Cadherin interaction probed by atomic force microscopy.

abstract：:The neuronal nucleus plays a vital role in information processing, but whether it supports computational functions such as paired-pulse facilitation, comparable to synapses, is unclear. Ca(2+)-dependent movement of calmodulin (CaM) to the nucleus is highly responsive to Ca(2+) entry through L-type channels and promote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mermelstein PG,Deisseroth K,Dasgupta N,Isaksen AL,Tsien RW

更新日期：2001-12-18 00:00:00

abstract：:We have found that poly(L-lysine) can be a very effective agent in preventing the growth of Ehrlich ascites tumors in mice. When given optimal doses of poly(L-lysine) (Mr 60 x 10(3)) intraperitoneally for 5 consecutive days, beginning on day 1 after inoculation with Ehrlich ascites cells. White Swiss mice show nearly ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arnold LJ Jr,Dagan A,Gutheil J,Kaplan NO

更新日期：1979-07-01 00:00:00

abstract：:We present evidence that the JAK-STAT signal transduction pathway regulates multiple developmental processes in Drosophila. We screened for second-site mutations that suppress the phenotype of the hyperactive hopTum-1 Jak kinase, and recovered a mutation that meiotically maps to the known chromosomal position of D-Sta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yan R,Luo H,Darnell JE Jr,Dearolf CR

更新日期：1996-06-11 00:00:00

abstract：:Foraminifera are unicellular organisms that inhabit the oceans in various ecosystems. The majority of the foraminifera precipitate calcitic shells and are among the major CaCO(3) producers in the oceans. They comprise an important component of the global carbon cycle and also provide valuable paleoceanographic informa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bentov S,Brownlee C,Erez J

更新日期：2009-12-22 00:00:00

abstract：:A discussion of the expected mechanism of radical reduction of carbonyl compounds by dihydroflavin as it relates to the structure of the carbonyl compound is provided. Factors which must be taken into account are the free energies of formation of the radical anions (CR2O), THE ACIDITY OF THE CONJUGATE ACID OF THE CARB...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Williams RF,Shinkai S,Bruice TC

更新日期：1975-05-01 00:00:00

abstract：:Membrane vesicles were extracted from etiolated and light-grown plants, a plant cell suspension culture, and an alga. Upon addition of ATP and Mg(2+), active Ca(2+) uptake into the vesicles against a concentration gradient was shown. The dependence of this uptake on ATP and Mg(2+) concentrations, pH, and temperature i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gross J,Marmé D

更新日期：1978-03-01 00:00:00

abstract：:The phenotype of several erythromycin-resistant mutants of Chlamydomonas reinhardi was further characterized in terms of the electrophoretic properties of their chloroplast ribosomal proteins. In mutant ery-M2d a single protein of the large (52 S) subunit has altered properties, which probably result from a change in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mets L,Bogorad L

更新日期：1972-12-01 00:00:00

abstract：:We examine the quantum confinement in the photoemission ionization energy in air and optical band gap of carbon nanoparticles (CNPs). Premixed, stretched-stabilized ethylene flames are used to generate the CNPs reproducibly over the range of 4-23 nm in volume median diameter. The results reveal that flame-formed CNPs ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu C,Singh AV,Saggese C,Tang Q,Chen D,Wan K,Vinciguerra M,Commodo M,De Falco G,Minutolo P,D'Anna A,Wang H

更新日期：2019-06-25 00:00:00

abstract：:Most human cancers are aneuploid and have chromosomal instability, which contrasts to the inability of human cells to normally tolerate aneuploidy. Noting that aneuploidy in human breast cancer correlates with increased expression levels of the Mps1 checkpoint gene, we investigated whether these high levels of Mps1 co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Daniel J,Coulter J,Woo JH,Wilsbach K,Gabrielson E

更新日期：2011-03-29 00:00:00

abstract：:DNA polymerases replicate DNA by adding nucleotides to a growing primer strand while avoiding frameshift and point mutations. Here we present a series of up to six successive replication events that were obtained by extension of a primed template directly in a crystal of the thermostable Bacillus DNA polymerase I. The...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Johnson SJ,Taylor JS,Beese LS

