A single mutation in poliovirus RNA-dependent RNA polymerase confers resistance to mutagenic nucleotide analogs via increased fidelity.

abstract：:Wildfire can influence climate directly and indirectly, but little is known about the relationships between wildfire and climate during the Quaternary, especially how wildfire patterns varied over glacial-interglacial cycles. Here, we present a high-resolution soot record from the Chinese Loess Plateau; this is a reco...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Han Y,An Z,Marlon JR,Bradley RS,Zhan C,Arimoto R,Sun Y,Zhou W,Wu F,Wang Q,Burr GS,Cao J

更新日期：2020-03-10 00:00:00

abstract：:Like many other social phenomena, prostitution is increasingly coordinated over the Internet. The online behavior affects the offline activity; the reverse is also true. We investigated the reported sexual contacts between 6,624 anonymous escorts and 10,106 sex buyers extracted from an online community from its beginn...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rocha LE,Liljeros F,Holme P

更新日期：2010-03-30 00:00:00

abstract：:The mechanisms controlling the transcription of gene sets in specific regions of a plant embryo shortly after fertilization remain unknown. Previously, we showed that G564 mRNA, encoding a protein of unknown function, accumulates to high levels in the giant suspensor of both Scarlet Runner Bean (SRB) and Common Bean e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Henry KF,Bui AQ,Kawashima T,Goldberg RB

更新日期：2018-06-19 00:00:00

abstract：:The use of matching variable number of tandem repeat (VNTR) profiles to link suspects with crimes is potentially very powerful, but it has been quite controversial. Initial debate over laboratory procedures has largely given way to debate over the statistical and population genetic issues involved in calculating the f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weir BS

更新日期：1992-12-15 00:00:00

abstract：:The basic theory of a newly discovered physical technique, steady-state electrophoresis, is described followed by analyses of several representative macro-ion systems with the technique. This method measures apparent moments of molar diminished charge (defined below) of solvated macro-ions from an analysis of a concen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Godfrey JE

更新日期：1989-06-01 00:00:00

abstract：:Genetic data are commonly used to estimate connectivity between putative populations, but translating them to demographic dispersal rates is complicated. Theoretical equations that infer a migration rate based on the genetic estimator F ST , such as Wright's equation, F ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spies I,Hauser L,Jorde PE,Knutsen H,Punt AE,Rogers LA,Stenseth NC

更新日期：2018-05-08 00:00:00

abstract：:Small noncoding microRNAs (miRNAs) can contribute to cancer development and progression and are differentially expressed in normal tissues and cancers. From a large-scale miRnome analysis on 540 samples including lung, breast, stomach, prostate, colon, and pancreatic tumors, we identified a solid cancer miRNA signatur...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Volinia S,Calin GA,Liu CG,Ambs S,Cimmino A,Petrocca F,Visone R,Iorio M,Roldo C,Ferracin M,Prueitt RL,Yanaihara N,Lanza G,Scarpa A,Vecchione A,Negrini M,Harris CC,Croce CM

更新日期：2006-02-14 00:00:00

abstract：:The energetics of the TiO(2) polymorphs (rutile, anatase, and brookite) were studied by high temperature oxide melt drop solution calorimetry. Relative to bulk rutile, bulk brookite is 0.71 +/- 0.38 kJ/mol (6) and bulk anatase is 2.61 +/- 0.41 kJ/mol higher in enthalpy. The surface enthalpies of rutile, brookite, and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ranade MR,Navrotsky A,Zhang HZ,Banfield JF,Elder SH,Zaban A,Borse PH,Kulkarni SK,Doran GS,Whitfield HJ

更新日期：2002-04-30 00:00:00

abstract：:Analysis of the mRNA capping apparatus of the malaria parasite Plasmodium falciparum illuminates an evolutionary connection to fungi rather than metazoans. We show that P. falciparum encodes separate RNA guanylyltransferase (Pgt1) and RNA triphosphatase (Prt1) enzymes and that the triphosphatase component is a member ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ho CK,Shuman S

