Truncated erythropoietin receptor causes dominantly inherited benign human erythrocytosis.

abstract：:The enzyme-AMP reaction intermediate of the 102-kDa bovine DNA ligase I was digested with trypsin, and the adenylylated peptide was isolated by chromatography under conditions that maintain the acid-labile phosphoramidate bond. Microsequencing of the peptide showed that it contains an internal trypsin-resistant lysine...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tomkinson AE,Totty NF,Ginsburg M,Lindahl T

更新日期：1991-01-15 00:00:00

abstract：:Using both heterologous rabbit antisera and mouse monoclonal antibody to RNA.DNA hybrids, we have mapped the in situ hybridization locus of the 18/28S ribosomal RNA fraction to a single large band on polytene autosome 3 in Drosophila heteroneura and Drosophila silvestris. This portion of the chromosome is not physical...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stuart WD,Bishop JG,Carson HL,Frank MB

更新日期：1981-06-01 00:00:00

abstract：:GT-2 is a plant transcriptional activator that contains two separate, but similar, trihelix DNA-binding domains. GT-1 is similar to GT-2, although it contains only one of such domains. cDNAs that encode GT-2 were isolated from rice (OS-GT2) and Arabidopsis (AT-GT2). Evidence is presented for the existence of an Arabid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smalle J,Kurepa J,Haegman M,Gielen J,Van Montagu M,Van Der Straeten D

更新日期：1998-03-17 00:00:00

abstract：:A search for potent toxins that inhibit neuronal calcium channels in Drosophila melanogaster has resulted in the identification of a presynaptic neurotoxin from the venom of the hunting spider Hololena curta. Using Drosophila neuromuscular junction as an assay, presynaptic inhibitory activity was purified using gel fi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bowers CW,Phillips HS,Lee P,Jan YN,Jan LY

更新日期：1987-05-01 00:00:00

abstract：:Chromosomal RNA, which is a component of the chromosomes of higher organisms, and whose participation is required for sequence-specific interaction of chromosomal proteins with chromosomal DNA, occurs in chromosomes bound to DNA. We have found that the DNA sequences to which chromosomal RNA binds are repetitive ones. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sivolap YM,Bonner J

更新日期：1971-02-01 00:00:00

abstract：:Understanding the complexity of anisotropic turbulent processes over a wide range of spatiotemporal scales in engineering shear turbulence as well as climate atmosphere ocean science is a grand challenge of contemporary science with important societal impact. In such inhomogeneous turbulent dynamical systems there is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Majda AJ

更新日期：2015-07-21 00:00:00

abstract：:In the filamentous fungus Neurospora crassa, several events in the process of conidiation are influenced by light. Two genes, con-6 and con-10, which were previously shown to be transcriptionally activated during conidiation and by exposure to light, were found to be unexpressed in mycelium maintained in constant dark...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lauter FR,Yanofsky C

更新日期：1993-09-01 00:00:00

abstract：:The roles of superoxide and H2O2 in the cytotoxicity of paraquat were assessed in Chinese hamster ovary cells. Neither catalase nor superoxide dismutase inhibited the loss of ability to form colonies when added to the medium. When introduced into the cells, superoxide dismutase but not catalase inhibited the toxicity ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bagley AC,Krall J,Lynch RE

更新日期：1986-05-01 00:00:00

abstract：:This communication reports a modulating effect of intracellular ATP on the steady-state and kinetic properties of the delayed rectifier of the giant axon of the squid. When internally dialyzed or perfused giant axons from Loligo plei or Loligo pealei are voltage clamped at -60 mV and washed free of ATP, the potassium ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bezanilla F,Caputo C,DiPolo R,Rojas H

更新日期：1986-04-01 00:00:00

abstract：:Wnt/beta-catenin signaling controls various cell fates in metazoan development and is misregulated in several cancers and developmental disorders. Binding of a Wnt ligand to its transmembrane coreceptors inhibits phosphorylation and degradation of the transcriptional coactivator beta-catenin, which then translocates t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cselenyi CS,Jernigan KK,Tahinci E,Thorne CA,Lee LA,Lee E

