Impaired attentional selection following lesions to human pulvinar: evidence for homology between human and monkey.

abstract：:Pseudomonas aeruginosa is a ubiquitous bacterium that survives in many environments, including as an acute and chronic pathogen in humans. Substantial evidence shows that P. aeruginosa behavior is affected by its motility, and appendages known as flagella and type IV pili (TFP) are known to confer such motility. The r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Anyan ME,Amiri A,Harvey CW,Tierra G,Morales-Soto N,Driscoll CM,Alber MS,Shrout JD

更新日期：2014-12-16 00:00:00

abstract：:The Notch signaling pathway is essential for many aspects of development, cell fate determination, and tissue homeostasis. Notch signaling can be modulated by posttranslational modifications to the Notch receptor, which are known to alter both ligand binding and receptor activation. We have modified the ligand-binding...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Taylor P,Takeuchi H,Sheppard D,Chillakuri C,Lea SM,Haltiwanger RS,Handford PA

更新日期：2014-05-20 00:00:00

abstract：:Helper T (Th) cells are classified as Th1 or Th2 cells by virtue of cytokine secretion and function as mediators of cellular or humoral immunity, respectively. Cytokines also regulate the differentiation of Th cells. For example, interleukin (IL)-12 promotes Th1 and suppresses Th2 cell development, suggesting that IL-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Milich DR,Wolf SF,Hughes JL,Jones JE

更新日期：1995-07-18 00:00:00

abstract：:We have used the 1.1 kilobases of the 5' upstream region of the platelet factor four (PF4) gene coupled to the prokaryotic beta-galactosidase gene to generate two lines of transgenic mice that express this construct. Studies of blood, bone marrow, spleen, and thymus reveal that platelets are the only circulating blood...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ravid K,Beeler DL,Rabin MS,Ruley HE,Rosenberg RD

更新日期：1991-02-15 00:00:00

abstract：:NY-ESO-1 is a "cancer-testis" antigen frequently expressed in epithelial ovarian cancer (EOC) and is among the most immunogenic tumor antigens defined to date. In an effort to understand in vivo tolerance mechanisms, we assessed the phenotype and function of NY-ESO-1-specific CD8(+) T cells derived from peripheral blo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Matsuzaki J,Gnjatic S,Mhawech-Fauceglia P,Beck A,Miller A,Tsuji T,Eppolito C,Qian F,Lele S,Shrikant P,Old LJ,Odunsi K

更新日期：2010-04-27 00:00:00

abstract：:To investigate the role of the myosin hinge region in muscle contraction, we examined the contraction characteristics and Mg-ATPase activity of glycerinated muscle fibers prepared from rabbit psoas in the presence and absence of polyclonal antibody directed against the subfragment 2 (S-2) region of myosin. The antibod...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sugi H,Kobayashi T,Gross T,Noguchi K,Karr T,Harrington WF

更新日期：1992-07-01 00:00:00

abstract：:Schizosaccharomyces pombe cells were transformed with an S. pombe expression vector containing a full-length cDNA of the Chlorella hexose transporter. The transformed cells accumulated 3-O-methylglucose up to 10-fold, whereas wild-type S. pombe and control transformants could only equilibrate this sugar analogue. In a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sauer N,Caspari T,Klebl F,Tanner W

更新日期：1990-10-01 00:00:00

abstract：:The neural cell adhesion molecule (NCAM) is a membrane-associated member of the immunoglobulin superfamily capable of both homophilic and heterophilic binding. To investigate the significance of this binding, a gene targeting strategy in embryonic stem (ES) cells was used to replace the membrane-associated forms of NC...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rabinowitz JE,Rutishauser U,Magnuson T

更新日期：1996-06-25 00:00:00

abstract：:A convenient technique for the partial purification of large quantities of functional, poly(adenylic acid)-rich mRNA is described. The method depends upon annealing poly(adenylic acid)-rich mRNA to oligothymidylic acid-cellulose columns and its elution with buffers of low ionic strength. Biologically active rabbit glo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aviv H,Leder P

更新日期：1972-06-01 00:00:00

abstract：:Messenger RNA from rat liver was partially purified by chromatography on cellulose on the basis of its poly(A) content. Microgram amounts of this RNA stimulate protein synthesis manyfold in a heterologous cell-free system, derived from Krebs ascites cells supplemented with reticulocyte initiation factors. The messenge...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schutz G,Beato M,Feigelson P

