The genetic basis for PRC1 complex diversity emerged early in animal evolution.

abstract：:Deregulation of microRNA (miRNA) expression can lead to cancer initiation and progression. However, limited information exists on the function of miRNAs in cancer maintenance. We examined these issues in the case of myeloproliferative diseases and neoplasms (MPN), a collection of hematopoietic neoplasms regarded as pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guo S,Bai H,Megyola CM,Halene S,Krause DS,Scadden DT,Lu J

更新日期：2012-10-09 00:00:00

abstract：:Scattering of light from dielectric particles whose size is on the order of an optical wavelength underlies a plethora of visual phenomena in nature and is a foundation for optical coatings and paints. Tailoring the internal nanoscale geometry of such "photonic particles" allows tuning their optical scattering charact...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tao G,Kaufman JJ,Shabahang S,Rezvani Naraghi R,Sukhov SV,Joannopoulos JD,Fink Y,Dogariu A,Abouraddy AF

更新日期：2016-06-21 00:00:00

abstract：:We explored the detection of genome-wide hypomethylation in plasma using shotgun massively parallel bisulfite sequencing as a marker for cancer. Tumor-associated copy number aberrations (CNAs) could also be observed from the bisulfite DNA sequencing data. Hypomethylation and CNAs were detected in the plasma DNA of pat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chan KC,Jiang P,Chan CW,Sun K,Wong J,Hui EP,Chan SL,Chan WC,Hui DS,Ng SS,Chan HL,Wong CS,Ma BB,Chan AT,Lai PB,Sun H,Chiu RW,Lo YM

更新日期：2013-11-19 00:00:00

abstract：:The mammalian form of the protozoan parasite Leishmania mexicana contains high activity of a cysteine proteinase (LmCPb) encoded on a tandem array of 19 genes (lmcpb). Homozygous null mutants for lmcpb have been produced by targeted gene disruption. All life-cycle stages of the mutant can be cultured in vitro, demonst...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mottram JC,Souza AE,Hutchison JE,Carter R,Frame MJ,Coombs GH

更新日期：1996-06-11 00:00:00

abstract：:Climate change, water supply limits, and continued population growth have intensified the search for measures to conserve water in irrigated agriculture, the world's largest water user. Policy measures that encourage adoption of water-conserving irrigation technologies are widely believed to make more water available ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ward FA,Pulido-Velazquez M

更新日期：2008-11-25 00:00:00

abstract：:Erythroid cells which are homogeneous with regard to stage of maturation are naturally available from the circulation of chick embryos at various times of development. This provides a convenient system for examining the changes in plasma membrane protein composition during red cell maturation. Plasma membranes are iso...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chan LL

更新日期：1977-03-01 00:00:00

abstract：:Stable structures of icosahedral symmetry can serve numerous functional roles, including chemical microencapsulation and delivery of drugs and biomolecules, epitope presentation to allow for an efficient immunization process, synthesis of nanoparticles of uniform size, observation of encapsulated reactive intermediate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Olson AJ,Hu YH,Keinan E

更新日期：2007-12-26 00:00:00

abstract：:The cAMP receptor protein (CRP) of Escherichia coli needs cAMP for an allosteric change to regulate gene expression by binding to specific DNA sites. The hinge region connecting the DNA-binding domain to the cAMP-binding domain has been proposed to participate in the cAMP-induced allosteric change necessary to adjust ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ryu S,Kim J,Adhya S,Garges S

更新日期：1993-01-01 00:00:00

abstract：:A predictive coarse-grained protein force field [associative memory, water-mediated, structure, and energy model for molecular dynamics (AWSEM)-MD] is used to study the energy landscapes and relative stabilities of amyloid-β protein (1-40) in the monomer and all of its oligomeric forms up to an octamer. We find that a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zheng W,Tsai MY,Chen M,Wolynes PG

更新日期：2016-10-18 00:00:00

abstract：:A synchronized heart beat is controlled by pacemaking impulses conducted through Purkinje fibers. In chicks, these impulse-conducting cells are recruited during embryogenesis from myocytes in direct association with developing coronary arteries. In culture, the vascular cytokine endothelin converts embryonic myocytes ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hyer J,Johansen M,Prasad A,Wessels A,Kirby ML,Gourdie RG,Mikawa T

