Bacterial inactivation by using near- and supercritical carbon dioxide.

abstract：:The goal of the current study was to investigate the role of exogenous and endogenous hydrogen sulfide (H(2)S) on neovascularization and wound healing in vitro and in vivo. Incubation of endothelial cells (ECs) with H(2)S enhanced their angiogenic potential, evidenced by accelerated cell growth, migration, and capilla...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Papapetropoulos A,Pyriochou A,Altaany Z,Yang G,Marazioti A,Zhou Z,Jeschke MG,Branski LK,Herndon DN,Wang R,Szabó C

更新日期：2009-12-22 00:00:00

abstract：:We demonstrate the use of self-assembly for the integration of freestanding micrometer-scale components, including single-crystal, silicon field-effect transistors (FETs) and diffusion resistors, onto flexible plastic substrates. Preferential self-assembly of multiple microcomponent types onto a common platform is ach...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stauth SA,Parviz BA

更新日期：2006-09-19 00:00:00

abstract：:We examined the contributions of the human pulvinar to goal directed selection of visual targets in 3 patients with chronic, unilateral lesions involving topographic maps in the ventral pulvinar. Observers completed 2 psychophysical tasks in which they discriminated the orientation of a lateralized target grating in t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Snow JC,Allen HA,Rafal RD,Humphreys GW

更新日期：2009-03-10 00:00:00

abstract：:Methane (CH4) impacts climate as the second strongest anthropogenic greenhouse gas and air quality by influencing tropospheric ozone levels. Space-based observations have identified the Four Corners region in the Southwest United States as an area of large CH4 enhancements. We conducted an airborne campaign in Four Co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Frankenberg C,Thorpe AK,Thompson DR,Hulley G,Kort EA,Vance N,Borchardt J,Krings T,Gerilowski K,Sweeney C,Conley S,Bue BD,Aubrey AD,Hook S,Green RO

更新日期：2016-08-30 00:00:00

abstract：:Cultured skin fibroblasts from patients with Menkes disease, an X-linked disorder involving a defect in copper metabolism, were analyzed for copper concentration by means of atomic absorption spectrophotometry. These cultures consistently exhibited elevated copper concentrations (mean = 335.5 ng of copper per mg of pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goka TJ,Stevenson RE,Hefferan PM,Howell RR

更新日期：1976-02-01 00:00:00

abstract：:A parathyroid hormone-like peptide (PTH-LP) has recently been identified in human tumors associated with the syndrome of humoral hypercalcemia of malignancy. The peptide appears to be encoded by a single-copy gene that gives rise to multiple mRNAs that are heterogeneous at both their 5' and their 3' ends. Alternative ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mangin M,Ikeda K,Dreyer BE,Broadus AE

更新日期：1989-04-01 00:00:00

abstract：:Despite the importance of tuberculosis as a public health problem, we know relatively little about the molecular mechanisms used by the causative organism, Mycobacterium tuberculosis, to persist in the host. To define these mechanisms, we have mutated virtually every nonessential gene of M. tuberculosis and determined...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sassetti CM,Rubin EJ

更新日期：2003-10-28 00:00:00

abstract：:To attempt to locate functionally important regions of the interferon (IFN) molecule, recombinant human IFN-alpha 2 was subjected to proteolytic digestion. The bacterial proteinase thermolysin produced two major complementary fragments, HuIFN-alpha 2-(1-110) and HuIFN-alpha 2-(111-153). After reduction with 2-mercapto...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ackerman SK,Zur Nedden D,Heintzelman M,Hunkapiller M,Zoon K

更新日期：1984-02-01 00:00:00

abstract：:Cell clones nonproductively transformed by the replication-defective Abelson strain of murine leukemia virus (AbLV) were analyzed for type C viral antigen expression by competition immunoassay. AbLV-transformed mink non-producer lines were found to express a 110,000- to 130,000-molecular weight polyprotein containing ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reynolds FH Jr,Sacks TL,Deobagkar DN,Stephenson JR

更新日期：1978-08-01 00:00:00

abstract：:Bones of the flightless sea duck (Chendytes lawi) from 14 archaeological sites along the California coast indicate that humans hunted the species for at least 8,000 years before it was driven to extinction. Direct (14)C dates on Chendytes bones show that the duck was exploited on the southern California islands as ear...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jones TL,Porcasi JF,Erlandson JM,Dallas H Jr,Wake TA,Schwaderer R

