Behavioral, neurochemical, and electrophysiological characterization of a genetic mouse model of depression.

abstract：:A coenzyme B12-dependent ribonucleotide reductase was purified from the archaebacterium Thermoplasma acidophila and partially sequenced. Using probes derived from the sequence, the corresponding gene was cloned, completely sequenced, and expressed in Escherichia coli. The deduced amino acid sequence shows that the cat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tauer A,Benner SA

更新日期：1997-01-07 00:00:00

abstract：:The programmed activation/repression of transcription factors in early hematopoietic differentiation has not yet been explored. The DNA-binding protein GATA-1 is required for normal erythroid development and regulates erythroid-expressed genes in maturing erythroblasts. We analyzed GATA-1 expression in early human adu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sposi NM,Zon LI,Carè A,Valtieri M,Testa U,Gabbianelli M,Mariani G,Bottero L,Mather C,Orkin SH

更新日期：1992-07-15 00:00:00

abstract：:mRNA for the large subunit (LS) of ribulose-1,5-bisphosphate carboxylase [3-phospho-D-glycerate carboxylase (dimerizing), EC 4.1.1.39] of Zea mays is complementary to an uninterrupted 1600-base-pair-long chloroplast DNA sequence that has been mapped precisely within the 4350-base-pair-long chloroplast DNA fragment Bam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Link G,Bogorad L

更新日期：1980-04-01 00:00:00

abstract：:Hyperpolarization of substrates for magnetic resonance spectroscopy (MRS) and imaging (MRI) by dissolution dynamic nuclear polarization (D-DNP) usually involves saturating the ESR transitions of polarizing agents (PAs; e.g., persistent radicals embedded in frozen glassy matrices). This approach has shown enormous pote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gajan D,Bornet A,Vuichoud B,Milani J,Melzi R,van Kalkeren HA,Veyre L,Thieuleux C,Conley MP,Grüning WR,Schwarzwälder M,Lesage A,Copéret C,Bodenhausen G,Emsley L,Jannin S

更新日期：2014-10-14 00:00:00

abstract：:Chemical coding in the sympathetic nervous system involves both noradrenergic and, for a minority of neurons, cholinergic neurotransmission. The expression of the cholinergic phenotype in the developing sympathetic nervous system was examined to determine if coding for cholinergic transmission occurs before or after i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schäfer MK,Schütz B,Weihe E,Eiden LE

更新日期：1997-04-15 00:00:00

abstract：:Migration of the cells in osteoblastic lineage, including preosteoblasts and osteoblasts, has been postulated to influence bone formation. However, the molecular bases that link preosteoblastic/osteoblastic cell migration and bone formation are incompletely understood. Nck (noncatalytic region of tyrosine kinase; coll...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aryal A C S,Miyai K,Izu Y,Hayata T,Notomi T,Noda M,Ezura Y

更新日期：2015-12-15 00:00:00

abstract：:The protein-protein interaction (PPI) network is crucial for cellular information processing and decision-making. With suitable inputs, PPI networks drive the cells to diverse functional outcomes such as cell proliferation or cell death. Here, we characterize the structural controllability of a large directed human PP...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vinayagam A,Gibson TE,Lee HJ,Yilmazel B,Roesel C,Hu Y,Kwon Y,Sharma A,Liu YY,Perrimon N,Barabási AL

更新日期：2016-05-03 00:00:00

abstract：:Covalent attachment of myristic acid (C14:0) to the NH2-terminal glycine residue of a number of cellular, viral, and oncogene-encoded proteins is essential for full expression of their biological function. Substitution of oxygen for methylene groups in this fatty acid does not produce a significant change in chain len...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Johnson DR,Cox AD,Solski PA,Devadas B,Adams SP,Leimgruber RM,Heuckeroth RO,Buss JE,Gordon JI

更新日期：1990-11-01 00:00:00

abstract：:The three members of the Brn-3 family of POU domain transcription factors are found in highly restricted sets of central nervous system neurons. Within the retina, these factors are present only within subsets of ganglion cells. We show here that in the developing mouse retina, Brn-3b protein is first observed in pres...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gan L,Xiang M,Zhou L,Wagner DS,Klein WH,Nathans J

更新日期：1996-04-30 00:00:00

abstract：:Down syndrome (DS) is the most common form of intellectual disability. The cognitive alterations in DS are thought to depend on brain regions critical for learning and memory such as the prefrontal cortex (PFC) and the hippocampus (HPC). Neuroimaging studies suggest that increased brain connectivity correlates with lo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alemany-González M,Gener T,Nebot P,Vilademunt M,Dierssen M,Puig MV

