当前位置： SCI文献检索 > PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA期刊下所有文献 > Mechanics dictate where and how freshwater planarians fission.

Mechanics dictate where and how freshwater planarians fission.

Abstract：

:Asexual freshwater planarians reproduce by tearing themselves into two pieces by a process called binary fission. The resulting head and tail pieces regenerate within about a week, forming two new worms. Understanding this process of ripping oneself into two parts poses a challenging biomechanical problem. Because planarians stop "doing it" at the slightest disturbance, this remained a centuries-old puzzle. We focus on Dugesia japonica fission and show that it proceeds in three stages: a local constriction ("waist formation"), pulsation-which increases waist longitudinal stresses-and transverse rupture. We developed a linear mechanical model with a planarian represented by a thin shell. The model fully captures the pulsation dynamics leading to rupture and reproduces empirical time scales and stresses. It asserts that fission execution is a mechanical process. Furthermore, we show that the location of waist formation, and thus fission, is determined by physical constraints. Together, our results demonstrate that where and how a planarian rips itself apart during asexual reproduction can be fully explained through biomechanics.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Malinowski PT,Cochet-Escartin O,Kaj KJ,Ronan E,Groisman A,Diamond PH,Collins ES

doi

10.1073/pnas.1700762114

subject

Has Abstract

pub_date

2017-10-10 00:00:00

pages

10888-10893

issue

41

eissn

0027-8424

issn

1091-6490

pii

1700762114

journal_volume

114

pub_type

杂志文章

相关文献

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA文献大全
  • Functional evolution of the p53 regulatory network through its target response elements.

    abstract：:Transcriptional network evolution is central to the development of complex biological systems. Networks can evolve through variation of master regulators and/or by changes in regulation of genes within networks. To gain insight into meaningful evolutionary differences in large networks, it is essential to address the ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0704694105

    authors： Jegga AG,Inga A,Menendez D,Aronow BJ,Resnick MA

    更新日期：2008-01-22 00:00:00

  • Sequence of spontaneous Epstein-Barr virus activation and selective DNA synthesis in activated cells in the presence of hydroxyurea.

    abstract：:The sequence of spontaneous Epstein-Barr virus activation was studied in P3HR-1 carrier cells and in P3HR-1(BrdU) cells made resistant to 5-bromodeoxyuridine. Virus activation was initiated during the normal cell cycle, and recruitment of additional virus-activated cells was prevented by the DNA inhibitors, 1-beta-D-a...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.69.9.2589

    authors： Hampar B,Derge JG,Martos LM,Tagamets MA,Burroughs MA

    更新日期：1972-09-01 00:00:00

  • A TRPM7 variant shows altered sensitivity to magnesium that may contribute to the pathogenesis of two Guamanian neurodegenerative disorders.

    abstract：:Guamanian amyotrophic lateral sclerosis (ALS-G) and parkinsonism dementia (PD-G) have been epidemiologically linked to an environment severely deficient in calcium (Ca2+) and magnesium (Mg2+). Transient receptor potential melastatin 7 (TRPM7) is a bifunctional protein containing both channel and kinase domains that ha...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0505149102

    authors： Hermosura MC,Nayakanti H,Dorovkov MV,Calderon FR,Ryazanov AG,Haymer DS,Garruto RM

    更新日期：2005-08-09 00:00:00

  • Covalent linkage of ribonuclease S-peptide to microinjected proteins causes their intracellular degradation to be enhanced during serum withdrawal.

    abstract：:The amino-terminal 20 amino acids are required for microinjected ribonuclease A (RNase A) to be taken up by lysosomes and degraded at an enhanced rate during serum withdrawal. We used water-soluble carbodiimides to covalently attach the RNase S-peptide (residues 1-20) to [3H]RNase S-protein (residues 21-124) at unspec...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.83.16.5830

    authors： Backer JM,Dice JF

    更新日期：1986-08-01 00:00:00

  • Achievements and challenges in the biology of environmental effects.

    abstract：:The starting point for the study of adverse experiences is that some have enduring consequences that continue after the period of exposure to the adversity. That raises four basic issues: whether social adversities can be considered homogeneous, whether the crucial effect lies in the "objective" or subjectively percei...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章,评审

    doi：10.1073/pnas.1121258109

    authors： Rutter M

    更新日期：2012-10-16 00:00:00

  • Early and multiple origins of metastatic lineages within primary tumors.

