Saa3 is a key mediator of the protumorigenic properties of cancer-associated fibroblasts in pancreatic tumors.

abstract：:Different polyubiquitin chain linkages direct substrates toward distinct cellular pathways. K63-linked ubiquitylation is known to regulate proteasome-independent events such as signal transduction, but its function in the context of heterogeneous ubiquitin chains remains unclear. Here, we report that K63 ubiquitylatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ohtake F,Tsuchiya H,Saeki Y,Tanaka K

更新日期：2018-02-13 00:00:00

abstract：:A methylcholanthrene-induced glioblastoma of the C57BL/6 inbred mouse strain was used to raise antibodies in C57BL/6 and C57BL/10 inbred mice and in (C57BL/6 x DBA/2) and (C57BL/6 x Balb/c) F(1) hybrids. When examined by the cytotoxicity test, these antibodies define a cell-surface component (or components) found excl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schachner M

更新日期：1974-05-01 00:00:00

abstract：:We have developed a cell-free system to study bacteriophage lambda DNA replication. Maximal DNA synthesis in vitro requires the four deoxynucleoside triphosphates, ATP, and exogenous lambda DNA. DNA synthesis requires the products of the phage O and P genes but is not inhibited by lambda repressor. The kinetics of syn...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shizuya H,Richardson CC

更新日期：1974-05-01 00:00:00

abstract：:Depression is a multifactorial illness and genetic factors play a role in its etiology. The understanding of its physiopathology relies on the availability of experimental models potentially mimicking the disease. Here we describe a model built up by selective breeding of mice with strikingly different responses in th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： El Yacoubi M,Bouali S,Popa D,Naudon L,Leroux-Nicollet I,Hamon M,Costentin J,Adrien J,Vaugeois JM

更新日期：2003-05-13 00:00:00

abstract：:Down-regulation of mitogenic signaling in mammalian cells relies in part on endosomal trafficking of activated receptors into lysosomes, where the receptors are degraded. These events are mediated by ubiquitination of the endosomal cargo and its consequent sorting into multivesicular bodies that form at the surfaces o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lu Q,Hope LW,Brasch M,Reinhard C,Cohen SN

更新日期：2003-06-24 00:00:00

abstract：:The crystal structure of the decapeptide Boc-Aib-Glu(OBzl)-Leu-Aib-Ala-Leu-Aib-Ala-Lys(Z)-Aib-OMe (where Aib is alpha-aminoisobutyryl, Boc is t-butoxycarbonyl, OBzl is benzyl ester, and Z is benzyloxycarbonyl) illustrates a parallel zipper arrangement of interacting helical peptide columns. Head-to-tail NH...OC hydrog...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Karle IL,Flippen-Anderson JL,Uma K,Balaram P

更新日期：1990-10-01 00:00:00

abstract：:One of the most fundamental functions of the brain is to predict upcoming events on the basis of the recent past. A closely related function is to signal when a prediction has been violated. The identity of the brain regions that mediate these functions is not known. We set out to determine whether they are implemente...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meyer T,Olson CR

更新日期：2011-11-29 00:00:00

abstract：:Numerous studies have shown that high olive oil intake reduces blood pressure (BP). These positive effects of olive oil have frequently been ascribed to its minor components, such as alpha-tocopherol, polyphenols, and other phenolic compounds that are not present in other oils. However, in this study we demonstrate th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Terés S,Barceló-Coblijn G,Benet M,Alvarez R,Bressani R,Halver JE,Escribá PV

更新日期：2008-09-16 00:00:00

abstract：:Antibodies previously used for immunofluorescence localization of a myosin heavy chain-like polypeptide to the nuclear envelope in higher eukaryotic cells crossreact with both muscle and nonmuscle isoforms of Drosophila myosin heavy chain. Analyses of Drosophila tissue culture cells and premyogenic embryos suggest tha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berrios M,Fisher PA,Matz EC

更新日期：1991-01-01 00:00:00

abstract：:The gal operon of Escherichia coli is negatively regulated by repressor binding to bipartite operators separated by 11 helical turns of DNA. Synergistic binding of repressor to separate sites on DNA results in looping, with the intervening DNA as a topologically closed domain containing the two promoters. A closed DNA...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Choy HE,Park SW,Parrack P,Adhya S

更新日期：1995-08-01 00:00:00

abstract：:Natal philopatry, the return of individuals to their natal area for reproduction, has advantages and disadvantages for animal populations. Natal philopatry may generate local genetic adaptation, but it may also increase the probability of inbreeding that can compromise persistence. Although natal philopatry is well do...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Salles OC,Pujol B,Maynard JA,Almany GR,Berumen ML,Jones GP,Saenz-Agudelo P,Srinivasan M,Thorrold SR,Planes S

