Abstract:
:Various reconstructive procedures have been attempted to restore a cosmetically acceptable phallus that would allow normal reproductive, sexual, and urinary function in patients requiring penile reconstruction. However, these procedures are limited by a shortage of native penile tissue. We previously demonstrated that a short segment of the penile corporal body can be replaced using naturally derived collagen matrices with autologous cells. In the current study, we examined the feasibility of engineering the entire pendular penile corporal bodies in a rabbit model. Neocorpora were engineered from cavernosal collagen matrices seeded with autologous cells using a multistep static/dynamic procedure, and these were implanted to replace the excised corpora. The bioengineered corpora demonstrated structural and functional parameters similar to native tissue and male rabbits receiving the bilateral implants were able to successfully impregnate females. This study demonstrates that neocorpora can be engineered for total pendular penile corporal body replacement. This technology has considerable potential for patients requiring penile reconstruction.
journal_name
Proc Natl Acad Sci U S Aauthors
Chen KL,Eberli D,Yoo JJ,Atala Adoi
10.1073/pnas.0909367106subject
Has Abstractpub_date
2010-02-23 00:00:00pages
3346-50issue
8eissn
0027-8424issn
1091-6490pii
0909367106journal_volume
107pub_type
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