Association of the "major histocompatibility complex subregion" I-J determinant with bioactive glycosylation-inhibiting factor.

abstract：:A coenzyme B12-dependent ribonucleotide reductase was purified from the archaebacterium Thermoplasma acidophila and partially sequenced. Using probes derived from the sequence, the corresponding gene was cloned, completely sequenced, and expressed in Escherichia coli. The deduced amino acid sequence shows that the cat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tauer A,Benner SA

更新日期：1997-01-07 00:00:00

abstract：:Pinus taeda L. (loblolly pine) and Arabidopsis thaliana differ greatly in form, ecological niche, evolutionary history, and genome size. Arabidopsis is a small, herbaceous, annual dicotyledon, whereas pines are large, long-lived, coniferous forest trees. Such diverse plants might be expected to differ in a large numbe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kirst M,Johnson AF,Baucom C,Ulrich E,Hubbard K,Staggs R,Paule C,Retzel E,Whetten R,Sederoff R

更新日期：2003-06-10 00:00:00

abstract：:Engineered calmodulins (CaMs), rendered Ca2+-insensitive by mutations, function as dominant negatives in heterologous systems, and have revealed mechanisms of ion channel modulation by Ca2+/CaM. The use of these CaMs in native mammalian cells now emerges as a strategy to unmask the biology of such Ca2+ feedback. Here,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alseikhan BA,DeMaria CD,Colecraft HM,Yue DT

更新日期：2002-12-24 00:00:00

abstract：:Both laboratory and field data suggest that people punish noncooperators even in one-shot interactions. Although such "altruistic punishment" may explain the high levels of cooperation in human societies, it creates an evolutionary puzzle: existing models suggest that altruistic cooperation among nonrelatives is evolu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boyd R,Gintis H,Bowles S,Richerson PJ

更新日期：2003-03-18 00:00:00

abstract：:The effect of Zn2+ on a voltage-dependent, transient potassium current (IA) in acutely dissociated neurons from the suprachiasmatic nucleus was studied with the whole-cell patch-clamp technique. At micromolar concentrations, Zn2+ markedly potentiated IA activated from a holding potential of -60 mV, which is the restin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang RC,Peng YW,Yau KW

更新日期：1993-12-15 00:00:00

abstract：:Behavioral and neural evidence reveal a prospective goal-directed decision process that relies on mental simulation of the environment, and a retrospective habitual process that caches returns previously garnered from available choices. Artificial systems combine the two by simulating the environment up to some depth ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Keramati M,Smittenaar P,Dolan RJ,Dayan P

更新日期：2016-11-08 00:00:00

abstract：:Estrogen receptors (ERs) protect pancreatic islet survival in mice through rapid extranuclear actions. ERalpha also enhances insulin synthesis in cultured islets. Whether ERalpha stimulates insulin synthesis in vivo and, if so, through which mechanism(s) remain largely unknown. To address these issues, we generated a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wong WP,Tiano JP,Liu S,Hewitt SC,Le May C,Dalle S,Katzenellenbogen JA,Katzenellenbogen BS,Korach KS,Mauvais-Jarvis F

更新日期：2010-07-20 00:00:00

abstract：:alpha-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)-type glutamate receptors undergo constitutive and ligand-induced internalization that requires dynamin and the clathrin adaptor complex AP-2. We report here that an atypical basic motif within the cytoplasmic tails of AMPA-type glutamate receptors directl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kastning K,Kukhtina V,Kittler JT,Chen G,Pechstein A,Enders S,Lee SH,Sheng M,Yan Z,Haucke V

更新日期：2007-02-20 00:00:00

abstract：:Collagen fibrils can exceed thousands of microns in length and are therefore the longest, largest, and most size-pleomorphic protein polymers in vertebrates; thus, knowing how cells transport collagen fibrils is essential for a more complete understanding of protein transport and its role in tissue morphogenesis. Here...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kalson NS,Starborg T,Lu Y,Mironov A,Humphries SM,Holmes DF,Kadler KE

更新日期：2013-12-03 00:00:00

abstract：:The recently evolved Hawaiian species Drosophila silvestris has a subdivided population structure and shows great spatial heterogeneity in chromosome inversion distributions and frequencies within its extremely limited geographic range. Pattern analysis of the 11 chromosomal polymorphisms in the context of the recentl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Craddock EM,Carson HL