    abstract：:Many aspects of the evolutionary process of tumorigenesis that are fundamental to cancer biology and targeted treatment have been challenging to reveal, such as the divergence times and genetic clonality of metastatic lineages. To address these challenges, we performed tumor phylogenetics using molecular evolutionary ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1525677113

    authors： Zhao ZM,Zhao B,Bai Y,Iamarino A,Gaffney SG,Schlessinger J,Lifton RP,Rimm DL,Townsend JP

    更新日期：2016-02-23 00:00:00

  • A ketogenic diet rescues hippocampal memory defects in a mouse model of Kabuki syndrome.

    abstract：:Kabuki syndrome is a Mendelian intellectual disability syndrome caused by mutations in either of two genes (KMT2D and KDM6A) involved in chromatin accessibility. We previously showed that an agent that promotes chromatin opening, the histone deacetylase inhibitor (HDACi) AR-42, ameliorates the deficiency of adult neur...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1611431114

    authors： Benjamin JS,Pilarowski GO,Carosso GA,Zhang L,Huso DL,Goff LA,Vernon HJ,Hansen KD,Bjornsson HT

    更新日期：2017-01-03 00:00:00

  • Making technological innovation work for sustainable development.

    abstract：:This paper presents insights and action proposals to better harness technological innovation for sustainable development. We begin with three key insights from scholarship and practice. First, technological innovation processes do not follow a set sequence but rather emerge from complex adaptive systems involving many...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1525004113

    authors： Anadon LD,Chan G,Harley AG,Matus K,Moon S,Murthy SL,Clark WC

    更新日期：2016-08-30 00:00:00

  • Utility of siRNA against Keap1 as a strategy to stimulate a cancer chemopreventive phenotype.

    abstract：:A duplex 21 nucleotide small interfering RNA (siRNA) against human Keap1 is described that represents a unique class of cancer chemopreventive agent. This siRNA can knockdown Keap1 mRNA and thereby relieve negative regulation of nuclear factor erythroid 2 p45-related factor 2 (Nrf2)-mediated gene expression. The siRNA...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0501475102

    authors： Devling TW,Lindsay CD,McLellan LI,McMahon M,Hayes JD

    更新日期：2005-05-17 00:00:00

  • The mitochondrial ribosome of Xenopus laevis.

    abstract：:A mitochondrial ribosome with an approximate sedimentation coefficient of 60 S has been isolated from the ovary of the South African clawed toad, Xenopus laevis. This ribosome is active in a submitochondrial protein-synthesizing system. It contains two species of RNA, designated as "21S" and 13S RNA, which have sequen...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.66.1.117

    authors： Swanson RF,Dawid IB

    更新日期：1970-05-01 00:00:00

  • An explicit test of the phospholipid saturation hypothesis of acquired cold tolerance in Caenorhabditis elegans.

    abstract：:Protection of poikilothermic animals from seasonal cold is widely regarded as being causally linked to changes in the unsaturation of membrane phospholipids, yet in animals this proposition remains formally untested. We have now achieved this by the genetic manipulation of lipid biosynthesis of Caenorhabditis elegans ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0609590104

    authors： Murray P,Hayward SA,Govan GG,Gracey AY,Cossins AR

    更新日期：2007-03-27 00:00:00

  • Enhancing T1 magnetic resonance imaging contrast with internalized gadolinium(III) in a multilayer nanoparticle.

    abstract：:Multifunctional nanoparticles for biomedical applications have shown extraordinary potential as contrast agents in various bioimaging modalities, near-IR photothermal therapy, and for light-triggered therapeutic release processes. Over the past several years, numerous studies have been performed to synthesize and enha...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1701944114

    authors： Marangoni VS,Neumann O,Henderson L,Kaffes CC,Zhang H,Zhang R,Bishnoi S,Ayala-Orozco C,Zucolotto V,Bankson JA,Nordlander P,Halas NJ

    更新日期：2017-07-03 00:00:00

  • Improving fatty acids production by engineering dynamic pathway regulation and metabolic control.

    abstract：:Global energy demand and environmental concerns have stimulated increasing efforts to produce carbon-neutral fuels directly from renewable resources. Microbially derived aliphatic hydrocarbons, the petroleum-replica fuels, have emerged as promising alternatives to meet this goal. However, engineering metabolic pathway...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1406401111

    authors： Xu P,Li L,Zhang F,Stephanopoulos G,Koffas M

    更新日期：2014-08-05 00:00:00

  • Functional analysis of Arabidopsis thaliana rRNA gene and spacer promoters in vivo and by transient expression.

