Effective and lesion-free cutaneous influenza vaccination.

abstract：:Infants' sensitivity to contingent reactivity as an indicator of intentional agency has been demonstrated by numerous referential gaze-following studies. Here we propose that variability of signal sequences in a turn-taking exchange provides an informative cue for infants to recognize interactions that may involve com...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tauzin T,Gergely G

更新日期：2019-07-30 00:00:00

abstract：:The template for transcription and replication of negative-stranded RNA viruses is a ribonucleoprotein structure, the nucleocapsid. We have developed a system that supports assembly of the negative-stranded RNA genome of a defective interfering (DI) particle of vesicular stomatitis virus (VSV) into a nucleocapsid in v...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mirakhur B,Peluso RW

更新日期：1988-10-01 00:00:00

abstract：:We have investigated the mycorrhizal associations of two nonphotosynthetic orchids from distant tribes within the Orchidaceae. The two orchids were found to associate exclusively with two distinct clades of ectomycorrhizal basidiomycetous fungi over wide geographic ranges. Yet both orchids retained the internal mycorr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Taylor DL,Bruns TD

更新日期：1997-04-29 00:00:00

abstract：:Biologically active (125)I-labeled bovine parathyroid hormone (prepared by electrolytic iodination) and its synthetic NH(2)-terminal (1-34) biologically active fragment bound rapidly and specifically to a purified plasma membrane preparation from bovine renal cortex. Binding of labeled intact hormone or labeled NH(2)-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Di Bella FP,Dousa TP,Miller SS,Arnaud CD

更新日期：1974-03-01 00:00:00

abstract：:Transcriptional repressors can be classified as short- or long-range, according to their range of activity. Functional analysis of identified short-range repressors has been carried out largely in transgenic Drosophila, but it is not known whether general properties of short-range repressors are evident in other types...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ryu JR,Olson LK,Arnosti DN

更新日期：2001-11-06 00:00:00

abstract：:IFN-gamma treatment of cells leads to tyrosine phosphorylation of signal transducer and activator of transcription (STAT) 1 followed by dimerization through a reciprocal Src homology 2-phosphotyrosine interaction near the -COOH end of each monomer, forming a parallel structure that accumulates in the nucleus to drive ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhong M,Henriksen MA,Takeuchi K,Schaefer O,Liu B,ten Hoeve J,Ren Z,Mao X,Chen X,Shuai K,Darnell JE Jr

更新日期：2005-03-15 00:00:00

abstract：:Life-long protection from disease through immunization can be accomplished through individual or community protection. Individual protection is the goal for vaccination against diseases that have inanimate or animal reservoirs or that pose risks for certain populations. Community protection is the goal for vaccination...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dowdle WR,Orenstein WA

更新日期：1994-03-29 00:00:00

abstract：:The infectious reovirus RNA system was used to construct a mutant with two temperature-sensitive (ts) lesions in genome segments M2 and S2, respectively. The double mutant is about 300 times more ts than either of its parents, which are about 1,500 and 170 times more ts than their wild-type parent reovirus ST3 strain ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roner MR,Nepliouev I,Sherry B,Joklik WK

更新日期：1997-06-24 00:00:00

abstract：:Excitation-evoked Ca(2+) influx is the fastest and most ubiquitous chemical trigger for cellular processes, including neurotransmitter release, muscle contraction, and gene expression. The voltage dependence and timing of Ca(2+) entry are thought to be functions of voltage-gated calcium (CaV) channels composed of a ce...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pantazis A,Savalli N,Sigg D,Neely A,Olcese R

更新日期：2014-12-23 00:00:00

abstract：:Unlike parasitic protist groups that are defined by the absence of mitochondria, the Pelobiontida is composed mostly of free-living species. Because of the presence of ultrastructural and cellular features that set them apart from all other eukaryotic organisms, it has been suggested that pelobionts are primitively am...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stiller JW,Duffield EC,Hall BD

更新日期：1998-09-29 00:00:00

abstract：:Pseudomonas aeruginosa is an opportunistic pathogen that requires preexisiting epithelial injury to cause acute infections. We report that P. aeruginosa inhibits mammalian cytokinesis in a type III secretion system and exotoxin T (ExoT)-dependent manner. ExoT is a bifunctional type III secretion system effector protei...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shafikhani SH,Engel J