更新日期：1989-06-01 00:00:00

abstract：:The maturation of 5S RNA in Escherichia coli is poorly understood. Although it is known that large precursors of 5S RNA accumulate in mutant cells lacking the endoribonuclease-RNase E, almost nothing is known about how the mature 5' and 3' termini of these molecules are generated. We have examined 5S RNA maturation in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li Z,Deutscher MP

更新日期：1995-07-18 00:00:00

abstract：:Recent work with prion diseases and synucleinopathies indicates that accurate diagnostic methods for protein-folding diseases can be based on the ultrasensitive, amplified measurement of pathological aggregates in biospecimens. A better understanding of the physicochemical factors that control the seeded polymerizatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Metrick MA 2nd,do Carmo Ferreira N,Saijo E,Hughson AG,Kraus A,Orrú C,Miller MW,Zanusso G,Ghetti B,Vendruscolo M,Caughey B

更新日期：2019-11-12 00:00:00

abstract：:The current study details efficient lesion-free cutaneous vaccination via vaccine delivery into an array of micropores in the skin, instead of bolus injection at a single site. Such delivery effectively segregated vaccine-induced inflammation, resulting in rapid resolution of the inflammation, provided that distances ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang J,Li B,Wu MX

更新日期：2015-04-21 00:00:00

abstract：:It is not yet clear how bacterial outer membrane proteins reach their correct destination after they are secreted across the cytoplasmic membrane. We show here that porin OmpF is secreted into the medium as a water-soluble monomeric protein by spheroplasts of Escherichia coli. Furthermore, this monomeric porin is take...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sen K,Nikaido H

更新日期：1990-01-01 00:00:00

abstract：:Conventional digital computers can execute advanced operations by a sequence of elementary Boolean functions of 2 or more bits. As a result, complicated tasks such as solving a linear system or solving a differential equation require a large number of computing steps and an extensive use of memory units to store indiv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sun Z,Pedretti G,Ambrosi E,Bricalli A,Wang W,Ielmini D

更新日期：2019-03-05 00:00:00

abstract：:Misfolded proteins are eliminated from the endoplasmic reticulum (ER) by retrotranslocation into the cytosol, a pathway hijacked by certain viruses to destroy MHC class I heavy chains. The translocation of polypeptides across the ER membrane requires their polyubiquitination and subsequent extraction from the membrane...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ye Y,Shibata Y,Kikkert M,van Voorden S,Wiertz E,Rapoport TA

更新日期：2005-10-04 00:00:00

abstract：:Coincidence cloning allows the isolation of sequences held in common by two genomic DNA populations. Human DNA from two human-hamster hybrid cell lines was amplified by Alu-repeat primers (Alu PCR) and the products originating from the shared human chromosomal region were cloned. To achieve this, human sequences were ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aslanidis C,de Jong PJ

更新日期：1991-08-01 00:00:00

abstract：:Siphoviridae is the most abundant viral family on earth which infects bacteria as well as archaea. All known siphophages infecting gram+ Lactococcus lactis possess a baseplate at the tip of their tail involved in host recognition and attachment. Here, we report analysis of the p2 phage baseplate structure by X-ray cry...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sciara G,Bebeacua C,Bron P,Tremblay D,Ortiz-Lombardia M,Lichière J,van Heel M,Campanacci V,Moineau S,Cambillau C

更新日期：2010-04-13 00:00:00

abstract：:Dendritic spines receive most synaptic inputs in the forebrain. Their morphology, with a spine head isolated from the dendrite by a slender neck, indicates a potential role in isolating inputs. Indeed, biochemical compartmentalization occurs at spine heads because of the diffusional bottleneck created by the spine nec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Araya R,Jiang J,Eisenthal KB,Yuste R

更新日期：2006-11-21 00:00:00

abstract：:Understanding the factors that shape macroevolutionary patterns in functional traits is a central goal of evolutionary biology. Alternative strategies of sexual reproduction (inbreeding vs. outcrossing) have divergent effects on population genetic structure and could thereby broadly influence trait evolution. However,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Campbell SA,Kessler A

