Cation-dependent mannose 6-phosphate receptor contains two internalization signals in its cytoplasmic domain.

abstract：:If H denotes the classical Hilbert transform and Hu(x) = v(x), then the functions u(x) and v(x) are the values on the real axis of a pair of conjugate functions, harmonic in the upper half-plane. This note gives a generalization of the above concepts in which the Laplace equation Deltau = 0 is replaced by the Yukawa e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Duffin RJ

更新日期：1972-12-01 00:00:00

abstract：:The plant photoreceptor phytochrome plays an important role in the nucleus as a regulator of transcription. Numerous studies imply, however, that phytochromes in both higher and lower plants mediate physiological reactions within the cytoplasm. In particular, the tip cells of moss protonemal filaments use phytochrome ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mittmann F,Brücker G,Zeidler M,Repp A,Abts T,Hartmann E,Hughes J

更新日期：2004-09-21 00:00:00

abstract：:Relying on a quantitative analysis of the patenting and assignment behavior of inventors, we highlight the evolution of institutions that encouraged trade in technology and a growing division of labor between those who invented new technologies and those who exploited them commercially over the nineteenth and early-tw...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lamoreaux NR,Sokoloff KL

更新日期：1996-11-12 00:00:00

abstract：:The Alu element has been a major source of new exons during primate evolution. Thousands of human genes contain spliced exons derived from Alu elements. However, identifying Alu exons that have acquired genuine biological functions remains a major challenge. We investigated the creation and establishment of Alu exons ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shen S,Lin L,Cai JJ,Jiang P,Kenkel EJ,Stroik MR,Sato S,Davidson BL,Xing Y

更新日期：2011-02-15 00:00:00

abstract：:Fluorescence photobleaching recovery and immunofluorescence methods have been used to study the lateral mobility and topographical distribution of a major cell surface glycoprotein (CSP). Both endogenous CSP and fluorescent-labeled exogenous CSP bind to the cell surface in a fibrillar pattern and are immobile on the e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schlessinger J,Barak LS,Hammes GG,Yamada KM,Pastan I,Webb WW,Elson EL

更新日期：1977-07-01 00:00:00

abstract：:Polycomb-group (Pc-G) proteins ensure late maintenance of transcriptional repression outside the expression domain of target genes in flies and vertebrates. They act in complexes, presumably by modulating chromatin structure. In Drosophila, they have been found to be associated with transcriptionally inactive loci but...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： d Graaff W,Tomotsune D,Oosterveen T,Takihara Y,Koseki H,Deschamps J

更新日期：2003-11-11 00:00:00

abstract：:We have measured the quantities of naturally occurring autoantibodies in the serum of normal, unmanipulated individuals. These changes over time following broad-band complex dynamical patterns that are similar in mouse and man. The patterns more likely reflect the network architecture of the natural antibody repertoir...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Varela F,Andersson A,Dietrich G,Sundblad A,Holmberg D,Kazatchkine M,Coutinho A

更新日期：1991-07-01 00:00:00

abstract：:How subduction-the sinking of cold lithospheric plates into the mantle-is initiated is one of the key mysteries in understanding why Earth has plate tectonics. One of the favored locations for subduction triggering is at passive margins, where sea floor abuts continental margins. Such passive margin collapse is proble...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bercovici D,Mulyukova E

更新日期：2021-01-26 00:00:00

abstract：:DNA vaccines, comprised of plasmid DNA encoding proteins from pathogens, allergens, and tumors, are being evaluated as prophylactic vaccines and therapeutic treatments for infectious diseases, allergies, and cancer; plasmids encoding normal human proteins are likewise being tested as vaccines and treatments for autoim...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu M,Acres B,Balloul JM,Bizouarne N,Paul S,Slos P,Squiban P

更新日期：2004-10-05 00:00:00

abstract：:We show that it is possible to direct particles entrained in a fluid along trajectories much like rays of light in classical optics. A microstructured, asymmetric post array forms the core hydrodynamic element and is used as a building block to construct microfluidic metamaterials and to demonstrate refractive, focusi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morton KJ,Loutherback K,Inglis DW,Tsui OK,Sturm JC,Chou SY,Austin RH

