Lead poisoning and the deceptive recovery of the critically endangered California condor.

abstract：:Okadaic acid is a non-phorbol 12-myristate 13-acetate (PMA)-type tumor promoter on mouse skin and known to be a potent inhibitor of serine/threonine protein phosphatases. Contrary to expectation from its tumor-promoting activity, okadaic acid was shown to have a potential to revert the phenotypes of cells transformed ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sakai R,Ikeda I,Kitani H,Fujiki H,Takaku F,Rapp U,Sugimura T,Nagao M

更新日期：1989-12-01 00:00:00

abstract：:Amyloid beta-protein (Abeta) is linked to neuronal injury and death in Alzheimer's disease (AD). Of particular relevance for elucidating the role of Abeta in AD is new evidence that oligomeric forms of Abeta are potent neurotoxins that play a major role in neurodegeneration and the strong association of the 42-residue...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bitan G,Kirkitadze MD,Lomakin A,Vollers SS,Benedek GB,Teplow DB

更新日期：2003-01-07 00:00:00

abstract：:The polymerization of mixtures of Hb S with hemoglobins A, A2, and F has been investigated by analysis of the proportions of S and non-S hemoglobin both in the supernate and in the pellet after centrifugation. In all cases the non-S hemoglobin was incorporated into the polymer even in the absence of hybrids in the ord...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benesch RE,Edalji R,Benesch R,Kwong S

更新日期：1980-09-01 00:00:00

abstract：:An intact T/E1A-binding domain (the pocket) is necessary, but not sufficient, for the retinoblastoma protein (RB) to bind to DNA-protein complexes containing E2F and for RB to induce a G1/S block. Indirect evidence suggests that the binding of RB to E2F may, in addition to inhibiting E2F transactivation function, gene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sellers WR,Rodgers JW,Kaelin WG Jr

更新日期：1995-12-05 00:00:00

abstract：:In Salmonella typhimurium, the CobU, CobS, CobT, and CobC proteins have been proposed to catalyze the late steps in adenosylcobalamin biosynthesis, which define the nucleotide loop assembly pathway. This paper reports the in vitro assembly of the nucleotide loop of adenosylcobalamin from its precursors adenosylcobinam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maggio-Hall LA,Escalante-Semerena JC

更新日期：1999-10-12 00:00:00

abstract：:Using a forward-mutation assay based on the inactivation of the tetracycline-resistance gene located on plasmid pBR322, we have determined the mutation spectrum induced in Escherichia coli by cisplatin [cis-diamminedichloroplatinum(II)], a widely used antitumor drug. Cisplatin is known to form mainly intrastrand diadd...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burnouf D,Duane M,Fuchs RP

更新日期：1987-06-01 00:00:00

abstract：:The autophagic ubiquitin-like protein (ublp) autophagy-related (ATG)12 is a component of the ATG12∼ATG5-ATG16L1 E3 complex that promotes lipid conjugation of members of the LC3 ublp family. A role of ATG12 in the E3 complex is to recruit the E2 enzyme ATG3. Here we report the identification of the ATG12 binding sequen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Metlagel Z,Otomo C,Takaesu G,Otomo T

更新日期：2013-11-19 00:00:00

abstract：:Apoptosis has been shown to be a significant form of cell loss in many diseases. Detachment of photoreceptors from the retinal pigment epithelium, as seen in various retinal disorders, causes photoreceptor loss and subsequent vision decline. Although caspase-dependent apoptotic pathways are activated after retinal det...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Trichonas G,Murakami Y,Thanos A,Morizane Y,Kayama M,Debouck CM,Hisatomi T,Miller JW,Vavvas DG

更新日期：2010-12-14 00:00:00

abstract：:Congenital defects, trauma, and disease can compromise the integrity and functionality of the skeletal system to the extent requiring implantation of bone grafts. Engineering of viable bone substitutes that can be personalized to meet specific clinical needs represents a promising therapeutic alternative. The aim of o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： de Peppo GM,Marcos-Campos I,Kahler DJ,Alsalman D,Shang L,Vunjak-Novakovic G,Marolt D

更新日期：2013-05-21 00:00:00

abstract：:Identified over a dozen years ago in the brain and pancreatic islet, βIV-spectrin is critical for the local organization of protein complexes throughout the nervous system. βIV-Spectrin targets ion channels and adapter proteins to axon initial segments and nodes of Ranvier in neurons, and βIV-spectrin dysfunction unde...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kline CF,Wright PJ,Koval OM,Zmuda EJ,Johnson BL,Anderson ME,Hai T,Hund TJ,Mohler PJ

