Synapsins regulate use-dependent synaptic plasticity in the calyx of Held by a Ca2+/calmodulin-dependent pathway.

abstract：:Human brain functional networks are embedded in anatomical space and have topological properties--small-worldness, modularity, fat-tailed degree distributions--that are comparable to many other complex networks. Although a sophisticated set of measures is available to describe the topology of brain networks, the selec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vértes PE,Alexander-Bloch AF,Gogtay N,Giedd JN,Rapoport JL,Bullmore ET

更新日期：2012-04-10 00:00:00

abstract：:Beckwith-Wiedemann syndrome (BWS) involves fetal overgrowth and predisposition to a wide variety of embryonal tumors of childhood. We have previously found that BWS is genetically linked to 11p15 and that this same band shows loss of heterozygosity in the types of tumors to which children with BWS are susceptible. How...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoovers JM,Kalikin LM,Johnson LA,Alders M,Redeker B,Law DJ,Bliek J,Steenman M,Benedict M,Wiegant J,Lengauer C,Taillon-Miller P,Schlessinger D,Edwards MC,Elledge SJ,Ivens A,Westerveld A,Little P,Mannens M,Feinberg AP

更新日期：1995-12-19 00:00:00

abstract：:Rat liver glutamine synthetase (s(20,w) 15.0 S; MW about 352,000) resembles ovine brain glutamine synthetase in that it (a) has 8 subunits, (b) acts on both L- and D-glutamate and certain glutamate analogs (e.g., beta-glutamate, cis-cycloglutamate, and alpha-methyl-L-glutamate), and (c) is irreversibly inhibited by L-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tate SS,Meister A

更新日期：1971-04-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small 19- to 24-nt noncoding RNAs that have the capacity to regulate fundamental biological processes essential for cancer initiation and progression. In cancer, miRNAs may function as oncogenes or tumor suppressors. Here, we conducted global profiling for miRNAs in a cohort of stage 1 nonsmall ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Peng Y,Dai Y,Hitchcock C,Yang X,Kassis ES,Liu L,Luo Z,Sun HL,Cui R,Wei H,Kim T,Lee TJ,Jeon YJ,Nuovo GJ,Volinia S,He Q,Yu J,Nana-Sinkam P,Croce CM

更新日期：2013-09-10 00:00:00

abstract：:In a recently discovered class of oncogenes, GTPase-inhibiting mutations constitutively activate alpha subunits of signal-transducing guanine nucleotide-binding proteins (G proteins). Somatic mutations in a subclass of endocrine tumors are found in the arginine-179 codon of the alpha subunit of Gi2 (alpha i2), creatin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pace AM,Wong YH,Bourne HR

更新日期：1991-08-15 00:00:00

abstract：:Escherichia coli infections, a leading cause of septic shock, remain a major threat to human health because of the fatal action to endotoxin (LPS). Therapeutic attempts to neutralize endotoxin currently focus on inhibiting the interaction of the toxic component lipid A with myeloid differentiating factor 2, which form...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gomery K,Müller-Loennies S,Brooks CL,Brade L,Kosma P,Di Padova F,Brade H,Evans SV

更新日期：2012-12-18 00:00:00

abstract：:In the cell, proteins are synthesized from N to C terminus and begin to fold during translation. Cotranslational folding mechanisms are therefore linked to elongation rate, which varies as a function of synonymous codon usage. However, synonymous codon substitutions can affect many distinct cellular processes, which h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Walsh IM,Bowman MA,Soto Santarriaga IF,Rodriguez A,Clark PL

更新日期：2020-02-18 00:00:00

abstract：:Animal foraging and competition are defined by the partitioning of three primary niche axes: space, time, and resources. Human disturbance is rapidly altering the spatial and temporal niches of animals, but the impact of humans on resource consumption and partitioning-arguably the most important niche axis-is poorly u...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Manlick PJ,Pauli JN

更新日期：2020-10-27 00:00:00

abstract：:An immunoglobulin light chain protein was isolated from the urine of an individual (BRE) with systemic amyloidosis. Complete amino acid sequence of the variable region of the light chain (VL) protein established it as a kappa I, which when compared with other kappa I amyloid associated proteins had unique residues, in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schormann N,Murrell JR,Liepnieks JJ,Benson MD

更新日期：1995-10-10 00:00:00

abstract：:Asexual freshwater planarians reproduce by tearing themselves into two pieces by a process called binary fission. The resulting head and tail pieces regenerate within about a week, forming two new worms. Understanding this process of ripping oneself into two parts poses a challenging biomechanical problem. Because pla...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Malinowski PT,Cochet-Escartin O,Kaj KJ,Ronan E,Groisman A,Diamond PH,Collins ES