更新日期：2008-05-27 00:00:00

abstract：:The phase transition for turbulent diffusion, reported by Avellaneda and Majda [Avellaneda, M. & Majda, A. J. (1994) Philos. Trans. R. Soc. London A 346, 205-233, and several earlier papers], is traced to a modeling assumption in which the energy spectrum of the turbulent fluid is singularly dependent on the viscosity...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wallstrom TC

更新日期：1995-11-21 00:00:00

abstract：:The 5' region of the mouse gamma-glutamyltransferase (gamma GT; EC 2.3.2.2) gene has been cloned and analyzed. This analysis, combined with sequence information obtained from gamma GT cDNA clones, indicates that in mouse a single gamma GT gene codes for six different mRNAs that differ in their 5' sequences. Analysis o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rajagopalan S,Wan DF,Habib GM,Sepulveda AR,McLeod MR,Lebovitz RM,Lieberman MW

更新日期：1993-07-01 00:00:00

abstract：:Little is known about how chromatin folds in its native state. Using optimized in situ hybridization and live imaging techniques have determined compaction ratios and fiber flexibility for interphase chromatin in budding yeast. Unlike previous studies, ours examines nonrepetitive chromatin at intervals short enough to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bystricky K,Heun P,Gehlen L,Langowski J,Gasser SM

更新日期：2004-11-23 00:00:00

abstract：:The excitatory neurotransmitter, glutamate, activates N-methyl-d-aspartate (NMDA) receptors to induce long-lasting synaptic changes through alterations in gene expression. It is believed that these long-lasting changes contribute to learning and memory, drug tolerance, and ischemic preconditioning. To identify NMDA-in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hong SJ,Li H,Becker KG,Dawson VL,Dawson TM

更新日期：2004-02-17 00:00:00

abstract：:Social behavior is often shaped by the rich storehouse of biographical information that we hold for other people. In our daily life, we rapidly and flexibly retrieve a host of biographical details about individuals in our social network, which often guide our decisions as we navigate complex social interactions. Even ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang Y,Collins JA,Koski J,Nugiel T,Metoki A,Olson IR

更新日期：2017-04-18 00:00:00

abstract：:Polyploidy, which results from whole genome duplication (WGD), has shaped the long-term evolution of eukaryotic genomes in all kingdoms. Polyploidy is also implicated in adaptation, domestication, and speciation. Yet when WGD newly occurs, the resulting neopolyploids face numerous challenges. A particularly pernicious...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morgan C,Zhang H,Henry CE,Franklin FCH,Bomblies K

更新日期：2020-04-21 00:00:00

abstract：:Antibodies to DNA in the left-handed (Z) conformation bind to acid-fixed polytene chromosomes of both Chironomus thummi and Drosophila melanogaster, as shown by direct and indirect immunofluorescence. Comparison of the phase-contrast, immunofluorescence, and DNA staining patterns shows a predominant localization of th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arndt-Jovin DJ,Robert-Nicoud M,Zarling DA,Greider C,Weimer E,Jovin TM

更新日期：1983-07-01 00:00:00

abstract：:Human T cell clones were analyzed for their susceptibility to activation-induced cell death (AICD) in response to CD3/T cell receptor ligation. AICD was observed only in Th1 clones and was Fas-mediated, whereas Th2 clones resisted AICD. Analysis of a panel of Th0 clones, characterized by their ability to secrete both ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Varadhachary AS,Perdow SN,Hu C,Ramanarayanan M,Salgame P

更新日期：1997-05-27 00:00:00

abstract：:G-protein-coupled receptors (GPCRs) have recently joined the list of cell surface receptors that dimerize. Dimerization has been shown to alter the ligand-binding, signaling, and trafficking properties of these receptors. Recent studies have shown that GPCRs heterodimerize with closely related members, resulting in th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jordan BA,Trapaidze N,Gomes I,Nivarthi R,Devi LA

更新日期：2001-01-02 00:00:00

abstract：:The size of an organism reflects its metabolic rate, growth rate, mortality, and other important characteristics; therefore, the distribution of body size is a major determinant of ecosystem structure and function. Body-size distributions often are multimodal, with several peaks of abundant sizes, and previous studies...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lampert A,Tlusty T

