Higher-rank zeta functions and SL n -zeta functions for curves.

abstract：:Cognitive flexibility depends on a fast neural learning mechanism for enhancing momentary relevant over irrelevant information. A possible neural mechanism realizing this enhancement uses fast spiking interneurons (FSIs) in the striatum to train striatal projection neurons to gate relevant and suppress distracting cor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Banaie Boroujeni K,Oemisch M,Hassani SA,Womelsdorf T

更新日期：2020-07-28 00:00:00

abstract：:We describe a model for early onset preeclampsia (EOPE) that uses induced pluripotent stem cells (iPSCs) generated from umbilical cords of EOPE and control (CTL) pregnancies. These iPSCs were then converted to placental trophoblast (TB) representative of early pregnancy. Marker gene analysis indicated that both sets o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sheridan MA,Yang Y,Jain A,Lyons AS,Yang P,Brahmasani SR,Dai A,Tian Y,Ellersieck MR,Tuteja G,Schust DJ,Schulz LC,Ezashi T,Roberts RM

更新日期：2019-03-05 00:00:00

abstract：:Photonic materials with positionally ordered structure can interact strongly with light to produce brilliant structural colors. Here, we found that the nonperiodic nematic liquid crystals of nanoplates can also display structural color with only significant orientational order. Owing to the loose stacking of the nemat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zeng M,King D,Huang D,Do C,Wang L,Chen M,Lei S,Lin P,Chen Y,Cheng Z

更新日期：2019-09-10 00:00:00

abstract：:Fusions with the bacterial gene for chloramphenicol acetyltransferase followed by P-element-mediated germ-line transformation in Drosophila have permitted localization of the DNA sequence that confers a high degree of developmental specificity on a pair of silkmoth eggshell (chorion) genes. The short, 272-base-pair, 5...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mitsialis SA,Spoerel N,Leviten M,Kafatos FC

更新日期：1987-11-01 00:00:00

abstract：:Genetically obese (ob/ob) mice, mice that became obese after treatment with gold thioglucose, and lean animals were studied in the euthyroid state, after induction of hypothyroidism, and after treatment with triiodothyronine. The activity of glycerol 3-phosphate dehydrogenase (sn-glycerol-3-phosphate:(acceptor) oxidor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： York DA,Bray GA,Yukimura Y

更新日期：1978-01-01 00:00:00

abstract：:The Dbf4Cdc7 kinase acts at the level of individual origins to promote the initiation of DNA replication. We demonstrate through both immunoprecipitation and two-hybrid assays that a domain comprising the first 296 aa of Dbf4p interacts with Orc2p and Orc3p subunits of the origin recognition complex (ORC). Given that ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Duncker BP,Shimada K,Tsai-Pflugfelder M,Pasero P,Gasser SM

更新日期：2002-12-10 00:00:00

abstract：:Parinaric acid (9,11,13,15-octadecatetraenoic acid), a conjugated tetraene fatty acid, undergoes a second-order photochemical reaction in phospholipid bilayers. The reaction results in the loss of the characteristic absorption of this chromophore and the development of new absorption demonstrating the presence of a tr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morgan CG,Hudson B,Wolber PK

更新日期：1980-01-01 00:00:00

abstract：:The relative importance of the roles of adaptation and chance in determining genetic diversity and evolution has received attention in the last 50 years, but our understanding is still incomplete. All statements about the relative effects of evolutionary factors, especially drift, need confirmation by strong demograph...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chiaroni J,Underhill PA,Cavalli-Sforza LL

更新日期：2009-12-01 00:00:00

abstract：:Purified diphtheria toxin is shown to inhibit protein synthesis in Ehrlich-Lettré ascites carcinoma cells in vitro. Protein synthesis in Ehrlich-Lettré cells is at least 10,000 times more sensitive to toxin than protein synthesis in normal mouse spleen or thymus cells. This sensitivity correlates with the observation ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Iglewski BH,Rittenberg MB

更新日期：1974-07-01 00:00:00

abstract：:Pleistocene residential sites with multiple contemporaneous human burials are extremely rare in the Americas. We report mitochondrial genomic variation in the first multiple mitochondrial genomes from a single prehistoric population: two infant burials (USR1 and USR2) from a common interment at the Upward Sun River Si...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tackney JC,Potter BA,Raff J,Powers M,Watkins WS,Warner D,Reuther JD,Irish JD,O'Rourke DH

