Antigen induces chronic idiotype suppression.

abstract：:Adrenodoxin reductase (AR; ferridoxin: NADP+ oxidoreductase, EC 1.18.1.2) is a flavoprotein that mediates electron transport from NADPH to all known mitochondrial forms of cytochrome P450. AR mRNA was found in all human adult and fetal tissues examined; however, it was vastly more abundant in tissues that synthesize s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brentano ST,Black SM,Lin D,Miller WL

更新日期：1992-05-01 00:00:00

abstract：:The SRC gene is the prototype for a family of closely related genes whose products have protein-tyrosine kinase activity. We recently described another member of this family, designated FYN, whose cDNA was isolated from normal human fibroblasts. To examine the possible role of FYN as an oncogene, we investigated the e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kawakami T,Kawakami Y,Aaronson SA,Robbins KC

更新日期：1988-06-01 00:00:00

abstract：:Recombinational repair of double-stranded DNA gaps was investigated in Ustilago maydis. The experimental system was designed for analysis of repair of an autonomously replicating plasmid containing a cloned gene disabled by an internal deletion. It was discovered that crossing over rarely accompanied gap repair. The s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ferguson DO,Holloman WK

更新日期：1996-05-28 00:00:00

abstract：:The liver plays a key role in the regulation of circulating levels of low density lipoproteins (LDL) because it is both the site for the production of and the major organ for the degradation of this class of lipoproteins. In this study, the effects of feeding polyunsaturated or saturated triacylglycerols on receptor-d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spady DK,Dietschy JM

更新日期：1985-07-01 00:00:00

abstract：:Accumulation of amyloid-beta (Aβ), which is associated with Alzheimer's disease, can be caused by excess production or insufficient clearance. Because of its β-sheet structure, fibrillar Aβ is resistant to proteolysis, which would contribute to slow degradation of Aβ plaques in vivo. Fibrillar Aβ can be internalized b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Solé-Domènech S,Rojas AV,Maisuradze GG,Scheraga HA,Lobel P,Maxfield FR

更新日期：2018-02-13 00:00:00

abstract：:Under particular circumstances like lactation and fasting, the blood-borne monocarboxylates acetoacetate, beta-hydroxybutyrate, and lactate represent significant energy substrates for the brain. Their utilization is dependent on a transport system present on both endothelial cells forming the blood-brain barrier and o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pellerin L,Pellegri G,Martin JL,Magistretti PJ

更新日期：1998-03-31 00:00:00

abstract：:Lon is an ATPase associated with cellular activities (AAA+) protease that controls cell division in response to stress and also degrades misfolded and damaged proteins. Subunits of Lon are known to assemble into ring-shaped homohexamers that enclose an internal degradation chamber. Here, we demonstrate that hexamers o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vieux EF,Wohlever ML,Chen JZ,Sauer RT,Baker TA

更新日期：2013-05-28 00:00:00

abstract：:Formation of duplex DNA from varphiX174 single-stranded DNA by extracts of E. coli was previously shown to require the gene product of dna B. Using as an assay the stimulation of varphiX174 DNA-dependent synthesis in inactivated extracts of dna B temperature-sensitive cells, we purified the dna B gene product from wil...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wright M,Wickner S,Hurwitz J

更新日期：1973-11-01 00:00:00

abstract：:The pathogenesis of tuberculous meningitis, a devastating complication of tuberculosis in man, is poorly understood. We previously reported that rabbits with experimental tuberculous meningitis were protected from death by a combination of antibiotics and thalidomide therapy. Survival was associated with inhibition of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsenova L,Bergtold A,Freedman VH,Young RA,Kaplan G

更新日期：1999-05-11 00:00:00

abstract：:Facial expressions of emotion in humans are believed to be produced by contracting one's facial muscles, generally called action units. However, the surface of the face is also innervated with a large network of blood vessels. Blood flow variations in these vessels yield visible color changes on the face. Here, we stu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benitez-Quiroz CF,Srinivasan R,Martinez AM

更新日期：2018-04-03 00:00:00

abstract：:Xenogeneic monoclonal antibodies were prepared to the murine interleukin 2 (IL-2)-dependent HT2 cell line. One rat IgM monoclonal antibody (7D4) was identified that inhibited proliferation of the HT2 cells and of IL-2-dependent CTLL cells in the presence of crude rat IL-2 as well as of purified human IL-2. The level o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Malek TR,Robb RJ,Shevach EM

