Abstract:
:Plasmodium parasites must complete development in the mosquito vector for transmission to occur. The mosquito innate immune response is remarkably efficient in limiting parasite numbers. Previous work has identified a LPS-induced TNFα transcription factor (LITAF)-like transcription factor, LITAF-like 3 (LL3), which significantly influences parasite numbers. Here, we demonstrate that LL3 does not influence invasion of the mosquito midgut epithelium or ookinete-to-oocyst differentiation but mediates a late-phase immune response that decreases oocyst survival. LL3 expression in the midgut and hemocytes is activated by ookinete midgut invasion and is independent of the mosquito microbiota, suggesting that LL3 may be a component of a wound-healing response. LL3 silencing abrogates the ability of mosquito hemocytes to differentiate and respond to parasite infection, implicating hemocytes as critical modulators of the late-phase immune response.
journal_name
Proc Natl Acad Sci U S Aauthors
Smith RC,Barillas-Mury C,Jacobs-Lorena Mdoi
10.1073/pnas.1420078112subject
Has Abstractpub_date
2015-06-30 00:00:00pages
E3412-20issue
26eissn
0027-8424issn
1091-6490pii
1420078112journal_volume
112pub_type
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