更新日期：2008-06-10 00:00:00

abstract：:p300 acetylates and activates the tumor suppressor p53 after DNA damage. Here, we show that MDM2, a negative-feedback regulator of p53, inhibited p300-mediated p53 acetylation by complexing with these two proteins. First, we purified a p300-MDM2-p53 protein complex from HeLa nuclear extracts, which was inactive in p53...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kobet E,Zeng X,Zhu Y,Keller D,Lu H

更新日期：2000-11-07 00:00:00

abstract：:A glycoprotein was isolated and purified to homogeneity from the serum of a patient with chronic non-A, non-B hepatitis. NaDodSO4/PAGE of the glycoprotein revealed a single major band at Mr approximately 77,000. Antibodies to this glycoprotein were shown to possess the following immunoreactivity: (i) they reacted by r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seto B,Gerety RJ

更新日期：1985-08-01 00:00:00

abstract：:In this study we report the X-ray crystal structure of the extracellular domain (ECD) of the human neuronal α2 nicotinic acetylcholine receptor (nAChR) subunit in complex with the agonist epibatidine at 3.2 Å. Interestingly, α2 was crystallized as a pentamer, revealing the intersubunit interactions in a wild type neur...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kouvatsos N,Giastas P,Chroni-Tzartou D,Poulopoulou C,Tzartos SJ

更新日期：2016-08-23 00:00:00

abstract：:A way to assess specific CD8+ T-cell activity in a skin test analogous to the conventional delayed-type hypersensitivity (DTH) reaction for CD4+ T cells is presented. Local injection of viral class I binding peptides caused a specific CD8+ T-cell-mediated DTH in footpads of virally infected mice. The DTH was inducible...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kündig TM,Althage A,Hengartner H,Zinkernagel RM

更新日期：1992-08-15 00:00:00

abstract：:Proper synaptic function requires the spatial and temporal compartmentalization of RNA metabolism via transacting RNA-binding proteins (RBPs). Loss of RBP activity leads to abnormal posttranscriptional regulation and results in diverse neurological disorders with underlying deficits in synaptic morphology and transmis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Klein ME,Younts TJ,Castillo PE,Jordan BA

更新日期：2013-02-19 00:00:00

abstract：:The role of chemotaxis in the virulence of gastrointestinal pathogens is ill defined. Counterintuitively, nonchemotactic mutants of the polarly flagellated pathogen Vibrio cholerae greatly out-compete the wild-type strain during infection of the small intestine. We show that the out-competition phenotype is dependent ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Butler SM,Camilli A

更新日期：2004-04-06 00:00:00

abstract：:To define the T-cell receptor signal transduction motif, we have transfected human and murine T-cell lines with a chimeric receptor consisting of the extracellular and transmembrane domains of human CD8 alpha and the membrane-proximal portion of CD3 zeta containing at its C terminus either an 18-amino acid segment (NQ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koyasu S,Tse AG,Moingeon P,Hussey RE,Mildonian A,Hannisian J,Clayton LK,Reinherz EL

更新日期：1994-07-05 00:00:00

abstract：:The fluorescence of the supposedly buried tryptophan in ribonuclease T1 has been found to be collisionally quenched by acrylamide with a rate constant of 3 X 10(8) M--1 sec--1. Only a slight decrease in the quenching rate is observed upon a 5-fold increase in the viscosity of the solution. For this to be the case, the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eftink MR,Ghiron CA

更新日期：1975-09-01 00:00:00

abstract：:Betidamino acids (a contraction of "beta" position and "amide") are N'-monoacylated (optionally, N'-monoacylated and N-mono- or N,N'-dialkylated) aminoglycine derivatives in which each N'acyl/alkyl group may mimic naturally occurring amino acid side chains or introduce novel functionalities. Betidamino acids are most ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rivier JE,Jiang G,Koerber SC,Porter J,Simon L,Craig AG,Hoeger CA

更新日期：1996-03-05 00:00:00

abstract：:The effect of 6 days' s.c. infusions of angiotensin II at increasing doses was determined on the uptake of rat or human low density lipoprotein (LDL) and of human fibrinogen by aorta in normal and spontaneously hypertensive rats. Rat or human LDL or human fibrinogen was injected i.v. 5 days after the start of infusion...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cardona-Sanclemente LE,Medina R,Born GV

