Yeast hormone response element assays detect and characterize GRIP1 coactivator-dependent activation of transcription by thyroid and retinoid nuclear receptors.

abstract：:It recently has been shown that epithelial Na(+) channels are controlled by a receptor for intracellular Na(+), a G protein (G(o)), and a ubiquitin-protein ligase (Nedd4). Furthermore, mutations in the epithelial Na(+) channel that underlie the autosomal dominant form of hypertension known as Liddle's syndrome inhibit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ishibashi H,Dinudom A,Harvey KF,Kumar S,Young JA,Cook DI

更新日期：1999-08-17 00:00:00

abstract：:Five instances of association between distinctive stromatolites and blue-green algal nannofossils are recorded from a 100-m sequence of carbonate rocks about 1.6 x 10(9) years old, along the south side of Paradise Creek, northwestern Queensland, Australia. No eukaryotes were identified in any of these systematically l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Licari GR,Cloud P

更新日期：1972-09-01 00:00:00

abstract：:A 320-base-pair repeated sequence was observed when DNA samples from the filarial parasites Brugia malayi and Brugia pahangi were digested with the restriction endonuclease Hha I. A 640-base-pair dimer of the repeated sequence from B. malayi was inserted into the plasmid pBR322. When dot hybridization was used, the co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McReynolds LA,DeSimone SM,Williams SA

更新日期：1986-02-01 00:00:00

abstract：:The fusion of inner mitochondrial membranes requires dynamin-like GTPases, Mgm1 in yeast and OPA1 in mammals, but how they mediate membrane fusion is poorly understood. Here, we determined the crystal structure of Saccharomyces cerevisiae short Mgm1 (s-Mgm1) in complex with GDP. It revealed an N-terminal GTPase (G) do...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yan L,Qi Y,Ricketson D,Li L,Subramanian K,Zhao J,Yu C,Wu L,Sarsam R,Wong M,Lou Z,Rao Z,Nunnari J,Hu J

更新日期：2020-02-25 00:00:00

abstract：:Hybridomas producing human monoclonal IgM antibodies (mAbs) against bacterial lipopolysaccharide (LPS) were generated by fusion of B lymphocytes from sensitized human spleen with heteromyeloma cells. The splenocytes were from patients undergoing splenectomy during staging for Hodgkin disease after vaccination with the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Teng NN,Kaplan HS,Hebert JM,Moore C,Douglas H,Wunderlich A,Braude AI

更新日期：1985-03-01 00:00:00

abstract：:Children with reading impairments have deficits in phonological awareness, phonemic categorization, speech-in-noise perception, and psychophysical tasks such as frequency and temporal discrimination. Many of these children also exhibit abnormal encoding of speech stimuli in the auditory brainstem, even though response...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hornickel J,Skoe E,Nicol T,Zecker S,Kraus N

更新日期：2009-08-04 00:00:00

abstract：:PSD-95 is a scaffolding protein that regulates the synaptic localization of many receptors, channels, and signaling proteins. The NLGN gene family encodes single-pass transmembrane postsynaptic cell adhesion molecules that are important for synapse assembly and function. At excitatory synapses, NLGN1 mediates transsyn...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jeong J,Pandey S,Li Y,Badger JD 2nd,Lu W,Roche KW

更新日期：2019-06-11 00:00:00

abstract：:The nucleosomal repeat lengths of bulk chromatin and the chromatin of transcriptionally active and inactive genes were analyzed in two mouse cell lines and adult mouse spleens. The adult beta-globin gene exhibits a nucleosomal repeat length approximately 11 base pairs longer than (i) an inactive embryonic globin gene,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith RD,Seale RL,Yu J

更新日期：1983-09-01 00:00:00

abstract：:The mechanisms ensuring balanced growth remain a critical question in developmental biology. In plants, this balance relies on spatiotemporal integration of hormonal signaling pathways, but the understanding of the precise contribution of each hormone is just beginning to take form. Brassinosteroid (BR) hormone is sho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vragović K,Sela A,Friedlander-Shani L,Fridman Y,Hacham Y,Holland N,Bartom E,Mockler TC,Savaldi-Goldstein S

