Abstract:
:The role of the products of the K and D loci of the H-2 complex as target antigens for cytotoxic T cells generated to modified syngeneic cells has been investigated. Spleen cells, when cocultured with trinitrophenyl-derivatized syngeneic cells, generate cytolytic T cells that lyse most effectively tumor or spleen targets that are trinitrophenyl-derivatized and H-2 identical to the sensitizing cell. Cytolysis is inhibited by alloantisera to the K and/or D specificities of the target cells and by anti-dinitrophenyl antisera. Cytolic cells generated in this manner are also able to lyse, though less efficiently, trinitrophenyl-derivatized tumor and spleen targets that do not share products of the K and D loci with the sensitizing cell, and this cytolysis is also blocked by alloantisera directed to the H-2 serological specificities of such targets.
journal_name
Proc Natl Acad Sci U S Aauthors
Burakoff SJ,Germain RN,Dorf ME,Benacerrah Bdoi
10.1073/pnas.73.2.625keywords:
subject
Has Abstractpub_date
1976-02-01 00:00:00pages
625-9issue
2eissn
0027-8424issn
1091-6490journal_volume
73pub_type
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