Flame-formed carbon nanoparticles exhibit quantum dot behaviors.

abstract：:The imino sugar N-butyldeoxynojirimycin (NBDNJ) is a potent inhibitor of the oligosaccharide-trimming enzyme alpha-glucosidase I. Hepatitis B virus (HBV) contains three surface proteins (HBs proteins) of different sizes that are singly or doubly N-glycosylated and are essential for the formation of infectious virus. T...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Block TM,Lu X,Platt FM,Foster GR,Gerlich WH,Blumberg BS,Dwek RA

更新日期：1994-03-15 00:00:00

abstract：:In colloidal systems, the interplay between the short range attraction and long-range repulsion can lead to a low density associated state consisting of clusters of individual particles. Recently, such an equilibrium cluster phase was also reported for concentrated solutions of lysozyme at low ionic strength and close...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shukla A,Mylonas E,Di Cola E,Finet S,Timmins P,Narayanan T,Svergun DI

更新日期：2008-04-01 00:00:00

abstract：:The thyroid hormone and retinoid X receptors form a heterodimer with each other and mediate thyroid hormone (T3)-dependent transcription. Retinoid X receptor, in addition, forms a homodimer and mediates 9-cis-retinoic acid-dependent transcription. Here, recombinant thyroid hormone receptor and recombinant retinoid X r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee IJ,Driggers PH,Medin JA,Nikodem VM,Ozato K

更新日期：1994-03-01 00:00:00

abstract：:Although the unifying hallmark of prion diseases is CNS neurodegeneration caused by conformational corruption of host prion protein (PrP) to its infective counterpart, contagious transmission of chronic wasting disease (CWD) results from shedding of prions produced at high titers in the periphery of diseased cervids. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bian J,Christiansen JR,Moreno JA,Kane SJ,Khaychuk V,Gallegos J,Kim S,Telling GC

更新日期：2019-06-18 00:00:00

abstract：:Transforming growth factor beta (TGF-beta) signals through a receptor complex containing the type I (TGF-beta RI) and type II (TGF-beta RII) receptors. We describe here biochemical studies on early events in the TGF-beta signaling pathways. TGF-beta RII is highly phosphorylated when expressed alone in COS-1 cells; its...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen F,Weinberg RA

更新日期：1995-02-28 00:00:00

abstract：:Methylmercury (MeHg) is a potent neurotoxin that is biomagnified approximately 1-10 million-fold in aquatic carnivores such as the Northern elephant seal (Mirounga angustirostris), whose excreta and molted pelage, in turn, constitute a source of environmental MeHg contamination at the base of marine food chains. The p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cossaboon JM,Ganguli PM,Flegal AR

更新日期：2015-09-29 00:00:00

abstract：:A common genetic mutation found in clear cell renal cell carcinoma (CC-RCC) is the loss of the von Hippel-Lindau (VHL) gene, which results in stabilization of hypoxia-inducible factors (HIFs), and contributes to cancer progression and metastasis. CUB-domain-containing protein 1 (CDCP1) was shown to promote metastasis ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Razorenova OV,Finger EC,Colavitti R,Chernikova SB,Boiko AD,Chan CK,Krieg A,Bedogni B,LaGory E,Weissman IL,Broome-Powell M,Giaccia AJ

更新日期：2011-02-01 00:00:00

abstract：:CD4(+) T cells are generally regarded as helpers and regulators of the immune response. Although cytolytic CD4(+) T cells have been described, whether those generated during the course of a viral infection play a role in virus control remains unknown. Here we show that during acute infection with ectromelia virus, the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fang M,Siciliano NA,Hersperger AR,Roscoe F,Hu A,Ma X,Shamsedeen AR,Eisenlohr LC,Sigal LJ

更新日期：2012-06-19 00:00:00

abstract：:In the present study the complete amino acid sequence of human plasma Zn-alpha 2-glycoprotein was determined. This protein whose biological function is unknown consists of a single polypeptide chain of 276 amino acid residues including 8 tryptophan residues and has a pyroglutamyl residue at the amino terminus. The loc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Araki T,Gejyo F,Takagaki K,Haupt H,Schwick HG,Bürgi W,Marti T,Schaller J,Rickli E,Brossmer R

