Nucleosome positioning in a model of active chromatin remodeling enzymes.

abstract：:The electrophysiological basis for higher brain activity during rest and internally directed cognition within the human default mode network (DMN) remains largely unknown. Here we use intracranial recordings in the human posteromedial cortex (PMC), a core node within the DMN, during conditions of cued rest, autobiogra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dastjerdi M,Foster BL,Nasrullah S,Rauschecker AM,Dougherty RF,Townsend JD,Chang C,Greicius MD,Menon V,Kennedy DP,Parvizi J

更新日期：2011-02-15 00:00:00

abstract：:Echolocating big brown bats (Eptesicus fuscus) broadcast ultrasonic frequency-modulated (FM) biosonar sounds (20-100 kHz frequencies; 10-50 microseconds periods) and perceive target range from echo delay. Knowing the acuity for delay resolution is essential to understand how bats process echoes because they perceive t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Simmons JA,Ferragamo MJ,Moss CF

更新日期：1998-10-13 00:00:00

abstract：:Pseudoxanthoma elasticum (PXE) is an autosomal recessive disease characterized by progressive ectopic mineralization of the skin, eyes, and arteries, for which no effective treatment exists. PXE is caused by inactivating mutations in the gene encoding ATP-binding cassette sub-family C member 6 (ABCC6), an ATP-dependen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jansen RS,Küçükosmanoglu A,de Haas M,Sapthu S,Otero JA,Hegman IE,Bergen AA,Gorgels TG,Borst P,van de Wetering K

更新日期：2013-12-10 00:00:00

abstract：:The brain disturbances that place a person at risk for developing depression are unknown. We imaged the brains of 131 individuals, ages 6 to 54 years, who were biological descendants (children or grandchildren) of individuals identified as having either moderate to severe, recurrent, and functionally debilitating depr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Peterson BS,Warner V,Bansal R,Zhu H,Hao X,Liu J,Durkin K,Adams PB,Wickramaratne P,Weissman MM

更新日期：2009-04-14 00:00:00

abstract：:The generalized seizures of status epilepticus (SE) trigger a series of molecular and cellular events that produce cognitive deficits and can culminate in the development of epilepsy. Known early events include opening of the blood-brain barrier (BBB) and astrocytosis accompanied by activation of brain microglia. Wher...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Varvel NH,Neher JJ,Bosch A,Wang W,Ransohoff RM,Miller RJ,Dingledine R

更新日期：2016-09-20 00:00:00

abstract：:Midbrain dopamine neurons play central roles in reward processing. It is widely assumed that all dopamine neurons encode the same information. Some evidence, however, suggests functional differences between subgroups of dopamine neurons, particularly with respect to processing nonrewarding, aversive stimuli. To direct...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brischoux F,Chakraborty S,Brierley DI,Ungless MA

更新日期：2009-03-24 00:00:00

abstract：:The phosphoinositide 3-kinase (PI3K) pathway is central to the metabolic actions of insulin on liver. Here, we show that mice with a liver-specific deletion of the p85alpha regulatory subunit of PI3K (L-Pik3r1KO) exhibit a paradoxical improvement of hepatic and peripheral insulin sensitivity. Although PI3K enzymatic a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Taniguchi CM,Tran TT,Kondo T,Luo J,Ueki K,Cantley LC,Kahn CR

更新日期：2006-08-08 00:00:00

abstract：:We advance a theory of resilience as it applies to the challenges of international development. The conceptualization we advance for development resilience focuses on the stochastic dynamics of individual and collective human well-being, especially on the avoidance of and escape from chronic poverty over time in the f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barrett CB,Constas MA

更新日期：2014-10-07 00:00:00

abstract：:We recently have introduced the term vasculogenic mimicry to describe the unique ability of aggressive melanoma tumor cells to form tubular structures and patterned networks in three-dimensional culture, which "mimics" embryonic vasculogenic networks formed by differentiating endothelial cells. In the current study, w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hendrix MJ,Seftor EA,Meltzer PS,Gardner LM,Hess AR,Kirschmann DA,Schatteman GC,Seftor RE

更新日期：2001-07-03 00:00:00

abstract：:A human beta-globin gene derived from an established human lymphoblast cell line was introduced into murine erythroleukemia (MEL) cells by cell fusion. The globin genes in MEL cells are inducible by dimethyl sulfoxide (Me2SO); induction leads to the accumulation of mouse globin mRNA and hemoglobin. Globin mRNA was not...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pyati J,Kucherlapati RS,Skoultchi AI

