:00:00

abstract：:Mismatch repair contributes to genetic stability, and inactivation of the mammalian pathway leads to tumor development. Mismatch correction occurs by an excision-repair mechanism and has been shown to depend on the 5' to 3' hydrolytic activity exonuclease 1 (Exo1) in eukaryotic cells. However, genetic and biochemical ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kadyrov FA,Genschel J,Fang Y,Penland E,Edelmann W,Modrich P

更新日期：2009-05-26 00:00:00

abstract：:Multifunctional nanoparticles for biomedical applications have shown extraordinary potential as contrast agents in various bioimaging modalities, near-IR photothermal therapy, and for light-triggered therapeutic release processes. Over the past several years, numerous studies have been performed to synthesize and enha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marangoni VS,Neumann O,Henderson L,Kaffes CC,Zhang H,Zhang R,Bishnoi S,Ayala-Orozco C,Zucolotto V,Bankson JA,Nordlander P,Halas NJ

更新日期：2017-07-03 00:00:00

abstract：:Biosynthesis of sucrose-6-P catalyzed by sucrose-phosphate synthase (SPS), and the presence of sucrose-phosphate phosphatase (SPP) leading to the formation of sucrose, have both been ascertained in a prokaryotic organism: Anabaena 7119, a filamentous heterocystic cyanobacterium. Two SPS activities (SPS-I and SPS-II) w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Porchia AC,Salerno GL

更新日期：1996-11-26 00:00:00

abstract：:Integrated hepadnaviral DNA in livers and tumors of chronic hepatitis B patients has been reported for many years. In this study, we investigated whether hepatitis B virus DNA integration occurs preferentially at sites of cell DNA damage. A single I-SceI homing endonuclease recognition site was introduced into the DNA...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bill CA,Summers J

更新日期：2004-07-27 00:00:00

abstract：:Contact of axons with target territories results in the formation of synapses, specific junctional complexes that may represent a final stage of neuronal maturation. Synaptosomal-associated protein 25 (SNAP-25) is a component of particular nerve terminals recently identified in rodent brain. To evaluate the structure ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Catsicas S,Larhammar D,Blomqvist A,Sanna PP,Milner RJ,Wilson MC

更新日期：1991-02-01 00:00:00

abstract：:Inward rectifying potassium (Kir) channels participate in regulating potassium concentration (K(+)) in the central nervous system (CNS), including in the retina. We explored the contribution of Kir channels to retinal function by delivering Kir antibodies (Kir-Abs) into the rat eye in vivo to interrupt channel activit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Raz-Prag D,Grimes WN,Fariss RN,Vijayasarathy C,Campos MM,Bush RA,Diamond JS,Sieving PA

更新日期：2010-07-13 00:00:00

abstract：:The callipyge mutation (CLPG) is an A to G transition that affects a muscle-specific long-range control element located in the middle of the 90-kb DLK1-GTL2 intergenic (IG) region. It causes ectopic expression of a 327-kb cluster of imprinted genes in skeletal muscle, resulting in the callipyge muscular hypertrophy an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takeda H,Caiment F,Smit M,Hiard S,Tordoir X,Cockett N,Georges M,Charlier C

更新日期：2006-05-23 00:00:00

abstract：:Brown-rot fungi such as Postia placenta are common inhabitants of forest ecosystems and are also largely responsible for the destructive decay of wooden structures. Rapid depolymerization of cellulose is a distinguishing feature of brown-rot, but the biochemical mechanisms and underlying genetics are poorly understood...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Martinez D,Challacombe J,Morgenstern I,Hibbett D,Schmoll M,Kubicek CP,Ferreira P,Ruiz-Duenas FJ,Martinez AT,Kersten P,Hammel KE,Vanden Wymelenberg A,Gaskell J,Lindquist E,Sabat G,Bondurant SS,Larrondo LF,Canessa P,Vic

更新日期：2009-02-10 00:00:00

abstract：:The plasma concentration of the major vitamin D metabolites; 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, and 24,25-dihydroxyvitamin D were measured during pregnancy and lactation in the adult female rat. The concentrations of these metabolites were also measured in rat pups during lactation and after weaning. The pl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Halloran BP,Barthell EN,DeLuca HF

更新日期：1979-11-01 00:00:00

abstract：:A rapid and convenient method has been devised to determine the binding sites for proteins on RNA. The procedure is an adaptation of one used to map DNA-protein complexes by protection against nuclease digestion. The method uses the cytotoxic ribonuclease alpha-sarcin, which hydrolyzes purines in both single- and doub...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huber PW,Wool IG

更新日期：1984-01-01 00:00:00

abstract：:The Drosophila kep1 gene encodes an RNA binding protein related to the murine QUAKING apoptotic inducer. We have previously shown that kep1 can induce apoptosis when transfected into different cell lines. To better define the role of Kep1 in apoptosis, we generated kep1 null flies. These flies were viable, but females...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Di Fruscio M,Styhler S,Wikholm E,Boulanger MC,Lasko P,Richard S

更新日期：2003-02-18 00:00:00

abstract：:Neutrophils are immune cells that bind to, engulf, and destroy bacterial and fungal pathogens in infected tissue, and their clearance by apoptosis is essential for the resolution of inflammation. Killing involves both oxidative and nonoxidative processes, the oxidative pathway requiring electrogenic production of supe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fay AJ,Qian X,Jan YN,Jan LY

更新日期：2006-11-14 00:00:00

abstract：:The extracellular hemoglobin of Ascaris has an extremely high oxygen affinity (P50 = 0.004 mmHg). It consists of eight identical subunits of molecular weight 40,600. Their sequence, determined by protein chemistry, shows two tandemly linked globin-like sequences and an 18-residue C-terminal extension. Two N-linked gly...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： De Baere I,Liu L,Moens L,Van Beeumen J,Gielens C,Richelle J,Trotman C,Finch J,Gerstein M,Perutz M

更新日期：1992-05-15 00:00:00

abstract：:DNA sequence analysis of a region contained within a large, interspersed repetitive family of mice reveals a long open reading frame. This sequence extends 978 base pairs between two stop codons, creating a reading frame that is open for 326 amino acids. The DNA sequence in this region is conserved between three dista...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Martin SL,Voliva CF,Burton FH,Edgell MH,Hutchison CA 3rd

更新日期：1984-04-01 00:00:00

abstract：:In the normal development of retinotectal connections, the site in the tectum at which an optic fiber synapses is related to the position of its ganglion-cell body in the retina. How and when the ganglion cells acquire information about their positions is unknown, but the positional information that each ganglion cell...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hunt RK,Jacobson M

更新日期：1972-10-01 00:00:00

abstract：:X-ray grating interferometry is a coherent imaging technique that bears tremendous potential for three-dimensional tomographic imaging of soft biological tissue and other specimens whose details exhibit very weak absorption contrast. It is intrinsically trimodal, delivering phase contrast, absorption contrast, and sca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zanette I,Bech M,Rack A,Le Duc G,Tafforeau P,David C,Mohr J,Pfeiffer F,Weitkamp T

更新日期：2012-06-26 00:00:00