更新日期：2017-10-10 00:00:00

abstract：:GT-2 is a plant transcriptional activator that contains two separate, but similar, trihelix DNA-binding domains. GT-1 is similar to GT-2, although it contains only one of such domains. cDNAs that encode GT-2 were isolated from rice (OS-GT2) and Arabidopsis (AT-GT2). Evidence is presented for the existence of an Arabid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smalle J,Kurepa J,Haegman M,Gielen J,Van Montagu M,Van Der Straeten D

更新日期：1998-03-17 00:00:00

abstract：:DNA sequences containing short adenine tracts are intrinsically curved and play a role in transcriptional regulation. Despite many high-resolution NMR and x-ray studies, the origins of curvature remain disputed. Long-range restraints provided by 85 residual dipolar couplings were measured for a DNA decamer containing ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barbic A,Zimmer DP,Crothers DM

更新日期：2003-03-04 00:00:00

abstract：:Purified diphtheria toxin is shown to inhibit protein synthesis in Ehrlich-Lettré ascites carcinoma cells in vitro. Protein synthesis in Ehrlich-Lettré cells is at least 10,000 times more sensitive to toxin than protein synthesis in normal mouse spleen or thymus cells. This sensitivity correlates with the observation ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Iglewski BH,Rittenberg MB

更新日期：1974-07-01 00:00:00

abstract：:Light chains were obtained from IgG rabbit antibodies to the group-specific carbohydrates of groups A and C streptococci. An analysis of the amino acid alternatives which exist at the first three positions of the N-terminus in both light-chain preparations shows a marked restriction in amino acid sequence heterogeneit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hood L,Lackland H,Eichman K,Kindt TJ,Braun DG,Krause RM

更新日期：1969-07-01 00:00:00

abstract：:Lipoxin B (LXB) was prepared by incubation of (15S)-15-hydroperoxy-5,8,11-cis-13-trans-icosatetraenoic acid (15-HPETE) with human leukocytes. Comparison with a number of trihydroxyicosatetraenes prepared by total synthesis showed that biologically derived LXB is (5S,14R,15S)-5,14,15-trihydroxy-6,10,12-trans-8-cis-icos...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Serhan CN,Hamberg M,Samuelsson B,Morris J,Wishka DG

更新日期：1986-04-01 00:00:00

abstract：:Canavan's disease (CD) is a fatal, hereditary disorder of CNS development that has been linked to mutations in the gene for the enzyme aspartoacylase (ASPA) (EC 3.5.1.15). ASPA acts to hydrolyze N-acetylaspartate (NAA) into l-aspartate and acetate, but the connection between ASPA deficiency and the failure of proper C...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Madhavarao CN,Arun P,Moffett JR,Szucs S,Surendran S,Matalon R,Garbern J,Hristova D,Johnson A,Jiang W,Namboodiri MA

更新日期：2005-04-05 00:00:00

abstract：:Urate oxidase (UOxase; urate:oxygen oxidoreductase, EC 1.7.3.3), which catalyzes the oxidation of uric acid to allantoin, is present in most mammals but is absent in humans and certain primates. A cDNA clone for UOxase containing an insert of 1.3 kilobases (kb) was isolated from a lambda gt11 cDNA library prepared fro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reddy PG,Nemali MR,Reddy MK,Reddy MN,Yuan PM,Yuen S,Laffler TG,Shiroza T,Kuramitsu HK,Usuda N

更新日期：1988-12-01 00:00:00

abstract：:Bacterial proteins often localize to distinct sites within the cell, but the primary cues that dictate localization are largely unknown. Recent evidence has shown that positive membrane curvature can serve as a cue for localization of a peripheral membrane protein. Here we report that localization of the peripheral me...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ramamurthi KS,Losick R

更新日期：2009-08-11 00:00:00

abstract：:Immunoprecipitation followed by mass spectrometry (IP/MS) has recently emerged as a preferred method in the analysis of protein complex components and cellular protein networks. Targeting endogenous protein complexes of higher eukaryotes, particularly in large-scale efforts, has been challenging due to cellular hetero...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Malovannaya A,Li Y,Bulynko Y,Jung SY,Wang Y,Lanz RB,O'Malley BW,Qin J

更新日期：2010-02-09 00:00:00

abstract：:The geographical structure of a population distributed continuously and homogeneously along an infinite linear habitat is explored. The analysis is restricted to a single locus in the absence of selection, and every mutant is assumed to be new to the population. An explicit formula is derived for the probability that ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nagylaki T

