Both chemotaxis and net motility greatly influence the infectivity of Vibrio cholerae.

abstract：:Efficient and productive virus infection often requires viral countermeasures that block innate immunity. The IFN-inducible 2',5'-oligoadenylate (2-5A) synthetases (OASs) and ribonuclease (RNase) L are components of a potent host antiviral pathway. We previously showed that murine coronavirus (MHV) accessory protein n...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang R,Jha BK,Ogden KM,Dong B,Zhao L,Elliott R,Patton JT,Silverman RH,Weiss SR

更新日期：2013-08-06 00:00:00

abstract：:The mechanism of contrast enhancement of tumors using magnetic resonance imaging was investigated in MCF7 human breast cancer implanted in nude mice. Dynamic contrast-enhanced images recorded at high spatial resolution were analyzed by an image analysis method based on a physiological model, which included the blood c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Furman-Haran E,Margalit R,Grobgeld D,Degani H

更新日期：1996-06-25 00:00:00

abstract：:Monosynaptic excitatory connections between cerebellar granule and Purkinje cells were studied in dissociated cell cultures, and identification of the transmitter and the postsynaptic receptor at this synapse was pharmacologically investigated. The presynaptic granule cell and the postsynaptic Purkinje cell were volta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hirano T,Hagiwara S

更新日期：1988-02-01 00:00:00

abstract：:A direct method for the determination of N-linked glycosylation sites in highly glycosylated proteins is described. Carcinoembryonic antigen (CEA) and a nonspecific crossreacting antigen (NCA) were chemically deglycosylated, and peptide maps were prepared by reverse-phase HPLC. The peptides were sequenced on a gas-pha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Paxton RJ,Mooser G,Pande H,Lee TD,Shively JE

更新日期：1987-02-01 00:00:00

abstract：:The addition of insulin to a mixture of plasma membrane and mitochondrial fractions from rat adipocytes results in a decrease in the phosphorylation of a mitochondrial protein identified as the alpha subunit of pyruvate dehydrogenase [pyruvate:lipoamide oxidoreductase (decarboxylating and acceptor-acetylating), EC 1.2...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seals JR,Jarett L

更新日期：1980-01-01 00:00:00

abstract：:Mammalian class A macrophage-specific scavenger receptors (SR-A) exhibit unusually broad binding specificity for a wide variety of polyanionic ligands. The properties of these receptors suggest that they may be involved in atherosclerosis and host defense. We have previously observed a similar receptor activity in Dro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pearson A,Lux A,Krieger M

更新日期：1995-04-25 00:00:00

abstract：:With threats to nature becoming increasingly prominent, in order for biodiversity levels to persist, there is a critical need to improve implementation of conservation measures. In the oceans, the surveillance of fisheries is complex and inadequate, such that quantifying and locating nondeclared and illegal fisheries ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weimerskirch H,Collet J,Corbeau A,Pajot A,Hoarau F,Marteau C,Filippi D,Patrick SC

更新日期：2020-02-11 00:00:00

abstract：:The LSD1-CoREST histone demethylase complex is required to repress neuronal genes in nonneuronal tissues. Here we show that sumoylation of Braf35, one of the subunits of the complex, is required to maintain full repression of neuron-specific genes and for occupancy of the LSD1-CoREST complex at its gene targets. Inter...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ceballos-Chávez M,Rivero S,García-Gutiérrez P,Rodríguez-Paredes M,García-Domínguez M,Bhattacharya S,Reyes JC

更新日期：2012-05-22 00:00:00

abstract：:A simple in vitro system that supports chromatin assembly was developed for Saccharomyces cerevisiae. The assembly reaction is ATP-dependent, uses soluble histones and assembly factors, and generates physiologically spaced nucleosomes. We analyze the pathway of histone recruitment into nucleosomes, using this system i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schultz MC,Hockman DJ,Harkness TA,Garinther WI,Altheim BA

更新日期：1997-08-19 00:00:00

abstract：:We purified microtubules from a mammalian mitotic extract and obtained an amino acid sequence from each microtubule-associated protein by using mass spectrometry. Most of these proteins are known spindle-associated components with essential functional roles in spindle organization. We generated antibodies against a pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mack GJ,Compton DA