更新日期：1999-11-09 00:00:00

abstract：:The adzuki bean beetle, Callosobruchus chinensis, is triple-infected with distinct lineages of Wolbachia endosymbiont, wBruCon, wBruOri, and wBruAus, which were identified by their wsp (Wolbachia surface protein) gene sequences. Whereas wBruCon and wBruOri caused cytoplasmic incompatibility of the host insect, wBruAus...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kondo N,Nikoh N,Ijichi N,Shimada M,Fukatsu T

更新日期：2002-10-29 00:00:00

abstract：:The association between poor paternal diet, perturbed embryonic development, and adult offspring ill health represents a new focus for the Developmental Origins of Health and Disease hypothesis. However, our understanding of the underlying mechanisms remains ill-defined. We have developed a mouse paternal low-protein ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Watkins AJ,Dias I,Tsuro H,Allen D,Emes RD,Moreton J,Wilson R,Ingram RJM,Sinclair KD

更新日期：2018-10-02 00:00:00

abstract：:Psychopathy is associated with persistent antisocial behavior and a striking lack of regret for the consequences of that behavior. Although explanatory models for psychopathy have largely focused on deficits in affective responsiveness, recent work indicates that aberrant value-based decision making may also play a ro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baskin-Sommers A,Stuppy-Sullivan AM,Buckholtz JW

更新日期：2016-12-13 00:00:00

abstract：:Electron spectroscopic imaging, a new technique that permits the quantitative detection of the spatial distributions of atomic elements at high resolution, has been applied to the epiphyseal zone of hypertrophy in the mouse for the visualization of calcium, phosphorus, and sulfur. Longitudinally sectioned epiphyseal g...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arsenault AL,Ottensmeyer FP

更新日期：1983-03-01 00:00:00

abstract：:With 13C NMR, phosphoglucose isomerase (PGI; D-glucose-6-phosphate ketol-isomerase, EC 5.3.1.9) is shown to produce mannose 6-phosphate (M6P) slowly from a much more rapidly catalyzed equilibrium between glucose 6-phosphate (G6P) and fructose 6-phosphate (F6P). The identity of M6P and its formation from G6P plus F6P a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seeholzer SH

更新日期：1993-02-15 00:00:00

abstract：:Addition of a 0.5 M KCl wash fraction from rabbit reticulocyte ribosomes causes a 3- to 10-fold increase in the extent of translation of natural mRNAs by Krebs-cell lysates. In the presence of the wash fraction, 1 pmol of rabbit or mouse 10S RNA directs the incorporation of 80 pmol of leucine into rabbit globin. The a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Metafora S,Terada M,Dow LW,Marks PA,Bank A

更新日期：1972-05-01 00:00:00

abstract：:Zif268, a zinc finger protein whose mRNA is rapidly activated in cells exposed to growth factors or other signaling agents, is thought to play a role in regulating the genetic program induced by extracellular ligands. We report that Zif268 has one of the characteristics of a transcriptional regulator, namely, sequence...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Christy B,Nathans D

更新日期：1989-11-01 00:00:00

abstract：:Human brain functional networks are embedded in anatomical space and have topological properties--small-worldness, modularity, fat-tailed degree distributions--that are comparable to many other complex networks. Although a sophisticated set of measures is available to describe the topology of brain networks, the selec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vértes PE,Alexander-Bloch AF,Gogtay N,Giedd JN,Rapoport JL,Bullmore ET

更新日期：2012-04-10 00:00:00

abstract：:Photosystem II (PSII), the light-driven water/plastoquinone photooxidoreductase, is of central importance in the planetary energy cycle. The product of the reaction, plastohydroquinone (PQH2), is released into the membrane from the QB site, where it is formed. A plastoquinone (PQ) from the membrane pool then binds int...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： De Causmaecker S,Douglass JS,Fantuzzi A,Nitschke W,Rutherford AW

更新日期：2019-09-24 00:00:00

abstract：:The fusion of inner mitochondrial membranes requires dynamin-like GTPases, Mgm1 in yeast and OPA1 in mammals, but how they mediate membrane fusion is poorly understood. Here, we determined the crystal structure of Saccharomyces cerevisiae short Mgm1 (s-Mgm1) in complex with GDP. It revealed an N-terminal GTPase (G) do...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yan L,Qi Y,Ricketson D,Li L,Subramanian K,Zhao J,Yu C,Wu L,Sarsam R,Wong M,Lou Z,Rao Z,Nunnari J,Hu J

更新日期：2020-02-25 00:00:00

abstract：:Performance on the visual paired-comparison task depends on the integrity of the hippocampal formation in humans, monkeys, and, for an analogous task, in rats. The present study sought additional evidence in healthy volunteers concerning the nature of this task. We found that performance on the visual paired-compariso...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Manns JR,Stark CE,Squire LR