更新日期：1980-06-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is characterized by the presence of abundant desmoplastic stroma primarily composed of cancer-associated fibroblasts (CAFs). It is generally accepted that CAFs stimulate tumor progression and might be implicated in drug resistance and immunosuppression. Here, we have compared th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Djurec M,Graña O,Lee A,Troulé K,Espinet E,Cabras L,Navas C,Blasco MT,Martín-Díaz L,Burdiel M,Li J,Liu Z,Vallespinós M,Sanchez-Bueno F,Sprick MR,Trumpp A,Sainz B Jr,Al-Shahrour F,Rabadan R,Guerra C,Barbacid M

更新日期：2018-02-06 00:00:00

abstract：:FtsZ, the ancestral homolog of eukaryotic tubulins, is a GTPase that assembles into a cytokinetic ring structure essential for cell division in prokaryotic cells. Similar to tubulin, purified FtsZ polymerizes into dynamic protofilaments in the presence of GTP; polymer assembly is accompanied by GTP hydrolysis. We used...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Margalit DN,Romberg L,Mets RB,Hebert AM,Mitchison TJ,Kirschner MW,RayChaudhuri D

更新日期：2004-08-10 00:00:00

abstract：:Antibodies against an inositol phospholipid-specific phospholipase C purified from bovine brain were used to screen rat brain lambda gt11 expression cDNA libraries. Complete sequences of three cDNA inserts yielded a cumulative sequence of 5106 base pairs. The deduced protein had 1289 amino acids with a calculated mole...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Suh PG,Ryu SH,Moon KH,Suh HW,Rhee SG

更新日期：1988-08-01 00:00:00

abstract：:Saccharomyces cerevisiae possesses a high-affinity estrogen binding protein and an endogenous ligand that displaces [3H]estradiol from both the yeast binding protein and mammalian estrogen receptors. Semipurified preparations of this ligand have been shown to exhibit estrogenic activity in mammalian systems. We now de...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Feldman D,Tökés LG,Stathis PA,Miller SC,Kurz W,Harvey D

更新日期：1984-08-01 00:00:00

abstract：:The extensive Early Jurassic continental strata of southern Africa have yielded an exceptional record of dinosaurs that includes scores of partial to complete skeletons of the sauropodomorph Massospondylus, ranging from embryos to large adults. In 1976 an incomplete egg clutch including in ovo embryos of this dinosaur...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reisz RR,Evans DC,Roberts EM,Sues HD,Yates AM

更新日期：2012-02-14 00:00:00

abstract：:Antischizophrenic neuroleptic drugs of the diphenylbutylpiperidine class, which includes pimozide, fluspirilene, penfluridol, and clopimozide, inhibit [3H]nitrendipine binding with IC50 values of 13-30 nM. This inhibition involves receptors for the verapamil/prenylamine class of calcium channel antagonists. These diph...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gould RJ,Murphy KM,Reynolds IJ,Snyder SH

更新日期：1983-08-01 00:00:00

abstract：:Autocatalytic activation of an initiator caspase triggers the onset of apoptosis. In dying cells, caspase-9 activation is mediated by a multimeric adaptor complex known as the Apaf-1 apoptosome. The molecular mechanism by which caspase-9 is activated by the Apaf-1 apoptosome remains largely unknown. Here we demonstrat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hu Q,Wu D,Chen W,Yan Z,Yan C,He T,Liang Q,Shi Y

更新日期：2014-11-18 00:00:00

abstract：:Half-cystine peptic peptides representing the intrachain disulfide bonds of the light chain from an apparently homogeneous rabbit anti-p-azobenzoate antibody were isolated in good yields after reduction and alkylation with [(14)C]iodoacetate, and their sequences were determined. The sequence of the first 21 amino-term...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Appella E,Chersi A,Roholt OA,Pressman D

更新日期：1971-10-01 00:00:00

abstract：:Immunoreactive and bioreactive corticotropin (ACTH-like) activities have been detected in the median eminence and remaining medial basal hypothalamus of both normal and hypophysectomized adult male rats: bioreactive ACTH (pg/100 mug of protein) 1028 in median eminence and 1289 in medial basal hypothalamus; immunoreact...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Krieger DT,Liotta A,Brownstein MJ