更新日期：2001-12-04 00:00:00

abstract：:Zeatin is the most active and ubiquitous of the naturally occurring cytokinins. The O-glucoside of zeatin, found in all plants examined, is considered to be important in cytokinin transport, storage, and protection against cytokinin oxidases. The enzyme UDPglucose:zeatin O-glucosyltransferase (EC 2.4.1.203) was previo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Martin RC,Mok MC,Mok DW

更新日期：1999-01-05 00:00:00

abstract：:Mutants of Arabidopsis that contain reduced levels of polyunsaturated fatty acids showed growth characteristics at 22 degrees C that were very similar to wild type. By contrast, at 12 degrees C, the mutants failed to undergo stem elongation during reproductive growth although they produced normal flowers and fertile s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miquel M,James D Jr,Dooner H,Browse J

更新日期：1993-07-01 00:00:00

abstract：:Work with non-human primates had previously demonstrated that the mid-dorsolateral frontal cortex, which comprises cytoarchitectonic areas 46 and 9, plays a critical role in the performance of non-spatial self-ordered working memory tasks, whereas the immediately adjacent posterior dorsolateral frontal cortex (area 8)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Petrides M,Alivisatos B,Evans AC,Meyer E

更新日期：1993-02-01 00:00:00

abstract：:The lineage-determining transcription factor CCAAT enhancer binding protein alpha (C/EBPalpha) is required for myeloid differentiation. Decreased function or expression of C/EBPalpha is often found in human acute myeloid leukemia. However, the precise impact of C/EBPalpha deficiency on the maturation arrest in leukemo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wagner K,Zhang P,Rosenbauer F,Drescher B,Kobayashi S,Radomska HS,Kutok JL,Gilliland DG,Krauter J,Tenen DG

更新日期：2006-04-18 00:00:00

abstract：:The RAD6 gene of Saccharomyces cerevisiae encodes a ubiquitin-conjugating enzyme (E2) that is required for DNA repair, damage-induced mutagenesis, and sporulation. We have cloned the two human RAD6 homologs, designated HHR6A and HHR6B. The two 152-amino acid human proteins share 95% sequence identity with each other a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koken MH,Reynolds P,Jaspers-Dekker I,Prakash L,Prakash S,Bootsma D,Hoeijmakers JH

更新日期：1991-10-15 00:00:00

abstract：:The carboxy-terminal domain (CTD) code encrypted within the Y1S2P3T4S5P6S7 heptad repeats of RNA polymerase II (Pol2) is deeply rooted in eukaryal biology. Key steps to deciphering the code are identifying the events in gene expression that are governed by individual "letters" and then defining a vocabulary of multile...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sanchez AM,Shuman S,Schwer B

更新日期：2018-11-06 00:00:00

abstract：:The relation between changes in brain and plasma concentrations of neurosteroids and the function and structure of gamma-aminobutyric acid type A (GABAA) receptors in the brain during pregnancy and after delivery was investigated in rats. In contrast with plasma, where all steroids increased in parallel, the kinetics ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Concas A,Mostallino MC,Porcu P,Follesa P,Barbaccia ML,Trabucchi M,Purdy RH,Grisenti P,Biggio G

更新日期：1998-10-27 00:00:00

abstract：:In clinical trials comparing two treatments, one would often like to control the probability of erroneous decision while minimizing not the total sample size but the number of patients given the inferior treatment. To do this obviously requires that one use a datadependent allocation rule for the two treatments rather...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Flehinger BJ,Louis TA,Robbins H,Singer BH

更新日期：1972-10-01 00:00:00

abstract：:Throughout the world, efforts are under way to restore watersheds, but restoration planning rarely accounts for future climate change. Using a series of linked models of climate, land cover, hydrology, and salmon population dynamics, we investigated the impacts of climate change on the effectiveness of proposed habita...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Battin J,Wiley MW,Ruckelshaus MH,Palmer RN,Korb E,Bartz KK,Imaki H

更新日期：2007-04-17 00:00:00

abstract：:Inactivation of the p53 pathway represents the most common molecular defect of human cancer. But in the setting of melanoma, a highly aggressive and invariably fatal malignancy in its advanced disseminated form, mutation/deletion of p53 is relatively rare, whereas its positive regulator ARF is often lost. Here, we sho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ha L,Ichikawa T,Anver M,Dickins R,Lowe S,Sharpless NE,Krimpenfort P,Depinho RA,Bennett DC,Sviderskaya EV,Merlino G

