Robust perfect adaptation in bacterial chemotaxis through integral feedback control.

abstract：:The rearrangement of immunoglobulin genes in B-lymphocyte precursors requires the expression of the recombination activating genes (Rag), which leads to the generation of a highly diverse B-cell repertoire. We can use the level of Rag-1 mRNA in the bone marrow as an index of its capacity to support the maturation of B...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ben-Yehuda A,Szabo P,Dyall R,Weksler ME

更新日期：1994-12-06 00:00:00

abstract：:Sialyl Lewis x (sLe(x)) and sialyl Lewis a (sLe(a)) glycans are expressed on highly metastatic colon cancer cells. They promote extravasation of cancer cells and tumor angiogenesis via interacting with E-selectin on endothelial cells. Recently, epithelial-mesenchymal transition (EMT) has been noted as a critical pheno...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sakuma K,Aoki M,Kannagi R

更新日期：2012-05-15 00:00:00

abstract：:RNA movements and localization pervade biology, from embryonic development to disease. To identify RNAs at specific locations, we developed a strategy in which a uridine-adding enzyme is anchored to subcellular sites, where it directly marks RNAs with 3' terminal uridines. This localized RNA recording approach yields ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Medina-Munoz HC,Lapointe CP,Porter DF,Wickens M

更新日期：2020-09-22 00:00:00

abstract：:The "chlamydial anomaly," first coined by James Moulder, describes the inability of researchers to detect or purify peptidoglycan (PG) from pathogenic Chlamydiae despite genetic and biochemical evidence and antibiotic susceptibility data that suggest its existence. We recently detected PG in Chlamydia trachomatis by a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Packiam M,Weinrick B,Jacobs WR Jr,Maurelli AT

更新日期：2015-09-15 00:00:00

abstract：:Receptors for platelet-derived growth factor (PDGF) have previously only been found on cells of mesenchymal and glial origin. This study shows PDGF receptors on an anaplastic thyroid carcinoma cell line, C 643, that was found to express thyroglobulin mRNA, confirming its origin from thyroid epithelium. Northern blot a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heldin NE,Gustavsson B,Claesson-Welsh L,Hammacher A,Mark J,Heldin CH,Westermark B

更新日期：1988-12-01 00:00:00

abstract：:The natural history of follicular lymphoma (FL) is frequently characterized by transformation to a more aggressive diffuse large B cell lymphoma (DLBCL). We compared the gene-expression profiles between transformed DLBCL and their antecedent FL. No genes were observed to increase or decrease their expression in all of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lossos IS,Alizadeh AA,Diehn M,Warnke R,Thorstenson Y,Oefner PJ,Brown PO,Botstein D,Levy R

更新日期：2002-06-25 00:00:00

abstract：:To test whether a 30S ribosomal subunitformylmethionyl-tRNA-mRNA complex is an obligatory intermediate in protein synthesis, 70S ribosomes from Escherichia coli were crosslinked with the bifunctional imidoester, dimethylsuberimidate. Crosslinked ribosomes contained covelently joined 30S and 50S subunits, as judged by ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Slobin LI

更新日期：1972-12-01 00:00:00

abstract：:Complementary DNA (cDNA) specific for chick globin mRNA sequences fails to hybridize to total RNA extracted from chicken fibroblasts. After infection by Rous sarcoma virus, RNA complementary to globin cDNA is detectable in 100-500 copies per cell. Infection of fibroblasts with the transformation defective (td) deletio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Groudine M,Weintraub H

更新日期：1975-11-01 00:00:00

abstract：:Knowing how motile bacteria move near and along a solid surface is crucial to understanding such diverse phenomena as the migration of infectious bacteria along a catheter, biofilm growth, and the movement of bacteria through the pore spaces of saturated soil, a critical step in the in situ bioremediation of contamina...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Frymier PD,Ford RM,Berg HC,Cummings PT

更新日期：1995-06-20 00:00:00

abstract：:The receptor-like tyrosine kinase (Ryk), a Wnt receptor, is important for cell fate determination during corticogenesis. During neuronal differentiation, the Ryk intracellular domain (ICD) is cleaved. Cleavage of Ryk and nuclear translocation of Ryk-ICD are required for neuronal differentiation. However, the mechanism...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang WH,Choi SH,Moon BS,Cai M,Lyu J,Bai J,Gao F,Hajjali I,Zhao Z,Campbell DB,Weiner LP,Lu W