更新日期：2020-05-26 00:00:00

abstract：:Marine Archaea are important players among microbial plankton and significantly contribute to biogeochemical cycles, but details regarding their community structure and long-term seasonal activity and dynamics remain largely unexplored. In this study, we monitored the interannual archaeal community composition of abun...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hugoni M,Taib N,Debroas D,Domaizon I,Jouan Dufournel I,Bronner G,Salter I,Agogué H,Mary I,Galand PE

更新日期：2013-04-09 00:00:00

abstract：:Epidermal growth factor (EGF), a mitogen, also stimulates neurite extension during development, but the underlying mechanism is elusive. This study reveals a functional role for kappa opioid receptor (KOR) in EGF-stimulated neurite extension, and the underlying mechanism. EGF and activated EGF receptor (EGFR) levels a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsai NP,Tsui YC,Pintar JE,Loh HH,Wei LN

更新日期：2010-02-16 00:00:00

abstract：:Microtubules (MTs) are polymers assembled from αβ-tubulin heterodimers that display the hallmark behavior of dynamic instability. MT dynamics are driven by GTP hydrolysis within the MT lattice, and are highly regulated by a number of MT-associated proteins (MAPs). How MAPs affect MTs is still not fully understood, par...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang R,LaFrance B,Nogales E

更新日期：2018-07-03 00:00:00

abstract：:Molecular adaptation is typically assumed to proceed by sequential fixation of beneficial mutations. In diploids, this picture presupposes that for most adaptive mutations, the homozygotes have a higher fitness than the heterozygotes. Here, we show that contrary to this expectation, a substantial proportion of adaptiv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sellis D,Callahan BJ,Petrov DA,Messer PW

更新日期：2011-12-20 00:00:00

abstract：:The ability to respond selectively to particular frequency components of sensory inputs is fundamental to signal processing in the ear. The frog (Rana pipiens) sacculus, which is used for social communication and escape behaviors, is an exquisitely sensitive detector of sounds and ground-borne vibrations in the 5- to ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rutherford MA,Roberts WM

更新日期：2006-02-21 00:00:00

abstract：:Shiverer (shi) is an autosomal recessive mutation in the mouse characterized by an almost total lack of central nervous system myelin. While small amounts of other myelin components are present in the brain of the shi mouse, the four forms of myelin basic protein (MBP) are not detectable. Previous investigations by us...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Molineaux SM,Engh H,de Ferra F,Hudson L,Lazzarini RA

更新日期：1986-10-01 00:00:00

abstract：:We obtain a classification of the irreducible (nonunitary) representations of a connected semisimple Lie group G, in terms of their restriction to a maximal compact subgroup K of G. (A classification in terms of analytic properties of the representations has been given by R. P. Langlands [(1973), mimeographed notes, I...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vogan DA

更新日期：1977-07-01 00:00:00

abstract：:Historical data provide a baseline against which to judge the significance of recent ecological shifts and guide conservation strategies, especially for species decimated by pre-20th century harvesting. Northern fur seals (NFS; Callorhinus ursinus) are a common pinniped species in archaeological sites from southern Ca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Newsome SD,Etnier MA,Gifford-Gonzalez D,Phillips DL,van Tuinen M,Hadly EA,Costa DP,Kennett DJ,Guilderson TP,Koch PL

更新日期：2007-06-05 00:00:00

abstract：:The alphavbeta3 integrins are linked to human bleeding disorders, and pathogenic hantaviruses regulate the function of alphavbeta3 integrins and cause acute vascular diseases. alphavbeta3 integrins are present in either extended (active) or dramatically bent (inactive) structures, and interconversion of alphavbeta3 co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Raymond T,Gorbunova E,Gavrilovskaya IN,Mackow ER

更新日期：2005-01-25 00:00:00

abstract：:Bacillus anthracis, the etiologic agent of anthrax, avoids immune surveillance and commandeers host macrophages as a vehicle for lymphatic spreading. Here, we show that B. anthracis edema toxin (ET), via its adenylyl cyclase activity, dramatically increases the motility of infected macrophages and the expression of va...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim C,Wilcox-Adelman S,Sano Y,Tang WJ,Collier RJ,Park JM

更新日期：2008-04-22 00:00:00

abstract：:Design and synthesis of 3D metallic carbon that is stable under ambient conditions has been a long-standing dream. We predict the existence of such phases, T6- and T14-carbon, consisting of interlocking hexagons. Their dynamic, mechanical, and thermal stabilities are confirmed by carrying out a variety of state-of-the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang S,Wang Q,Chen X,Jena P

