Simple models of human brain functional networks.

abstract：:Human P-glycoprotein (Pgp) confers multidrug resistance to cancer cells by ATP-dependent extrusion of a great many structurally dissimilar hydrophobic compounds. The manner in which Pgp recognizes these different substrates is unknown. The protein shows internal homology between its N- and C-terminal halves, each comp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dey S,Ramachandra M,Pastan I,Gottesman MM,Ambudkar SV

更新日期：1997-09-30 00:00:00

abstract：:Transitions in dealing with the root causes of environmental problems are advocated to achieve environmental sustainability. These transformations include (i) a demographic transition, (ii) a technology transition that includes the "green" automobile, (iii) an economic transition to one in which prices reflect full en...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Speth JG

更新日期：1992-02-01 00:00:00

abstract：:Amnesia produced by protein synthesis inhibitors such as anisomycin provides major support for the prevalent view that the formation of long-lasting memories requires de novo protein synthesis. However, inhibition of protein synthesis might disrupt other neural functions to interfere with memory formation. Intraamygda...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Canal CE,Chang Q,Gold PE

更新日期：2007-07-24 00:00:00

abstract：:In the primary visual cortex (V1) of many mammalian species, neurons are spatially organized according to their preferred orientation into a highly ordered map. However, whether and how the various presynaptic inputs to V1 neurons are organized relative to the neuronal orientation map remain unclear. To address this i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang QF,Li H,Chen M,Guo A,Wen Y,Poo MM

更新日期：2018-05-29 00:00:00

abstract：:The x-ray structure of rubredoxin has been refined by energy minimization. The computed structure is constrained to have standard bond lengths, bond angles, and planar trans peptide groups. Also, since most of the steric overlaps have been relieved, it has a very low energy. As judged by the root mean square (RMS) dev...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rasse D,Warme PK,Scheraga HA

更新日期：1974-09-01 00:00:00

abstract：:Different polyubiquitin chain linkages direct substrates toward distinct cellular pathways. K63-linked ubiquitylation is known to regulate proteasome-independent events such as signal transduction, but its function in the context of heterogeneous ubiquitin chains remains unclear. Here, we report that K63 ubiquitylatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ohtake F,Tsuchiya H,Saeki Y,Tanaka K

更新日期：2018-02-13 00:00:00

abstract：:A proton NMR method is described for determining the orientation of a porphyrin within the heme pocket of a hemoprotein. The pattern of the hyperfine-shifted heme methyl resonances in low-spin ferric model compounds is demonstrated to characteristically reflect the position of a localized low-symmetry perturbation on ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： La Mar GN,Budd DL,Viscio DB,Smith KM,Langry KC

更新日期：1978-12-01 00:00:00

abstract：:Transcription, splicing, and translation are potentially coordinately regulatable in a temporospatial-dependent manner, although supporting experimental evidence for this notion is scarce. Yeast two-hybrid screening of a mammary gland cDNA library with human p21-activated kinase 1 (Pak1) as bait identified polyC-RNA-b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meng Q,Rayala SK,Gururaj AE,Talukder AH,O'Malley BW,Kumar R

更新日期：2007-04-03 00:00:00

abstract：:3S(-)-N-(2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4- benzodiazepine-3-yl)-1H-indole-2-carboxamide (L-364,718) interacted in a competitive manner with rat pancreatic cholecystokinin (CCK) receptors as determined by Scatchard analysis of the specific binding of 125I-labeled CCK. The affinity of L-364,718 for both pancre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang RS,Lotti VJ

更新日期：1986-07-01 00:00:00

abstract：:p-Coumaric acid is the precursor of phenylpropanoids, which are plant secondary metabolites that are beneficial to human health. Tyrosine ammonia lyase catalyzes the production of p-coumaric acid from tyrosine. Because of their photosynthetic ability and biosynthetic versatility, cyanobacteria are promising candidates...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xue Y,Zhang Y,Cheng D,Daddy S,He Q

更新日期：2014-07-01 00:00:00

abstract：:Reducible compounds that participate in crosslinking were analyzed in hydroxylysine-deficient collagens of patients with a heritable disorder of connective tissue. After treatment with [(3)H]sodium borohydride, new compounds, as well as a totally different pattern of tritiated compounds, were found in hydroxylysine-de...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eyre DR,Glimcher MJ