更新日期：2003-04-01 00:00:00

abstract：:Autophagy is a cellular catabolic pathway by which long-lived proteins and damaged organelles are targeted for degradation. Activation of autophagy enhances cellular tolerance to various stresses. Recent studies indicate that a class of anticancer agents, histone deacetylase (HDAC) inhibitors, can induce autophagy. On...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gammoh N,Lam D,Puente C,Ganley I,Marks PA,Jiang X

更新日期：2012-04-24 00:00:00

abstract：:It was previously shown that coexpression of the lactose permease of Escherichia coli in two contiguous fragments leads to functional complementation. We demonstrate here that site-directed thiol crosslinking of coexpressed permease fragments can be used to determine helix proximity in situ without the necessity of pu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu J,Kaback HR

更新日期：1996-12-10 00:00:00

abstract：:Little is known about how members of the indigenous microflora interact with their mammalian hosts to establish mutually beneficial relationships. We have used a gnotobiotic mouse model to show that Bacteroides thetaiotaomicron, a component of the intestinal microflora of mice and humans, uses a repressor, FucR, as a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hooper LV,Xu J,Falk PG,Midtvedt T,Gordon JI

更新日期：1999-08-17 00:00:00

abstract：:Sensory receptor neurons match their dynamic range to ecologically relevant stimulus intensities. How this tuning is achieved is poorly understood in most receptors. The roundworm Caenorhabditis elegans avoids 21% O2 and hypoxia and prefers intermediate O2 concentrations. We show how this O2 preference is sculpted by ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oda S,Toyoshima Y,de Bono M

更新日期：2017-06-06 00:00:00

abstract：:Nucleotide excision repair proteins have been implicated in genetic recombination by experiments in Saccharomyces cerevisiae and Drosophila melanogaster, but their role, if any, in mammalian cells is undefined. To investigate the role of the nucleotide excision repair gene ERCC1, the hamster homologue to the S. cerevi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sargent RG,Rolig RL,Kilburn AE,Adair GM,Wilson JH,Nairn RS

更新日期：1997-11-25 00:00:00

abstract：:Human liver alkaline phosphatase [ortho-phosphoric monoester phosphohydrolase (alkaline optimum), EC 3.1.3.1] was purified, and some of its physical and chemical properties were examined and compared to those of human placental alkaline phosphatase. The results indicated a different peptide structure for each, based u...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Badger KS,Sussman HH

更新日期：1976-07-01 00:00:00

abstract：:Distinguishing tumor from normal glandular breast tissue is an important step in breast-conserving surgery. Because this distinction can be challenging in the operative setting, up to 40% of patients require an additional operation when traditional approaches are used. Here, we present a proof-of-concept study to dete...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Calligaris D,Caragacianu D,Liu X,Norton I,Thompson CJ,Richardson AL,Golshan M,Easterling ML,Santagata S,Dillon DA,Jolesz FA,Agar NY

更新日期：2014-10-21 00:00:00

abstract：:Mechanism of photo-induced electron transfer and the subsequent hole transfer in DNA has been studied extensively, but so far we are not aware of any reliable report of the observation of the long-distance hole-transfer process. In this article, we demonstrate the results of direct observation for the long-distance ho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takada T,Kawai K,Fujitsuka M,Majima T

更新日期：2004-09-28 00:00:00

abstract：:There are many sources of genetic diversity, ranging from programmed mutagenesis in antibody genes to random mutagenesis during species evolution or development of cancer. We propose that mutations in DNA sequence-specific transcription factors that target response elements (REs) in many genes can also provide for rap...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Resnick MA,Inga A

更新日期：2003-08-19 00:00:00

abstract：:Graphene superlattices were shown to exhibit high-temperature quantum oscillations due to periodic emergence of delocalized Bloch states in high magnetic fields such that unit fractions of the flux quantum pierce a superlattice unit cell. Under these conditions, semiclassical electron trajectories become straight agai...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Krishna Kumar R,Mishchenko A,Chen X,Pezzini S,Auton GH,Ponomarenko LA,Zeitler U,Eaves L,Fal'ko VI,Geim AK