更新日期：1983-09-01 00:00:00

abstract：:Growth hormone receptor (GHR) has been demonstrated to be nuclear localized both in vivo and in vitro, but the significance of this observation has remained elusive. Here we show that nuclear GHR is strongly correlated with proliferative status in vivo by using a liver regeneration model. In vitro, nuclear translocati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Conway-Campbell BL,Wooh JW,Brooks AJ,Gordon D,Brown RJ,Lichanska AM,Chin HS,Barton CL,Boyle GM,Parsons PG,Jans DA,Waters MJ

更新日期：2007-08-14 00:00:00

abstract：:We have carried out free energy perturbation calculations on DNA double-stranded hexanucleotides. The sequence d(CGCGCG)2 has been "mutated" into d(CGTGCG).d(CGCACG) with the oligonucleotide in the A, B, and Z structural forms, both in vacuo and in aqueous solution. In addition, model free energy calculations have bee...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dang LX,Pearlman DA,Kollman PA

更新日期：1990-06-01 00:00:00

abstract：:Thrombin induces platelet aggregation and formation of a fibrin clot in platelet-rich plasma; leupeptin, a protease inhibitor, partially inhibits platelet aggregation, but it does not inhibit fibrin clot formation. Indomethacin does not inhibit either thrombin-induced platelet aggregation or fibrin clot formation. How...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ruggiero M,Lapetina EG

更新日期：1986-05-01 00:00:00

abstract：:Carbon fixation is the process by which CO(2) is incorporated into organic compounds. In modern agriculture in which water, light, and nutrients can be abundant, carbon fixation could become a significant growth-limiting factor. Hence, increasing the fixation rate is of major importance in the road toward sustainabili...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bar-Even A,Noor E,Lewis NE,Milo R

更新日期：2010-05-11 00:00:00

abstract：:The ability to modulate the collective properties of correlated electron systems at their interfaces and surfaces underpins the burgeoning field of "designer" quantum materials. Here, we show how an electronic reconstruction driven by surface polarity mediates a Stoner-like magnetic instability to itinerant ferromagne...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mazzola F,Sunko V,Khim S,Rosner H,Kushwaha P,Clark OJ,Bawden L,Marković I,Kim TK,Hoesch M,Mackenzie AP,King PDC

更新日期：2018-12-18 00:00:00

abstract：:A fundamental problem in cell biology is to understand how spatial information is recognized and integrated into morphogenetic responses. Budding yeast undergoes differentiation to filamentous growth, which involves changes in cell polarity through mechanisms that remain obscure. Here we define a regulatory input wher...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Basu S,Vadaie N,Prabhakar A,Li B,Adhikari H,Pitoniak A,Chow J,Chavel CA,Cullen PJ

更新日期：2016-04-05 00:00:00

abstract：:Up to half of all transcription termination events in bacteria rely on the RNA-dependent helicase Rho. However, the nucleic acid sequences that promote Rho-dependent termination remain poorly characterized. Defining the molecular determinants that confer Rho-dependent termination is especially important for understand...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hollands K,Sevostiyanova A,Groisman EA

更新日期：2014-05-13 00:00:00

abstract：:The [A] allele of SNP rs965513 in 9q22 has been consistently shown to be highly associated with increased papillary thyroid cancer (PTC) risk with an odds ratio of ∼1.8 as determined by genome-wide association studies, yet the molecular mechanisms remain poorly understood. Previously, we noted that the expression of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： He H,Li W,Liyanarachchi S,Srinivas M,Wang Y,Akagi K,Wang Y,Wu D,Wang Q,Jin V,Symer DE,Shen R,Phay J,Nagy R,de la Chapelle A

更新日期：2015-05-12 00:00:00

abstract：:Protein kinase P (PK-P) activated by histones or certain other basic compounds has been purified previously from yeast [Yanagita, Y., Abdel-Ghany, M., Raden, D., Nelson, N. & Racker, E. (1987) Proc. Natl. Acad. Sci. USA 84, 925-929]. It is shown here that PK-P is present in solubilized membranes of A-431 carcinoma cel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Abdel-Ghany M,Kole HK,Racker E