更新日期：2013-01-02 00:00:00

abstract：:We have generated transgenic mice harboring a glycine-to-cysteine mutation in residue 85 of the triple helical domain of mouse type II collagen. The offspring of different founders displayed a phenotype of severe chondrodysplasia characterized by short limbs and trunk, cranio-facial deformities, and cleft palate. The ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Garofalo S,Vuorio E,Metsaranta M,Rosati R,Toman D,Vaughan J,Lozano G,Mayne R,Ellard J,Horton W

更新日期：1991-11-01 00:00:00

abstract：:The chemokine stromal cell-derived factor 1, SDF-1, is an important regulator of leukocyte and hematopoietic precursor migration and pre-B cell proliferation. The receptor for SDF-1, CXCR4, also functions as a coreceptor for T-tropic HIV-1 entry. We find that mice deficient for CXCR4 die perinatally and display profou...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ma Q,Jones D,Borghesani PR,Segal RA,Nagasawa T,Kishimoto T,Bronson RT,Springer TA

更新日期：1998-08-04 00:00:00

abstract：:Cotranslational folding (CTF) is a fundamental molecular process that ensures efficient protein biosynthesis and minimizes the formation of misfolded states. However, the complexity of this process makes it extremely challenging to obtain structural characterizations of CTF pathways. Here, we correlate observations of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Waudby CA,Wlodarski T,Karyadi ME,Cassaignau AME,Chan SHS,Wentink AS,Schmidt-Engler JM,Camilloni C,Vendruscolo M,Cabrita LD,Christodoulou J

更新日期：2018-09-25 00:00:00

abstract：:Expression of luminescence in Escherichia coli was recently achieved by cloning genes from the marine bacterium Vibrio fischeri. One DNA fragment on a hybrid plasmid encoded regulatory functions and enzymatic activities necessary for light production. We report the results of a genetic analysis to identify the lumines...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Engebrecht J,Silverman M

更新日期：1984-07-01 00:00:00

abstract：:The up-regulation of the 25-hydroxyvitamin D(3)-24-hydroxylase by 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] is well established and occurs at the transcriptional level through two vitamin D response elements in the promoter of the gene. However, the mechanism of down-regulation of the 24-hydroxylase by parathyroid ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zierold C,Mings JA,DeLuca HF

更新日期：2001-11-20 00:00:00

abstract：:A 16-amino acid residue peptide derived from a consensus motif of natural ferredoxins incorporates a tetranuclear iron sulfur cluster under physiological conditions. Successful assembly of the [4Fe-4S]2+/1+ cluster within a monomeric peptide was demonstrated using size exclusion chromatography, UV-visible, visible CD,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gibney BR,Mulholland SE,Rabanal F,Dutton PL

更新日期：1996-12-24 00:00:00

abstract：:The feeling of being observed or merely participating in an experiment can affect individuals' behavior. Referred to as the Hawthorne effect, this inconsistently observed phenomenon can both provide insight into individuals' behavior and confound the interpretation of experimental manipulations. Here, we pursue both t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schwartz D,Fischhoff B,Krishnamurti T,Sowell F

更新日期：2013-09-17 00:00:00

abstract：:Numerous international bodies have advocated the development of strategies to achieve the sustainability of marine environments. Typically, such strategies are based on information from expert groups about causes of degradation and policy options to address them, but these strategies rarely take into account assessed ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gelcich S,Buckley P,Pinnegar JK,Chilvers J,Lorenzoni I,Terry G,Guerrero M,Castilla JC,Valdebenito A,Duarte CM

更新日期：2014-10-21 00:00:00

abstract：:Vertebrae are derived from the sclerotomal moities of the somites. Sclerotomal cells migrate ventrally to surround the notochord, where they form the vertebral body, and dorsolaterally to form the neural arch, which is dorsally closed by the spinous process. Precursor cells of the spinous process as well as superficia...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Monsoro-Burq AH,Bontoux M,Teillet MA,Le Douarin NM

更新日期：1994-10-25 00:00:00

abstract：:Hypercholesterolemia, high serum cholesterol in the form of LDL, is a major risk factor for atherosclerosis. LDL is mostly degraded in the liver after its cellular internalization with the LDL receptor (LDLR). This clathrin-mediated endocytosis depends on the protein autosomal recessive hypercholesterolemia (ARH), whi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dvir H,Shah M,Girardi E,Guo L,Farquhar MG,Zajonc DM

更新日期：2012-05-01 00:00:00