更新日期：2016-11-15 00:00:00

abstract：:Protein kinases are important mediators of much of the signal transduction that occurs in eukaryotic cells. Unfortunately, the identification of protein kinase substrates has proven to be a difficult task, and we generally know few, if any, of the physiologically relevant targets of any particular kinase. Here, we des...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Budovskaya YV,Stephan JS,Deminoff SJ,Herman PK

更新日期：2005-09-27 00:00:00

abstract：:We isolated erythroleukemic cell lines arrested at different levels of the erythroid differentiation pathway. One cell line (CB5), established from mice infected with the helper-independent Friend murine leukemia virus (F-MuLV), exhibited properties similar to those of the normal erythroid progenitor burst-forming cel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shibuya T,Mak TW

更新日期：1983-06-01 00:00:00

abstract：:Pancreatic cancer is one of the most deadly cancers affecting the Western world. Because the disease is highly metastatic and difficult to diagnosis until late stages, the 5-y survival rate is around 5%. The identification of molecular cancer drivers is critical for furthering our understanding of the disease and deve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mann KM,Ward JM,Yew CC,Kovochich A,Dawson DW,Black MA,Brett BT,Sheetz TE,Dupuy AJ,Australian Pancreatic Cancer Genome Initiative.,Chang DK,Biankin AV,Waddell N,Kassahn KS,Grimmond SM,Rust AG,Adams DJ,Jenkins NA,Copela

更新日期：2012-04-17 00:00:00

abstract：:Incubation of physiological concentrations of 125I-labeled insulin with liver membranes in the presence of anti-insulin IgG results in a 7- to 15-fold increase in the specific binding of the hormone. The low-affinity/high-capacity binding sites are replaced by an apparently homogeneous class of high-affinity sites, an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shechter Y,Chang KJ,Jacobs S,Cuatrecasas P

更新日期：1979-06-01 00:00:00

abstract：:The formation of several acyl groups and an amide group of Taxol is catalyzed by regioselective CoA thioester-dependent acyltransferases. Several full-length acyltransferase sequences, obtained from a cDNA library constructed from mRNA isolated from Taxus cuspidata cells induced for Taxol production with methyl jasmon...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Walker K,Long R,Croteau R

更新日期：2002-07-09 00:00:00

abstract：:The SKW-3 cell line, which was established from the malignant cells of a patient with T-cell chronic lymphocytic leukemia, is characterized by a translocation involving chromosome 8 (band q24) and chromosome 14 (band q11) [t(8;14)(q24;q11)]. To determine the position of the gene encoding the alpha chain of the T-cell ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shima EA,Le Beau MM,McKeithan TW,Minowada J,Showe LC,Mak TW,Minden MD,Rowley JD,Diaz MO

更新日期：1986-05-01 00:00:00

abstract：:The human chemokine receptors CCR5 and CXCR4 have emerged as the predominant cofactors, along with CD4, for cellular entry of HIV-1 in vivo whereas the contribution of other chemokine receptors to HIV disease has not been yet determined. CCR5-specific (R5) viruses predominate during primary HIV-1 infection whereas vir...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Penn ML,Grivel JC,Schramm B,Goldsmith MA,Margolis L

更新日期：1999-01-19 00:00:00

abstract：:In early stages of various pulmonary diseases, such as emphysema and fibrosis, the change in X-ray attenuation is not detectable with absorption-based radiography. To monitor the morphological changes that the alveoli network undergoes in the progression of these diseases, we propose using the dark-field signal, which...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schleede S,Meinel FG,Bech M,Herzen J,Achterhold K,Potdevin G,Malecki A,Adam-Neumair S,Thieme SF,Bamberg F,Nikolaou K,Bohla A,Yildirim AÖ,Loewen R,Gifford M,Ruth R,Eickelberg O,Reiser M,Pfeiffer F

更新日期：2012-10-30 00:00:00

abstract：:In the penis, nitric oxide (NO) can be formed by both neuronal NO synthase and endothelial NOS (eNOS). eNOS is activated by viscous drag/shear stress in blood vessels to produce NO continuously, a process mediated by the phosphatidylinositol 3-kinase (PI3kinase)/Akt pathway. Here we show that PI3-kinase/Akt physiologi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hurt KJ,Musicki B,Palese MA,Crone JK,Becker RE,Moriarity JL,Snyder SH,Burnett AL