更新日期：1988-02-01 00:00:00

abstract：:Limited trypsinization of the fatty acid synthetase multienzyme complex from rat mammary gland results in the release of a protein, molecular weight 32,000, with thioesterase activity. The other components of the multienzyme complex--the acyl carrier protein, acetyl and malonyl transferases, condensing enzyme, keto re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith S,Agradi E,Libertini L,Dileepan KN

更新日期：1976-04-01 00:00:00

abstract：:Many bacterial pathogens produce diffusible signal factor (DSF)-type quorum sensing (QS) signals in modulation of virulence and biofilm formation. Previous work on Xanthomonas campestris showed that the RpfC/RpfG two-component system is involved in sensing and responding to DSF signals, but little is known in other mi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Deng Y,Schmid N,Wang C,Wang J,Pessi G,Wu D,Lee J,Aguilar C,Ahrens CH,Chang C,Song H,Eberl L,Zhang LH

更新日期：2012-09-18 00:00:00

abstract：:Both polarities of the satellite RNA of tobacco ringspot virus are sources of self-cleaving sequences. RNA of the less abundant, negative polarity, designated sTobRV-(-)RNA, has cleaving activity that was mapped previously to two noncontiguous regions of the polyribonucleotide chain. Endoribonucleolytic oligoribonucle...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Feldstein PA,Buzayan JM,van Tol H,deBear J,Gough GR,Gilham PT,Bruening G

更新日期：1990-04-01 00:00:00

abstract：:We describe preliminary studies of the pharmacokinetics, biodistribution, and excretion of an oligodeoxy-nucleotide phosphorothioate ([S]oligonucleotide) in mice. After either intravenous or intraperitoneal administration of a single dose (30 mg/kg of body weight), [S]oligonucleotide (35S-labeled at each internucleoti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Agrawal S,Temsamani J,Tang JY

更新日期：1991-09-01 00:00:00

abstract：:A ribosomal RNA-encoding DNA (rDNA) cloned sequence, consisting of a 0.8-kilobase fragment from the 26S/nontranscribed spacer region, was used to identify diagnostic restriction enzyme fragments that distinguish the Moreton and Torresian subspecies of the grasshopper Caledia captiva. These restriction fragments were t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arnold ML,Shaw DD,Contreras N

更新日期：1987-06-01 00:00:00

abstract：:We report the in vitro long-term (20 wk) changes in cells exposed to well-characterized gold nanoparticles (Au NPs) with varying shapes and surface coatings under both chronic (exposure to Au NPs continuously over 20 wk) and nonchronic (initial acute cell exposure to Au NPs, followed by 20 wk in NP-free cell media) co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Falagan-Lotsch P,Grzincic EM,Murphy CJ

更新日期：2016-11-22 00:00:00

abstract：:The opportunistic pathogen Candida albicans can undergo phenotypic switching between a benign, unicellular phenotype and an invasive, multicellular form that causes candidiasis. Increasingly, strains of Candida are becoming resistant to antifungal drugs, making the treatment of candidiasis difficult, especially in imm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Uchida M,McDermott G,Wetzler M,Le Gros MA,Myllys M,Knoechel C,Barron AE,Larabell CA

更新日期：2009-11-17 00:00:00

abstract：:Focal electric stimulation of the auditory cortex is well suited for exploration of the function of the corticofugal (descending) system and the neural mechanism of plasticity in the central auditory system, because it evokes changes in frequency-tuning, called best frequency (BF) shifts, as does auditory fear conditi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xiao Z,Suga N

更新日期：2005-12-27 00:00:00

abstract：:Dihydropteridine reductase (EC 1.6.99.7) is a member of the recently identified family of proteins known as short-chain dehydrogenases. When the x-ray structure of dihydropteridine reductase is correlated with conserved amino acid sequences characteristic of this enzyme class, two important common structural regions c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Varughese KI,Xuong NH,Kiefer PM,Matthews DA,Whiteley JM

更新日期：1994-06-07 00:00:00

abstract：:The mechanism of nuclear DNA replication in radicles of germinating cotton (Gossypium barbadense) was investigated. Pulse-labeling with [(3)H]thymidine indicates that replication intermediates are of small molecular weight (4-10S) and behave as if single-stranded. Prolonged labeling indicates that intermediates are of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clay WF,Bartels PG,Katterman FR

更新日期：1976-09-01 00:00:00

abstract：:It has long been recognized that the renal proximal tubular epithelium of the hamster is a bona fide estrogen target tissue. The effect of estrogens on the growth of proximal tubule cell explants and dissociated single cells derived from these explant outgrowths has been studied in culture. Renal tubular cells were gr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oberley TD,Lauchner LJ,Pugh TD,Gonzalez A,Goldfarb S,Li SA,Li JJ

