Secretion of human hepatitis B virus is inhibited by the imino sugar N-butyldeoxynojirimycin.

abstract：:Hypertension increases the pressure load on the heart and is associated with a poorly understood chronic systemic inflammatory state. Interleukin 33 (IL-33) binds to membrane-bound ST2 (ST2L) and has antihypertrophic and antifibrotic effects in the myocardium. In contrast, soluble ST2 appears to act as a decoy recepto...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen WY,Hong J,Gannon J,Kakkar R,Lee RT

更新日期：2015-06-09 00:00:00

abstract：:During the development of a macronucleus from a micronucleus after cell mating in hypotrichs all the genes (approximately 20,000) are excised from micronuclear chromosomes as individual small DNA molecules. Telomeres are added to the ends of each gene-sized molecule and each is amplified, mostly by approximately 1000-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Greslin AF,Prescott DM,Oka Y,Loukin SH,Chappell JC

更新日期：1989-08-01 00:00:00

abstract：:Patients with primary (AL) cardiac amyloidosis suffer from progressive cardiomyopathy with a median survival of less than 8 months and a 5-year survival of <10%. Contributing to this poor prognosis is the fact that these patients generally do not tolerate standard heart failure therapies. The molecular mechanisms unde...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shi J,Guan J,Jiang B,Brenner DA,Del Monte F,Ward JE,Connors LH,Sawyer DB,Semigran MJ,Macgillivray TE,Seldin DC,Falk R,Liao R

更新日期：2010-03-02 00:00:00

abstract：:Membrane-mediated particle interactions depend both on the properties of the particles themselves and the membrane environment in which they are suspended. Experiments have shown that chiral rod-like inclusions dissolved in a colloidal membrane of opposite handedness assemble into colloidal rafts, which are finite-siz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miller JM,Joshi C,Sharma P,Baskaran A,Baskaran A,Grason GM,Hagan MF,Dogic Z

更新日期：2019-08-06 00:00:00

abstract：:A recently determined set of 20 NMR-derived conformations of a 48-residue all-alpha-helical protein, (PDB ID code 2JVD), is validated here by comparing the observed (13)C(alpha) chemical shifts with those computed at the density functional level of theory. In addition, a recently introduced physics-based method, aimed...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vila JA,Aramini JM,Rossi P,Kuzin A,Su M,Seetharaman J,Xiao R,Tong L,Montelione GT,Scheraga HA

更新日期：2008-09-23 00:00:00

abstract：:Excess activation of glutamate receptors and production of free radicals including nitric oxide may result in severe and irreversible damage to the mammalian central nervous system (CNS), but endogenous defense systems that protect neurons from these insults are poorly understood. Here, we purified and isolated a neur...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kume T,Asai N,Nishikawa H,Mano N,Terauchi T,Taguchi R,Shirakawa H,Osakada F,Mori H,Asakawa N,Yonaga M,Nishizawa Y,Sugimoto H,Shimohama S,Katsuki H,Kaneko S,Akaike A

更新日期：2002-03-05 00:00:00

abstract：:The Escherichia coli mutS gene product is involved in mismatch correction in this organism. We have purified a biologically active form of the 97,000 Mr protein to near homogeneity from an overproducing strain. Enzymatic and chemical protection ("footprinting") experiments have demonstrated that mutS-encoded protein s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Su SS,Modrich P

更新日期：1986-07-01 00:00:00

abstract：:Clathrin-coated vesicles are known to be involved in the transport of proteins from the Golgi to the vacuole in plant cells. The mechanisms by which proteins are directed into this pathway are not known. Here we identify an integral membrane protein of approximately 80 kDa, extracted from clathrin-coated vesicles of d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kirsch T,Paris N,Butler JM,Beevers L,Rogers JC

更新日期：1994-04-12 00:00:00

abstract：:Previous studies of legume nodules have indicated that formation of the heme moiety of leghemoglobin is a function of the bacterial symbiont. We now show that a hemA mutant of Bradyrhizobium japonicum that cannot carry out the first step in heme biosynthesis forms fully effective nodules on soybeans. The bacterial mut...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guerinot ML,Chelm BK

更新日期：1986-03-01 00:00:00

abstract：:The severity of Helicobacter pylori-related disease is correlated with a pathogenicity island (the Cag region of about 26 genes) whose presence is associated with the up-regulation of an IL-8 cytokine inflammatory response in gastric epithelial cells. Statistical analysis of the Cag gene sequences calculated from the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu G,McDaniel TK,Falkow S,Karlin S