    abstract：:In eukaryotes, RNA polymerase I transcription is controlled by DNA elements located within the spacers that separate the tandemly arranged rRNA genes. Unlike rRNA coding sequences, the intergenic spacers evolve rapidly and have little sequence similarity even among closely related species. Nonetheless, the arrangement...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.90.16.7528

    authors： Doelling JH,Gaudino RJ,Pikaard CS

    更新日期：1993-08-15 00:00:00

  • Equilibrium and stability code for a diffuse plasma.

    abstract：:A computer code to investigate the equilibrium and stability of a diffuse plasma in three dimensions is described that generalizes earlier work on a sharp free boundary model. Toroidal equilibria of a plasma are determined by considering paths of steepest descent associated with a new version of the variational princi...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.73.4.984

    authors： Betancourt O,Garabedian P

    更新日期：1976-04-01 00:00:00

  • Withdrawal of IL-7 induces Bax translocation from cytosol to mitochondria through a rise in intracellular pH.

    abstract：:IL-7 functions as a trophic factor during T lymphocyte development by a mechanism that is partly based on the induction of Bcl-2, which protects cells from apoptosis. Here we report a mechanism by which cytokine withdrawal activates the prodeath protein Bax. On loss of IL-7 in a dependent cell line, Bax protein transl...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.96.25.14476

    authors： Khaled AR,Kim K,Hofmeister R,Muegge K,Durum SK

    更新日期：1999-12-07 00:00:00

  • The geographic mosaic of coevolution in mutualistic networks.

    abstract：:Ecological interactions shape adaptations through coevolution not only between pairs of species but also through entire multispecies assemblages. Local coevolution can then be further altered through spatial processes that have been formally partitioned in the geographic mosaic theory of coevolution. A major current c...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1809088115

    authors： Medeiros LP,Garcia G,Thompson JN,Guimarães PR Jr

    更新日期：2018-11-20 00:00:00

  • Unveiling functional protein motions with picosecond x-ray crystallography and molecular dynamics simulations.

    abstract：:A joint analysis of all-atom molecular dynamics (MD) calculations and picosecond time-resolved x-ray structures was performed to gain single-molecule insights into mechanisms of protein function. Ensemble-averaged MD simulations of the L29F mutant of myoglobin after ligand dissociation reproduce the direction, amplitu...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0405295101

    authors： Hummer G,Schotte F,Anfinrud PA

    更新日期：2004-10-26 00:00:00

  • CXCR4 utilization is sufficient to trigger CD4+ T cell depletion in HIV-1-infected human lymphoid tissue.

    abstract：:The human chemokine receptors CCR5 and CXCR4 have emerged as the predominant cofactors, along with CD4, for cellular entry of HIV-1 in vivo whereas the contribution of other chemokine receptors to HIV disease has not been yet determined. CCR5-specific (R5) viruses predominate during primary HIV-1 infection whereas vir...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.96.2.663

    authors： Penn ML,Grivel JC,Schramm B,Goldsmith MA,Margolis L

    更新日期：1999-01-19 00:00:00

  • Chimeric plant calcium/calmodulin-dependent protein kinase gene with a neural visinin-like calcium-binding domain.

    abstract：:Calcium, a universal second messenger, regulates diverse cellular processes in eukaryotes. Ca2+ and Ca2+/calmodulin-regulated protein phosphorylation play a pivotal role in amplifying and diversifying the action of Ca(2+)-binding domain was cloned and characterized from lily. The cDNA clone contains an open reading fr...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.92.11.4897

    authors： Patil S,Takezawa D,Poovaiah BW

    更新日期：1995-05-23 00:00:00

  • In vivo and in vitro observations on laminin production by Schwann cells.

    abstract：:Recent reports on the dystrophic mouse mutant suggest that the prominent extracellular matrix component of peripheral nerve tissues plays an important role in peripheral nerve development. We have examined the disposition of two prominent extracellular matrix components, fibronectin and laminin, both in mature periphe...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.80.12.3850

    authors： Cornbrooks CJ,Carey DJ,McDonald JA,Timpl R,Bunge RP

    更新日期：1983-06-01 00:00:00

  • The Homo floresiensis cranium (LB1): size, scaling, and early Homo affinities.

    abstract：:The skeletal remains of a diminutive small-brained hominin found in Late Pleistocene cave deposits on the island of Flores, Indonesia were assigned to a new species, Homo floresiensis [Brown P, et al. (2004) A new small-bodied hominin from the Late Pleistocene of Flores, Indonesia. Nature 431: 1055-1061]. A dramatical...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 历史文章,杂志文章

    doi：10.1073/pnas.0710041105

    authors： Gordon AD,Nevell L,Wood B

    更新日期：2008-03-25 00:00:00

  • In vivo imaging of pyrrole-imidazole polyamides with positron emission tomography.

