Abstract:
:The inositol 1,4,5-trisphosphate receptor (IP3R) associated with plasma membranes of lymphocytes differs in terminal sugar content and binding specificity from the cerebellar receptor, which is localized to endoplasmic reticulum. Lectin column chromatography reveals that 30% of IP3R in the thymus contains sialic acid, reflecting a plasma membrane association, in contrast to 5% of cerebellar IP3R. IP3R in thymus and plasma membrane fractions of Jurkat lymphocytes differs from IP3R of Jurkat microsomes and cerebellum in inositol phosphate specificity. The plasma membrane IP3R has lower affinity for IP3 but higher affinity for inositol 1,3,4,5-tetrakisphosphate, which may reflect a unique regulation of calcium at the plasma membrane by inositol phosphates.
journal_name
Proc Natl Acad Sci U S Aauthors
Khan AA,Steiner JP,Snyder SHdoi
10.1073/pnas.89.7.2849keywords:
subject
Has Abstractpub_date
1992-04-01 00:00:00pages
2849-53issue
7eissn
0027-8424issn
1091-6490journal_volume
89pub_type
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