更新日期：2008-03-18 00:00:00

abstract：:African sleeping sickness is a fatal disease that is caused by the protozoan parasite Trypanosoma brucei. Polyamine biosynthesis is an essential pathway in the parasite and is a validated drug target for treatment of the disease. S-adenosylmethionine decarboxylase (AdoMetDC) catalyzes a key step in polyamine biosynthe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Willert EK,Fitzpatrick R,Phillips MA

更新日期：2007-05-15 00:00:00

abstract：:Heat-shock factor 1 (HSF1) is the master transcriptional regulator of the cellular response to heat and a wide variety of other stressors. We previously reported that HSF1 promotes the survival and proliferation of malignant cells. At this time, however, the clinical and prognostic significance of HSF1 in cancer is un...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Santagata S,Hu R,Lin NU,Mendillo ML,Collins LC,Hankinson SE,Schnitt SJ,Whitesell L,Tamimi RM,Lindquist S,Ince TA

更新日期：2011-11-08 00:00:00

abstract：:Green fluorescent protein (GFP) is widely used as a reporter gene in both prokaryotes and eukaryotes. However, the fluorescence levels of wild-type GFP (wtGFP) are not bright enough for fluorescence-activated cell sorting or flow cytometry. Several GFP variants were generated that are brighter or have altered excitati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Anderson MT,Tjioe IM,Lorincz MC,Parks DR,Herzenberg LA,Nolan GP,Herzenberg LA

更新日期：1996-08-06 00:00:00

abstract：:Precise, quantitative measurements of the hydration status of skin can yield important insights into dermatological health and skin structure and function, with additional relevance to essential processes of thermoregulation and other features of basic physiology. Existing tools for determining skin water content expl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kwon K,Wang H,Lim J,Chun KS,Jang H,Yoo I,Wu D,Chen AJ,Gu CG,Lipschultz L,Kim JU,Kim J,Jeong H,Luan H,Park Y,Su CJ,Ishida Y,Madhvapathy SR,Ikoma A,Kwak JW,Yang DS,Banks A,Xu S,Huang Y,Chang JK,Rogers JA

更新日期：2021-02-02 00:00:00

abstract：:Large-scale biogeographical shifts in vegetation are predicted in response to the altered precipitation and temperature regimes associated with global climate change. Vegetation shifts have profound ecological impacts and are an important climate-ecosystem feedback through their alteration of carbon, water, and energy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Adams HD,Guardiola-Claramonte M,Barron-Gafford GA,Villegas JC,Breshears DD,Zou CB,Troch PA,Huxman TE

更新日期：2009-04-28 00:00:00

abstract：:Phytochrome is the photoreceptor that controls red light-mediated morphogenesis in higher plants. It exists in two photointerconvertible forms, a red light-absorbing form, Pr, and a far-red light-absorbing form, Pfr. Because photoconversion of Pr to Pfr by a brief light pulse decreases the in vivo half-life of this ch...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shanklin J,Jabben M,Vierstra RD

更新日期：1987-01-01 00:00:00

abstract：:We report on preparation of rhodopsin proteoliposomes with the cytoplasmic domain of rhodopsin facing the exterior of the proteoliposomes. Rhodopsin purified from rod outer segments of bovine retinae by immunoaffinity chromatography in octyl glucoside was reconstituted into liposomes prepared from soybean phospholipid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Niu L,Kim JM,Khorana HG

更新日期：2002-10-15 00:00:00

abstract：:An intense investigation of possible non-Fermi liquid states of matter has been inspired by two of the most intriguing phenomena discovered in the past quarter century, namely, high-temperature superconductivity and the fractional quantum Hall effect. Despite enormous conceptual strides, these two fields have develope...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jain JK,Anderson PW

更新日期：2009-06-09 00:00:00

abstract：:Accumulation of (45)Ca(++) was found to occur in membrane vesicles of E. coli prepared by lysis with a French pressure cell. The uptake occurs by active transport, requiring an energy source. Substrates of the electron transport chain, including D-lactate, reduced phenazine methosulfate, and NADH, stimulated accumulat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rosen BP,McClees JS

更新日期：1974-12-01 00:00:00

abstract：:Reactive oxygen species (ROS) are known to be important signal molecules that are involved in biotic and abiotic stress responses as well as in growth regulation. However, the molecular mechanisms by which ROS act as a growth regulator, as well as how ROS-dependent growth regulation relates to its roles in stress resp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mabuchi K,Maki H,Itaya T,Suzuki T,Nomoto M,Sakaoka S,Morikami A,Higashiyama T,Tada Y,Busch W,Tsukagoshi H