更新日期：1972-09-01 00:00:00

abstract：:The atomic displacements associated with the freezing of metals and salts are calculated by treating crystal growth as an assignment problem through the use of an optimal transport algorithm. Converting these displacements into timescales based on the dynamics of the bulk liquid, we show that we can predict the activa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sun G,Hawken A,Harrowell P

更新日期：2020-02-18 00:00:00

abstract：:For a series of different proteins, including a structural protein, enzyme, inhibitor, protein marker, and a charge-transfer system, we have quantified the higher affinity of Na+ over K+ to the protein surface by means of molecular dynamics simulations and conductivity measurements. Both approaches show that sodium bi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vrbka L,Vondrásek J,Jagoda-Cwiklik B,Vácha R,Jungwirth P

更新日期：2006-10-17 00:00:00

abstract：:Using an expression cloning approach, we have isolated a cDNA encoding GD3 synthase (CMP-NeuAc:NeuAc alpha 2-3Gal beta 1-4Glc beta 1-1'Cer alpha 2,8-sialyltransferase, EC 2.4.99.8), which is a key regulatory enzyme determining the prominence of the ganglioside biosynthesis pathway. The cloned cDNA encodes a 341-amino ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nara K,Watanabe Y,Maruyama K,Kasahara K,Nagai Y,Sanai Y

更新日期：1994-08-16 00:00:00

abstract：:Future nuclear arms reduction efforts will require technologies to verify that warheads slated for dismantlement are authentic without revealing any sensitive weapons design information to international inspectors. Despite several decades of research, no technology has met these requirements simultaneously. Recent wor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vavrek JR,Henderson BS,Danagoulian A

更新日期：2018-04-24 00:00:00

abstract：:Understanding the factors that shape macroevolutionary patterns in functional traits is a central goal of evolutionary biology. Alternative strategies of sexual reproduction (inbreeding vs. outcrossing) have divergent effects on population genetic structure and could thereby broadly influence trait evolution. However,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Campbell SA,Kessler A

更新日期：2013-03-05 00:00:00

abstract：:The sense of body ownership represents a fundamental aspect of our self-awareness, but is disrupted in many neurological, psychiatric, and psychological conditions that are also characterized by disruption of skin temperature regulation, sometimes in a single limb. We hypothesized that skin temperature in a specific l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moseley GL,Olthof N,Venema A,Don S,Wijers M,Gallace A,Spence C

更新日期：2008-09-02 00:00:00

abstract：:Tubulin cofactor B (TCoB) plays an important role in microtubule dynamics by facilitating the dimerization of alpha- and beta-tubulin. Recent evidence suggests that p21-activated kinase 1 (Pak1), a major signaling nodule in eukaryotic cells, phosphorylates TCoB on Ser-65 and Ser-128 and plays an essential role in micr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rayala SK,Martin E,Sharina IG,Molli PR,Wang X,Jacobson R,Murad F,Kumar R

更新日期：2007-12-04 00:00:00

abstract：:Knowledge of vibratory patterns in the cochlea is crucial to understanding the stimulation of mechanosensory cells. Experiments to determine the motion of the cochlear partition and surrounding fluid are extremely challenging. As a result, the motion data are incomplete and often contradictory. The bending mechanism o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cai H,Shoelson B,Chadwick RS

更新日期：2004-04-20 00:00:00

abstract：:Patterns of interacting amino acids are so preserved within protein families that the sole analysis of evolutionary comutations can identify pairs of contacting residues. It is also known that evolution conserves functional dynamics, i.e., the concerted motion or displacement of large protein regions or domains. Is it...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Granata D,Ponzoni L,Micheletti C,Carnevale V

更新日期：2017-12-12 00:00:00

abstract：:Turkey erythrocyte membranes showed specific binding of [(3)H]epinephrine. The concentration of hormone required for half-maximal binding (30 muM) was the same as that required for half-maximal activation of the adenylate cyclase located in the same membrane preparation. The binding reaction at 37 degrees C reached co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schramm M,Feinstein H,Naim E,Lang E,Lasser M