更新日期：1994-04-12 00:00:00

abstract：:Nerve growth factor (NGF) serum levels were measured in 49 patients with asthma and/or rhinoconjunctivitis and/or urticaria-angioedema. Clinical and biochemical parameters, such as bronchial reactivity, total and specific serum IgE levels, and circulating eosinophil cationic protein levels, were evaluated in relation ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bonini S,Lambiase A,Bonini S,Angelucci F,Magrini L,Manni L,Aloe L

更新日期：1996-10-01 00:00:00

abstract：:The excitatory neurotransmitter, glutamate, activates N-methyl-d-aspartate (NMDA) receptors to induce long-lasting synaptic changes through alterations in gene expression. It is believed that these long-lasting changes contribute to learning and memory, drug tolerance, and ischemic preconditioning. To identify NMDA-in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hong SJ,Li H,Becker KG,Dawson VL,Dawson TM

更新日期：2004-02-17 00:00:00

abstract：:The serine proteases sequentially activated to form a fibrin clot are inhibited primarily by members of the serpin family, which use a unique beta-sheet expansion mechanism to trap and destroy their targets. Since the discovery that serpins were a family of serine protease inhibitors there has been controversy as to t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baglin TP,Carrell RW,Church FC,Esmon CT,Huntington JA

更新日期：2002-08-20 00:00:00

abstract：:A complex between soluble dextran and human hemoglobin has been synthesized by two different methods. In the alkylation method, hemoglobin was allowed to react with bromoacetyl groups incorporated into the dextran; the yield of the complex was about 80% in terms of the hemoglobin used. In the dialdehyde method, hemogl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tam SC,Blumenstein J,Wong JT

更新日期：1976-06-01 00:00:00

abstract：:Phylogenetic analysis of Plasmodium parasites has indicated that their modern-day distribution is a result of a series of human-mediated dispersals involving transport between Africa, Europe, America, and Asia. A major outstanding question is the phylogenetic affinity of the malaria causing parasites Plasmodium vivax ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gelabert P,Sandoval-Velasco M,Olalde I,Fregel R,Rieux A,Escosa R,Aranda C,Paaijmans K,Mueller I,Gilbert MT,Lalueza-Fox C

更新日期：2016-10-11 00:00:00

abstract：:The emergence of Vibrio cholerae O139 Bengal during 1992-1993 was associated with large epidemics of cholera in India and Bangladesh and, initially, with a total displacement of the existing V. cholerae O1 strains. However, the O1 strains reemerged in 1994 and initiated a series of disappearance and reemergence of eit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Faruque SM,Sack DA,Sack RB,Colwell RR,Takeda Y,Nair GB

更新日期：2003-02-04 00:00:00

abstract：:The c-Jun NH(2)-terminal kinase (JNK) is activated when cells are exposed to environmental stress, including UV radiation. Gene disruption studies demonstrate that JNK is essential for UV-stimulated apoptosis mediated by the mitochondrial pathway by a Bax/Bak-dependent mechanism. Here, we demonstrate that JNK phosphor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lei K,Davis RJ

更新日期：2003-03-04 00:00:00

abstract：:In clinical trials comparing two treatments, one would often like to control the probability of erroneous decision while minimizing not the total sample size but the number of patients given the inferior treatment. To do this obviously requires that one use a datadependent allocation rule for the two treatments rather...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Flehinger BJ,Louis TA,Robbins H,Singer BH

更新日期：1972-10-01 00:00:00

abstract：:Development of effective chemopreventive agents against prostate cancer (CaP) for humans requires conclusive evidence of their efficacy in animal models that closely emulates human disease. The autochthonous transgenic adenocarcinoma of the mouse prostate (TRAMP) model, which spontaneously develops metastatic CaP, is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gupta S,Hastak K,Ahmad N,Lewin JS,Mukhtar H

更新日期：2001-08-28 00:00:00

abstract：:We describe the partial purification of an endonuclease from calf thymus that nicks phage PM2 DNA irradiated with UV doses producing only a few pyrimidine dimers per molecule. It has much less activity on DNA that has been subjected to enzymatic photoreactivation after UV irradiation. The calf thymus endonuclease is d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Waldstein EA,Peller S,Setlow RB

更新日期：1979-08-01 00:00:00