Pseudomonas aeruginosa type III-secreted toxin ExoT inhibits host-cell division by targeting cytokinesis at multiple steps.

abstract：:The notion of stability of a local ring arises naturally in investigating completed moduli spaces via geometric invariant theory. A scheme corresponding to a boundary point of a moduli space of nonsingular varieties cannot have unstable singular points. This paper reports some results concerning the stability of surfa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shah J

更新日期：1978-09-01 00:00:00

abstract：:An obstacle in the utilization of catalytic Abs for selective prodrug activation in cancer therapy has been systemic tumor targeting. Here we report the generation of catalytic Abs that effectively target tumor cells with undiminished prodrug activation capability. Ab conjugates were prepared by covalent conjugation o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Abraham S,Guo F,Li LS,Rader C,Liu C,Barbas CF 3rd,Lerner RA,Sinha SC

更新日期：2007-03-27 00:00:00

abstract：:Escherichia coli glutamine synthetase (GS) was inactivated by a nonenzymic mixed-function oxidation system composed of ascorbate, O2, and Fe(III). Partial inactivation of GS by this system leads to the formation of hybrid GS molecules (dodecamers) composed of both active and inactive subunits. Subunit interactions in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakamura K,Stadtman ER

更新日期：1984-04-01 00:00:00

abstract：:T helper 17 (TH17) cells represent a discrete TH cell subset instrumental in the immune response to extracellular bacteria and fungi. However, TH17 cells are considered to be detrimentally involved in autoimmune diseases like multiple sclerosis (MS). In contrast to TH17 cells, regulatory T (Treg) cells were shown to b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ulges A,Witsch EJ,Pramanik G,Klein M,Birkner K,Bühler U,Wasser B,Luessi F,Stergiou N,Dietzen S,Brühl TJ,Bohn T,Bündgen G,Kunz H,Waisman A,Schild H,Schmitt E,Zipp F,Bopp T

更新日期：2016-09-06 00:00:00

abstract：:Heparinase I from Flavobacterium heparinum has important uses for elucidating the complex sequence heterogeneity of heparin-like glycosaminoglycans (HLGAGs). Understanding the biological function of HLGAGs has been impaired by the limited methods for analysis of pure or mixed oligosaccharide fragments. Here, we use me...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ernst S,Rhomberg AJ,Biemann K,Sasisekharan R

更新日期：1998-04-14 00:00:00

abstract：:The androgen receptor (AR) binds to androgen response elements and regulates target genes via a mechanism involving coregulators. Here we demonstrate that the AR can interact with the testicular orphan receptor-4 (TR4) and function as a repressor to down-regulate the TR4 target genes by preventing the TR4 binding to i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee YF,Shyr CR,Thin TH,Lin WJ,Chang C

更新日期：1999-12-21 00:00:00

abstract：:The primary DNA lesion induced by malondialdehyde, a byproduct of lipid peroxidation and prostaglandin synthesis, is 3-(2'-deoxy-beta-D-erythro-pentofuranosyl)-pyrimido[1, 2-a]purin-10(3H)-one (M1G). When placed opposite cytosine (underlined) at neutral pH in either the d(GGTMTCCG).d(CGGACACC) or d(ATCGCMCGGCATG). d(C...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mao H,Schnetz-Boutaud NC,Weisenseel JP,Marnett LJ,Stone MP

更新日期：1999-06-08 00:00:00

abstract：:Signaling in the nervous system requires matching of neurotransmitter receptors with cognate neurotransmitters at synapses. The vertebrate neuromuscular junction is the best studied cholinergic synapse, but the mechanisms by which acetylcholine is matched with acetylcholine receptors are not fully understood. Because ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Borodinsky LN,Spitzer NC

更新日期：2007-01-02 00:00:00

abstract：:Advances in vaccine technology over the past two centuries have facilitated far-reaching impact in the control of many infections, and today's emerging vaccines could likewise open new opportunities in the control of several diseases. Here we consider the potential, population-level effects of a particular class of em...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arinaminpathy N,Lavine JS,Grenfell BT

