Abstract:
:Interleukin 2 (IL-2) occupies a central position in the cascade of events involved in the immune response. We were interested in determining whether IL-2 could function as an adjuvant to vaccination, to increase the immune response to vaccine immunogens. Using the National Institutes of Health test for rabies vaccine potency, we found that daily systemic administration of IL-2 in conjunction with inactivated rabies virus can increase the potency of vaccination in outbred mice at least 25-fold, as measured by survival following challenge with virulent rabies virus. Enhanced protection is not correlated with an increase in virus-neutralizing antibody titers, and we suggest that IL-2 acts to increase the cellular immune response to vaccination.
journal_name
Proc Natl Acad Sci U S Aauthors
Nunberg JH,Doyle MV,York SM,York CJdoi
10.1073/pnas.86.11.4240subject
Has Abstractpub_date
1989-06-01 00:00:00pages
4240-3issue
11eissn
0027-8424issn
1091-6490journal_volume
86pub_type
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