Airborne methane remote measurements reveal heavy-tail flux distribution in Four Corners region.

abstract：:The 89-kDa cell surface glycoprotein, P3.58, is detectable on advanced human melanomas in situ but not on benign melanocytes or early melanomas. cDNA cloning of P3.58 from melanoma cells was accomplished by screening a lambda zap expression vector library with monoclonal antibodies produced against the denatured antig...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Johnson JP,Stade BG,Holzmann B,Schwäble W,Riethmüller G

更新日期：1989-01-01 00:00:00

abstract：:Store-operated calcium entry (SOCE), an important mechanism of Ca2+ signaling in a wide range of cell types, is mediated by stromal interaction molecule (STIM), which senses the depletion of endoplasmic reticulum Ca2+ stores and binds and activates Orai channels in the plasma membrane. This inside-out mechanism of Ca2...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim KM,Wijerathne T,Hur JH,Kang UJ,Kim IH,Kweon YC,Lee AR,Jeong SJ,Lee SK,Lee YY,Sim BW,Lee JH,Baig C,Kim SU,Chang KT,Lee KP,Park CY

更新日期：2018-05-15 00:00:00

abstract：:Genetic analysis has revealed that the accumulation of several chloroplast mRNAs of the green alga Chlamydomonas reinhardtii requires specific nucleus-encoded functions. To gain insight into this process, we have cloned the nuclear gene encoding the Mbb1 factor by genomic rescue of a mutant specifically deficient in t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vaistij FE,Boudreau E,Lemaire SD,Goldschmidt-Clermont M,Rochaix JD

更新日期：2000-12-19 00:00:00

abstract：:A neuroethological approach to human and nonhuman primate behavior and cognition predicts biological specializations for social life. Evidence reviewed here indicates that ancestral mechanisms are often duplicated, repurposed, and differentially regulated to support social behavior. Focusing on recent research from no...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang SW,Brent LJ,Adams GK,Klein JT,Pearson JM,Watson KK,Platt ML

更新日期：2013-06-18 00:00:00

abstract：:Field cancerization predisposes the upper aerodigestive tract mucosa to the formation of multiple primary tumors, when exposed to environmental carcinogens. Up-regulation of epidermal growth factor receptor occurs early in squamous cell carcinogenesis and is critical for the loss of growth control in a variety of huma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grandis JR,Drenning SD,Zeng Q,Watkins SC,Melhem MF,Endo S,Johnson DE,Huang L,He Y,Kim JD

更新日期：2000-04-11 00:00:00

abstract：:We describe preliminary studies of the pharmacokinetics, biodistribution, and excretion of an oligodeoxy-nucleotide phosphorothioate ([S]oligonucleotide) in mice. After either intravenous or intraperitoneal administration of a single dose (30 mg/kg of body weight), [S]oligonucleotide (35S-labeled at each internucleoti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Agrawal S,Temsamani J,Tang JY

更新日期：1991-09-01 00:00:00

abstract：:According to the Dobzhansky-Muller model, hybrid sterility is a consequence of the independent evolution of related taxa resulting in incompatible genomic interactions of their hybrids. The model implies that the incompatibilities evolve randomly, unless a particular gene or nongenic sequence diverges much faster than...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bhattacharyya T,Gregorova S,Mihola O,Anger M,Sebestova J,Denny P,Simecek P,Forejt J

更新日期：2013-02-05 00:00:00

abstract：:Ca channel currents were studied in freshly dispersed bovine adrenal glomerulosa cells to better understand the control of aldosterone secretion by extracellular K concentration (Ko) and angiotensin II (AII). The whole-cell variation of the patch voltage clamp technique was used. Two types of Ca channels were found. O...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cohen CJ,McCarthy RT,Barrett PQ,Rasmussen H

更新日期：1988-04-01 00:00:00

abstract：:New neurons are continuously generated in restricted regions of the adult mammalian brain. Although these adult-born neurons have been shown to receive synaptic inputs, little is known about their synaptic outputs. Using retrovirus-mediated birth-dating and labeling in combination with serial section electron microsco...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Faulkner RL,Jang MH,Liu XB,Duan X,Sailor KA,Kim JY,Ge S,Jones EG,Ming GL,Song H,Cheng HJ

更新日期：2008-09-16 00:00:00

abstract：:The GTP/GDP nucleotide switch in Ras superfamily GTPases generally involves differential affinity toward downstream effectors, with the GTP-bound state having a higher affinity for effector than the GDP-bound state. We have developed a quantitative model of allosteric regulation of the Wiskott-Aldrich syndrome protein...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leung DW,Rosen MK