更新日期：2018-05-15 00:00:00

abstract：:Activation of phospholipase Cgamma1 (PLCgamma1) by vascular endothelial growth factor receptor-2 (VEGFR-2) in endothelial cells in part is responsible for angiogenesis in vivo. The cellular mechanisms exerting negative control over PLCgamma1 activation, however, remain unaddressed. Here by using in vitro and in vivo b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Singh AJ,Meyer RD,Navruzbekov G,Shelke R,Duan L,Band H,Leeman SE,Rahimi N

更新日期：2007-03-27 00:00:00

abstract：:Pyramidal cells in piriform cortex receive excitatory inputs from two different sources that are segregated onto adjacent segments of their apical dendrites. The present studies show that excitatory postsynaptic potentials (EPSPs) evoked by primary olfactory tract afferents that terminate on distal apical segments dis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bower JM,Haberly LB

更新日期：1986-02-01 00:00:00

abstract：:gC1qR is one of the C1q receptors implicated in the regulation of innate and adaptive immunity. We found that gC1qR inhibits RIG-I and MDA5-dependent antiviral signaling. Double stranded RNA and virus trigger the translocation of gC1qR to the mitochondrial outer membrane leading to the interaction of gC1qR with the RI...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu L,Xiao N,Liu F,Ren H,Gu J

更新日期：2009-02-03 00:00:00

abstract：:The infectivity of cloned hepatitis B viral DNA (HBV) has been tested in chimpanzees to identify a fully functional HBV genome and to assess the risk associated with its handling. Only one of two HBV DNA sequence variants tested was shown to be infectious. "Clone purified" virus of predicted nucleotide sequence was pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Will H,Cattaneo R,Darai G,Deinhardt F,Schellekens H,Schaller H

更新日期：1985-02-01 00:00:00

abstract：:Adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] activity of purified secretory vesicle membranes from the adrenal medulla is inhibited by I-isoproterenol and I-epinephrine, as well as by nerve growth factor (NGF). The effect of these agents was found to be dose-dependent and, in the case of the cat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nikodijevic O,Nikodijevic B,Zinder O,Yu MY,Guroff G,Pollard HB

更新日期：1976-03-01 00:00:00

abstract：:Integral feedback control is a basic engineering strategy for ensuring that the output of a system robustly tracks its desired value independent of noise or variations in system parameters. In biological systems, it is common for the response to an extracellular stimulus to return to its prestimulus value even in the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yi TM,Huang Y,Simon MI,Doyle J

更新日期：2000-04-25 00:00:00

abstract：:Recombinant plasmids containing mutant or wild-type adenovirus serotype 2 EIa genes that produce the 12S mRNA alone, the 13S mRNA alone, or both mRNAs were cotransfected into HeLa cells with plasmids containing the viral EIIa or EIII transcription units. The amount of RNA produced from the EIIa and EIII promoters was ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leff T,Elkaim R,Goding CR,Jalinot P,Sassone-Corsi P,Perricaudet M,Kédinger C,Chambon P

更新日期：1984-07-01 00:00:00

abstract：:Since 1930, areas of state-managed forest in the central Himalayas of India have increasingly been devolved to management by local communities. This article studies the long-run effects of the devolution on the cost of forest management and on forest conservation. Village council-management costs an order of magnitude...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Somanathan E,Prabhakar R,Mehta BS

更新日期：2009-03-17 00:00:00

abstract：:cGMP is a key regulatory molecule in visual transduction, integration of neuronal response to excitatory neurotransmitters, relaxation of smooth muscle, intestinal secretion of water and salt, and reabsorption of sodium and water in the distal tubules of the nephron. Some of these cellular functions are associated wit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ruth P,Wang GX,Boekhoff I,May B,Pfeifer A,Penner R,Korth M,Breer H,Hofmann F

更新日期：1993-04-01 00:00:00

abstract：:Brain function depends on adaptive self-organization of large-scale neural assemblies, but little is known about quantitative network parameters governing these processes in humans. Here, we describe the topology and synchronizability of frequency-specific brain functional networks using wavelet decomposition of magne...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bassett DS,Meyer-Lindenberg A,Achard S,Duke T,Bullmore E

更新日期：2006-12-19 00:00:00