A remarkably effective copper(II)-dipyridylphosphine catalyst system for the asymmetric hydrosilylation of ketones in air.

abstract：:The brain continuously influences and perceives the physiological condition of the body. Related cortical representations have been proposed to shape emotional experience and guide behavior. Although previous studies have identified brain regions recruited during autonomic processing, neurological lesion studies have ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guo CC,Sturm VE,Zhou J,Gennatas ED,Trujillo AJ,Hua AY,Crawford R,Stables L,Kramer JH,Rankin K,Levenson RW,Rosen HJ,Miller BL,Seeley WW

更新日期：2016-04-26 00:00:00

abstract：:The three most common methods of sterilization in use today are ethylene oxide exposure, gamma-irradiation, and steam sterilization. Each of these methods has serious limitations for the sterilization of some materials used in medicine, especially thermally and hydrolytically sensitive polymers by themselves and in co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dillow AK,Dehghani F,Hrkach JS,Foster NR,Langer R

更新日期：1999-08-31 00:00:00

abstract：:Fuchs endothelial corneal dystrophy (FECD) is a leading cause of corneal endothelial (CE) degeneration resulting in impaired visual acuity. It is a genetically complex and age-related disorder, with higher incidence in females. In this study, we established a nongenetic FECD animal model based on the physiologic outco...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu C,Miyajima T,Melangath G,Miyai T,Vasanth S,Deshpande N,Kumar V,Ong Tone S,Gupta R,Zhu S,Vojnovic D,Chen Y,Rogan EG,Mondal B,Zahid M,Jurkunas UV

更新日期：2020-01-07 00:00:00

abstract：:Concentrations and isotopic compositions of ethane and propane in cold, deeply buried sediments from the southeastern Pacific are best explained by microbial production of these gases in situ. Reduction of acetate to ethane provides one feasible mechanism. Propane is enriched in (13)C relative to ethane. The amount is...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hinrichs KU,Hayes JM,Bach W,Spivack AJ,Hmelo LR,Holm NG,Johnson CG,Sylva SP

更新日期：2006-10-03 00:00:00

abstract：:Calcicludine (CaC) is a 60-amino acid polypeptide from the venom of Dendroaspis angusticeps. It is structurally homologous to the Kunitz-type protease inhibitor, to dendrotoxins, which block K+ channels, and to the protease inhibitor domain of the amyloid beta protein that accumulates in Alzheimer disease. Voltage-cla...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schweitz H,Heurteaux C,Bois P,Moinier D,Romey G,Lazdunski M

更新日期：1994-02-01 00:00:00

abstract：:In 1999, the population of Vancouver Island, Canada, began to experience an outbreak of a fatal fungal disease caused by a highly virulent lineage of Cryptococcus gattii. This organism has recently spread to the Canadian mainland and Pacific Northwest, but the molecular cause of the outbreak remains unknown. Here we s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ma H,Hagen F,Stekel DJ,Johnston SA,Sionov E,Falk R,Polacheck I,Boekhout T,May RC

更新日期：2009-08-04 00:00:00

abstract：:Phosphatidylinositol (3,4,5)-triphosphate (PtdInsP(3)) mediates intracellular signaling for directional sensing and pseudopod extension at the leading edge of migrating cells during chemotaxis. How this PtdInsP(3) signal is translated into remodeling of the actin cytoskeleton is poorly understood. Here, using a proteo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang P,Wang Y,Sesaki H,Iijima M

更新日期：2010-06-29 00:00:00

abstract：:Distribution studies disclosed that all major cerebral arteries and cortical arterioles of the cat were invested with fine varicose nerve fibers that contained calcitonin gene-related peptide (CGRP)-like immunoreactivity; the trigeminal ganglia likewise contained CGRP immunoreactivity. Sequential immunostaining with a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McCulloch J,Uddman R,Kingman TA,Edvinsson L

更新日期：1986-08-01 00:00:00

abstract：:Previous studies have shown that in mammalian cells proteins of large molecular weight are degraded more rapidly than small ones. Evidence is presented here that half-lives of proteins are also related to their isoelectric points. A double-isotope method was used to compare degradative rates of soluble proteins separa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dice JF,Goldberg AL