更新日期：2000-10-24 00:00:00

abstract：:With the goal of developing techniques for DNA insertional mutagenesis in zebrafish, we established procedures for rapidly obtaining and injecting large numbers of fertilized eggs. Using either of two plasmid constructs, we injected uncut DNA into fertilized eggs at the one- or two-cell stage. Fish hatched from inject...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Culp P,Nüsslein-Volhard C,Hopkins N

更新日期：1991-09-15 00:00:00

abstract：:One-half of pituitary-intact or sham-operated rats survive infection with 10(9) colony-forming units of Salmonella typhimurium, whereas rats without a pituitary gland all die within a few days. When the dose of S. typhimurium is reduced 600-fold, 15-25% of the hypophysectomized rats survive, and the survival rate is s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Edwards CK 3rd,Yunger LM,Lorence RM,Dantzer R,Kelley KW

更新日期：1991-03-15 00:00:00

abstract：:Different experimental structures of the same protein or of proteins with high sequence similarity contain many small variations. Here we construct ensembles of "high-sequence similarity Protein Data Bank" (HSP) structures and consider the extent to which such ensembles represent the structural heterogeneity of the na...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Best RB,Lindorff-Larsen K,DePristo MA,Vendruscolo M

更新日期：2006-07-18 00:00:00

abstract：:Sands from various geographic locations reduce N(2) from the air to NH(3) and traces of N(2)H(4) on exposure to sunlight. This N(2) photofixation occurs under sterile conditions on the surface of finely dispersed titanium minerals such as rutile, utilizing reducing equivalents generated through the photolysis of chemi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schrauzer GN,Strampach N,Hui LN,Palmer MR,Salehi J

更新日期：1983-06-01 00:00:00

abstract：:We have used fast time-resolved infrared spectroscopy to characterize a series of organometallic methane and ethane complexes in solution at room temperature: W(CO)5(CH4) and M(eta5-C5R5)(CO)2(L) [where M = Mn or Re, R = H or CH3 (Re only); and L = CH4 or C2H6]. In all cases, the methane complexes are found to be shor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cowan AJ,Portius P,Kawanami HK,Jina OS,Grills DC,Sun XZ,McMaster J,George MW

更新日期：2007-04-24 00:00:00

abstract：:The excision and reintegration of transposable elements (TEs) restructure their host genomes, generating cellular diversity involved in evolution, development, and the etiology of human diseases. Our current knowledge of TE behavior primarily results from bulk techniques that generate time and cell ensemble averages, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim NH,Lee G,Sherer NA,Martini KM,Goldenfeld N,Kuhlman TE

更新日期：2016-06-28 00:00:00

abstract：:Theory predicts that double-core-hole (DCH) spectroscopy can provide a new powerful means of differentiating between similar chemical systems with a sensitivity not hitherto possible. Although DCH ionization on a single site in molecules was recently measured with double- and single-photon absorption, double-core hole...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berrah N,Fang L,Murphy B,Osipov T,Ueda K,Kukk E,Feifel R,van der Meulen P,Salen P,Schmidt HT,Thomas RD,Larsson M,Richter R,Prince KC,Bozek JD,Bostedt C,Wada S,Piancastelli MN,Tashiro M,Ehara M

更新日期：2011-10-11 00:00:00

abstract：:Polarization of optical fields is a crucial degree of freedom in the all-optical analogue of electromagnetically induced transparency (EIT). However, the physical origins of EIT and polarization-induced phenomena have not been well distinguished, which can lead to confusion in associated applications such as slow ligh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang C,Jiang X,Sweeney WR,Hsu CW,Liu Y,Zhao G,Peng B,Zhang M,Jiang L,Stone AD,Yang L

更新日期：2021-01-19 00:00:00

abstract：:Inactivating mutations of the pro-opiomelanocortin (POMC) gene in both mice and humans leads to hyperphagia and obesity. To further examine the mechanisms whereby POMC-deficiency leads to disordered energy homeostasis, we have generated mice lacking all POMC-derived peptides. Consistent with a previously reported mode...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Challis BG,Coll AP,Yeo GS,Pinnock SB,Dickson SL,Thresher RR,Dixon J,Zahn D,Rochford JJ,White A,Oliver RL,Millington G,Aparicio SA,Colledge WH,Russ AP,Carlton MB,O'Rahilly S

更新日期：2004-03-30 00:00:00