更新日期：2018-05-15 00:00:00

abstract：:Current therapeutic interventions for the treatment of respiratory infections are hampered by the evolution of multidrug resistance in pathogens as well as the lack of effective cellular targets. Despite the identification of multiple region-specific lung progenitor cells, the identity of molecules that might be thera...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Khatri A,Kraft BD,Tata PR,Randell SH,Piantadosi CA,Pendergast AM

更新日期：2019-01-29 00:00:00

abstract：:If X(1), X(2),... are independent random variables with zero expectation and finite variances, the cumulative sums S(n) are, on the average, of the order of magnitude S(n), where S(n) (2) = E(S(n) (2)). The occasional maxima of the ratios S(n)/S(n) are surprisingly large and the problem is to estimate the extent of th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Feller W

更新日期：1969-07-01 00:00:00

abstract：:Bacterial populations are subject to complex processes of diversification that involve mutation and horizontal DNA transfer mediated by transformation, transduction, or conjugation. Tracing the evolutionary events leading to genetic changes allows us to infer the history of a microbe. Here, we combine experimental and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brochet M,Rusniok C,Couvé E,Dramsi S,Poyart C,Trieu-Cuot P,Kunst F,Glaser P

更新日期：2008-10-14 00:00:00

abstract：:BRCA1 is a breast and ovarian cancer-specific tumor suppressor that seems to be involved in transcription and DNA repair. Here we report that BRCA1 exhibits a bona fide ubiquitin (Ub) protein ligase (E3) activity, and that cancer-predisposing mutations within the BRCA1 RING domain abolish its Ub ligase activity. Furth...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ruffner H,Joazeiro CA,Hemmati D,Hunter T,Verma IM

更新日期：2001-04-24 00:00:00

abstract：:Precipitation extreme changes are often assumed to scale with, or are constrained by, the change in atmospheric moisture content. Studies have generally confirmed the scaling based on moisture content for the midlatitudes but identified deviations for the tropics. In fact half of the twelve selected Intergovernmental ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sugiyama M,Shiogama H,Emori S

更新日期：2010-01-12 00:00:00

abstract：:We carried out a large-scale screen to identify interactions between integral membrane proteins of Saccharomyces cerevisiae by using a modified split-ubiquitin technique. Among 705 proteins annotated as integral membrane, we identified 1,985 putative interactions involving 536 proteins. To ascribe confidence levels to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miller JP,Lo RS,Ben-Hur A,Desmarais C,Stagljar I,Noble WS,Fields S

更新日期：2005-08-23 00:00:00

abstract：:Underacetylation of histone H4 is thought to be involved in the molecular mechanism of mammalian X chromosome inactivation, which is an important model system for large-scale genetic control in eukaryotes. However, it has not been established whether histone underacetylation plays a critical role in the multistep inac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wakefield MJ,Keohane AM,Turner BM,Graves JA

更新日期：1997-09-02 00:00:00

abstract：:The respiratory burst oxidase of neutrophils can be activated in a cell-free system in which plasma membranes, cytosol, Mg2+, and a membrane-perturbing detergent, such as arachidonate or sodium dodecyl sulfate, are all required. Using the technique of preparative isoelectric focusing, the cytosol factor required for o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Curnutte JT,Scott PJ,Mayo LA

更新日期：1989-02-01 00:00:00

abstract：:N-Acetylaspartylglutamate, an endogenous brain peptide that binds with high affinity to a subpopulation of glutamate-binding sites in rat brain, is excitatory on rat piriform cortex pyramidal cells studied in a perfused brain slice. Both the monosynaptic excitation of the pyramidal cells elicited by stimulation of the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ffrench-Mullen JM,Koller K,Zaczek R,Coyle JT,Hori N,Carpenter DO

更新日期：1985-06-01 00:00:00

abstract：:The effects of selected heme analogues on heme oxygenase activity in tissues and on human and rabbit bone marrow hematopoietic colony growth were examined. Zinc protoporphyrin (ZnPP) and zinc mesoporphyrin (ZnMP), at concentrations ranging between 1 and 20 microM, produced significant inhibition of human and rabbit bo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lutton JD,Abraham NG,Drummond GS,Levere RD,Kappas A

更新日期：1997-02-18 00:00:00