更新日期：1975-10-01 00:00:00

abstract：:We examined the interaction of ethanol with the gamma-aminobutyric acid (GABA)ergic system in neurons of slices of the rat central amygdala nucleus (CeA), a brain region thought to be critical for the reinforcing effects of ethanol. Brief superfusion of 11-66 mM ethanol significantly increased GABA type A (GABA(A)) re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roberto M,Madamba SG,Moore SD,Tallent MK,Siggins GR

更新日期：2003-02-18 00:00:00

abstract：:Fine finger and hand movements in humans, monkeys, and rats are under the direct control of the corticospinal tract (CST). CST lesions lead to severe, long-term deficits of precision movements. We transected completely both CSTs in adult rats and treated the animals for 2 weeks with an antibody that neutralized the ce...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Raineteau O,Fouad K,Noth P,Thallmair M,Schwab ME

更新日期：2001-06-05 00:00:00

abstract：:The ten-eleven translocation (TET) family of methylcytosine dioxygenases initiates demethylation of DNA and is associated with tumorigenesis in many cancers; however, the mechanism is mostly unknown. Here we identify upstream activators and downstream effectors of TET1 in breast cancer using human breast cancer cells ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sun M,Song CX,Huang H,Frankenberger CA,Sankarasharma D,Gomes S,Chen P,Chen J,Chada KK,He C,Rosner MR

更新日期：2013-06-11 00:00:00

abstract：:Timelapse video microscopy has been used to record the motility and dynamic interactions between an H-2Db-restricted murine cytotoxic T lymphocyte clone (F5) and Db-transfected L929 mouse fibroblasts (LDb) presenting normal or variant antigenic peptides from human influenza nucleoprotein. F5 cells will kill LDb target...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shotton DM,Attaran A

更新日期：1998-12-22 00:00:00

abstract：:Yeast centromeric DNA (CEN DNA) binding factor 3 (CBF3) is a multisubunit protein complex that binds to the essential CDEIII element in CEN DNA. The four CBF3 proteins are required for accurate chromosome segregation and are considered to be core components of the yeast kinetochore. We have examined the structure of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pietrasanta LI,Thrower D,Hsieh W,Rao S,Stemmann O,Lechner J,Carbon J,Hansma H

更新日期：1999-03-30 00:00:00

abstract：:CCR5 encodes a cell surface chemokine receptor molecule that serves as the principal coreceptor, with CD4, for HIV-type 1 (HIV-1). Varied HIV-1 susceptibility and time to progression to AIDS have been associated with polymorphisms in CCR5. Many of these polymorphisms are located in the 5' cis-regulatory region of CCR5...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bamshad MJ,Mummidi S,Gonzalez E,Ahuja SS,Dunn DM,Watkins WS,Wooding S,Stone AC,Jorde LB,Weiss RB,Ahuja SK

更新日期：2002-08-06 00:00:00

abstract：:The effects of pyrophosphate on RNA binding and ATPase activities of Escherichia coli transcription termination factor rho have been studied. Mutant rho-115 protein has a temperature-sensitive RNA-dependent ATPase activity due to the thermolability of binding to RNA [Kent, R.B. & Guterman, S.K. (1981) Fed. Proc. Fed. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kent RB,Guterman SK

更新日期：1982-07-01 00:00:00

abstract：:G proteins are activated when they associate with G protein-coupled receptors (GPCRs), often in response to agonist-mediated receptor activation. It is generally thought that agonist-induced receptor-G protein association necessarily promotes G protein activation and, conversely, that activated GPCRs do not interact w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Okashah N,Wright SC,Kawakami K,Mathiasen S,Zhou J,Lu S,Javitch JA,Inoue A,Bouvier M,Lambert NA

更新日期：2020-09-01 00:00:00

abstract：:Genetic and biochemical studies on enzymes known to be involved in regulating DNA supercoiling yield a complex spectrum of effects on the Escherichia coli SOS system. Previous studies indicated that only inhibition of DNA gyrase by antibiotics that act on the DNA gyrase A subunit results in turning on the E. coli SOS ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith CL

更新日期：1983-05-01 00:00:00

abstract：:The lactate racemase enzyme (LarA) of Lactobacillus plantarum harbors a (SCS)Ni(II) pincer complex derived from nicotinic acid. Synthesis of the enzyme-bound cofactor requires LarB, LarC, and LarE, which are widely distributed in microorganisms. The functions of the accessory proteins are unknown, but the LarB C termi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Desguin B,Soumillion P,Hols P,Hausinger RP