更新日期：1999-06-08 00:00:00

abstract：:To test directly whether fibrin(ogen) is a key binding site for apolipoprotein(a) [apo(a)] in vessel walls, apo(a) transgenic mice and fibrinogen knockout mice were crossed to generate fibrin(ogen)-deficient apo(a) transgenic mice and control mice. In the vessel wall of apo(a) transgenic mice, fibrin(ogen) deposition ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lou XJ,Boonmark NW,Horrigan FT,Degen JL,Lawn RM

更新日期：1998-10-13 00:00:00

abstract：:The state-to-state transfer of rotational and vibrational energy has been studied for S1 glyoxal (CHOCHO) in collisions with D2, N2, CO and C2H4 using crossed molecular beams. A laser is used to pump glyoxal seeded in He to its S1 zero point level with zero angular momentum about its top axis (K' = 0). The inelastic s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Parmenter CS,Clegg SM,Krajnovich DJ,Lu S

更新日期：1997-08-05 00:00:00

abstract：:The dorsolateral striatum (DLS) is essential for motor and procedure learning, but the role of DLS spiny projection neurons (SPNs) of direct and indirect pathways, as marked, respectively, by D1 and D2 receptor (D1R and D2R) expression, remains to be clarified. Long-term two-photon calcium imaging of the same neuronal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sheng MJ,Lu D,Shen ZM,Poo MM

更新日期：2019-05-28 00:00:00

abstract：:Rapamycin is a potent immunosuppressant that blocks the G1/S transition in antigen-activated T cells and in yeast. The similar effects of rapamycin in animal cells and yeast suggest that the biochemical steps affected by rapamycin are conserved. Using a two-hybrid system we isolated mammalian clones that interact with...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chiu MI,Katz H,Berlin V

更新日期：1994-12-20 00:00:00

abstract：:Single molecule fluorescence polarization techniques have been used for three-dimensional (3D) orientation measurements to observe the dynamic properties of single molecules. However, only few techniques can simultaneously measure 3D orientation and position. Furthermore, these techniques often require complex equipme...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ohmachi M,Komori Y,Iwane AH,Fujii F,Jin T,Yanagida T

更新日期：2012-04-03 00:00:00

abstract：:We use age distributions of sea otters (Enhydra lutris) found dead on beaches of western Prince William Sound, Alaska, between 1976 and 1998 in conjunction with time-varying demographic models to test for lingering effects from the 1989 Exxon Valdez oil spill. Our results show that sea otters in this area had decrease...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Monson DH,Doak DF,Ballachey BE,Johnson A,Bodkin JL

更新日期：2000-06-06 00:00:00

abstract：:The improvement of motor behavior, based on experience, is a form of learning that is critically dependent on the cerebellum. A well studied example of cerebellar motor learning is short-term saccadic adaptation (STSA). In STSA, information on saccadic errors is used to improve future saccades. The information optimiz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Catz N,Dicke PW,Thier P

更新日期：2008-05-20 00:00:00

abstract：:Active immunization using tumor antigen-loaded dendritic cells holds promise for the adjuvant treatment of cancer to eradicate or control residual disease, but so far, most dendritic cell trials have been performed in end-stage cancer patients with high tumor loads. Here, in a phase I/II trial, we investigated the eff...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Van Tendeloo VF,Van de Velde A,Van Driessche A,Cools N,Anguille S,Ladell K,Gostick E,Vermeulen K,Pieters K,Nijs G,Stein B,Smits EL,Schroyens WA,Gadisseur AP,Vrelust I,Jorens PG,Goossens H,de Vries IJ,Price DA,Oji Y

更新日期：2010-08-03 00:00:00

abstract：:We have employed a combination of temperature-dependent UV absorption spectroscopy, circular dichroism, and batch calorimetry to characterize the binding of actinomycin D to a series of oligomeric DNA duplexes. We find the duplex [d(CGTCGACG)]2 to be unique in its ability to bind actinomycin D strongly despite the abs...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Snyder JG,Hartman NG,D'Estantoit BL,Kennard O,Remeta DP,Breslauer KJ

更新日期：1989-06-01 00:00:00

abstract：:Humans assess the credibility of information gained from others on a daily basis; this ongoing assessment is especially crucial for avoiding exploitation by others. We used a repeated, two-person bargaining game and a cognitive hierarchy model to test how subjects judge the information sent asymmetrically from one pla...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bhatt MA,Lohrenz T,Camerer CF,Montague PR