更新日期：2001-03-13 00:00:00

abstract：:3T3 cells that have undergone adipose differentiation in vitro secrete into the culture medium a potent growth stimulatory activity for bovine aortic endothelial cells. When medium containing 2% fetal calf serum, which does not support significant endothelial cell growth, is conditioned by 3T3-F442A adipocytes, the en...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Castellot JJ Jr,Karnovsky MJ,Spiegelman BM

更新日期：1980-10-01 00:00:00

abstract：:Enolase genes from land plants and apicomplexa (intracellular parasites, including the malarial parasite, Plasmodium) share two short insertions. This observation has led to the suggestion that the apicomplexan enolase is the product of a lateral transfer event involving the algal endosymbiont from which the apicomple...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Keeling PJ,Palmer JD

更新日期：2001-09-11 00:00:00

abstract：:Brain serotonin (5-HT) deficiency and exposure to psychosocial stress have both been implicated in the etiology of depression and anxiety disorders, but whether 5-HT deficiency influences susceptibility to depression- and anxiety-like phenotypes induced by psychosocial stress has not been formally established. Most cl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sachs BD,Ni JR,Caron MG

更新日期：2015-02-24 00:00:00

abstract：:We have previously shown that mammary epithelial specific expression of the activated erbB2 allele under the control of the endogenous promoter in mice resulted in the formation of mammary adenocarcinomas. To assess whether mammary tumorigenesis in this model is influenced by the developmental window of expression, we...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Andrechek ER,Hardy WR,Laing MA,Muller WJ

更新日期：2004-04-06 00:00:00

abstract：:Erythropoietin regulates the proliferation and differentiation of erythroid precursor cells. Its effect is mediated by the erythropoietin receptor (EPOR), a member of a large family of cytokine receptors. The EPOR gene has recently been cloned, sequenced, and characterized. As shown experimentally, its intracellular C...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： de la Chapelle A,Träskelin AL,Juvonen E

更新日期：1993-05-15 00:00:00

abstract：:Vibrio cholerae, the causative agent of cholera, has reservoirs in fresh and brackish water where it interacts with virulent bacteriophages. Phages are the most abundant biological entity on earth and coevolve with bacteria. It was reported that concentrations of phage and V. cholerae inversely correlate in aquatic re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Silva-Valenzuela CA,Camilli A

更新日期：2019-01-29 00:00:00

abstract：:The self-organization of multicomponent tetrarosette assemblies into ordered nanostructures on graphite surfaces has been studied by atomic force microscopy (AFM). Real-space information on the level of individual molecules allowed us to analyze the underlying structure in unprecedented detail. In highly ordered nanor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schönherr H,Paraschiv V,Zapotoczny S,Crego-Calama M,Timmerman P,Frank CW,Vancso GJ,Reinhoudt DN

更新日期：2002-04-16 00:00:00

abstract：:Fluctuations in resting-state functional connectivity occur but their behavioral significance remains unclear, largely because correlating behavioral state with dynamic functional connectivity states (DCS) engages probes that disrupt the very behavioral state we seek to observe. Observing spontaneous eyelid closures f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang C,Ong JL,Patanaik A,Zhou J,Chee MW

更新日期：2016-08-23 00:00:00

abstract：:Immune function is an energetically costly physiological activity that potentially diverts calories away from less immediately essential life tasks. Among developing organisms, the allocation of energy toward immune function may lead to tradeoffs with physical growth, particularly in high-pathogen, low-resource enviro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Urlacher SS,Ellison PT,Sugiyama LS,Pontzer H,Eick G,Liebert MA,Cepon-Robins TJ,Gildner TE,Snodgrass JJ

更新日期：2018-04-24 00:00:00

abstract：:We have analyzed ligand-receptor complexes resulting from (i) the incubation of canine hepatic plasma membranes with [125I]iodoglucagon and (ii) subsequent gentle solubilization of receptor-bound ligand with digitonin. The complexes (molecular weight approximately equal to 500,000) retain the radiolabeled ligand durin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mason JC,Tager HS

更新日期：1985-10-01 00:00:00

abstract：:The benzo[a]pyrene 4,5-, 7,8-, and 9,10-oxides and the six corresponding phenols (4-, 5-, 7-, 8-, 9-, and 10-hydroxybenzo[a]pyrene) have been tested for mutagenic and cytotoxic activity in bacteria and in a mammalian cell culture system. Benzo[a]pyrene 4,5-oxide (K-region) was highly mutagenic in two histidine-depende...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wood AW,Goode RL,Chang RL,Levin W,Conney AH,Yagi H,Dansette PM,Jerina DM