更新日期：2015-01-20 00:00:00

abstract：:The Notch-signaling pathway controls cellular differentiation, including proliferation and cell death in all higher metazoans (including flies and men). Signal transduction through activated Notch involves the CSL group of transcriptional regulators. Notch signals need to be tightly regulated, and in Drosophila they a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maier D,Nagel AC,Preiss A

更新日期：2002-11-26 00:00:00

abstract：:It has often been suggested that the frequently observed Watson-Crick base-pair compensatory substitutions in RNA helical structures occur mainly through a slightly deleterious G.U intermediate state. We have scored base substitutions in a set of 82 related Drosophila species for the D1 and D2 variable domains of the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rousset F,Pélandakis M,Solignac M

更新日期：1991-11-15 00:00:00

abstract：:Electronic nematicity, a correlated state that spontaneously breaks rotational symmetry, is observed in several layered quantum materials. In contrast to their liquid-crystal counterparts, the nematic director cannot usually point in an arbitrary direction (XY nematics), but is locked by the crystal to discrete direct...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ishida K,Tsujii M,Hosoi S,Mizukami Y,Ishida S,Iyo A,Eisaki H,Wolf T,Grube K,V Löhneysen H,Fernandes RM,Shibauchi T

更新日期：2020-03-24 00:00:00

abstract：:MicroRNAs (miRNAs) are small 19- to 24-nt noncoding RNAs that have the capacity to regulate fundamental biological processes essential for cancer initiation and progression. In cancer, miRNAs may function as oncogenes or tumor suppressors. Here, we conducted global profiling for miRNAs in a cohort of stage 1 nonsmall ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Peng Y,Dai Y,Hitchcock C,Yang X,Kassis ES,Liu L,Luo Z,Sun HL,Cui R,Wei H,Kim T,Lee TJ,Jeon YJ,Nuovo GJ,Volinia S,He Q,Yu J,Nana-Sinkam P,Croce CM

更新日期：2013-09-10 00:00:00

abstract：:Selection of mammalian cells in progressively increasing concentrations of methotrexate results in selective amplification of DNA sequences coding for dihydrofolate reductase (tetrahydrofolate dehydrogenase, 5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase, EC 1.5.1.3). In some cell variants the amplified genes are stabl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaufman RJ,Brown PC,Schimke RT

更新日期：1979-11-01 00:00:00

abstract：:We have reexamined the balance between cell birth, cell maturation, and cell death in the thymus by labeling dividing thymocytes and their progeny in vivo with [3H]-thymidine, isolating clearly defined subpopulations by fluorescence-activated cell sorting, and determining the distribution of label by autoradiography. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Egerton M,Scollay R,Shortman K

更新日期：1990-04-01 00:00:00

abstract：:Societies are complex systems, which tend to polarize into subgroups of individuals with dramatically opposite perspectives. This phenomenon is reflected-and often amplified-in online social networks, where, however, humans are no longer the only players and coexist alongside with social bots-that is, software-control...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stella M,Ferrara E,De Domenico M

更新日期：2018-12-04 00:00:00

abstract：:X-ray diffraction studies have produced a low resolution image and also located the iron atoms of a monomeric hemerythrin from muscles of a sipunculan worm. These results reveal the course of the polypeptide chain and some details of the active center. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hendrickson WA,Klippenstein GL,Ward KB

更新日期：1975-06-01 00:00:00

abstract：:Erythroid cells which are homogeneous with regard to stage of maturation are naturally available from the circulation of chick embryos at various times of development. This provides a convenient system for examining the changes in plasma membrane protein composition during red cell maturation. Plasma membranes are iso...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chan LL

更新日期：1977-03-01 00:00:00

abstract：:Severe traumatic brain injury (TBI) elicits destruction of both gray and white matter, which is exacerbated by secondary proinflammatory responses. Although white matter injury (WMI) is strongly correlated with poor neurological status, the maintenance of white matter integrity is poorly understood, and no current the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang G,Shi Y,Jiang X,Leak RK,Hu X,Wu Y,Pu H,Li WW,Tang B,Wang Y,Gao Y,Zheng P,Bennett MV,Chen J

更新日期：2015-03-03 00:00:00

abstract：:A new type of self-assembling peptide (sapeptide) scaffolds that serve as substrates for neurite outgrowth and synapse formation is described. These peptide-based scaffolds are amenable to molecular design by using chemical or biotechnological syntheses. They can be tailored to a variety of applications. The sapeptide...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Holmes TC,de Lacalle S,Su X,Liu G,Rich A,Zhang S