更新日期：2016-05-17 00:00:00

abstract：:Muscle contraction and relaxation is regulated by transient elevations of myoplasmic Ca(2+). Ca(2+) is released from stores in the lumen of the sarco(endo)plasmic reticulum (SER) to initiate formation of the Ca(2+) transient by activation of a class of Ca(2+) release channels referred to as ryanodine receptors (RyRs) ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Amador FJ,Liu S,Ishiyama N,Plevin MJ,Wilson A,MacLennan DH,Ikura M

更新日期：2009-07-07 00:00:00

abstract：:The acetylcholine receptor is a protein that contains certain critical disulfide bonds. Experiments were designed to determine the role such bonds might play in the physiological activity of the receptor. Modification of the receptor with sodium bisulfite and diamide produced an increase in the time constants of the m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Steinacker A,Zuazaga DC

更新日期：1981-12-01 00:00:00

abstract：:Treatment of small resting B cells with soluble F(ab')2 fragments of anti-IgM, an analogue of T-independent type 2 antigens, induced activation characterized by proliferation and the expression of surface CD5. In contrast, B cells induced to proliferate in response to thymus-dependent inductive signals provided by eit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wortis HH,Teutsch M,Higer M,Zheng J,Parker DC

更新日期：1995-04-11 00:00:00

abstract：:Several polypeptides contained in the coat and the core of adenovirus type 2 particles have been identified as virus gene products. They are synthesized in vitro by a cell-free protein-making system programmed by adenovirus type 2 messenger RNA that has been hybridized with and eluted from virus DNA. Fractionation by ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eron L,Westphal H

更新日期：1974-09-01 00:00:00

abstract：:Despite the importance of valuing another person's welfare for prosocial behavior, currently we have only a limited understanding of how these values are represented in the brain and, more importantly, how they give rise to individual variability in prosociality. In the present study, participants underwent functional...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sul S,Tobler PN,Hein G,Leiberg S,Jung D,Fehr E,Kim H

更新日期：2015-06-23 00:00:00

abstract：:The shape of the presynaptic action potential (AP) has a strong impact on neurotransmitter release. Because of the small size of most terminals in the central nervous system, little is known about the regulation of their AP shape during natural firing patterns in vivo. The calyx of Held is a giant axosomatic terminal ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sierksma MC,Borst JGG

更新日期：2017-04-18 00:00:00

abstract：:Recent experiments have shown that spreading epithelial sheets exhibit a long-range coordination of motility forces that leads to a buildup of tension in the tissue, which may enhance cell division and the speed of wound healing. Furthermore, the edges of these epithelial sheets commonly show finger-like protrusions w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Basan M,Elgeti J,Hannezo E,Rappel WJ,Levine H

更新日期：2013-02-12 00:00:00

abstract：:We have studied ten phenotypically similar patients with complete androgen insensitivity. All of the patients tested had significantly elevated serum luteinizing hormone and plasma androgens within or above the normal adult male range. On the basis of specific dihydrotestosterone binding by skin fibroblasts, we identi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Amrhein JA,Meyer WJ 3rd,Jones HW Jr,Migeon CJ

更新日期：1976-03-01 00:00:00

abstract：:The human aspects of conservation are often overlooked but will be critical for identifying strategies for biological conservation in the face of climate change. We surveyed the behavioral intentions of coastal landowners with respect to various conservation strategies aimed at facilitating ecosystem migration for tid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Field CR,Dayer AA,Elphick CS

更新日期：2017-08-22 00:00:00

abstract：:Species expanding into new habitats as a result of climate change or human introductions will frequently encounter resident competitors. Theoretical models suggest that such interspecific competition can alter the speed of expansion and the shape of expanding range boundaries. However, competitive interactions are rar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Legault G,Bitters ME,Hastings A,Melbourne BA

更新日期：2020-10-27 00:00:00

abstract：:We investigated the ultrafast structural transitions of the heme induced by nitric oxide (NO) binding for several heme proteins by subpicosecond time-resolved resonance Raman and femtosecond transient absorption spectroscopy. We probed the heme iron motion by the evolution of the iron-histidine Raman band intensity af...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kruglik SG,Yoo BK,Franzen S,Vos MH,Martin JL,Negrerie M

更新日期：2010-08-03 00:00:00