更新日期：2007-06-26 00:00:00

abstract：:Overlapping cDNAs derived from the chicken alpha-fibrinogen mRNA have been sequenced, beginning from within the coding region for the signal peptide of this subunit and terminating within the poly(A) extension. The predicted size of chicken alpha-fibrinogen is 54,187 daltons, which is the smallest of any alpha chain r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weissbach L,Grieninger G

更新日期：1990-07-01 00:00:00

abstract：:Maintaining the fidelity of nascent peptide chain (NP) synthesis is essential for proteome integrity and cellular health. Ribosome-associated quality control (RQC) serves to resolve stalled translation, during which untemplated Ala/Thr residues are added C terminally to stalled peptide, as shown during C-terminal Ala ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li S,Wu Z,Tantray I,Li Y,Chen S,Dong J,Glynn S,Vogel H,Snyder M,Lu B

更新日期：2020-10-06 00:00:00

abstract：:We use age distributions of sea otters (Enhydra lutris) found dead on beaches of western Prince William Sound, Alaska, between 1976 and 1998 in conjunction with time-varying demographic models to test for lingering effects from the 1989 Exxon Valdez oil spill. Our results show that sea otters in this area had decrease...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Monson DH,Doak DF,Ballachey BE,Johnson A,Bodkin JL

更新日期：2000-06-06 00:00:00

abstract：:Various reconstructive procedures have been attempted to restore a cosmetically acceptable phallus that would allow normal reproductive, sexual, and urinary function in patients requiring penile reconstruction. However, these procedures are limited by a shortage of native penile tissue. We previously demonstrated that...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen KL,Eberli D,Yoo JJ,Atala A

更新日期：2010-02-23 00:00:00

abstract：:The E2F1 transcription factor has a well-characterized activation domain at its C terminus and the E1A protein has a recently defined activation domain at its N terminus. Here we show that these activation domains are highly related in sequence. The sequence homology reflects, at least partly, the conservation of comm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Trouche D,Kouzarides T

更新日期：1996-02-20 00:00:00

abstract：:Networks are widely used in the biological, physical, and social sciences as a concise mathematical representation of the topology of systems of interacting components. Understanding the structure of these networks is one of the outstanding challenges in the study of complex systems. Here we describe a general techniq...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Newman ME,Leicht EA

更新日期：2007-06-05 00:00:00

abstract：:Embryonic stem cells (ESCs) represent an important research tool and a potential resource for regenerative medicine. Generally, ESCs are cocultured with a supportive feeder cell layer of murine embryonic fibroblasts, which maintain the ESCs' capacity for self-renewal and block spontaneous differentiation. These cumber...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miyabayashi T,Teo JL,Yamamoto M,McMillan M,Nguyen C,Kahn M

更新日期：2007-03-27 00:00:00

abstract：:Using a novel technique of modulated photo-dissociation of carbon monoxide from hemoglobin, we have obtained the rates for conversion between the two quaternary states, R, and T, at 3-fold ligation. Our measurements at pH 7 and 22 degrees give rates of 780 +/- 40 sec-1 for going from R to T, and 2500 +/- 200 sec-1 fro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ferrone FA,Hopfield JJ

更新日期：1976-12-01 00:00:00

abstract：:The Ser52Pro variant of transthyretin (TTR) produces aggressive, highly penetrant, autosomal-dominant systemic amyloidosis in persons heterozygous for the causative mutation. Together with a minor quantity of full-length wild-type and variant TTR, the main component of the ex vivo fibrils was the residue 49-127 fragme...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mangione PP,Porcari R,Gillmore JD,Pucci P,Monti M,Porcari M,Giorgetti S,Marchese L,Raimondi S,Serpell LC,Chen W,Relini A,Marcoux J,Clatworthy IR,Taylor GW,Tennent GA,Robinson CV,Hawkins PN,Stoppini M,Wood SP,Pepys

更新日期：2014-01-28 00:00:00

abstract：:An electrophoretic karyotype of Aspergillus nidulans has been obtained using contour-clamped homogeneous electric field gel electrophoresis. Six chromosomal bands were separated, with two of the bands migrating as doublets. Using the Schizosaccharomyces pombe and Saccharomyces cerevisiae chromosomes as size standards,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brody H,Carbon J

更新日期：1989-08-01 00:00:00