更新日期：2000-06-06 00:00:00

abstract：:The biconcave disk shape and deformability of mammalian RBCs rely on the membrane skeleton, a viscoelastic network of short, membrane-associated actin filaments (F-actin) cross-linked by long, flexible spectrin tetramers. Nonmuscle myosin II (NMII) motors exert force on diverse F-actin networks to control cell shapes,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith AS,Nowak RB,Zhou S,Giannetto M,Gokhin DS,Papoin J,Ghiran IC,Blanc L,Wan J,Fowler VM

更新日期：2018-05-08 00:00:00

abstract：:Bacteria in the human oral cavity often grow in an attached multispecies biofilm community. Members of this community display defined interactions that have an impact on the physiology of the individual and the group. Here, we show that during coculture growth with streptococci, the oral pathogen Aggregatibacter actin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ramsey MM,Whiteley M

更新日期：2009-02-03 00:00:00

abstract：:Plants can recognize and resist invading pathogens by signaling the induction of rapid defense responses. Often these responses are mediated by single dominant resistance genes (R genes). The products of R genes have been postulated to recognize the pathogen and trigger rapid host defense responses. Here we describe i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dinesh-Kumar SP,Whitham S,Choi D,Hehl R,Corr C,Baker B

更新日期：1995-05-09 00:00:00

abstract：:A distinct phosphodiesterasic activity (EC 3.1.4) was found in both mono- and dicotyledonous plants that catalyzes the hydrolytic breakdown of ADPglucose (ADPG) to produce equimolar amounts of glucose-1-phosphate and AMP. The enzyme responsible for this activity, referred to as ADPG pyrophosphatase (AGPPase), was puri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rodriguez-López M,Baroja-Fernández E,Zandueta-Criado A,Pozueta-Romero J

更新日期：2000-07-18 00:00:00

abstract：:Transcription is a central step in gene expression, in which the DNA template is processively read by RNA polymerase II (Pol II), synthesizing a complementary messenger RNA transcript. At each cycle, Pol II moves exactly one register along the DNA, a process known as translocation. Although X-ray crystal structures ha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Silva DA,Weiss DR,Pardo Avila F,Da LT,Levitt M,Wang D,Huang X

更新日期：2014-05-27 00:00:00

abstract：:Pain reduction and enhancement can be produced by means of conditioning procedures, yet the role of awareness during the acquisition stage of classical conditioning is unknown. We used psychophysical measures to establish whether conditioned analgesic and hyperalgesic responses could be acquired by unseen (subliminall...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jensen K,Kirsch I,Odmalm S,Kaptchuk TJ,Ingvar M

更新日期：2015-06-23 00:00:00

abstract：:3H-Labeled complementary DNA specific for the envelope glycoprotein (env) gene of avian leukosis-sarcoma viruses was isolated by selective nucleic acid hybridization techniques, and used to analyze the expression of the endogenous provirus. The endogenous provirus in certain cell types termed chicken helper factor pos...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hayward WS,Hanafusa H

更新日期：1976-07-01 00:00:00

abstract：:In earlier papers L.W. introduced two sequences of higher-rank zeta functions associated to a smooth projective curve over a finite field, both of them generalizing the Artin zeta function of the curve. One of these zeta functions is defined geometrically in terms of semistable vector bundles of rank n over the curve ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weng L,Zagier D

更新日期：2020-03-24 00:00:00

abstract：:This paper examines the relationship between various treatment parameters within a latent variable model when the effects of treatment depend on the recipient's observed and unobserved characteristics. We show how this relationship can be used to identify the treatment parameters when they are identified and to bound ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heckman JJ,Vytlacil EJ

更新日期：1999-04-13 00:00:00

abstract：:Viral genome packaging into capsids is powered by high-force-generating motor proteins. In the presence of all packaging components, ATP-powered translocation in vitro expels all detectable tightly bound YOYO-1 dye from packaged short dsDNA substrates and removes all aminoacridine dye from packaged genomic DNA in vivo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dixit AB,Ray K,Black LW

更新日期：2012-12-11 00:00:00