Amyloid beta-peptide disrupts carbachol-induced muscarinic cholinergic signal transduction in cortical neurons.

abstract：:The replication initiator protein of plasmid R6K preferentially repressed transcription initiated in vitro from the promoter of the initiator protein cistron. DNase I protection experiments revealed that the sequences in the region of the promoter recognized by the initiator protein partially overlapped the sequences ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kelley W,Bastia D

更新日期：1985-05-01 00:00:00

abstract：:Integrated assessment models of climate and the economy provide estimates of the social cost of carbon and inform climate policy. We create a variant of the Regional Integrated model of Climate and the Economy (RICE)-a regionally disaggregated version of the Dynamic Integrated model of Climate and the Economy (DICE)-i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dennig F,Budolfson MB,Fleurbaey M,Siebert A,Socolow RH

更新日期：2015-12-29 00:00:00

abstract：:Transfer RNA is one of the most richly modified biological molecules. Biosynthetic pathways that introduce these modifications are underexplored, largely because their absence does not lead to obvious phenotypes under normal growth conditions. Queuosine (Q) is a hypermodified base found in the wobble positions of tRNA...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miles ZD,McCarty RM,Molnar G,Bandarian V

更新日期：2011-05-03 00:00:00

abstract：:The satellite RNA of tobacco ringspot virus depends upon tobacco ringspot virus for its replication and source of coat protein. The satellite RNA reduces virus accumulation and the severity of virus-induced symptoms. Repetitive sequence, dimeric, and higher forms of the satellite RNA are known to autolytically process...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Buzayan JM,Gerlach WL,Bruening G

更新日期：1986-12-01 00:00:00

abstract：:The use of proteasome inhibitors to target cancer's dependence on altered protein homeostasis has been greatly limited by intrinsic and acquired resistance. Analyzing data from thousands of cancer lines and tumors, we find that those with suppressed expression of one or more 19S proteasome subunits show intrinsic prot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsvetkov P,Sokol E,Jin D,Brune Z,Thiru P,Ghandi M,Garraway LA,Gupta PB,Santagata S,Whitesell L,Lindquist S

更新日期：2017-01-10 00:00:00

abstract：:Recent evidence suggests that tumor necrosis factor alpha (TNFalpha) signaling in vascular cells can have antiatherogenic consequences, but the mechanisms are poorly understood. TNFalpha is released by free cholesterol-loaded apoptotic macrophages, and the clearance of these cells by phagocytic macrophages may help to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gerbod-Giannone MC,Li Y,Holleboom A,Han S,Hsu LC,Tabas I,Tall AR

更新日期：2006-02-28 00:00:00

abstract：:The effect of reflex splanchnic nerve stimulation on proenkephalin A biosynthesis was investigated in the rat adrenal medulla. Tissue levels of native [Met5]enkephalin-like immunoreactivity (IR) (measured by direct RIA of tissue extracts), cryptic [Met5]enkephalin-like IR (calculated as the increase in [Met5]enkephali...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kanamatsu T,Unsworth CD,Diliberto EJ Jr,Viveros OH,Hong JS

更新日期：1986-12-01 00:00:00

abstract：:Hapten coupled to isologous gamma globulin can substitute for anti-idiotypic antibody in the induction of neonatal chronic idiotype suppression. The immunologically suppressed animals fail to express an idiotypically defined subset of anti-hapten antibodies in later life and harbor regulatory T cells that prevent the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tokuhisa T,Rajewsky K

更新日期：1985-06-01 00:00:00

abstract：:Primary transcripts made in vitro on bacteriophage T4 DNA by RNA polymerase isolated from normal or T4-infected Escherichia coli were compared by gel electrophoresis. Bacteriophage-modified RNA polymerase fails to initiate transcription at certain promoters recognized by unmodified enzyme. In the T4tRNA gene region, o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goldfarb A

更新日期：1981-06-01 00:00:00

abstract：:We use alternating-laser excitation to achieve fluorescence-aided molecule sorting (FAMS) and enable simultaneous analysis of biomolecular structure and interactions at the level of single molecules. This was performed by labeling biomolecules with fluorophores that serve as donor-acceptor pairs for Förster resonance ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kapanidis AN,Lee NK,Laurence TA,Doose S,Margeat E,Weiss S

