Insulin growth factor signaling is regulated by microRNA-486, an underexpressed microRNA in lung cancer.

abstract：:The first step in poliovirus replication is binding of virus to a cellular receptor. Mouse L cells, which are resistant to poliovirus infection because they do not bear a poliovirus receptor, were transformed with HeLa cell (human) DNA to poliovirus sensitivity at a frequency of approximately 1 in 50,000 transformants...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mendelsohn C,Johnson B,Lionetti KA,Nobis P,Wimmer E,Racaniello VR

更新日期：1986-10-01 00:00:00

abstract：:Nodules harboring nitrogen-fixing rhizobia are a well-known trait of legumes, but nodules also occur in other plant lineages, with rhizobia or the actinomycete Frankia as microsymbiont. It is generally assumed that nodulation evolved independently multiple times. However, molecular-genetic support for this hypothesis ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： van Velzen R,Holmer R,Bu F,Rutten L,van Zeijl A,Liu W,Santuari L,Cao Q,Sharma T,Shen D,Roswanjaya Y,Wardhani TAK,Kalhor MS,Jansen J,van den Hoogen J,Güngör B,Hartog M,Hontelez J,Verver J,Yang WC,Schijlen E,Repin

更新日期：2018-05-15 00:00:00

abstract：:Epstein-Barr virus (EBV), an oncogenic herpesvirus, encodes two small RNAs (EBERs) that are expressed at high levels during latent transformation of human B lymphocytes. Here we report that a 15-kDa cellular protein called EAP (for EBER associated protein), previously shown to bind EBER1, is in fact the ribosomal prot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Toczyski DP,Matera AG,Ward DC,Steitz JA

更新日期：1994-04-12 00:00:00

abstract：:We have cloned an additional member (GC-D) of the membrane receptor guanylyl cyclase [GTP pyrophosphate-lyase (cyclizing), EC 4.6.1.2] family that is specifically expressed in a subpopulation of olfactory sensory neurons. The extracellular, putative ligand-binding domain of the olfactory cyclase is similar in primary ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fülle HJ,Vassar R,Foster DC,Yang RB,Axel R,Garbers DL

更新日期：1995-04-11 00:00:00

abstract：:USF1 and USF2 are ubiquitously expressed transcription factors implicated as antagonists of the c-Myc protooncoprotein in the control of cellular proliferation. To determine the biological role of the USF proteins, mutant mice were generated by homologous recombination in embryonic stem cells. USF1-null mice were viab...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sirito M,Lin Q,Deng JM,Behringer RR,Sawadogo M

更新日期：1998-03-31 00:00:00

abstract：:Increased cardiovascular mortality occurs in diabetic patients with or without coronary artery disease and is attributed to the presence of diabetic cardiomyopathy. One potential mechanism is hyperglycemia that has been reported to activate protein kinase C (PKC), preferentially the beta isoform, which has been associ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wakasaki H,Koya D,Schoen FJ,Jirousek MR,Ways DK,Hoit BD,Walsh RA,King GL

更新日期：1997-08-19 00:00:00

abstract：:Gene regulation by imposed localization was studied by using designed zinc finger proteins that bind 18-bp DNA sequences in the 5' untranslated regions of the protooncogenes erbB-2 and erbB-3. Transcription factors were generated by fusion of the DNA-binding proteins to repression or activation domains. When introduce...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Beerli RR,Dreier B,Barbas CF 3rd

更新日期：2000-02-15 00:00:00

abstract：:Drosophila heteroneura and D. silvestris are sympatric species living on the island of Hawaii, while D. planitibia is allopatric on the nearby island of Maui. A pronounced ethological isolation is found between the sympatric species, and none between allopatric ones, except that D. planitibia females discriminate agai...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ahearn JN,Carson HL,Dobzhansky T,Kaneshiro KY

更新日期：1974-03-01 00:00:00

abstract：:Monoclonal antibodies were used to isolate nonneutralizable antigenic variants in the hemagglutinin-neuraminidase glycoprotein of Newcastle disease virus. It had been found that a large percentage of virus retains infectivity despite binding neutralizing antibody. This high persistent fraction of nonneutralized virus ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Iorio RM,Bratt MA