更新日期：1975-08-01 00:00:00

abstract：:Oxygen isotherms of human hemoglobin measured in distilled water and in solutions of sodium chloride in the concentration range from 0.02 to 3.0 M indicate that the oxygen affinity decreases up to about 1 M salt and then begins to increase. The isotherms obtained in the range from 0.02 to 0.6 M sodium chloride, at 37 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Haire RN,Hedlund BE

更新日期：1977-10-01 00:00:00

abstract：:Social networks exhibit strikingly systematic patterns across a wide range of human contexts. Although genetic variation accounts for a significant portion of the variation in many complex social behaviors, the heritability of egocentric social network attributes is unknown. Here, we show that 3 of these attributes (i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fowler JH,Dawes CT,Christakis NA

更新日期：2009-02-10 00:00:00

abstract：:The interaction between cells and nanostructured materials is attracting increasing interest, because of the possibility to open up novel concepts for the design of smart nanobiomaterials with active biological functionalities. In this frame we investigated the response of human neuroblastoma cell line (SH-SY5Y) to go...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brunetti V,Maiorano G,Rizzello L,Sorce B,Sabella S,Cingolani R,Pompa PP

更新日期：2010-04-06 00:00:00

abstract：:Language and analytic processing are currently thought to be represented in the left hemisphere, whereas spatial and holistic processing would involve primarily the right hemisphere in man. An experimental paradigm for engaging the nonlanguage hemisphere (generally the right) is described. This involves active touch e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Desmedt JE

更新日期：1977-09-01 00:00:00

abstract：:The kidney has an extraordinary ability to maintain stable fractional solute and fluid reabsorption over a wide range of glomerular filtration rates (GFRs). Internalization of filtered low molecular weight proteins, vitamins, hormones, and other small molecules is mediated by the proximal tubule (PT) multiligand recep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Raghavan V,Rbaibi Y,Pastor-Soler NM,Carattino MD,Weisz OA

更新日期：2014-06-10 00:00:00

abstract：:We have established a transformation system for Dictyostelium discoideum. The transformation vector contains the protein coding region of the Tn5 neomycin resistance gene fused to the proposed promoter of the Dictyostelium actin 8 gene; the vector also contains a sequence that acts as an autonomously replicating seque...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hirth KP,Edwards CA,Firtel RA

更新日期：1982-12-01 00:00:00

abstract：:Tangier disease is a familial disorder characterized by orange tonsils, cholesterol ester deposition in reticuloendothelial cells, abnormal chylomicron remnants, and a marked reduction in high density lipoproteins. Plasma concentrations of the apolipoproteins apo-A-I and apoA-II in patients with Tangier disease are ap...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kay LL,Ronan R,Schaefer EJ,Brewer HB Jr

更新日期：1982-04-01 00:00:00

abstract：:Whereas the importance of macrophages in chronic inflammatory diseases is well recognized, there is an increasing awareness that neutrophils may also play an important role. In addition to the well-documented heterogeneity of macrophage phenotypes and functions, neutrophils also show remarkable phenotypic diversity am...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weiss M,Byrne AJ,Blazek K,Saliba DG,Pease JE,Perocheau D,Feldmann M,Udalova IA

更新日期：2015-09-01 00:00:00

abstract：:Glucocorticoids (GCs) are potent anti-inflammatory agents that block cytokine production. We investigated whether GCs also block cytokine signaling via the Janus kinase (Jak)-signal transducer and activator of transcription (STAT) pathway. Dexamethasone inhibited IL-2-induced DNA binding, tyrosine phosphorylation, and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bianchi M,Meng C,Ivashkiv LB

更新日期：2000-08-15 00:00:00

abstract：:In multiple binding of ligands to a protein, the binding sites may seem to behave as if they are partitioned equally between two modalities. This paper analyzes three different molecular situations in which two actual assemblages appear: (i) two classes of sites exist at the outset in the ligand-free macromolecule; (i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Klotz IM,Hunston DL

更新日期：1977-11-01 00:00:00