更新日期：2012-12-04 00:00:00

abstract：:The possibility that glycolate oxidation in unicellular green algae is linked to mitochondrial electron transport, rather than to peroxisomal metabolism as in higher plants and animals, was studied in a mutant of Chlamydomonas reinhardtii (dk97) deficient in cytochrome oxidase. This mutant had normal rates of dark res...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Husic DW,Tolbert NE

更新日期：1987-03-01 00:00:00

abstract：:Clinically isolated syndrome (CIS) refers to the earliest clinical manifestation of multiple sclerosis (MS). Currently there are no prognostic biological markers that accurately predict conversion of CIS to clinically definite MS (CDMS). Furthermore, the earliest molecular events in MS are still unknown. We used micro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Corvol JC,Pelletier D,Henry RG,Caillier SJ,Wang J,Pappas D,Casazza S,Okuda DT,Hauser SL,Oksenberg JR,Baranzini SE

更新日期：2008-08-19 00:00:00

abstract：:Signaling pathways regulating proliferation, differentiation, and apoptosis are commonly mediated through protein-protein interactions as well as reversible phosphorylation of proteins. To facilitate the study of regulated protein-protein interactions in cells and living animals, we optimized firefly luciferase protei...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luker KE,Smith MC,Luker GD,Gammon ST,Piwnica-Worms H,Piwnica-Worms D

更新日期：2004-08-17 00:00:00

abstract：:A densely packed granular system is an example of an out-of-equilibrium system in the jammed state. It has been a longstanding problem to determine whether this class of systems can be described by concepts arising from equilibrium statistical mechanics, such as an effective temperature and compactivity. The measureme...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Song C,Wang P,Makse HA

更新日期：2005-02-15 00:00:00

abstract：:Multiple studies have established that microRNAs (miRNAs) are involved in the initiation and progression of cancer. Notably, miR-155 is one of the most overexpressed miRNAs in several solid and hematological malignancies. Ectopic miR-155 expression in mice B cells (Eμ-miR-155 transgenic mice) has been shown to induce ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sandhu SK,Volinia S,Costinean S,Galasso M,Neinast R,Santhanam R,Parthun MR,Perrotti D,Marcucci G,Garzon R,Croce CM

更新日期：2012-12-04 00:00:00

abstract：:An expression is produced for the Casimir energy of a dielectric medium with a spherically symmetrical dielectric discontinuity. Tests based on dielectric and geometrical limits are successful. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schwinger J

更新日期：1992-12-01 00:00:00

abstract：:The usual way to compute Hartree-Fock type functions for molecules is by an expansion of the one-electron functions (molecular orbitals) in a linear combination of analytical functions (LCAO-MO-SCF, linear combination of atomic orbitals-Molecular Orbital-Self Consistent field). The expansion coefficients are obtained ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clementi E

更新日期：1972-10-01 00:00:00

abstract：:Hereditary hemochromatosis (HH) is a disorder of iron metabolism caused by common mutations in the gene HFE. The HFE protein binds to transferrin receptor-1 (TfR1) in competition with transferrin, and in vitro, reduces cellular iron by reducing iron uptake. However, in vivo, HFE is strongly expressed by liver macropha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Drakesmith H,Sweetland E,Schimanski L,Edwards J,Cowley D,Ashraf M,Bastin J,Townsend AR

更新日期：2002-11-26 00:00:00

abstract：:The cAMP receptor protein (CRP) of Escherichia coli needs cAMP for an allosteric change to regulate gene expression by binding to specific DNA sites. The hinge region connecting the DNA-binding domain to the cAMP-binding domain has been proposed to participate in the cAMP-induced allosteric change necessary to adjust ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ryu S,Kim J,Adhya S,Garges S

更新日期：1993-01-01 00:00:00

abstract：:Cancer stem-like cells (CSCs) are a highly tumorigenic cell type present as a minority population in developmentally diverse tumors and cell lines. Using a genetic screen in an inducible model of CSC formation in a breast cell line, we identify microRNAs (miRNAs) that inhibit CSC growth and are down-regulated in CSCs....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Polytarchou C,Iliopoulos D,Struhl K

更新日期：2012-09-04 00:00:00

abstract：:G protein-coupled receptors (GPCRs) play central roles in almost all physiological functions; mutations in GPCRs are responsible for more than 30 disorders. There is a great deal of information about GPCR structure but little information that directly relates structure to protein trafficking or to activation. The gona...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Janovick JA,Conn PM