更新日期：2004-06-15 00:00:00

abstract：:Malignant spreading of cancer cells requires cell surface proteases that cleave the crosslinked collagenous matrix of connective tissues. From correlating the morphologically defined invasiveness of tumor cells with the presence of specific membrane-associated proteases, we have identified a malignant human melanoma c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aoyama A,Chen WT

更新日期：1990-11-01 00:00:00

abstract：:IL-17-producing CD27(-) γδ cells (γδ(27-) cells) are widely viewed as innate immune cells that make critical contributions to host protection and autoimmunity. However, factors that promote them over IFN-γ-producing γδ(27+) cells are poorly elucidated. Moreover, although human IL-17-producing γδ cells are commonly imp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Michel ML,Pang DJ,Haque SF,Potocnik AJ,Pennington DJ,Hayday AC

更新日期：2012-10-23 00:00:00

abstract：:Programmed cell death (PCD) of mammary alveolar cells during involution commences within hours of the end of suckling. Locally, milk accumulates within alveolar lumens; systemically, levels of lactogenic hormones fall. Four experimental models were used to define the role of local factors as compared with systemic hor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li M,Liu X,Robinson G,Bar-Peled U,Wagner KU,Young WS,Hennighausen L,Furth PA

更新日期：1997-04-01 00:00:00

abstract：:Von Willebrand protein is present in the extracellular matrix of endothelial cells where it codistributes with fibronectin and types IV and V collagen. Bacterial collagenase digestion of endothelial cells removed fibrillar collagen, but the pattern of fibronectin and of von Willebrand protein remained undisturbed. Exo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wagner DD,Urban-Pickering M,Marder VJ

更新日期：1984-01-01 00:00:00

abstract：:Cobra venom factor (CVF) is the complement-activating protein in cobra venom. Like C3b, CVF forms with factor B and factor D in human and mammalian serum the bimolecular C3/C5 convertase. This functional similarity of CVF and C3 correlates with many structural similarities, which led to the suggestion that CVF is evol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fritzinger DC,Bredehorst R,Vogel CW

更新日期：1994-12-20 00:00:00

abstract：:Atherosclerosis is a complex disease resulting from the interaction of multiple genes. We have used the Ldlr knockout mouse model in an interspecific genetic cross to map atherosclerosis susceptibility loci. A total of 174 (MOLF/Ei x B6.129S7-Ldlr(tm1Her)) x C57BL/6J-Ldlr(tm1Her) backcross mice, homozygous for the Ldl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Welch CL,Bretschger S,Latib N,Bezouevski M,Guo Y,Pleskac N,Liang CP,Barlow C,Dansky H,Breslow JL,Tall AR

更新日期：2001-07-03 00:00:00

abstract：:Legionella pneumophila is the cause of Legionnaires' disease, which is a form of potentially fatal pneumonia. To identify genes required for virulence of the bacterium, a library of 1,386 L. pneumophila signature tagged transposon mutants was studied for guinea pig virulence. The mutants were screened in pools of 96 e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Edelstein PH,Edelstein MA,Higa F,Falkow S

更新日期：1999-07-06 00:00:00

abstract：:The role of the products of the K and D loci of the H-2 complex as target antigens for cytotoxic T cells generated to modified syngeneic cells has been investigated. Spleen cells, when cocultured with trinitrophenyl-derivatized syngeneic cells, generate cytolytic T cells that lyse most effectively tumor or spleen targ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burakoff SJ,Germain RN,Dorf ME,Benacerrah B

更新日期：1976-02-01 00:00:00

abstract：:We are interested in the balance of energy and protein synthesis in bacterial growth. How has evolution optimized this balance? We describe an analytical model that leverages extensive literature data on growth laws to infer the underlying fitness landscape and to draw inferences about what evolution has optimized in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maitra A,Dill KA

更新日期：2015-01-13 00:00:00

abstract：:The difficulty of achieving robust functional expression of insect nicotinic acetylcholine receptors (nAChRs) has hampered our understanding of these important molecular targets of globally deployed neonicotinoid insecticides at a time when concerns have grown regarding the toxicity of this chemotype to insect pollina...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ihara M,Furutani S,Shigetou S,Shimada S,Niki K,Komori Y,Kamiya M,Koizumi W,Magara L,Hikida M,Noguchi A,Okuhara D,Yoshinari Y,Kondo S,Tanimoto H,Niwa R,Sattelle DB,Matsuda K