更新日期：2015-11-10 00:00:00

abstract：:Although the ribosome is a very general catalyst, it cannot synthesize all protein sequences equally well. For example, ribosomes stall on the secretion monitor (SecM) leader peptide to regulate expression of a downstream gene. Using a genetic selection in Escherichia coli, we identified additional nascent peptide mot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Woolstenhulme CJ,Parajuli S,Healey DW,Valverde DP,Petersen EN,Starosta AL,Guydosh NR,Johnson WE,Wilson DN,Buskirk AR

更新日期：2013-03-05 00:00:00

abstract：:Translation of injected mRNA in oocytes of Xenopus laevis has been used as a highly sensitive and quantitative assay for interferon mRNA. Injection into oocytes of polyadenylylated RNA extracted from poly(I).poly(C)-induced human diploid fibroblasts (FS-4) leads to the synthesis of biologically active human fibroblast...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sehgal PB,Dobberstein B,Tamm I

更新日期：1977-08-01 00:00:00

abstract：:During endoplasmic reticulum-associated degradation, the multifunctional AAA ATPase p97 is part of a protein degradation complex. p97 associates via its N-terminal domain with various cofactors to recruit ubiquitinated substrates. It also interacts with alternative substrate-processing cofactors, such as Ufd2, Ufd3, a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhao G,Zhou X,Wang L,Li G,Schindelin H,Lennarz WJ

更新日期：2007-05-22 00:00:00

abstract：:Light activates rod outer segment (ROS) phosphodiesterase (PDEase), as shown by previous biochemical and physiological studies. We have further investigated the role of PDEase in this system by injecting trypsin-activated PDEase, purified from bovine ROS, into single ROS of the isolated retina of the toad Bufo marinus...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shimoda Y,Hurley JB,Miller WH

更新日期：1984-01-01 00:00:00

abstract：:Angiogenesis restores blood flow to healing tissues, a process that is inhibited by high doses of glucocorticoids. However, the role of endogenous glucocorticoids and the potential for antiglucocorticoid therapy to enhance angiogenesis is unknown. Using in vitro and in vivo models of angiogenesis in mice, we examined ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Small GR,Hadoke PW,Sharif I,Dover AR,Armour D,Kenyon CJ,Gray GA,Walker BR

更新日期：2005-08-23 00:00:00

abstract：:Glial fibrillary acidic protein (GFAP) is an intermediate-filament (IF) protein that is highly specific for cells of astroglial lineage, although its tissue-specific role is speculative. Determination of the primary structure of this protein should be of importance for understanding the functional role it plays in ast...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reeves SA,Helman LJ,Allison A,Israel MA

更新日期：1989-07-01 00:00:00

abstract：:Understanding the origin, nature, and functional significance of complex patterns of neural activity, as recorded by diverse electrophysiological and neuroimaging techniques, is a central challenge in neuroscience. Such patterns include collective oscillations emerging out of neural synchronization as well as highly h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： di Santo S,Villegas P,Burioni R,Muñoz MA

更新日期：2018-02-13 00:00:00

abstract：:Hairs, feathers, and scales normally exhibit precise orientations with respect to the body axes. In Frizzled6 (Fz6)(-/-) mice, the global orientation of hair follicles is disrupted, leading to waves, whorls, and tufts, each comprising many hundreds of hairs. By analyzing the orientation of developing hair follicles, w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang Y,Badea T,Nathans J

更新日期：2006-12-26 00:00:00

abstract：:To study the structure and function of the gene for parathyroid hormone, we obtained recombinant plasmids containing bovine parathyroid hormone cDNA. The nucleotide sequence at the 5' terminus (relative to the sense strand) of the cDNA insert in a recombinant plasmid, pPTHi4, was different from that previously reporte...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weaver CA,Gordon DF,Kemper B

更新日期：1981-07-01 00:00:00

abstract：:The maintenance of robust blood flow to the brain is crucial to the health of brain tissue. We examined the pial network of the middle cerebral artery, which distributes blood from the cerebral arteries to the penetrating arterioles that source neocortical microvasculature, to characterize how vascular topology may su...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blinder P,Shih AY,Rafie C,Kleinfeld D