更新日期：2017-12-12 00:00:00

abstract：:The total amount of noncoding sequences on chromosomes of contemporary organisms varies significantly from species to species. We propose a hypothesis for the origin of these noncoding sequences that assumes that (i) an approximately equal to 0.55-kilobase (kb)-long reading frame composed the primordial gene and (ii) ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Naora H,Miyahara K,Curnow RN

更新日期：1987-09-01 00:00:00

abstract：:Humans' remarkable ability to quickly and accurately discriminate among thousands of highly similar complex objects demands rapid and precise neural computations. To elucidate the process by which this is achieved, we used magnetoencephalography to measure spatiotemporal patterns of neural activity with high temporal ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vida MD,Nestor A,Plaut DC,Behrmann M

更新日期：2017-01-10 00:00:00

abstract：:The temperature dependence of migration rate and of the thermotactic sensitivity of pseudoplasmodia of Dictyostelium discoideum has been measured. Migration rate increases with temperature to 20 degrees, is temperature insensitive from 20 degrees to 27.5 degrees, and decreases with temperature to 29 degrees, above whi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Poff KL,Skokut M

更新日期：1977-05-01 00:00:00

abstract：:An effective plant alkaloid chemical defense requires a variety of transport processes, but few alkaloid transporters have been characterized at the molecular level. Previously, a gene fragment encoding a putative plasma membrane proton symporter was isolated, because it was coordinately regulated with several nicotin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hildreth SB,Gehman EA,Yang H,Lu RH,Ritesh KC,Harich KC,Yu S,Lin J,Sandoe JL,Okumoto S,Murphy AS,Jelesko JG

更新日期：2011-11-01 00:00:00

abstract：:The bioluminescent bacterium Vibrio fischeri initiates a specific, persistent symbiosis in the light organ of the squid Euprymna scolopes. During the early stages of colonization, V. fischeri is exposed to host-derived nitric oxide (NO). Although NO can be both an antimicrobial component of innate immunity and a key s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang Y,Dufour YS,Carlson HK,Donohue TJ,Marletta MA,Ruby EG

更新日期：2010-05-04 00:00:00

abstract：:Cerebral arteriovenous malformations (AVMs) are common vascular malformations, which may result in hemorrhagic strokes and neurological deficits. Bone morphogenetic protein (BMP) and Notch signaling are both involved in the development of cerebral AVMs, but the cross-talk between the two signaling pathways is poorly u...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yao Y,Yao J,Radparvar M,Blazquez-Medela AM,Guihard PJ,Jumabay M,Boström KI

更新日期：2013-11-19 00:00:00

abstract：:In the present study the complete amino acid sequence of human plasma Zn-alpha 2-glycoprotein was determined. This protein whose biological function is unknown consists of a single polypeptide chain of 276 amino acid residues including 8 tryptophan residues and has a pyroglutamyl residue at the amino terminus. The loc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Araki T,Gejyo F,Takagaki K,Haupt H,Schwick HG,Bürgi W,Marti T,Schaller J,Rickli E,Brossmer R

更新日期：1988-02-01 00:00:00

abstract：:Defining prospective pathways by which zoonoses evolve and emerge as human pathogens is critical for anticipating and controlling both natural and deliberate pandemics. However, predicting tenable pathways of animal-to-human movement has been hindered by challenges in identifying reservoir species, cultivating zoonoti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Becker MM,Graham RL,Donaldson EF,Rockx B,Sims AC,Sheahan T,Pickles RJ,Corti D,Johnston RE,Baric RS,Denison MR

更新日期：2008-12-16 00:00:00

abstract：:Electrical stimulation of the primary spines (greater than 10 cm long) of the tropical sea urchin Diadema antillarum elicits graded compound action potentials that are conducted at a constant speed of approximately equal to 27 cm/sec. Ion substitution experiments suggest that these are due to the summation of calcium ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith DS,Brink D,del Castillo J

更新日期：1985-03-01 00:00:00

abstract：:Many fatal neurodegenerative diseases such as Alzheimer's, Parkinson, the prion-related diseases, and non-neurodegenerative disorders such as type II diabetes are characterized by abnormal amyloid fiber aggregates, suggesting a common mechanism of pathogenesis. We have discovered that a class of systematically designe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hauser CA,Deng R,Mishra A,Loo Y,Khoe U,Zhuang F,Cheong DW,Accardo A,Sullivan MB,Riekel C,Ying JY,Hauser UA