更新日期：2010-03-02 00:00:00

abstract：:The stimulatory activity of peptides from the alpha 1 domain of the major histocompatibility complex (MHC) class I antigen on adipose cell glucose transport was previously shown to require a preformed, ordered conformation of the peptide. The two peptides studied previously were Dk-(61-85) (ERETQIAKGNEQSFRVDLRTLLRYY) ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stagsted J,Mapelli C,Meyers C,Matthews BW,Anfinsen CB,Goldstein A,Olsson L

更新日期：1993-08-15 00:00:00

abstract：:Soybean plants and Rhizobium japonicum 122 DES, a hydrogen uptake-positive strain, were cultured in media purified to remove Ni. Supplemental Ni had no significant effect on the dry matter or total N content of plants. However, the addition of Ni to both nitrate-grown and symbiotically grown plants resulted in a 7- to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Klucas RV,Hanus FJ,Russell SA,Evans HJ

更新日期：1983-04-01 00:00:00

abstract：:Artificially aminoacylated suppressor tRNAs were used to introduce photoreactive amino acids into model mitochondrial precursor proteins to probe the environment along the protein import pathway. Amino acids with benzophenone side chains of various lengths [DL-2-amino-3-(p-benzoylphenyl)propanoic acid (1) and DL-2-ami...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kanamori T,Nishikawa S,Shin I,Schultz PG,Endo T

更新日期：1997-01-21 00:00:00

abstract：:Two factors that contribute to the progression of Parkinson disease are a brain defect in mitochondrial respiration and the generation of hydrogen peroxide (H2O2) by monoamine oxidase (MAO). Here we show that the two are linked. Metabolism of the neurotransmitter dopamine, or other monoamines (benzylamine, tyramine), ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cohen G,Farooqui R,Kesler N

更新日期：1997-05-13 00:00:00

abstract：:The differentiation of the female gamete into a developmentally competent oocyte relies on the protected environment of the ovarian follicle. The oocyte plays a key role in establishing this microenvironment by releasing paracrine factors that control the functions of surrounding somatic cells. Growth differentiation ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cakmak H,Franciosi F,Zamah AM,Cedars MI,Conti M

更新日期：2016-03-01 00:00:00

abstract：:Utilizing [3H]phorbol dibutyrate [P(Bu)2], we have developed an assay for high-affinity phorbol ester receptors in intact rat embryo fibroblasts. At 37 degrees C, binding of [3H]P(Bu)2 reached a maximum within 10 min and was rapidly reversible. The tumor promoters 12-O-tetradecanoyl-phorbol 13-acetate, teleocidin B, a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Horowitz AD,Greenebaum E,Weinstein IB

更新日期：1981-04-01 00:00:00

abstract：:The traditional disciplines of science are grounded in the observation and measurement of object properties. Recent advances in digital computer technology have spawned numerous computer-based imaging systems that extend the range of observation and measurement into realms that would otherwise be inaccessible. More im...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Beck RN

更新日期：1993-11-01 00:00:00

abstract：:Reconnections of coherent filamentary structures play a key role in the dynamics of fluids, redistributing energy and helicity among the length scales, triggering dissipative effects, and inducing fine-scale mixing. Unlike ordinary (classical) fluids where vorticity is a continuous field, in superfluid helium and in a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Galantucci L,Baggaley AW,Parker NG,Barenghi CF

更新日期：2019-06-18 00:00:00

abstract：:Membrane lipids were once thought to be homogenously distributed in the 2D surface of a membrane, but the lipid raft theory suggests that cholesterol and sphingolipids partition away from other membrane lipids. Lipid raft theory further implicates these cholesterol-rich domains in many processes such as signaling and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Foster LJ,De Hoog CL,Mann M

更新日期：2003-05-13 00:00:00

abstract：:Although current theories of color vision differ in many respects, they all assume the existence of a uniquely defined neutral point in chromaticity space. It generally is assumed that this point satisfies several criteria simultaneously. One of these criteria is that it is perceived as achromatic. A further criterion...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ekroll V,Faul F,Niederée R,Richter E

更新日期：2002-10-01 00:00:00