更新日期：2005-04-19 00:00:00

abstract：:Highly expanded Cretaceous-Paleogene (K-Pg) boundary section from the Chicxulub peak ring, recovered by International Ocean Discovery Program (IODP)-International Continental Scientific Drilling Program (ICDP) Expedition 364, provides an unprecedented window into the immediate aftermath of the impact. Site M0077 inclu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gulick SPS,Bralower TJ,Ormö J,Hall B,Grice K,Schaefer B,Lyons S,Freeman KH,Morgan JV,Artemieva N,Kaskes P,de Graaff SJ,Whalen MT,Collins GS,Tikoo SM,Verhagen C,Christeson GL,Claeys P,Coolen MJL,Goderis S,Goto K,

更新日期：2019-09-24 00:00:00

abstract：:Concepts organize the relationship among individual stimuli or events by highlighting shared features. Often, new goals require updating conceptual knowledge to reflect relationships based on different goal-relevant features. Here, our aim is to determine how hippocampal (HPC) object representations are organized and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mack ML,Love BC,Preston AR

更新日期：2016-11-15 00:00:00

abstract：:Plants produce a wide range of allelochemicals to defend against herbivore attack, and generalist herbivores have evolved mechanisms to avoid, sequester, or detoxify a broad spectrum of natural defense compounds. Successful arthropod pests have also developed resistance to diverse classes of pesticides and this adapta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dermauw W,Wybouw N,Rombauts S,Menten B,Vontas J,Grbic M,Clark RM,Feyereisen R,Van Leeuwen T

更新日期：2013-01-08 00:00:00

abstract：:Climate change over the next century is predicted to cause widespread maladaptation in natural systems. This prediction, as well as many sustainable management and conservation practices, assumes that species are adapted to their current climate. However, this assumption is rarely tested. Using a large-scale common ga...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Browne L,Wright JW,Fitz-Gibbon S,Gugger PF,Sork VL

更新日期：2019-12-10 00:00:00

abstract：:Polycomb group proteins are essential regulators of developmental processes across animals. Despite their importance, studies on Polycomb are often restricted to classical model systems and, as such, little is known about the evolution of these important chromatin regulators. Here we focus on Polycomb Repressive Compl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gahan JM,Rentzsch F,Schnitzler CE

更新日期：2020-09-15 00:00:00

abstract：:Male (NZW x BXSB)F1 (W/BF1) mice develop systemic autoimmunity involving autoantibodies, thrombocytopenia, lupus nephritis, and coronary vascular disease (CVD) with myocardial infarction. To determine whether this murine lupus-associated CVD can be prevented by the reduction of dietary calories, male W/BF1 mice were s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mizutani H,Engelman RW,Kinjoh K,Kurata Y,Ikehara S,Matsuzawa Y,Good RA

更新日期：1994-05-10 00:00:00

abstract：:Src homology 2 (SH2) domains are phosphotyrosine-binding modules found within various signal-transducing proteins. We have determined by 125I competition assay and surface plasmon resonance that the SH2 domains of Src and Lck bind to a variety of phosphopeptides with similar affinity and specificity. Both bound with h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Payne G,Shoelson SE,Gish GD,Pawson T,Walsh CT

更新日期：1993-06-01 00:00:00

abstract：:The central administration of the fatty acid synthase (FAS) inhibitor, C75, rapidly suppresses the expression of orexigenic neuropeptides [neuropeptide Y (NPY) and agouti-related protein (AgRP)] and activates expression of anorexigenic neuropeptides [proopiomelanocortin (POMC) and cocaine- and amphetamine-regulated tr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hu Z,Cha SH,van Haasteren G,Wang J,Lane MD

更新日期：2005-03-15 00:00:00

abstract：:The acid-sensing ion channel-1 (ASIC1) contributes to synaptic plasticity and may influence the response to cerebral ischemia and acidosis. We found that cAMP-dependent protein kinase phosphorylated heterologously expressed ASIC1 and endogenous ASIC1 in brain slices. ASIC1 also showed significant phosphorylation under...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leonard AS,Yermolaieva O,Hruska-Hageman A,Askwith CC,Price MP,Wemmie JA,Welsh MJ

更新日期：2003-02-18 00:00:00

abstract：:The structure of the Rous sarcoma virus envelope glycoprotein complex was studied by sedimentation gradient centrifugation analyses of detergent-solubilized wild-type and mutant envelope (env) gene products. These studies show that the envelope glycoprotein forms an oligomer during biosynthesis, which is most likely a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Einfeld D,Hunter E

