Abstract:
:We have measured the quantities of naturally occurring autoantibodies in the serum of normal, unmanipulated individuals. These changes over time following broad-band complex dynamical patterns that are similar in mouse and man. The patterns more likely reflect the network architecture of the natural antibody repertoire, regulating the activation and decay of individual clones. The temporal changes of both disease-specific and nonspecific autoantibodies are consistently modified in autoimmune individuals.
journal_name
Proc Natl Acad Sci U S Aauthors
Varela F,Andersson A,Dietrich G,Sundblad A,Holmberg D,Kazatchkine M,Coutinho Adoi
10.1073/pnas.88.13.5917subject
Has Abstractpub_date
1991-07-01 00:00:00pages
5917-21issue
13eissn
0027-8424issn
1091-6490journal_volume
88pub_type
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doi:10.1073/pnas.69.4.885
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journal_title:Proceedings of the National Academy of Sciences of the United States of America
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