更新日期：2013-10-22 00:00:00

abstract：:Transfer RNA is one of the most richly modified biological molecules. Biosynthetic pathways that introduce these modifications are underexplored, largely because their absence does not lead to obvious phenotypes under normal growth conditions. Queuosine (Q) is a hypermodified base found in the wobble positions of tRNA...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miles ZD,McCarty RM,Molnar G,Bandarian V

更新日期：2011-05-03 00:00:00

abstract：:Methanogenic archaea are major contributors to the global carbon cycle and were long thought to belong exclusively to the euryarchaeal phylum. Discovery of the methanogenesis gene cluster methyl-coenzyme M reductase (Mcr) in the Bathyarchaeota, and thereafter the Verstraetearchaeota, led to a paradigm shift, pushing b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berghuis BA,Yu FB,Schulz F,Blainey PC,Woyke T,Quake SR

更新日期：2019-03-12 00:00:00

abstract：:DBA/2 mice immunized with poly(A).poly(U) complexed with methylated bovine serum albumin and emulsified in Freund's complete adjuvant were protected against challenge with Friend leukemia virus. There was no correlation between the level of antibody to the immunogen in the prechallenge serum and induced resistance to ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nahon-Merlin E,Lacour F,Friend C,Revoltella R

更新日期：1979-04-01 00:00:00

abstract：:By considering temperature effects on the mechanical unfolding rates of proteins and RNA, whose energy landscape is rugged, the question posed in the title is answered in the affirmative. Adopting a theory by Zwanzig [Zwanzig, R. (1988) Proc. Natl. Acad. Sci. USA 85, 2029-2030], we show that, because of roughness char...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hyeon C,Thirumalai D

更新日期：2003-09-02 00:00:00

abstract：:Previous work has demonstrated a role for the E2F1 gene product in signaling apoptosis, both as a result of the deregulation of the Rb/E2F pathway as well as in response to DNA damage. We now show that the ability of cells to suppress the apoptotic potential of E2F1, as might occur during the course of normal cellular...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hallstrom TC,Nevins JR

更新日期：2003-09-16 00:00:00

abstract：:The myocardin family proteins (myocardin, MRTF-A, and MRTF-B) are serum response factor (SRF) cofactors and potent transcription activators. Gene-ablation studies have indicated important developmental functions for myocardin family proteins primarily in regulation of cardiac and smooth muscle development. Using Xenop...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meadows SM,Warkman AS,Salanga MC,Small EM,Krieg PA

更新日期：2008-02-05 00:00:00

abstract：:A transient transfection assay using Drosophila S2 tissue culture cells and WT and mutant Drosophila vnd/NK-2 homeobox cDNAs was used to localize repression and activation domains of vnd/NK-2 homeodomain protein. A repression domain was identified near the N terminus of vnd/NK-2 homeodomain protein (amino acid residue...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stepchenko A,Nirenberg M

更新日期：2004-09-07 00:00:00

abstract：:Hereditary deficiency of factor IXa (fIXa), a key enzyme in blood coagulation, causes hemophilia B, a severe X chromosome-linked bleeding disorder afflicting 1 in 30,000 males; clinical studies have identified nearly 500 deleterious variants. The x-ray structure of porcine fIXa described here shows the atomic origins ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brandstetter H,Bauer M,Huber R,Lollar P,Bode W

更新日期：1995-10-10 00:00:00

abstract：:Although current theories of color vision differ in many respects, they all assume the existence of a uniquely defined neutral point in chromaticity space. It generally is assumed that this point satisfies several criteria simultaneously. One of these criteria is that it is perceived as achromatic. A further criterion...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ekroll V,Faul F,Niederée R,Richter E

更新日期：2002-10-01 00:00:00

abstract：:Human tuberculosis is caused by members of the Mycobacterium tuberculosis complex (MTBC) that vary in virulence and transmissibility. While genome-wide association studies have uncovered several mutations conferring drug resistance, much less is known about the factors underlying other bacterial phenotypes. Variation ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Øyås O,Borrell S,Trauner A,Zimmermann M,Feldmann J,Liphardt T,Gagneux S,Stelling J,Sauer U,Zampieri M