更新日期：2006-10-17 00:00:00

abstract：:Cooperation via production of common goods is found in diverse life forms ranging from viruses to social animals. However, natural selection predicts a "tragedy of the commons": Cheaters, benefiting from without producing costly common goods, are more fit than cooperators and should destroy cooperation. In an attempt ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Waite AJ,Shou W

更新日期：2012-11-20 00:00:00

abstract：:The rat brain increases >6x in mass from birth to adulthood, presumably through the addition of glial cells and increasing neuronal size, without the addition of neurons. To test this hypothesis, here we investigate quantitatively the postnatal changes in the total number of neuronal and non-neuronal cells in the deve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bandeira F,Lent R,Herculano-Houzel S

更新日期：2009-08-18 00:00:00

abstract：:Amplitude-modulated phosphorescence/microwave double-resonance (AM-PMDR) spectra are reported for complexes of methylmercury(II) cation, designated CH3Hg(II), with tryptophan and glyceraldehyde-3-phosphate dehydrogenase (GPDHase; from rabbit muscle). Wavelength shifts are observed in the AM-PMDR spectra of CH3Hg(II)-t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Davis JM,Maki AH

更新日期：1982-07-01 00:00:00

abstract：:The extent to which stratospheric intrusions on synoptic scales influence the tropospheric ozone (O3) levels remains poorly understood, because quantitative detection of stratospheric air has been challenging. Cosmogenic 35S mainly produced in the stratosphere has the potential to identify stratospheric air masses at ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin M,Su L,Shaheen R,Fung JC,Thiemens MH

更新日期：2016-10-04 00:00:00

abstract：:Carney-Stratakis syndrome, an inherited condition predisposing affected individuals to gastrointestinal stromal tumor (GIST) and paraganglioma, is caused by germline mutations in succinate dehydrogenase (SDH) subunits B, C, or D, leading to dysfunction of complex II of the electron transport chain. We evaluated the ro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Janeway KA,Kim SY,Lodish M,Nosé V,Rustin P,Gaal J,Dahia PL,Liegl B,Ball ER,Raygada M,Lai AH,Kelly L,Hornick JL,NIH Pediatric and Wild-Type GIST Clinic.,O'Sullivan M,de Krijger RR,Dinjens WN,Demetri GD,Antonescu CR,F

更新日期：2011-01-04 00:00:00

abstract：:HetR is an essential regulator of heterocyst development in cyanobacteria. Many mutations in HetR render Anabaena incapable of nitrogen fixation. The protein binds to a DNA palindrome upstream of hetP and other genes. We have determined the crystal structures of HetR complexed with palindromic DNA targets, 21, 23, and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim Y,Ye Z,Joachimiak G,Videau P,Young J,Hurd K,Callahan SM,Gornicki P,Zhao J,Haselkorn R,Joachimiak A

更新日期：2013-05-07 00:00:00

abstract：:Growing human and ecological costs due to increasing wildfire are an urgent concern in policy and management, particularly given projections of worsening fire conditions under climate change. Thus, understanding the relationship between climatic variation and fire activity is a critically important scientific question...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Syphard AD,Keeley JE,Pfaff AH,Ferschweiler K

更新日期：2017-12-26 00:00:00

abstract：:Society makes substantial investments in biomedical research, searching for ways to better human health. The product of this research is principally information published in scientific journals. Continued investment in science relies on society's confidence in the accuracy, honesty, and utility of research results. A ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bowen A,Casadevall A

更新日期：2015-09-08 00:00:00

abstract：:Many studies have reported age-related changes in immune responses that could be due to alterations in lymphoid cell numbers or functions. Here we report the results of studies using immunofluorescent staining and in vitro assays of cellular function to compare the expression of cell surface antigens on lymphocytes fr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sidman CL,Luther EA,Marshall JD,Nguyen KA,Roopenian DC,Worthen SM

更新日期：1987-11-01 00:00:00

abstract：:Behavioral models indicate that persistent small afferent input, as generated by tissue injury, results in a hyperalgesia at the site of injury and a tactile allodynia in areas adjacent to the injury site. Hyperalgesia reflects a sensitization of the peripheral terminal and a central facilitation evoked by the persist...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yaksh TL,Hua XY,Kalcheva I,Nozaki-Taguchi N,Marsala M