更新日期：1985-10-01 00:00:00

abstract：:The mitochondrial trifunctional protein (TFP) catalyzes three reactions in the fatty acid β-oxidation process. Mutations in the two TFP subunits cause mitochondrial trifunctional protein deficiency and acute fatty liver of pregnancy that can lead to death. Here we report a 4.2-Å cryo-electron microscopy α2β2 tetrameri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liang K,Li N,Wang X,Dai J,Liu P,Wang C,Chen XW,Gao N,Xiao J

更新日期：2018-07-03 00:00:00

abstract：:Modulation of gene expression by steroid hormones is mediated by receptor proteins that associate with regulatory elements of responsive genes upon binding the hormone ligand. The finding that two glucocorticoid responsive elements act cooperatively to stimulate transcription of the tyrosine aminotransferase gene prom...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ankenbauer W,Strähle U,Schütz G

更新日期：1988-10-01 00:00:00

abstract：:Successful treatment in allergic, autoimmune, and infectious diseases often requires altering the nature of a detrimental immune response mediated by a particular CD4+ T helper (Th) cell subset. While several factors contribute to the development of CD4+ Th1 and Th2 cells, the requirements for switching an established...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nabors GS,Afonso LC,Farrell JP,Scott P

更新日期：1995-04-11 00:00:00

abstract：:The study of specific trans-acting transcription factors in prokaryotes and lower eukaryotes has been greatly facilitated by genetic analysis of mutant strains deficient in such factors. We have developed such a system to study mammalian trans-acting factors that regulate the transcription of class II major histocompa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Calman AF,Peterlin BM

更新日期：1988-12-01 00:00:00

abstract：:Targeting the endothelial cell cycle as an antiangiogenic strategy has been difficult given the ubiquitous expression of critical cell cycle regulators. Here, we show that the antiangiogenic drug TNP-470 displays striking cell-type specificity insofar as it induces the expression of p21(CIP/WAF), a cyclin-dependent ki...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yeh JR,Mohan R,Crews CM

更新日期：2000-11-07 00:00:00

abstract：:Results are reported showing that pituitary extracts stimulate growth of 3T3 cells, an established line of mouse fibroblast. Cells were cultured in medium containing an organic buffer (HEPES; N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid), which increases the serum requirement for cell growth. The pituitary grow...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Armelin HA

更新日期：1973-09-01 00:00:00

abstract：:Arsenic poisoning affects millions of people worldwide. Human arsenic intake from rice consumption can be substantial because rice is particularly efficient in assimilating arsenic from paddy soils, although the mechanism has not been elucidated. Here we report that two different types of transporters mediate transpor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ma JF,Yamaji N,Mitani N,Xu XY,Su YH,McGrath SP,Zhao FJ

更新日期：2008-07-22 00:00:00

abstract：:There is considerable interest in engineering plant cell wall components, particularly lignin, to improve forage quality and biomass properties for processing to fuels and bioproducts. However, modifying lignin content and/or composition in transgenic plants through down-regulation of lignin biosynthetic enzymes can i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gallego-Giraldo L,Liu C,Pose-Albacete S,Pattathil S,Peralta AG,Young J,Westpheling J,Hahn MG,Rao X,Knox JP,De Meester B,Boerjan W,Dixon RA

更新日期：2020-02-11 00:00:00

abstract：:Induction, maintenance, and amplification of tumor-protective immunity after cytokine gene therapy is essential for the clinical success of immunotherapeutic approaches. We investigated whether this could be achieved by single-chain IL-12 (scIL-12) gene therapy followed by tumor-targeted IL-2 using a fusion protein co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lode HN,Xiang R,Duncan SR,Theofilopoulos AN,Gillies SD,Reisfeld RA

更新日期：1999-07-20 00:00:00

abstract：:The nucleus accumbens (NAc) regulates motivated behavior by, in part, processing excitatory synaptic projections from several brain regions. Among these regions, the prefrontal cortex (PFC) and basolateral amygdala, convey executive control and affective states, respectively. Whereas glutamatergic synaptic transmissio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Suska A,Lee BR,Huang YH,Dong Y,Schlüter OM