更新日期：1973-04-01 00:00:00

abstract：:Tubulin cofactor B (TCoB) plays an important role in microtubule dynamics by facilitating the dimerization of alpha- and beta-tubulin. Recent evidence suggests that p21-activated kinase 1 (Pak1), a major signaling nodule in eukaryotic cells, phosphorylates TCoB on Ser-65 and Ser-128 and plays an essential role in micr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rayala SK,Martin E,Sharina IG,Molli PR,Wang X,Jacobson R,Murad F,Kumar R

更新日期：2007-12-04 00:00:00

abstract：:The utilization of the isoaccepting species of leucyl-tRNA in protein synthesis has been examined in E. coli. Two minor leucyl-tRNA species, isoacceptors tRNA3Leu and tRNA4Leu, are the predominant species found bound to ribosomes during exponential growth in minimal medium. In rich medium, an increased proportion of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Holmes WM,Goldman E,Miner TA,Hatfield GW

更新日期：1977-04-01 00:00:00

abstract：:A polypeptide was isolated from acid extracts of porcine hypothalami on the basis of its high ability to stimulate the release of corticotropin from superfused rat pituitary cells. After an initial separation by gel filtration on Sephadex G-25, further purification was carried out by reversed-phase HPLC. The isolated ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Patthy M,Horvath J,Mason-Garcia M,Szoke B,Schlesinger DH,Schally AV

更新日期：1985-12-01 00:00:00

abstract：:Chemical cross-linking mass spectrometry (CXMS) is being increasingly used to study protein assemblies and complex protein interaction networks. Existing CXMS chemical cross-linkers target only Lys, Cys, Glu, and Asp residues, limiting the information measurable. Here we report a "plant-and-cast" cross-linking strateg...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang B,Wu H,Schnier PD,Liu Y,Liu J,Wang N,DeGrado WF,Wang L

更新日期：2018-10-30 00:00:00

abstract：:Adaptive radiation is the evolution of ecological and phenotypic diversity within a rapidly multiplying lineage. Recent studies have identified general patterns in adaptive radiation and inferred that resource competition is a primary factor driving phenotypic divergence. The role and importance of other processes, su...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nosil P,Crespi BJ

更新日期：2006-06-13 00:00:00

abstract：:A method has been developed that enables us to identify intracellular degradation intermediates of fructose-bisphosphate aldolase B (D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase, EC 4.1.2.13). This method is based on the use of antibody against thoroughly denatured purified aldolase. This antibody ha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reznick AZ,Rosenfelder L,Shpund S,Gershon D

更新日期：1985-09-01 00:00:00

abstract：:The 72-kDa spleen tyrosine kinase (Syk) and Src-family kinase p53/56Lyn (Lyn) contribute to signaling via the B-cell antigen receptor complex. Here we show that Syk and Lyn from human B lymphocytes can interact directly. Syk and Lyn coimmunoprecipitated from mature and activated B-cell lines, and gel-purified Syk and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sidorenko SP,Law CL,Chandran KA,Clark EA

更新日期：1995-01-17 00:00:00

abstract：:Acquired resistance against antimalarial drugs has further increased the need for an effective malaria vaccine. The current leading candidate, RTS,S, is a recombinant circumsporozoite protein (CSP)-based vaccine against Plasmodium falciparum that contains 19 NANP repeats followed by a thrombospondin repeat domain. Alt...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oyen D,Torres JL,Wille-Reece U,Ockenhouse CF,Emerling D,Glanville J,Volkmuth W,Flores-Garcia Y,Zavala F,Ward AB,King CR,Wilson IA

更新日期：2017-11-28 00:00:00

abstract：:Charybdotoxin (ChTX), a K+ channel blocker, depolarizes human peripheral T lymphocytes and renders them insensitive to activation by mitogen. We observed four types of K+ channels in human T cells: one voltage-activated, and three Ca(2+)-activated. To discern the mechanism by which ChTX depolarizes T cells, we examine...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leonard RJ,Garcia ML,Slaughter RS,Reuben JP

更新日期：1992-11-01 00:00:00

abstract：:Soot particles produced by incomplete combustion processes are one of the major components of urban air pollution. Chemistry at their surfaces lead to the heterogeneous conversion of several key trace gases; for example NO(2) interacts with soot and is converted into HONO, which rapidly photodissociates to form OH in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Monge ME,D'Anna B,Mazri L,Giroir-Fendler A,Ammann M,Donaldson DJ,George C