更新日期：2020-07-14 00:00:00

abstract：:In normal adult rats anesthetized with urethane, intravenous injections of beta-endorphin (30--150 micrograms kg-1) induced a transient fall of blood pressure followed by a small hypertension and a prolonged hypotension. Prior administration of naloxone completely blocked these effects, whereas naloxone, given 1 hr af...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lemaire I,Tseng R,Lemaire S

更新日期：1978-12-01 00:00:00

abstract：:Mutations in the ATRX gene on the human X chromosome cause X-linked alpha-thalassemia and mental retardation. XY patients with deletions or mutations in this gene display varying degrees of sex reversal, implicating ATRX in the development of the human testis. To explore further the role of ATRX in mammalian sex diffe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pask A,Renfree MB,Marshall Graves JA

更新日期：2000-11-21 00:00:00

abstract：:The plasmid construct pSVO-CAT has been used to test adenovirus promoter activities in the unmethylated or methylated state. We have now observed that the E2A late promoter of adenovirus type 2 (Ad2) DNA also activated the chloramphenicol acetyltransferase (CAT) gene upon transfection of the pAd2E2A-CAT construct into...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Langner KD,Weyer U,Doerfler W

更新日期：1986-03-01 00:00:00

abstract：:The persistent tetrodotoxin (TTX)-sensitive sodium current, detected in neurons of many regions of mammalian brains, is associated with many essential neuronal activities, including boosting of excitatory synaptic inputs, acceleration of firing rates, and promotion of oscillatory neuronal activities. However, the orig...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu Z,Song W,Dong K

更新日期：2004-08-10 00:00:00

abstract：:The repair of DNA double-strand breaks (DSBs) requires open, flexible chromatin domains. The NuA4-Tip60 complex creates these flexible chromatin structures by exchanging histone H2A.Z onto nucleosomes and promoting acetylation of histone H4. Here, we demonstrate that the accumulation of H2A.Z on nucleosomes at DSBs is...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gursoy-Yuzugullu O,Ayrapetov MK,Price BD

更新日期：2015-06-16 00:00:00

abstract：:Lentiviruses, including HIV-1, have transmembrane envelope (Env) glycoproteins with cytoplasmic tails that are quite long compared with those of other retroviruses. However, mainly because of the lack of biochemical studies performed in cell types that are targets for HIV-1 infection, no clear consensus exists regardi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murakami T,Freed EO

更新日期：2000-01-04 00:00:00

abstract：:Myosins are molecular motors that power diverse cellular processes, such as rapid organelle transport, muscle contraction, and tension-sensitive anchoring. The structural adaptations in the motor that allow for this functional diversity are not known, due, in part, to the lack of high-resolution structures of highly t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shuman H,Greenberg MJ,Zwolak A,Lin T,Sindelar CV,Dominguez R,Ostap EM

更新日期：2014-02-11 00:00:00

abstract：:Peanut or groundnut (Arachis hypogaea L.), a legume of South American origin, has high seed oil content (45-56%) and is a staple crop in semiarid tropical and subtropical regions, partially because of drought tolerance conferred by its geocarpic reproductive strategy. We present a draft genome of the peanut A-genome p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen X,Li H,Pandey MK,Yang Q,Wang X,Garg V,Li H,Chi X,Doddamani D,Hong Y,Upadhyaya H,Guo H,Khan AW,Zhu F,Zhang X,Pan L,Pierce GJ,Zhou G,Krishnamohan KA,Chen M,Zhong N,Agarwal G,Li S,Chitikineni A,Zhang GQ

更新日期：2016-06-14 00:00:00

abstract：:The polyamines, putrescine, spermidine, and spermine, are essential polycations, intimately involved in the regulation of cellular proliferation. Although polyamines exert dynamic effects on the conformation of nucleic acids and macromolecular synthesis in vitro, their specific functions in vivo are poorly understood....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mandal S,Mandal A,Johansson HE,Orjalo AV,Park MH

更新日期：2013-02-05 00:00:00

abstract：:The first crystal structure of the neurotransmitter/sodium symporter homolog LeuT revealed an occluded binding pocket containing leucine and 2 Na(+); later structures showed tricyclic antidepressants (TCAs) in an extracellular vestibule approximately 11 A above the bound leucine and 2 Na(+). We recently found this reg...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Quick M,Winther AM,Shi L,Nissen P,Weinstein H,Javitch JA

更新日期：2009-04-07 00:00:00