更新日期：1988-11-01 00:00:00

abstract：:Energetics of resting and evoked fMRI signals were related to localized ensemble firing rates (nu) measured by electrophysiology in rats. Two different unstimulated, or baseline, states were established by anesthesia. Halothane and alpha-chloralose established baseline states of high and low energy, respectively, in w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maandag NJ,Coman D,Sanganahalli BG,Herman P,Smith AJ,Blumenfeld H,Shulman RG,Hyder F

更新日期：2007-12-18 00:00:00

abstract：:For beta-D-glucosylisophosphoramide mustard (beta-D-Glc-IPM), a new alkylating drug in which isophosphoramide mustard is stabilized, a higher selectivity and lower myelotoxicity was observed than for the currently used cytostatic ifosfamide. Because beta-D-Glc-IPM is hydrophilic and does not diffuse passively through ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Veyhl M,Wagner K,Volk C,Gorboulev V,Baumgarten K,Weber WM,Schaper M,Bertram B,Wiessler M,Koepsell H

更新日期：1998-03-17 00:00:00

abstract：:Using the Luria-Delbrück fluctuation analysis, we have examined the lung tumor-forming ability of a series of parallel clones derived from the KHT tumor, grown to small defined sizes. From these studies, we conclude that metastatic variants arise spontaneously in the clonal lines during their growth, at an apparent ra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harris JF,Chambers AF,Hill RP,Ling V

更新日期：1982-09-01 00:00:00

abstract：:Although major research efforts have focused on how specific components of foodstuffs affect health, relatively little is known about a more fundamental aspect of diet, the frequency and circadian timing of meals, and potential benefits of intermittent periods with no or very low energy intakes. The most common eating...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mattson MP,Allison DB,Fontana L,Harvie M,Longo VD,Malaisse WJ,Mosley M,Notterpek L,Ravussin E,Scheer FA,Seyfried TN,Varady KA,Panda S

更新日期：2014-11-25 00:00:00

abstract：:To address devastating environmental crises and to improve human well-being, China has been implementing a number of national policies on payments for ecosystem services. Two of them, the Natural Forest Conservation Program (NFCP) and the Grain to Green Program (GTGP), are among the biggest programs in the world becau...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu J,Li S,Ouyang Z,Tam C,Chen X

更新日期：2008-07-15 00:00:00

abstract：:Colonization of land by plants was a major transition on Earth, but the developmental and genetic innovations required for this transition remain unknown. Physiological studies and the fossil record strongly suggest that the ability of the first land plants to form symbiotic associations with beneficial fungi was one ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Delaux PM,Radhakrishnan GV,Jayaraman D,Cheema J,Malbreil M,Volkening JD,Sekimoto H,Nishiyama T,Melkonian M,Pokorny L,Rothfels CJ,Sederoff HW,Stevenson DW,Surek B,Zhang Y,Sussman MR,Dunand C,Morris RJ,Roux C,Wong GK

更新日期：2015-10-27 00:00:00

abstract：:Cytochrome c peroxidase reacts with peroxide to form compound I, which contains an oxyferryl heme and an indolyl radical at Trp-191. The indolyl free radical has a half-life of several hours at room temperature, and this remarkable stability is essential for the catalytic function of cytochrome c peroxidase. To probe ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miller MA,Han GW,Kraut J

更新日期：1994-11-08 00:00:00

abstract：:alpha-Isopropylmalate synthase [3-hydroxy-4-methyl-3-carboxyvalerate 2-oxo-3-methylbutyrate-lyase (CoA-acetylating); EC 4.1.3.12], the enzyme catalyzing the first committed step in leucine biosynthesis, and homocitrate synthase [3-hydroxy-3-carboxyadipate 2-oxoglutarate-lyase (CoA-acetylating); EC 4.1.3.21], the first...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tracy JW,Kohlhaw GB

更新日期：1975-05-01 00:00:00

abstract：:Explants of human endometrium were cultured to study the release of matrix metalloproteinases (MMPs). Analysis of conditioned media by zymography revealed latent and active forms of collagenase (MMP-1, EC 3.4.24.7), 72-kDa gelatinase A (MMP-2, EC 3.4.24.24), and 92-kDa gelatinase B (MMP-9, EC 3.4.24.35). These protein...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marbaix E,Donnez J,Courtoy PJ,Eeckhout Y

更新日期：1992-12-15 00:00:00

abstract：:Conformationally compromised oncogenic mutants of the tumor suppressor protein p53 can, in principle, be rescued by small molecules that bind the native, but not the denatured state. We describe a strategy for the rational search for such molecules. A nine-residue peptide, CDB3, which was derived from a p53 binding pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Friedler A,Hansson LO,Veprintsev DB,Freund SM,Rippin TM,Nikolova PV,Proctor MR,Rüdiger S,Fersht AR

更新日期：2002-01-22 00:00:00