更新日期：1977-02-01 00:00:00

abstract：:Reactive oxygen species (ROS) mediate apoptosis in many different cell types. We have previously shown that the antioxidant Mn(III) tetrakis(5,10,15,20-benzoic acid)porphyrin (MnTBAP) decreased intracellular ROS and prevented the apoptosis of activated T cells in vitro. To determine the mechanism(s) by which MnTBAP af...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hildeman DA,Mitchell T,Aronow B,Wojciechowski S,Kappler J,Marrack P

更新日期：2003-12-09 00:00:00

abstract：:Waves and patterns in living systems are often driven by biochemical reactions with enzymes as catalysts and regulators. We present a reaction-diffusion system catalyzed by the enzyme glucose oxidase that exhibits traveling wave patterns in a spatially extended medium. Fronts and pulses propagate as a result of the co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Míguez DG,Vanag VK,Epstein IR

更新日期：2007-04-24 00:00:00

abstract：:We have used a semiselective Hahn spin-echo sequence of the form (1331)-tau-(2662)-tau-AQ, delivered by a surface coil to obtain high-resolution 1H NMR spectra from the brains of intact dead rats. This sequence gave suppression of the tissue water resonance by a factor of 80,000 when tau = 68 ms. Delivery of a frequen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hetherington HP,Avison MJ,Shulman RG

更新日期：1985-05-01 00:00:00

abstract：:CD11c, also known as integrin alpha X, is the most widely used defining marker for dendritic cells (DCs). CD11c can bind complement iC3b and mediate phagocytosis in vitro, for which it is also referred to as complement receptor 4. However, the functions of this prominent marker protein in DCs, especially in vivo, rema...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu J,Wu H,An J,Ballantyne CM,Cyster JG

更新日期：2018-06-26 00:00:00

abstract：:Recently, single molecule-based superresolution fluorescence microscopy has surpassed the diffraction limit to improve resolution to the order of 20 nm or better. These methods typically use image fitting that assumes an isotropic emission pattern from the single emitters as well as control of the emitter concentratio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Backlund MP,Lew MD,Backer AS,Sahl SJ,Grover G,Agrawal A,Piestun R,Moerner WE

更新日期：2012-11-20 00:00:00

abstract：:The effect of x-rays on the rate of semiconservative DNA replication was investigated by autoradiography in single cells obtained from normal individuals and from patients having ataxia-telangiectasia (AT). In the five AT cell strains studied, the rate of DNA synthesis was inhibited to a lesser extent that in two norm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jaspers NG,Bootsma D

更新日期：1982-04-01 00:00:00

abstract：:Most genetic regulatory mechanisms involve protein-DNA interactions. In these processes, the classical Watson-Crick DNA structure sometimes is distorted severely, which in turn enables the precise recognition of the specific sites by the protein. Despite its key importance, very little is known about such deformation ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leger JF,Robert J,Bourdieu L,Chatenay D,Marko JF

更新日期：1998-10-13 00:00:00

abstract：:Signal transducer and activator of transcription 3 (STAT3) is a multifunctional protein that participates in signaling pathways initiated by various growth factors and cytokines. It exists in multiple forms including those phosphorylated on Tyr(705) (pYSTAT3) or Ser(727) (pSSTAT3) as well as the unphosphorylated prote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koo MY,Park J,Lim JM,Joo SY,Shin SP,Shim HB,Chung J,Kang D,Woo HA,Rhee SG

更新日期：2014-04-29 00:00:00

abstract：:Significant attention has focused on the role of low-density lipoprotein (LDL) in the pathogenesis of atherosclerosis. However, recent advances have identified triglyceride-rich lipoproteins [e.g., very LDL (VLDL)] as independent risk predictors for this disease. We have previously demonstrated peroxisome proliferator...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee CH,Kang K,Mehl IR,Nofsinger R,Alaynick WA,Chong LW,Rosenfeld JM,Evans RM

更新日期：2006-02-14 00:00:00

abstract：:The aspartate receptor involved in chemotaxis is modified by methyl esterification at four distinct glutamate residues during the adaptive response of this receptor. To explain the high degree of specificity of this modification, it has been proposed that the methyltransferase recognizes the sequence Glu-Glu-Xaa-Xaa-A...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Terwilliger TC,Wang JY,Koshland DE Jr

更新日期：1986-09-01 00:00:00

abstract：:Interleukin 2 (IL-2) occupies a central position in the cascade of events involved in the immune response. We were interested in determining whether IL-2 could function as an adjuvant to vaccination, to increase the immune response to vaccine immunogens. Using the National Institutes of Health test for rabies vaccine ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nunberg JH,Doyle MV,York SM,York CJ

更新日期：1989-06-01 00:00:00