更新日期：1999-07-06 00:00:00

abstract：:Adenosine, dibutyryl cyclic AMP, monobutyryl cyclic AMP, cyclic AMP, and 5'-AMP have a remarkable morphogenetic effect on cultured iris epithelial cells obtained from adult newt. They alter the broad undulating membrane of the cell into branching strands of cytoplasm, a configuration that has been named "stellate." Th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ortiz JR,Yamada T,Hsie AW

更新日期：1973-08-01 00:00:00

abstract：:Neonates suffer high morbidity and mortality in infection, presumably because of the lack of a fully developed adaptive and innate immune system. Evidence of poor innate responses in neonates has been shown by using a model that sensitizes the host to Toll-like receptor (TLR)-mediated inflammation with d-galactosamine...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhao J,Kim KD,Yang X,Auh S,Fu YX,Tang H

更新日期：2008-05-27 00:00:00

abstract：:The anaphase-promoting complex/cyclosome (APC/C) is a cell cycle-regulated E3 ubiquitin ligase that controls the degradation of substrate proteins at mitotic exit and throughout the G1 phase. We have identified an APC/C substrate and cell cycle-regulated protein, KIAA0101/PAF15. PAF15 protein levels peak in the G2/M p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Emanuele MJ,Ciccia A,Elia AE,Elledge SJ

更新日期：2011-06-14 00:00:00

abstract：:Mammalian CLC proteins function as Cl(-) channels or as electrogenic Cl(-)/H(+) exchangers and are present in the plasma membrane and intracellular vesicles. We now show that the ClC-6 protein is almost exclusively expressed in neurons of the central and peripheral nervous systems, with a particularly high expression ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Poët M,Kornak U,Schweizer M,Zdebik AA,Scheel O,Hoelter S,Wurst W,Schmitt A,Fuhrmann JC,Planells-Cases R,Mole SE,Hübner CA,Jentsch TJ

更新日期：2006-09-12 00:00:00

abstract：:Y chromosomes are different from other chromosomes because of a lack of recombination. Until now, complete sequence information of Y chromosomes has been available only for some primates, although considerable information is available for other organisms, e.g., several species of Drosophila. Here, we report the gene o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamato KT,Ishizaki K,Fujisawa M,Okada S,Nakayama S,Fujishita M,Bando H,Yodoya K,Hayashi K,Bando T,Hasumi A,Nishio T,Sakata R,Yamamoto M,Yamaki A,Kajikawa M,Yamano T,Nishide T,Choi SH,Shimizu-Ueda Y,Hanajiri T,Sa

更新日期：2007-04-10 00:00:00

abstract：:Ca(2+) influx through L-type Ca(2+) channels (LTCCs) influences numerous physiological processes ranging from contraction in muscle and memory in neurons to gene expression in many cell types. However, the spatiotemporal organization of functional LTCCs has been nearly impossible to investigate because of methodologic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Navedo MF,Amberg GC,Votaw VS,Santana LF

更新日期：2005-08-02 00:00:00

abstract：:Accounting for enzyme-mediated active sliding, disassembly, and sequence-dependent positioning of nucleosomes, we simulate nucleosome occupancy over cell-cycle-scale times using a stochastic kinetic model. We show that ATP-dependent active nucleosome sliding and nucleosome removal processes are essential to obtain in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Padinhateeri R,Marko JF

更新日期：2011-05-10 00:00:00

abstract：:Natural killer T (NKT) cells provide an innate-type immune response upon T cell receptor interaction with CD1d-presented antigens. We demonstrate through equilibrium tetramer binding and antigen presentation assays with Valpha14i-positive NKT cell hybridomas that the Sphingomonas glycolipid alpha-galacturonosyl cerami...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu D,Zajonc DM,Fujio M,Sullivan BA,Kinjo Y,Kronenberg M,Wilson IA,Wong CH

更新日期：2006-03-14 00:00:00

abstract：:The copy number of plasmid ColE1 has been known to increase when the Hae II-C segment downstream from the replication origin is deleted. The presence of the 306-base-pair (bp) Hpa II region in the segment is sufficient for reduction of the copy number. Plasmids harboring the region express a trans-acting function that...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Som T,Tomizawa J

更新日期：1983-06-01 00:00:00