Abstract:
:Although peroxynitrite is harmful to the host, the beneficial effects of peroxynitrite are less well understood. We explored the role of peroxynitrite in the host immune response to Coxsackievirus infection. Peroxynitrite inhibits viral replication in vitro, in part by inhibiting viral RNA entry into the host cell. Nitrotyrosine, a marker for peroxynitrite production, is colocalized with viral antigens in the hearts of infected mice but not control mice. Nitrotyrosine coprecipitates with the viral polypeptide VP1 as well. Guanidinoethyl disulfide, a scavenger of peroxynitrite, blocks peroxynitrite inhibition of viral replication in vitro and permits an increase in viral replication in vivo. These data suggest that peroxynitrite is an endogenous effector of the immune response to viruses.
journal_name
Proc Natl Acad Sci U S Aauthors
Padalko E,Ohnishi T,Matsushita K,Sun H,Fox-Talbot K,Bao C,Baldwin WM 3rd,Lowenstein CJdoi
10.1073/pnas.0400518101keywords:
subject
Has Abstractpub_date
2004-08-10 00:00:00pages
11731-6issue
32eissn
0027-8424issn
1091-6490pii
0400518101journal_volume
101pub_type
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