更新日期：1972-02-01 00:00:00

abstract：:We examined the distributions of short tandemly repeated DNAs (microsatellites) in nine complete microbial genomes (Saccharomyces cerevisiae, Archaeoglobus fulgidus, Escherichia coli, Haemophilus influenzae, Helicobacter pylori, Methanococcus jannaschii, Mycoplasma pneumoniae, M. genitalium, and Synechocystis PCC6803....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Field D,Wills C

更新日期：1998-02-17 00:00:00

abstract：:The binding of thyroid hormone to the thyroid hormone receptor (TR) mediates important physiological effects. However, the transcriptional effects of TR mediated by the thyroid response element (TRE) cannot explain many actions of thyroid hormone. We postulate that TR can initiate rapid, non-TRE-mediated effects in th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hiroi Y,Kim HH,Ying H,Furuya F,Huang Z,Simoncini T,Noma K,Ueki K,Nguyen NH,Scanlan TS,Moskowitz MA,Cheng SY,Liao JK

更新日期：2006-09-19 00:00:00

abstract：:Using brain transcriptomic profiles from 853 individual honey bees exhibiting 48 distinct behavioral phenotypes in naturalistic contexts, we report that behavior-specific neurogenomic states can be inferred from the coordinated action of transcription factors (TFs) and their predicted target genes. Unsupervised hierar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chandrasekaran S,Ament SA,Eddy JA,Rodriguez-Zas SL,Schatz BR,Price ND,Robinson GE

更新日期：2011-11-01 00:00:00

abstract：:In suspension cultures of mouse spleen cells, the addition of small amounts (1-100 ng) of a heterologous antigen to which the donor mice had been primed significantly increased the number of anti-sheep erythrocyte plaques appearing after stimulation with sheep erythrocytes. A similar addition to identical cultures fro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rubin AS,Coons AH

更新日期：1971-08-01 00:00:00

abstract：:Various enzymatic derivatives of the murine myeloma protein IgA(MOPC-315) were subjected to hapten-binding quantitation and circular dichroic analysis in an attempt to ascertain the structural localization and functional definition of the immunoglobulin active site. The extrinsic Cotton effects observed with near satu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Merz DC,Litman GW,Good RA

更新日期：1974-05-01 00:00:00

abstract：:The yeast genome becomes unstable during stress, which often results in adaptive aneuploidy, allowing rapid activation of protective mechanisms that restore cellular homeostasis. In this study, we performed a genetic screen in Saccharomyces cerevisiae to identify genome adaptations that confer resistance to tunicamyci...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Beaupere C,Dinatto L,Wasko BM,Chen RB,VanValkenburg L,Kiflezghi MG,Lee MB,Promislow DEL,Dang W,Kaeberlein M,Labunskyy VM

更新日期：2018-09-18 00:00:00

abstract：:An unstable allele of the bronze 2 (bz2) locus was isolated from a Robertson's Mutator Zea mays line containing a family of active transposable Mu elements. This mutation is somatically unstable, resulting in numerous revertant purple sectors on a bronze kernel. By following the variegated kernel phenotype through two...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chandler VL,Walbot V

更新日期：1986-03-01 00:00:00

abstract：:The mouse glucocorticoid receptor-interacting protein (GRIP1) is a member of the ERAP160 family of nuclear receptor (NR) coactivators (including SRC-1 and TIF2) which function as bridging proteins between ligand-activated NRs bound to cognate hormone-response elements (HREs) and the transcription initiation apparatus ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Walfish PG,Yoganathan T,Yang YF,Hong H,Butt TR,Stallcup MR

更新日期：1997-04-15 00:00:00

abstract：:We obtain a general connection between a large quantum advantage in communication complexity and Bell nonlocality. We show that given any protocol offering a sufficiently large quantum advantage in communication complexity, there exists a way of obtaining measurement statistics that violate some Bell inequality. Our m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Buhrman H,Czekaj Ł,Grudka A,Horodecki M,Horodecki P,Markiewicz M,Speelman F,Strelchuk S

更新日期：2016-03-22 00:00:00