更新日期：1987-12-01 00:00:00

abstract：:Ocean acidification represents a key threat to coral reefs by reducing the calcification rate of framework builders. In addition, acidification is likely to affect the relationship between corals and their symbiotic dinoflagellates and the productivity of this association. However, little is known about how acidificat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Anthony KR,Kline DI,Diaz-Pulido G,Dove S,Hoegh-Guldberg O

更新日期：2008-11-11 00:00:00

abstract：:Through a multiplex promoter spanning 218 kb, the phase II UDP-glucuronosyltransferase 1A (UGT1) gene encodes at least eight differently regulated mRNAs whose protein products function as the principal means to eliminate a vast array of steroids, heme metabolites, environmental toxins, and drugs. The orphan nuclear re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xie W,Yeuh MF,Radominska-Pandya A,Saini SP,Negishi Y,Bottroff BS,Cabrera GY,Tukey RH,Evans RM

更新日期：2003-04-01 00:00:00

abstract：:Significant efforts have been directed to understanding the factors that influence the lineage commitment of stem cells. This paper demonstrates that cell shape, independent of soluble factors, has a strong influence on the differentiation of human mesenchymal stem cells (MSCs) from bone marrow. When exposed to compet...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kilian KA,Bugarija B,Lahn BT,Mrksich M

更新日期：2010-03-16 00:00:00

abstract：:In Caenorhabditis elegans, pre-mRNA for the essential splicing factor U2AF65 sometimes is spliced to produce an RNA that includes an extra 216-bp internal exon, exon 3. Inclusion of exon 3 inserts an in-frame stop codon, yet this RNA is not subject to SMG-mediated RNA surveillance. To test whether exon 3 causes RNA to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： MacMorris MA,Zorio DA,Blumenthal T

更新日期：1999-03-30 00:00:00

abstract：:Neurons in the mammalian suprachiasmatic nuclei (SCN) generate daily rhythms in physiology and behavior, but it is unclear how they maintain and synchronize these rhythms in vivo. We hypothesized that parallel signaling pathways in the SCN are required to synchronize rhythms in these neurons for coherent output. We re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aton SJ,Huettner JE,Straume M,Herzog ED

更新日期：2006-12-12 00:00:00

abstract：:The molecular basis of short-day-induced growth cessation and dormancy in the meristems of perennial plants (e.g., forest trees growing in temperate and high-latitude regions) is poorly understood. Using global transcript profiling, we show distinct stage-specific alterations in auxin responsiveness of the transcripto...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baba K,Karlberg A,Schmidt J,Schrader J,Hvidsten TR,Bako L,Bhalerao RP

更新日期：2011-02-22 00:00:00

abstract：:To test whether gravity is required for normal amphibian development, Xenopus laevis females were induced to ovulate aboard the orbiting Space Shuttle. Eggs were fertilized in vitro, and although early embryonic stages showed some abnormalities, the embryos were able to regulate and produce nearly normal larvae. These...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Souza KA,Black SD,Wassersug RJ

更新日期：1995-03-14 00:00:00

abstract：:The replication of simian virus 40 (SV40) DNA is dependent upon a single viral protein [tumor (T) antigen] and multiple cellular proteins. To define the required cellular proteins, we have made use of a cell-free system that supports the replication of plasmid DNA molecules containing the SV40 origin of replication. W...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Virshup DM,Kelly TJ

更新日期：1989-05-01 00:00:00

abstract：:The marine nitrogen fixing microorganisms (diazotrophs) are a major source of nitrogen to open ocean ecosystems and are predicted to be limited by iron in most marine environments. Here we use global and targeted proteomic analyses on a key unicellular marine diazotroph Crocosphaera watsonii to reveal large scale diel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saito MA,Bertrand EM,Dutkiewicz S,Bulygin VV,Moran DM,Monteiro FM,Follows MJ,Valois FW,Waterbury JB

更新日期：2011-02-08 00:00:00

abstract：:We have measured high-resolution x-ray absorption spectra of lanthanide (Ln) and heavy transition metal complexes that display prominent narrow absorption peaks near the L2 and L3 absorption edges. The anomalous scattering factors (f' and f"), which are mathematically related to the absorption cross section, have corr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lye RC,Phillips JC,Kaplan D,Doniach S,Hodgson KO

更新日期：1980-10-01 00:00:00