更新日期：2013-01-08 00:00:00

abstract：:We previously reported that laminar flow activates peroxisome proliferator-activated receptor gamma (PPARgamma) in vascular endothelial cells in a ligand-dependent manner that involves phospholipase A2 and cytochrome P450 epoxygenases. In this study, we investigated whether epoxyeicosatrienoic acids (EETs), the cataly...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu Y,Zhang Y,Schmelzer K,Lee TS,Fang X,Zhu Y,Spector AA,Gill S,Morisseau C,Hammock BD,Shyy JY

更新日期：2005-11-15 00:00:00

abstract：:Signaling lymphocytic activation molecule family 3 (SLAMF3/Ly9) is a coregulatory molecule implicated in T-cell activation and differentiation. Systemic lupus erythematosus (SLE) is characterized by aberrant T-cell activation and compromised IL-2 production, leading to abnormal regulatory T-cell (Treg) development/fun...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Comte D,Karampetsou MP,Kis-Toth K,Yoshida N,Bradley SJ,Mizui M,Kono M,Solomon JR,Kyttaris VC,Tsokos GC

更新日期：2016-08-16 00:00:00

abstract：:Hydrocarbon films confined between smooth mica surfaces have long provided an experimental playground for model studies of structure and dynamics of confined liquids. However, fundamental questions regarding the phase behavior and shear properties in this simple system remain unsolved. With ultrasensitive resolution i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith AM,Hallett JE,Perkin S

更新日期：2019-12-17 00:00:00

abstract：:Freezing avoidance conferred by different types of antifreeze proteins in various polar and subpolar fishes represents a remarkable example of cold adaptation, but how these unique proteins arose is unknown. We have found that the antifreeze glycoproteins (AFGPs) of the predominant Antarctic fish taxon, the notothenio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen L,DeVries AL,Cheng CH

更新日期：1997-04-15 00:00:00

abstract：:A ribosomal RNA-encoding DNA (rDNA) cloned sequence, consisting of a 0.8-kilobase fragment from the 26S/nontranscribed spacer region, was used to identify diagnostic restriction enzyme fragments that distinguish the Moreton and Torresian subspecies of the grasshopper Caledia captiva. These restriction fragments were t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arnold ML,Shaw DD,Contreras N

更新日期：1987-06-01 00:00:00

abstract：:Some cells from cultured embryonic mouse hypothalamus were found to express aromatic-L-amino acid decarboxylase (EC 4.1.1.28) activity and serotonin uptake and storage. These neuron-like cells differed from serotoninergic neurons in cultured embryonic mouse brain stem since they did not contain tryptophan hydroxylase....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： De Vitry F,Hamon M,Catelon J,Dubois M,Thibault J

更新日期：1986-11-01 00:00:00

abstract：:The chemosmotic model provides a framework for visualizing energy-coupled reactions (vectorial reaction sequences, membrane-dependent gradient formation, and charge separation of reacting species) and a mechanism for energy coupling (indirect coupling between the driving and driven reaction sequences mediated by a mem...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Green DE

更新日期：1981-04-01 00:00:00

abstract：:The immunocytochemical demonstration of (pro)insulin on intracellular membrane compartments of the pancreatic B cell reveals that the immunolabeling detected by the protein A/gold method is associated, at the level of the Golgi apparatus, with the inner aspect of the cisternal membranes; on the secretory granules, by ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Orci L,Ravazzola M,Perrelet A

更新日期：1984-11-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR)-regulated gene expression is stimulated independently by the cellular trans-activator NF-kappa B and the viral protein Tat. Noncytotoxic concentrations of the drug pentoxifylline (PTX) inhibited interaction of NF-kappa B with its motif and the stim...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Biswas DK,Ahlers CM,Dezube BJ,Pardee AB

更新日期：1993-12-01 00:00:00

abstract：:Argonaute (Ago) proteins are the key component of the RNA-induced silencing complex and mediate RNA interference (RNAi) in association with small RNAs. Although overall the mechanism of RNAi is well understood, many molecular details of this complex process are not. Here we report about in-depth steady-state and, in p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Deerberg A,Willkomm S,Restle T

更新日期：2013-10-29 00:00:00

abstract：:Two striking differences between humans and our closest living relatives, chimpanzees and gorillas, are the size of our brains (larger by a factor of three or four) and our life span (longer by a factor of about two). Our thesis is that these two distinctive features of humans are products of coevolutionary selection....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaplan HS,Robson AJ

更新日期：2002-07-23 00:00:00