    abstract：:The biodistribution profiles in mice of two pyrrole-imidazole polyamides were determined by PET. Pyrrole-imidazole polyamides are a class of small molecules that can be programmed to bind a broad repertoire of DNA sequences, disrupt transcription factor-DNA interfaces, and modulate gene expression pathways in cell cul...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0806308105

    authors： Harki DA,Satyamurthy N,Stout DB,Phelps ME,Dervan PB

    更新日期：2008-09-02 00:00:00

  • Identification of 1,25-dihydroxycholecalciferol, a form of vitamin D3 metabolically active in the intestine.

    abstract：:A biologically active vitamin D(3) metabolite ("peak V metabolite") more polar than 25-hydroxycholecalciferol has been isolated from chicken intestines in pure form as a mono(trimethylsilyl)ether derivative. The molecule has been identified as 1,25-dihydroxycholecalciferol by means of mass spectrometry, ultraviolet ab...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.68.4.803

    authors： Holick MF,Schnoes HK,DeLuca HF

    更新日期：1971-04-01 00:00:00

  • nanos function is essential for development and regeneration of planarian germ cells.

    abstract：:Germ cells are required for the successful propagation of sexually reproducing species. Understanding the mechanisms by which these cells are specified and how their totipotency is established and maintained has important biomedical and evolutionary implications. Freshwater planarians serve as fascinating models for s...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0609708104

    authors： Wang Y,Zayas RM,Guo T,Newmark PA

    更新日期：2007-04-03 00:00:00

  • Molecular and electrophysiological characterization of a mechanosensitive channel expressed in the chloroplasts of Chlamydomonas.

    abstract：:MscS is a mechanosensitive channel that is ubiquitous among bacteria. Recent progress in the genome projects has revealed that homologs of MscS are also present in eukaryotes, but whether they operate as ion channels is unknown. In this study we cloned MSC1, a homolog of MscS in Chlamydomonas, and examined its functio...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0609996104

    authors： Nakayama Y,Fujiu K,Sokabe M,Yoshimura K

    更新日期：2007-04-03 00:00:00

  • C factor, a cell-surface-associated intercellular signaling protein, stimulates the cytoplasmic Frz signal transduction system in Myxococcus xanthus.

    abstract：:C factor, an intercellular signaling protein, is required for aggregation and sporulation of the social bacterium, Myxococcus xanthus. We report that C factor, which normally is associated with the cell surface, provides input to the Frz signal transduction cascade. Elements of this cascade have sequence homology to b...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.93.7.2675

    authors： Søgaard-Andersen L,Kaiser D

    更新日期：1996-04-02 00:00:00

  • Microbiota promotes systemic T-cell survival through suppression of an apoptotic factor.

    abstract：:Symbiotic microbes impact the severity of a variety of diseases through regulation of T-cell development. However, little is known regarding the molecular mechanisms by which this is accomplished. Here we report that a secreted factor, Erdr1, is regulated by the microbiota to control T-cell apoptosis. Erdr1 expression...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1619336114

    authors： Soto R,Petersen C,Novis CL,Kubinak JL,Bell R,Stephens WZ,Lane TE,Fujinami RS,Bosque A,O'Connell RM,Round JL

    更新日期：2017-05-23 00:00:00

  • Mutations simultaneously affecting endonuclease II and exonuclease III in Escherichia coli.

    abstract：:We studied mutants of E. coli originally identified as being deficient in either endonuclease II (deoxyribonucleate oligonucleotidohydrolase, EC 3.1.4.30) or exonuclease III [deoxyribonucleate (double-stranded) 5'-nucleotidohydrolase, EC 3.1.4.27] activity. Twelve independently derived mutants were tested, including t...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.72.2.688

    authors： Yajko DM,Weiss B

    更新日期：1975-02-01 00:00:00

  • Placental overgrowth in mice lacking the imprinted gene Ipl.

    abstract：:The Ipl (Tssc3) gene lies in an extended imprinted region of distal mouse chromosome 7, which also contains the Igf2 gene. Expression of Ipl is highest in placenta and yolk sac, where its mRNA is derived almost entirely from the maternal allele. Ipl encodes a small cytoplasmic protein with a pleckstrin-homology (PH) d...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.122039999

    authors： Frank D,Fortino W,Clark L,Musalo R,Wang W,Saxena A,Li CM,Reik W,Ludwig T,Tycko B

    更新日期：2002-05-28 00:00:00