更新日期：2010-04-13 00:00:00

abstract：:In many species that form pair bonds, males display to their mate after pair formation. These displays elevate the female's investment into the brood. This is a form of cooperation because without the display, female investment is reduced to levels that are suboptimal for both sexes. The presence of such displays is p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Servedio MR,Powers JM,Lande R,Price TD

更新日期：2019-11-12 00:00:00

abstract：:The solar system formed from interstellar dust and gas in a molecular cloud. Astronomical observations show that typical interstellar dust consists of amorphous (a-) silicate and organic carbon. Bona fide physical samples for laboratory studies would yield unprecedented insight about solar system formation, but they w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ishii HA,Bradley JP,Bechtel HA,Brownlee DE,Bustillo KC,Ciston J,Cuzzi JN,Floss C,Joswiak DJ

更新日期：2018-06-26 00:00:00

abstract：:High-resolution maps integrated with the enhanced location data base software (LDB+) give improved estimates of genetic parameters and reveal characteristics of cytogenetic bands. Chiasma interference is intermediate between Kosambi and Carter-Falconer levels, as in Drosophila and the mouse. The autosomal genetic map ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Collins A,Frezal J,Teague J,Morton NE

更新日期：1996-12-10 00:00:00

abstract：:Mutations are introduced into rearranged Ig variable genes at a frequency of 10(-2) mutations per base pair by an unknown mechanism. Assuming that DNA repair pathways generate or remove mutations, the frequency and pattern of mutation will be different in variable genes from mice defective in repair. Therefore, hyperm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Winter DB,Phung QH,Umar A,Baker SM,Tarone RE,Tanaka K,Liskay RM,Kunkel TA,Bohr VA,Gearhart PJ

更新日期：1998-06-09 00:00:00

abstract：:Most growth factors are initially synthesized as precursor proteins and subsequently processed into their mature form by proteolytic cleavage, resulting in simultaneous removal of a pro-peptide. However, compared with that of mature form, the biological role of the pro-peptide is poorly understood. Here, we investigat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mizui T,Ishikawa Y,Kumanogoh H,Lume M,Matsumoto T,Hara T,Yamawaki S,Takahashi M,Shiosaka S,Itami C,Uegaki K,Saarma M,Kojima M

更新日期：2015-06-09 00:00:00

abstract：:The composition, insertion, and turnover of externally disposed proteins on the macrophage plasma membrane were analyzed. Cells labeled with [35S]methionine were incubated with the nonpermeant reagent trinitrobenzene sulfonic acid to introduce the trinitrophenyl moiety on free amino groups of externally oriented membr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaplan G,Unkeless JC,Cohn ZA

更新日期：1979-08-01 00:00:00

abstract：:Several 400- to 800-kb murine chromosome domains switch from early to late replication during loss of pluripotency, accompanied by a stable form of gene silencing that is resistant to reprogramming. We found that, whereas enhanced nuclease accessibility correlated with early replication genome-wide, domains that switc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takebayashi S,Dileep V,Ryba T,Dennis JH,Gilbert DM

更新日期：2012-07-31 00:00:00

abstract：:To explore the basis for the template specificities of the bacteriophage T3 and T7 RNA polymerases (EC 2.7.7.6), we determined the nucleotide sequences of six promoters recognized by the T3 RNA polymerase and compared them with the previously determined promoter sequences recognized by the bacteriophage T7 RNA polymer...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bailey JN,Klement JF,McAllister WT

更新日期：1983-05-01 00:00:00

abstract：:The timing of neocortical regional specification was examined using a monoclonal antibody, designated PC3.1, that binds a 29-kDa polypeptide and recognizes a neuronal subpopulation located in the lateral but not dorsomedial neocortex in the rat. When lateral cortical tissue fragments at embryonic days 12 and 16 were m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arimatsu Y,Miyamoto M,Nihonmatsu I,Hirata K,Uratani Y,Hatanaka Y,Takiguchi-Hayashi K

更新日期：1992-10-01 00:00:00

abstract：:Insulin-degrading enzyme (IDE) selectively degrades the monomer of amyloidogenic peptides and contributes to clearance of amyloid β (Aβ). Thus, IDE retards the progression of Alzheimer's disease. IDE possesses an enclosed catalytic chamber that engulfs and degrades its peptide substrates; however, the molecular mechan...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McCord LA,Liang WG,Dowdell E,Kalas V,Hoey RJ,Koide A,Koide S,Tang WJ

更新日期：2013-08-20 00:00:00