更新日期：2002-03-19 00:00:00

abstract：:The H2O2-requiring ligninase of the basidiomycete Phanerochaete chrysosporium oxidatively cleaves both lignin and lignin model compounds between C alpha and C beta (C-1 and C-2) of their aliphatic side chains. Previous work has demonstrated a reaction mechanism by which ligninase oxidizes aromatic substrates to their ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hammel KE,Kalyanaraman B,Kirk TK

更新日期：1986-06-01 00:00:00

abstract：:The kappa-selective opioid peptide dynorphin A (DYN) inhibits neuronal adenylate cyclase activity and reduces neuronal voltage-dependent calcium currents. It is not yet known, however, whether the regulation of calcium channel activity is dependent on or independent of the adenylate cyclase/cAMP system. We used the wh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gross RA,Moises HC,Uhler MD,Macdonald RL

更新日期：1990-09-01 00:00:00

abstract：:Each person's genome sequence has thousands of missense variants. Practical interpretation of their functional significance must rely on computational inferences in the absence of exhaustive experimental measurements. Here we analyzed the efficacy of these inferences in 33 de novo missense mutations revealed by sequen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miosge LA,Field MA,Sontani Y,Cho V,Johnson S,Palkova A,Balakishnan B,Liang R,Zhang Y,Lyon S,Beutler B,Whittle B,Bertram EM,Enders A,Goodnow CC,Andrews TD

更新日期：2015-09-15 00:00:00

abstract：:Incorporation experiments with labeled sirohydrochlorin and trimethylisobacteriochlorin demonstrate that ring contraction in vivo to the corrin macrocycle of vitamin B12 liberates acetic acid. The C-20 atom of the precursors becomes the acetate carboxyl carbon. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Battersby AR,Bushell MJ,Jones C,Lewis NG,Pfenninger A

更新日期：1981-01-01 00:00:00

abstract：:O(6)-methylguanine (O(6)meG) and related modifications of guanine in double-stranded DNA are functionally severe lesions that can be produced by many alkylating agents, including N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), a potent carcinogen. O(6)meG is repaired through its demethylation by the O(6)-alkylguanine-DNA...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hwang CS,Shemorry A,Varshavsky A

更新日期：2009-02-17 00:00:00

abstract：:Acute promyelocytic leukemia (APL) is associated with the t(15;17) translocation, which generates a PML/RAR alpha fusion protein between PML, a growth suppressor localized on nuclear matrix-associated bodies, and RAR alpha, a nuclear receptor for retinoic acid (RA). PML/RAR alpha was proposed to block myeloid differen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhu J,Koken MH,Quignon F,Chelbi-Alix MK,Degos L,Wang ZY,Chen Z,de Thé H

更新日期：1997-04-15 00:00:00

abstract：:Sex is thought to facilitate accumulation of initially rare beneficial mutations by allowing simultaneous allele replacements at many loci. However, this advantage of sex depends on a restrictive assumption that the fitness of a genotype is determined by fitness potential, a single intermediate variable to which all l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kondrashov FA,Kondrashov AS

更新日期：2001-10-09 00:00:00

abstract：:Liver ischemia and reperfusion injury (IRI) is a major challenge in liver surgery. Diet restriction reduces liver damage by increasing stress resistance; however, the underlying molecular mechanisms remain unclear. We investigated the preventive effect of 12-h fasting on mouse liver IRI. Partial warm hepatic IRI model...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miyauchi T,Uchida Y,Kadono K,Hirao H,Kawasoe J,Watanabe T,Ueda S,Okajima H,Terajima H,Uemoto S

更新日期：2019-07-02 00:00:00

abstract：:The POT1 (protection of telomeres 1) protein binds the ssDNA overhangs at the ends of chromosomes in diverse eukaryotes. POT1 is essential for chromosome end-protection, as best demonstrated in fission yeast. In human cells, hPOT1 is also involved in telomere-length regulation. We now show that telomeric oligonucleoti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zaug AJ,Podell ER,Cech TR

更新日期：2005-08-02 00:00:00

abstract：:The rise of peptides with secondary structures and functions would have been a key step in the chemical evolution which led to life. As with modern biology, amino acid sequence would have been a primary determinant of peptide structure and activity in an origins-of-life scenario. It is a commonly held hypothesis that ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Forsythe JG,Petrov AS,Millar WC,Yu SS,Krishnamurthy R,Grover MA,Hud NV,Fernández FM

更新日期：2017-09-12 00:00:00