更新日期：2011-01-25 00:00:00

abstract：:Gamma-Glutamyl transpeptidase, which consists of two nonidentical subunits, is rapidly inactivated with respect to its transpeptidase and hydrolase activities by the gamma-glutamyl analogs 6-diazo-5-oxo-L-norleucine and L-azaserine. Inactivation, which is prevented by gamma-glutamyl substrates (but not by acceptor sub...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tate SS,Meister A

更新日期：1977-03-01 00:00:00

abstract：:Silicon, with its great abundance and mature infrastructure, is a foundational material for a range of applications, such as electronics, sensors, solar cells, batteries, and thermoelectrics. These applications rely on the purification of Si to different levels. Recently, it has been shown that nanosized silicon can o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zong L,Zhu B,Lu Z,Tan Y,Jin Y,Liu N,Hu Y,Gu S,Zhu J,Cui Y

更新日期：2015-11-03 00:00:00

abstract：:The interactions between cancer cells and the surrounding host stromal tissue play a critical role in tumor progression and metastasis, but the molecular nature of this relationship remains largely uncharacterized. Furthermore, although genetic changes of neoplastic cells in tumors contribute significantly to tumor pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pelham RJ,Rodgers L,Hall I,Lucito R,Nguyen KC,Navin N,Hicks J,Mu D,Powers S,Wigler M,Botstein D

更新日期：2006-12-26 00:00:00

abstract：:The observation that the age-specific incidence curve of many carcinomas is approximately linear on a double logarithmic plot has led to much speculation regarding the number and nature of the critical events involved in carcinogenesis. By a consideration of colorectal and pancreatic cancers in the Surveillance Epidem...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meza R,Jeon J,Moolgavkar SH,Luebeck EG

更新日期：2008-10-21 00:00:00

abstract：:An extracellular patch electrode was used to record ionic currents from individual complement-induced channels in the membranes of antibody-coated skeletal muscle. The amplitude of the single-channel currents leads to an estimate of 90 pS for the unit conductance. The kinetics of channel opening and closing show marke...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jackson MB,Stephens CL,Lecar H

更新日期：1981-10-01 00:00:00

abstract：:To monitor inaccuracy in gene expression in living cells, we designed an experimental system in the bacterium Bacillus subtilis whereby spontaneous errors can be visualized and quantified at a single-cell level. Our strategy was to introduce mutations into a chromosomally encoded gfp allele, such that errors in protei...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meyerovich M,Mamou G,Ben-Yehuda S

更新日期：2010-06-22 00:00:00

abstract：:p150Glued was first identified as a polypeptide that copurifies with cytoplasmic dynein, the minus-end-directed microtubule-based motor protein, and has more recently been shown to be present as a member of the oligomeric dynactin complex, which includes the actin-related protein centractin (Arp-1). Dynactin is though...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Waterman-Storer CM,Karki S,Holzbaur EL

更新日期：1995-02-28 00:00:00

abstract：:The vacuolar (H(+))-ATPases (V-ATPases) are ATP-dependent proton pumps that acidify intracellular compartments and pump protons across specialized plasma membranes. Proton translocation occurs through the integral V(0) domain, which contains five different subunits (a, d, c, c', and c"). Proton transport is critically...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kawasaki-Nishi S,Nishi T,Forgac M

更新日期：2001-10-23 00:00:00

abstract：:Specific binding properties of the tritium-labeled delta opiate receptor agonist [3H][2-D-penicillamine, 5-D-penicillamine]enkephalin [( 3H][D-Pen2, D-Pen5]enkephalin) were characterized in the rat brain and in a mouse neuroblastoma-rat glioma hybrid cell line (NG 108-15). Saturation isotherms of [3H][D-Pen2, D-Pen5]e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Akiyama K,Gee KW,Mosberg HI,Hruby VJ,Yamamura HI

更新日期：1985-04-01 00:00:00

abstract：:Efforts to increase the potency of transcriptional activators are generally unsuccessful because poor expression of activators in mammalian cells limits their delivery to target promoters. Here we report that the effectiveness of chimeric activators can be dramatically improved by expressing them as noncovalent tetram...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Natesan S,Molinari E,Rivera VM,Rickles RJ,Gilman M

更新日期：1999-11-23 00:00:00