更新日期：2020-04-14 00:00:00

abstract：:A human lambdaV (Mcg) and a human lambdaII (Vil) myeloma protein have identical sequences in their first hypervariable segments although they differ at 21 positions throughout the variable region. If a different structural gene is responsible for each subgroup, the findings favor insertion of information for the hyper...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu TT,Kabat EA,Bilofsky H

更新日期：1975-12-01 00:00:00

abstract：:The drought of progress in clinical brain tumor therapy provides an impetus for developing new treatments as well as methods for testing therapeutics in animal models. The inability of traditional assays to simultaneously measure tumor size, location, growth kinetics, and cell kill achieved by a treatment complicates ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ross BD,Zhao YJ,Neal ER,Stegman LD,Ercolani M,Ben-Yoseph O,Chenevert TL

更新日期：1998-06-09 00:00:00

abstract：:Physical forces have a profound effect on growth, morphology, locomotion, and survival of organisms. At the level of individual cells, the role of mechanical forces is well recognized in eukaryotic physiology, but much less is known about prokaryotic organisms. Recent findings suggest an effect of physical forces on b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Genova LA,Roberts MF,Wong YC,Harper CE,Santiago AG,Fu B,Srivastava A,Jung W,Wang LM,Krzemiński Ł,Mao X,Sun X,Hui CY,Chen P,Hernandez CJ

更新日期：2019-12-17 00:00:00

abstract：:Pheromone biosynthesis-activating neuropeptide (PBAN) regulates sex pheromone biosynthesis in female Helicoverpa (Heliothis) zea. Two oligonucleotide probes representing two overlapping amino acid regions of PBAN were used to screen 2.5 x 10(5) recombinant plaques, and a positive recombinant clone was isolated. Sequen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Davis MT,Vakharia VN,Henry J,Kempe TG,Raina AK

更新日期：1992-01-01 00:00:00

abstract：:The discovery of arbuscules in Aglaophyton major, an Early Devonian land plant, provides unequivocal evidence that mycorrhizae were established >400 million years ago. Nonseptate hyphac and arbuscules occur in a specialized meristematic region of the cortex that continually provided new cells for fungal infection. Arb...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Remy W,Taylor TN,Hass H,Kerp H

更新日期：1994-12-06 00:00:00

abstract：:Monoclonal antibodies provide an attractive alternative to small-molecule therapies for a wide range of diseases. Given the importance of G protein-coupled receptors (GPCRs) as pharmaceutical targets, there has been an immense interest in developing therapeutic monoclonal antibodies that act on GPCRs. Here we present ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ishchenko A,Wacker D,Kapoor M,Zhang A,Han GW,Basu S,Patel N,Messerschmidt M,Weierstall U,Liu W,Katritch V,Roth BL,Stevens RC,Cherezov V

更新日期：2017-08-01 00:00:00

abstract：:Several hypolipidemic drugs and certain industrial plasticizers induce proliferation of peroxisomes, enhance the activity of peroxisome-associated beta-oxidation of fatty acids, and produce hepatocellular carcinomas in the livers of rodents. Because these chemicals themselves are not mutagens and do not covalently mod...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fahl WE,Lalwani ND,Watanabe T,Goel SK,Reddy JK

更新日期：1984-12-01 00:00:00

abstract：:Cell adhesion molecules (CAMs) may act as regulators of morphogenesis by constraining cell motion, forming borders, and controlling intercellular communications that lead to embryonic induction. This postulated causal role of CAMs in inductive events was tested here in an in vitro system of feather induction. In the d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gallin WJ,Chuong CM,Finkel LH,Edelman GM

更新日期：1986-11-01 00:00:00

abstract：:Regional cerebral blood flow was measured with positron-emission tomography during two encoding and two retrieval tasks that were designed to compare memory for object features with memory for object locations. Bilateral increases in regional cerebral blood flow were observed in both anterior and posterior regions of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Owen AM,Milner B,Petrides M,Evans AC

更新日期：1996-08-20 00:00:00

abstract：:The Miocene is characterized by a series of key climatic events that led to the founding of the late Cenozoic icehouse mode and the dawn of modern biota. The processes that caused these developments, and particularly the role of atmospheric CO2 as a forcing factor, are poorly understood. Here we present a CO2 record b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kürschner WM,Kvacek Z,Dilcher DL

更新日期：2008-01-15 00:00:00