更新日期：1974-08-01 00:00:00

abstract：:In the retina, dopamine plays a central role in neural adaptation to light. Progress in the study of dopaminergic amacrine (DA) cells has been limited because they are very few (450 in each mouse retina, 0.005% of retinal neurons). Here, we applied transgenic technology, single-cell global mRNA amplification, and cDNA...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gustincich S,Contini M,Gariboldi M,Puopolo M,Kadota K,Bono H,LeMieux J,Walsh P,Carninci P,Hayashizaki Y,Okazaki Y,Raviola E

更新日期：2004-04-06 00:00:00

abstract：:During the late Pleistocene, early anatomically modern humans coexisted in Europe with the anatomically archaic Neandertals for some thousand years. Under the recent variants of the multiregional model of human evolution, modern and archaic forms were different but related populations within a single evolving species,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Caramelli D,Lalueza-Fox C,Vernesi C,Lari M,Casoli A,Mallegni F,Chiarelli B,Dupanloup I,Bertranpetit J,Barbujani G,Bertorelle G

更新日期：2003-05-27 00:00:00

abstract：:Targeted disruption of the pp60(src) (Src) gene has implicated this tyrosine kinase in osteoclast-mediated bone resorption and as a therapeutic target for the treatment of osteoporosis and other bone-related diseases. Herein we describe the discovery of a nonpeptide inhibitor (AP22408) of Src that demonstrates in vivo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shakespeare W,Yang M,Bohacek R,Cerasoli F,Stebbins K,Sundaramoorthi R,Azimioara M,Vu C,Pradeepan S,Metcalf C 3rd,Haraldson C,Merry T,Dalgarno D,Narula S,Hatada M,Lu X,van Schravendijk MR,Adams S,Violette S,Smith J,

更新日期：2000-08-15 00:00:00

abstract：:Precise genome editing is a valuable tool to study gene function in model organisms. Prime editing, a precise editing system developed in mammalian cells, does not require double-strand breaks or donor DNA and has low off-target effects. Here, we applied prime editing for the model organism Drosophila melanogaster and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bosch JA,Birchak G,Perrimon N

更新日期：2021-01-05 00:00:00

abstract：:Using a tissue culture system based on a nearly pure population of avian precartilage mesenchymal cells, we have found that ambient glucose levels as little as 50% lower, or 100% higher, than normally present in embryonic sera are deleterious to cartilage development, as measured by the accumulation of highly sulfated...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leonard CM,Bergman M,Frenz DA,Macreery LA,Newman SA

更新日期：1989-12-01 00:00:00

abstract：:Receptors for platelet-derived growth factor (PDGF) have previously only been found on cells of mesenchymal and glial origin. This study shows PDGF receptors on an anaplastic thyroid carcinoma cell line, C 643, that was found to express thyroglobulin mRNA, confirming its origin from thyroid epithelium. Northern blot a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heldin NE,Gustavsson B,Claesson-Welsh L,Hammacher A,Mark J,Heldin CH,Westermark B

更新日期：1988-12-01 00:00:00

abstract：:Staphylococcal protein A (SpA) is anchored to the cell wall envelope of Staphylococcus aureus by sortase A, which links the threonyl (T) of its C-terminal LPXTG motif to peptidoglycan cross-bridges (i.e., Gly5). SpA binds the Fcγ domains of IgG and protects staphylococci from opsonophagocytic clearance. Moreover, SpA ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Becker S,Frankel MB,Schneewind O,Missiakas D

更新日期：2014-01-28 00:00:00

abstract：:The human renin gene was isolated from a Charon 4A human genomic library and characterized. The gene spans about 11.7 kilobases and consists of 10 exons and 9 introns that map at points that could be variable surface loops of the enzyme. The complete coding regions, the 5'- and 3'-flanking regions, and the exon-intron...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miyazaki H,Fukamizu A,Hirose S,Hayashi T,Hori H,Ohkubo H,Nakanishi S,Murakami K

更新日期：1984-10-01 00:00:00

abstract：:The response of nerve cells to synaptic inputs and the propagation of this activation is critically dependent on the cell-surface distribution of ion channels. In the hippocampus, Ca2+ influx through N-methyl-D-aspartate receptors (NMDAR) and/or voltage-dependent calcium channels on dendrites is thought to be critical...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benke TA,Jones OT,Collingridge GL,Angelides KJ

更新日期：1993-08-15 00:00:00

abstract：:Cyclotides are plant defense peptides that have been extensively investigated for pharmaceutical and agricultural applications, but key details of their posttranslational biosynthesis have remained elusive. Asparaginyl endopeptidases are crucial in the final stage of the head-to-tail cyclization reaction, but the enzy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rehm FBH,Jackson MA,De Geyter E,Yap K,Gilding EK,Durek T,Craik DJ

更新日期：2019-04-16 00:00:00