更新日期：1989-03-01 00:00:00

abstract：:Several authors have considered Markov processes defined by the motion of a particle on a fixed line with a random velocity(1, 6, 8, 10) or a random diffusivity.(5, 12) A "random evolution" is a natural but apparently new generalization of this notion. In this note we hope to show that this concept leads to simple and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Griego RJ,Hersh R

更新日期：1969-02-01 00:00:00

abstract：:Chromosome translocations between Ig (Ig) and non-Ig genes are frequently associated with B-cell lymphomas in humans and mice. The best characterized of these is c-myc/IgH translocation, which is associated with Burkitt's lymphoma. These translocations are caused by activation-induced cytidine deaminase (AID), which p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jankovic M,Robbiani DF,Dorsett Y,Eisenreich T,Xu Y,Tarakhovsky A,Nussenzweig A,Nussenzweig MC

更新日期：2010-01-05 00:00:00

abstract：:The oscillator of the circadian clock of cyanobacteria is composed of three proteins, KaiA, KaiB, and KaiC, which together generate a self-sustained ∼24-h rhythm of phosphorylation of KaiC. The mechanism propelling this oscillator has remained elusive, however. We show that stacking interactions between the CI and CII...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang YG,Tseng R,Kuo NW,LiWang A

更新日期：2012-10-16 00:00:00

abstract：:Phospholipid flippases (P4-ATPases) utilize ATP to translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes, thus generating and maintaining transmembrane lipid asymmetry essential for a variety of cellular processes. P4-ATPases belong to the P-type ATPase prote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tadini-Buoninsegni F,Mikkelsen SA,Mogensen LS,Molday RS,Andersen JP

更新日期：2019-08-13 00:00:00

abstract：:Previous studies have established that humans and monkeys with damage to striate cortex are able to detect and localize bright targets within the resultant scotoma. Electrophysiological evidence in monkeys suggests that residual vision also might include sensitivity to direction of visual motion. We tested whether mac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moore T,Rodman HR,Gross CG

更新日期：2001-01-02 00:00:00

abstract：:Insulin binding to insulin receptors, on skin fibroblasts established in culture from an infant with insulin resistance and clinical features of leprechaunism was markedly decreased in comparison with cultures from an age-matched control. By contrast, the binding of epidermal growth factor, a polypeptide growth factor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schilling EE,Rechler MM,Grunfeld C,Rosenberg AM

更新日期：1979-11-01 00:00:00

abstract：:The rate of leucine incorporation into a specific estrogen-induced protein of immature rat isolated by gel electrophoresis declines rapidly between 2-4 hr after estrogen stimulation in vivo followed by incubation in vitro. Actinomycin D present during the in vitro phase prevents this decline, and elicits a "superinduc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： DeAngelo AB,Fujimoto GI

更新日期：1973-01-01 00:00:00

abstract：:Molecular beacons are FRET-based target-activatable probes. They offer control of fluorescence emission in response to specific cancer targets, thus are useful tools for in vivo cancer imaging. Photodynamic therapy (PDT) is a cell-killing process by light activation of a photosensitizer (PS) in the presence of oxygen....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zheng G,Chen J,Stefflova K,Jarvi M,Li H,Wilson BC

更新日期：2007-05-22 00:00:00

abstract：:Mycobacterium abscessus (Mabs) is a rapidly growing Mycobacterium and an emerging pathogen in humans. Transitioning from a smooth (S) high-glycopeptidolipid (GPL) producer to a rough (R) low-GPL producer is associated with increased virulence in zebrafish, which involves the formation of massive serpentine cords, absc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Halloum I,Carrère-Kremer S,Blaise M,Viljoen A,Bernut A,Le Moigne V,Vilchèze C,Guérardel Y,Lutfalla G,Herrmann JL,Jacobs WR Jr,Kremer L

更新日期：2016-07-19 00:00:00

abstract：:We present an algorithm to generate complete evolutionary profiles that represent the topology of the molecular phylogenetic tree of the homologous group. The method, based on the multidimensional QR factorization of numerically encoded multiple sequence alignments, removes redundancy from the alignments and orders th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sethi A,O'Donoghue P,Luthey-Schulten Z

更新日期：2005-03-15 00:00:00