更新日期：2012-05-29 00:00:00

abstract：:The transport of moisture in the tropics is a critical process for the global energy budget and on geologic timescales, has markedly influenced continental landscapes, migratory pathways, and biological evolution. Here we present a continuous, first-of-its-kind 1.3-My record of continental hydroclimate and lake-level ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lyons RP,Scholz CA,Cohen AS,King JW,Brown ET,Ivory SJ,Johnson TC,Deino AL,Reinthal PN,McGlue MM,Blome MW

更新日期：2015-12-22 00:00:00

abstract：:Human appropriation of net primary production (HANPP), the aggregate impact of land use on biomass available each year in ecosystems, is a prominent measure of the human domination of the biosphere. We present a comprehensive assessment of global HANPP based on vegetation modeling, agricultural and forestry statistics...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Haberl H,Erb KH,Krausmann F,Gaube V,Bondeau A,Plutzar C,Gingrich S,Lucht W,Fischer-Kowalski M

更新日期：2007-07-31 00:00:00

abstract：:Newly formed hepatic granulomas around Schistosoma mansoni eggs become progressively smaller during the chronic (greater than or equal to 15 weeks after infection) phase of the disease. This reduction in granuloma size, termed "modulation," is known to be caused in part by a T lymphocyte that can adoptively transfer m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Green WF,Colley DG

更新日期：1981-02-01 00:00:00

abstract：:A temperature-sensitive (ts) mutant, GA 907/7, was isolated after mutagen treatment of avian myeloblastosis virus. When bone marrow cells or secondary yolk sac macrophages were infected with GA 907/7, the expression of transformation was greatly reduced at 41 degrees C. The results of temperature-shift experiments sug...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moscovici MG,Moscovici C

更新日期：1983-03-01 00:00:00

abstract：:Summertime Arctic shipboard observations of oxygenated volatile organic compounds (OVOCs) such as organic acids, key precursors of climatically active secondary organic aerosol (SOA), are consistent with a novel source of OVOCs to the marine boundary layer via chemistry at the sea surface microlayer. Although this sou...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mungall EL,Abbatt JPD,Wentzell JJB,Lee AKY,Thomas JL,Blais M,Gosselin M,Miller LA,Papakyriakou T,Willis MD,Liggio J

更新日期：2017-06-13 00:00:00

abstract：:Purified dihydropyridine-sensitive calcium channels from rabbit skeletal muscle were reconstituted into phosphatidylcholine vesicles to evaluate the effect of phosphorylation by cyclic AMP-dependent protein kinase (PK-A) on their function. Both the rate and extent of 45Ca2+ uptake into vesicles containing reconstitute...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nunoki K,Florio V,Catterall WA

更新日期：1989-09-01 00:00:00

abstract：:Conventional asymmetric PCR is inefficient and difficult to optimize because limiting the concentration of one primer lowers its melting temperature below the reaction annealing temperature. Linear-After-The-Exponential (LATE)-PCR describes a new paradigm for primer design that renders assays as efficient as symmetric...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sanchez JA,Pierce KE,Rice JE,Wangh LJ

更新日期：2004-02-17 00:00:00

abstract：:The signals required for rapid internalization of the bovine cation-dependent mannose 6-phosphate receptor have been localized to two distinct regions of the 67-amino acid cytoplasmic domain. One signal includes phenylalanine 13 and phenylalanine 18, while the other involves tyrosine 45. The former signal is more pote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Johnson KF,Chan W,Kornfeld S

更新日期：1990-12-01 00:00:00

abstract：:Mutations in profilin 1 (PFN1) are associated with amyotrophic lateral sclerosis (ALS); however, the pathological mechanism of PFN1 in this fatal disease is unknown. We demonstrate that ALS-linked mutations severely destabilize the native conformation of PFN1 in vitro and cause accelerated turnover of the PFN1 protein...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boopathy S,Silvas TV,Tischbein M,Jansen S,Shandilya SM,Zitzewitz JA,Landers JE,Goode BL,Schiffer CA,Bosco DA

更新日期：2015-06-30 00:00:00

abstract：:Complementary DNA (cDNA) specific for chick globin mRNA sequences fails to hybridize to total RNA extracted from chicken fibroblasts. After infection by Rous sarcoma virus, RNA complementary to globin cDNA is detectable in 100-500 copies per cell. Infection of fibroblasts with the transformation defective (td) deletio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Groudine M,Weintraub H

更新日期：1975-11-01 00:00:00