更新日期：2013-03-05 00:00:00

abstract：:Integrated hepadnaviral DNA in livers and tumors of chronic hepatitis B patients has been reported for many years. In this study, we investigated whether hepatitis B virus DNA integration occurs preferentially at sites of cell DNA damage. A single I-SceI homing endonuclease recognition site was introduced into the DNA...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bill CA,Summers J

更新日期：2004-07-27 00:00:00

abstract：:Ezrin and moesin are components of actin-rich cell surface structures that are thought to function as membrane-cytoskeletal linking proteins. Here we show that a stable complex of ezrin and moesin can be isolated from cultured cells by immunoprecipitation with specific antibodies. The capacity of these two proteins to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gary R,Bretscher A

更新日期：1993-11-15 00:00:00

abstract：:We examined the MLL genomic translocation breakpoint in acute myeloid leukemia of infant twins. Southern blot analysis in both cases showed two identical MLL gene rearrangements indicating chromosomal translocation. The rearrangements were detectable in the second twin before signs of clinical disease and the intensit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Megonigal MD,Rappaport EF,Jones DH,Williams TM,Lovett BD,Kelly KM,Lerou PH,Moulton T,Budarf ML,Felix CA

更新日期：1998-05-26 00:00:00

abstract：:The secreted Bv8 protein has been recently characterized as a regulator of myeloid cell mobilization and a neutrophil-derived mediator of tumor angiogenesis in several xenografts, but its role in tumor progression in an endogenous setting was unknown. The rat insulin promoter (RIP)-T-antigen (Tag) is a well characteri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shojaei F,Singh M,Thompson JD,Ferrara N

更新日期：2008-02-19 00:00:00

abstract：:The voltage-gated proton channel Hv1 plays a critical role in the fast proton translocation that underlies a wide range of physiological functions, including the phagocytic respiratory burst, sperm motility, apoptosis, and metastatic cancer. Both voltage activation and proton conduction are carried out by a voltage-se...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li Q,Shen R,Treger JS,Wanderling SS,Milewski W,Siwowska K,Bezanilla F,Perozo E

更新日期：2015-11-03 00:00:00

abstract：:Acute promyelocytic leukemia (APL) is associated with the t(15;17) translocation, which generates a PML/RAR alpha fusion protein between PML, a growth suppressor localized on nuclear matrix-associated bodies, and RAR alpha, a nuclear receptor for retinoic acid (RA). PML/RAR alpha was proposed to block myeloid differen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhu J,Koken MH,Quignon F,Chelbi-Alix MK,Degos L,Wang ZY,Chen Z,de Thé H

更新日期：1997-04-15 00:00:00

abstract：:Glycosylation is one of the most common posttranslational modifications to occur in protein biosynthesis, yet its effect on the thermodynamics and kinetics of proteins is poorly understood. A minimalist model based on the native protein topology, in which each amino acid and sugar ring was represented by a single bead...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shental-Bechor D,Levy Y

更新日期：2008-06-17 00:00:00

abstract：:This paper presents insights and action proposals to better harness technological innovation for sustainable development. We begin with three key insights from scholarship and practice. First, technological innovation processes do not follow a set sequence but rather emerge from complex adaptive systems involving many...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Anadon LD,Chan G,Harley AG,Matus K,Moon S,Murthy SL,Clark WC

更新日期：2016-08-30 00:00:00

abstract：:The shape of the presynaptic action potential (AP) has a strong impact on neurotransmitter release. Because of the small size of most terminals in the central nervous system, little is known about the regulation of their AP shape during natural firing patterns in vivo. The calyx of Held is a giant axosomatic terminal ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sierksma MC,Borst JGG

更新日期：2017-04-18 00:00:00

abstract：:Green fluorescent protein (GFP) is widely used as a reporter gene in both prokaryotes and eukaryotes. However, the fluorescence levels of wild-type GFP (wtGFP) are not bright enough for fluorescence-activated cell sorting or flow cytometry. Several GFP variants were generated that are brighter or have altered excitati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Anderson MT,Tjioe IM,Lorincz MC,Parks DR,Herzenberg LA,Nolan GP,Herzenberg LA

更新日期：1996-08-06 00:00:00