更新日期：2013-11-19 00:00:00

abstract：:Glucocorticoids rapidly and completely inhibit intracellular plasminogen activator activity in rat hepatoma cells, as assayed by the solubilization of 125I-labeled fibrin. Experiments in which extracts of dexamethasone-treated cells are mixed with extracts of control cells demonstrate an inhibitor of protease activity...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seifert SC,Gelehrter TD

更新日期：1978-12-01 00:00:00

abstract：:Oxidation of genomic DNA forms the guanine lesion 7,8-dihydro-8-oxoguanine (8-oxoG). When in the template base position during DNA synthesis the 8-oxoG lesion has dual coding potential by virtue of its anti- and syn-conformations, base pairing with cytosine and adenine, respectively. This impacts mutagenesis, because ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Batra VK,Shock DD,Beard WA,McKenna CE,Wilson SH

更新日期：2012-01-03 00:00:00

abstract：:To study the role of low-abundance, embryonic muscle-specific gene transcripts, we have developed a method to screen cDNA clones from embryonic muscle for such sequences. The protocol involves two stages: first, partial enrichment for cDNA clones carrying possible embryo-specific sequences by selecting clones of low-a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ordahl CP,Kioussis D,Tilghman SM,Ovitt CE,Fornwald J

更新日期：1980-08-01 00:00:00

abstract：:The Wnts are a family of glycoproteins that regulate cell proliferation, fate decisions, and differentiation. In our study, we examined the contribution of Wnts to the development of ventral midbrain (VM) dopaminergic (DA) neurons. Our results show that beta-catenin is expressed in DA precursor cells and that beta-cat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Castelo-Branco G,Wagner J,Rodriguez FJ,Kele J,Sousa K,Rawal N,Pasolli HA,Fuchs E,Kitajewski J,Arenas E

更新日期：2003-10-28 00:00:00

abstract：:Invariant natural killer T (iNKT) cells recognize self lipid antigens presented by CD1d molecules. The nature of the self-antigens involved in the development and maturation of iNKT cells is poorly defined. Lysophospholipids are self-antigens presented by CD1d that are generated through the action of phospholipases A1...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Paduraru C,Bezbradica JS,Kunte A,Kelly R,Shayman JA,Veerapen N,Cox LR,Besra GS,Cresswell P

更新日期：2013-03-26 00:00:00

abstract：:The combination of catalytic amounts of optically active dipyridylphosphine and CuF(2) along with hydride donor PhSiH(3) generated in situ a remarkably reactive catalyst system (substrate-to-ligand molar ratio up to 100,000) for the highly enantioselective hydrosilylation of a broad spectrum of aryl alkyl ketones (up ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu J,Ji JX,Chan AS

更新日期：2005-03-08 00:00:00

abstract：:Endocytic protein trafficking is directed by sorting signals on cargo molecules that are recognized by cytosolic adaptor proteins. However, the steps necessary to segregate the variety of cargoes during endocytosis remain poorly defined. Using Caenorhabditis elegans, we demonstrate that multiple plasma membrane endocy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mayers JR,Wang L,Pramanik J,Johnson A,Sarkeshik A,Wang Y,Saengsawang W,Yates JR 3rd,Audhya A

更新日期：2013-07-16 00:00:00

abstract：:Mutations in the GABA(A) receptor gamma2 subunit are associated with childhood absence epilepsy and febrile seizures. To understand better the molecular basis of absence epilepsy in man, we developed a mouse model harboring a gamma2 subunit point mutation (R43Q) found in a large Australian family. Mice heterozygous fo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tan HO,Reid CA,Single FN,Davies PJ,Chiu C,Murphy S,Clarke AL,Dibbens L,Krestel H,Mulley JC,Jones MV,Seeburg PH,Sakmann B,Berkovic SF,Sprengel R,Petrou S

更新日期：2007-10-30 00:00:00

abstract：:Cyclooxygenase-2 (COX-2) expression is induced by mitogenic and proinflammatory factors. Its overexpression plays a causal role in inflammation and tumorigenesis. COX-2 expression is tightly regulated, but the mechanisms are largely unclear. Here we show the control of COX-2 expression by an endogenous tryptophan meta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheng HH,Kuo CC,Yan JL,Chen HL,Lin WC,Wang KH,Tsai KK,Guvén H,Flaberg E,Szekely L,Klein G,Wu KK

更新日期：2012-08-14 00:00:00