更新日期：2010-07-13 00:00:00

abstract：:The amino acid sequence for chicken smooth muscle myosin light chain kinase (smMLCK) was deduced from a full-length cDNA. This has allowed definition of both the complete sequence of the inactive 64-kDa proteolytic fragment, which contains the pseudosubstrate autoregulatory sequence, and of the active 61-kDa Ca2+/calm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Olson NJ,Pearson RB,Needleman DS,Hurwitz MY,Kemp BE,Means AR

更新日期：1990-03-01 00:00:00

abstract：:Ciliary neurotrophic factor (CNTF) receptor controls a pathway supporting the differentiation and survival of a wide range of neural cell types during development and in adulthood. Cardiotrophin-like cytokine (CLC)-cytokine-like factor 1 (CLF) composite cytokine is a second ligand for the CNTF alpha-component receptor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rousseau F,Gauchat JF,McLeod JG,Chevalier S,Guillet C,Guilhot F,Cognet I,Froger J,Hahn AF,Knappskog PM,Gascan H,Boman H

更新日期：2006-06-27 00:00:00

abstract：:Mutational processes of simple sequence repeats (SSRs) in complex genomes are poorly understood. We examined these processes by introducing a two-phase mutation model. In this model, most mutations are single-step changes, but infrequent large jumps in repeat number also occur. We used computer simulations to determin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Di Rienzo A,Peterson AC,Garza JC,Valdes AM,Slatkin M,Freimer NB

更新日期：1994-04-12 00:00:00

abstract：:Pneumococcal peptidoglycan amidase (N-acetylmuramoyl-L-alanine amidase, EC 3.5.1.28) and phage CPL1 lysozyme degrade a common substrate (choline-containing pneumococcal cell walls); the former hydrolyzes the bond between muramic acid and alanine, whereas the latter breaks down the linkage between muramic acid and gluc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Díaz E,López R,García JL

更新日期：1990-10-01 00:00:00

abstract：:Glycan-protein interactions are emerging as important modulators of membrane protein organization and dynamics, regulating multiple cellular functions. In particular, it has been postulated that glycan-mediated interactions regulate surface residence time of glycoproteins and endocytosis. How this precisely occurs is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Torreno-Pina JA,Castro BM,Manzo C,Buschow SI,Cambi A,Garcia-Parajo MF

更新日期：2014-07-29 00:00:00

abstract：:Peroxisomes play an essential role in a number of different metabolic pathways, including the beta-oxidation of a distinct set of fatty acids and fatty acid derivatives. The importance of the peroxisomal beta-oxidation system in humans is made apparent by the existence of a group of inherited diseases in which peroxis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： van Grunsven EG,van Berkel E,Ijlst L,Vreken P,de Klerk JB,Adamski J,Lemonde H,Clayton PT,Cuebas DA,Wanders RJ

更新日期：1998-03-03 00:00:00

abstract：:This paper finds that a 10-μg/m3 increase in airborne particulate matter [particulate matter smaller than 10 μm (PM10)] reduces life expectancy by 0.64 years (95% confidence interval = 0.21-1.07). This estimate is derived from quasiexperimental variation in PM10 generated by China's Huai River Policy, which provides f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ebenstein A,Fan M,Greenstone M,He G,Zhou M

更新日期：2017-09-26 00:00:00

abstract：:Aerobic glycolysis (AG), that is, the nonoxidative metabolism of glucose, contributes significantly to anabolic pathways, rapid energy generation, task-induced activity, and neuroprotection; yet high AG is also associated with pathological hallmarks such as amyloid-β deposition. An important yet unresolved question is...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen Y,Lin Q,Liao X,Zhou C,He Y

更新日期：2021-01-05 00:00:00

abstract：:The human Thy-1 gene has been isolated and sequenced and compared to the rat and mouse Thy-1 genes. All three genes are organized in the same way: one exon encoding the majority of the signal peptide, another encoding the transmembrane segment, and a third encoding the remainder of the protein. One major structural di...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seki T,Spurr N,Obata F,Goyert S,Goodfellow P,Silver J

更新日期：1985-10-01 00:00:00

abstract：:Recent advances in our understanding of the immune response are allowing for the logical design of new approaches to cancer immunization. One area of interest is the development of new immune adjuvants. Immunostimulatory oligodeoxynucleotides containing the CpG motif (CpG ODN) can induce production of a wide variety o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weiner GJ,Liu HM,Wooldridge JE,Dahle CE,Krieg AM

更新日期：1997-09-30 00:00:00